ENSG00000135862

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258341 ENSG00000135862 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMC1 protein_coding protein_coding 41.11775 40.48114 48.69284 5.918961 3.46165 0.2663997 31.7481335 32.20725 36.785763 4.734993 1.0497459 0.19170638 0.77545417 0.7962333 0.7606667 -0.03556667 8.716133e-01 2.241469e-17 FALSE  
ENST00000478064 ENSG00000135862 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMC1 protein_coding processed_transcript 41.11775 40.48114 48.69284 5.918961 3.46165 0.2663997 0.7611235 0.00000 2.478021 0.000000 0.3755059 7.95885506 0.01584583 0.0000000 0.0504000 0.05040000 2.241469e-17 2.241469e-17 FALSE  
ENST00000495918 ENSG00000135862 HEK293_OSMI2_6hA HEK293_TMG_6hB LAMC1 protein_coding processed_transcript 41.11775 40.48114 48.69284 5.918961 3.46165 0.2663997 7.2434044 7.58380 7.682789 1.526227 1.5243017 0.01868478 0.17704583 0.1844667 0.1551333 -0.02933333 8.147250e-01 2.241469e-17 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000135862 E001 209.6822662 0.0072431927 5.144699e-01 7.113334e-01 1 183023420 183024134 715 + 2.334 2.315 -0.063
ENSG00000135862 E002 0.2852693 0.2898130980 2.627422e-01   1 183096544 183096620 77 + 0.214 0.000 -10.650
ENSG00000135862 E003 323.7613357 0.0003018649 1.808115e-08 8.015127e-07 1 183103328 183103632 305 + 2.561 2.456 -0.348
ENSG00000135862 E004 238.0345910 0.0002722598 8.932928e-07 2.575143e-05 1 183108276 183108406 131 + 2.429 2.326 -0.343
ENSG00000135862 E005 228.5843076 0.0003097597 1.329003e-04 1.896281e-03 1 183110488 183110580 93 + 2.401 2.321 -0.266
ENSG00000135862 E006 191.5748170 0.0038508569 9.880950e-02 2.797154e-01 1 183110581 183110654 74 + 2.313 2.260 -0.177
ENSG00000135862 E007 317.3858857 0.0022628757 2.410295e-02 1.093723e-01 1 183114531 183114719 189 + 2.531 2.475 -0.186
ENSG00000135862 E008 256.2893579 0.0003517955 2.415988e-03 1.978542e-02 1 183115520 183115637 118 + 2.438 2.380 -0.193
ENSG00000135862 E009 234.3237923 0.0002833569 8.774831e-05 1.339477e-03 1 183116577 183116675 99 + 2.410 2.329 -0.270
ENSG00000135862 E010 225.8184055 0.0002156090 1.339647e-02 7.201507e-02 1 183116767 183116903 137 + 2.377 2.331 -0.154
ENSG00000135862 E011 3.7916936 0.0119950761 2.073709e-01 4.386416e-01 1 183116904 183116986 83 + 0.768 0.589 -0.753
ENSG00000135862 E012 228.0352764 0.0003300553 4.150379e-03 2.999786e-02 1 183117320 183117442 123 + 2.385 2.328 -0.190
ENSG00000135862 E013 342.2808992 0.0002546300 1.011080e-05 2.116674e-04 1 183117534 183117723 190 + 2.570 2.494 -0.252
ENSG00000135862 E014 260.7834635 0.0002187271 4.347794e-03 3.108211e-02 1 183118034 183118146 113 + 2.442 2.391 -0.170
ENSG00000135862 E015 343.2910640 0.0001899893 2.021414e-01 4.322765e-01 1 183121723 183121944 222 + 2.542 2.530 -0.039
ENSG00000135862 E016 375.3687265 0.0001976818 1.335400e-01 3.373472e-01 1 183122063 183122251 189 + 2.581 2.566 -0.051
ENSG00000135862 E017 421.6636538 0.0007012629 6.936060e-01 8.314292e-01 1 183124631 183124876 246 + 2.622 2.627 0.016
ENSG00000135862 E018 0.7906259 0.2326504953 2.576008e-01   1 183125188 183125396 209 + 0.121 0.359 1.994
ENSG00000135862 E019 291.1722793 0.0002483799 3.943511e-01 6.238810e-01 1 183125397 183125550 154 + 2.448 2.480 0.107
ENSG00000135862 E020 282.6753813 0.0004503732 8.767947e-01 9.396086e-01 1 183126120 183126262 143 + 2.448 2.458 0.034
ENSG00000135862 E021 384.9460620 0.0002748271 6.491120e-01 8.029232e-01 1 183127226 183127404 179 + 2.583 2.588 0.017
ENSG00000135862 E022 151.0174841 0.0014318993 2.691867e-01 5.089522e-01 1 183128594 183128595 2 + 2.193 2.169 -0.081
ENSG00000135862 E023 417.6974186 0.0004566142 3.841096e-01 6.156647e-01 1 183128596 183128750 155 + 2.622 2.619 -0.011
ENSG00000135862 E024 0.1779838 0.0352850647 4.705671e-01   1 183128751 183128820 70 + 0.122 0.000 -11.094
ENSG00000135862 E025 515.8560183 0.0001794076 1.828329e-01 4.076681e-01 1 183130344 183130549 206 + 2.714 2.706 -0.027
ENSG00000135862 E026 358.6333934 0.0001545981 2.870138e-01 5.277800e-01 1 183131299 183131378 80 + 2.559 2.552 -0.022
ENSG00000135862 E027 422.5281244 0.0001547203 9.188928e-01 9.616542e-01 1 183132400 183132537 138 + 2.621 2.632 0.040
ENSG00000135862 E028 432.5777539 0.0001311623 3.563358e-02 1.432929e-01 1 183133406 183133550 145 + 2.610 2.660 0.167
ENSG00000135862 E029 248.8867344 0.0002151397 6.719754e-03 4.330318e-02 1 183134660 183134689 30 + 2.357 2.433 0.253
ENSG00000135862 E030 373.8401543 0.0001882046 2.410308e-02 1.093723e-01 1 183134690 183134809 120 + 2.544 2.601 0.188
ENSG00000135862 E031 373.0708154 0.0014724763 3.883077e-01 6.191520e-01 1 183135042 183135156 115 + 2.554 2.592 0.125
ENSG00000135862 E032 451.8992925 0.0017310686 1.907429e-02 9.273114e-02 1 183136386 183136585 200 + 2.615 2.692 0.257
ENSG00000135862 E033 431.5418149 0.0012712326 5.485968e-03 3.714243e-02 1 183137669 183137827 159 + 2.591 2.674 0.276
ENSG00000135862 E034 5.6703613 0.1061619661 5.588562e-01 7.424383e-01 1 183137828 183137905 78 + 0.887 0.780 -0.417
ENSG00000135862 E035 367.7462682 0.0018302084 1.614311e-02 8.230668e-02 1 183140404 183140503 100 + 2.521 2.603 0.275
ENSG00000135862 E036 2739.2033244 0.0011370198 3.085723e-05 5.535298e-04 1 183142534 183145592 3059 + 3.395 3.473 0.258