ENSG00000135838

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367553 ENSG00000135838 HEK293_OSMI2_6hA HEK293_TMG_6hB NPL protein_coding protein_coding 3.53062 2.311012 3.06496 0.2749453 0.3091366 0.4058134 1.25927667 0.17707941 1.5247789 0.17707941 0.26468805 3.0363081 0.35157083 0.08510000 0.52213333 0.437033333 0.15773046 0.01899245 FALSE TRUE
ENST00000367554 ENSG00000135838 HEK293_OSMI2_6hA HEK293_TMG_6hB NPL protein_coding protein_coding 3.53062 2.311012 3.06496 0.2749453 0.3091366 0.4058134 0.17795126 0.09434244 0.1481163 0.03329738 0.01706718 0.5996603 0.05330000 0.04503333 0.04830000 0.003266667 0.94038959 0.01899245 FALSE TRUE
ENST00000479721 ENSG00000135838 HEK293_OSMI2_6hA HEK293_TMG_6hB NPL protein_coding processed_transcript 3.53062 2.311012 3.06496 0.2749453 0.3091366 0.4058134 0.37739099 0.51949008 0.4794242 0.32583425 0.26742953 -0.1135182 0.10598333 0.20086667 0.14110000 -0.059766667 0.98696216 0.01899245 FALSE FALSE
ENST00000488424 ENSG00000135838 HEK293_OSMI2_6hA HEK293_TMG_6hB NPL protein_coding processed_transcript 3.53062 2.311012 3.06496 0.2749453 0.3091366 0.4058134 0.09154503 0.02211817 0.2005496 0.02211817 0.06382310 2.7126985 0.02449583 0.01063333 0.06896667 0.058333333 0.25577456 0.01899245 FALSE TRUE
ENST00000614468 ENSG00000135838 HEK293_OSMI2_6hA HEK293_TMG_6hB NPL protein_coding protein_coding 3.53062 2.311012 3.06496 0.2749453 0.3091366 0.4058134 0.49453820 0.40392802 0.3657850 0.05374962 0.25990307 -0.1394725 0.13660417 0.18330000 0.10580000 -0.077500000 0.74408350 0.01899245 FALSE TRUE
MSTRG.2706.5 ENSG00000135838 HEK293_OSMI2_6hA HEK293_TMG_6hB NPL protein_coding   3.53062 2.311012 3.06496 0.2749453 0.3091366 0.4058134 0.53894993 0.47431988 0.1017164 0.07792648 0.06010911 -2.1161190 0.15467083 0.20886667 0.02980000 -0.179066667 0.01899245 0.01899245 FALSE TRUE
MSTRG.2706.6 ENSG00000135838 HEK293_OSMI2_6hA HEK293_TMG_6hB NPL protein_coding   3.53062 2.311012 3.06496 0.2749453 0.3091366 0.4058134 0.07681238 0.14379767 0.0000000 0.14379767 0.00000000 -3.9429617 0.02337500 0.07213333 0.00000000 -0.072133333 0.84621830 0.01899245 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000135838 E001 0.3641499 0.032230485 0.868788672   1 182789293 182789448 156 + 0.110 0.134 0.324
ENSG00000135838 E002 0.8439712 0.033920829 0.264785638   1 182789449 182789736 288 + 0.333 0.134 -1.675
ENSG00000135838 E003 0.1426347 0.031784991 0.599500699   1 182789737 182789740 4 + 0.110 0.000 -9.284
ENSG00000135838 E004 1.1302857 0.016139554 0.089945420   1 182789741 182789766 26 + 0.437 0.134 -2.268
ENSG00000135838 E005 1.2611538 0.024396762 0.259041179   1 182789767 182789768 2 + 0.437 0.235 -1.272
ENSG00000135838 E006 1.4638881 0.014854418 0.497881789 0.69941681 1 182789769 182789772 4 + 0.437 0.318 -0.682
ENSG00000135838 E007 1.4521216 0.151160870 0.957915930 0.98083360 1 182789773 182789782 10 + 0.392 0.384 -0.047
ENSG00000135838 E008 7.6213090 0.024396580 0.888525109 0.94592460 1 182789783 182789805 23 + 0.945 0.930 -0.058
ENSG00000135838 E009 3.2539633 0.008092248 0.003940274 0.02880911 1 182789806 182789904 99 + 0.388 0.830 1.997
ENSG00000135838 E010 1.1937092 0.523091309 0.858084384   1 182791248 182791330 83 + 0.339 0.324 -0.091
ENSG00000135838 E011 0.4873834 0.218321977 0.502866275   1 182792231 182792231 1 + 0.109 0.238 1.347
ENSG00000135838 E012 13.4603200 0.007007088 0.610895264 0.77754011 1 182792232 182792286 55 + 1.137 1.187 0.178
ENSG00000135838 E013 0.6709767 0.039012227 0.430647708   1 182794350 182794355 6 + 0.271 0.134 -1.264
ENSG00000135838 E014 16.6042574 0.022271312 0.708466278 0.84081916 1 182794356 182794439 84 + 1.259 1.218 -0.145
ENSG00000135838 E015 0.9444795 0.017410262 0.579574539   1 182795730 182795840 111 + 0.333 0.236 -0.680
ENSG00000135838 E016 17.4797065 0.003117442 0.207656556 0.43902205 1 182803698 182803771 74 + 1.302 1.199 -0.364
ENSG00000135838 E017 22.6820763 0.001916179 0.581980191 0.75837510 1 182806145 182806232 88 + 1.392 1.355 -0.130
ENSG00000135838 E018 3.5124434 0.006707775 0.179448459 0.40326689 1 182806233 182806531 299 + 0.556 0.755 0.851
ENSG00000135838 E019 0.3337900 0.027705684 0.872225631   1 182806532 182806532 1 + 0.110 0.134 0.322
ENSG00000135838 E020 1.0709555 0.015375049 0.001649199   1 182809185 182809307 123 + 0.000 0.546 12.697
ENSG00000135838 E021 0.3503582 0.029170960 0.874330827   1 182809843 182809970 128 + 0.110 0.134 0.321
ENSG00000135838 E022 19.8820710 0.001859478 0.116129835 0.30937654 1 182812156 182812213 58 + 1.371 1.254 -0.410
ENSG00000135838 E023 16.8836014 0.008965249 0.370538639 0.60437761 1 182814783 182814858 76 + 1.294 1.216 -0.277
ENSG00000135838 E024 14.3509229 0.002847867 0.693603419 0.83142925 1 182816714 182816806 93 + 1.172 1.208 0.128
ENSG00000135838 E025 17.0747792 0.003056104 0.361724068 0.59707113 1 182818541 182818637 97 + 1.227 1.303 0.266
ENSG00000135838 E026 14.6357804 0.002185233 0.119209278 0.31457207 1 182818638 182818689 52 + 1.127 1.263 0.479
ENSG00000135838 E027 12.8054663 0.003040757 0.278093996 0.51820658 1 182818813 182818859 47 + 1.088 1.189 0.360
ENSG00000135838 E028 8.7365474 0.047446105 0.667617826 0.81468687 1 182822115 182822199 85 + 0.999 0.942 -0.212
ENSG00000135838 E029 9.5786209 0.085125890 0.720582909 0.84858260 1 182825781 182825820 40 + 1.044 0.980 -0.234
ENSG00000135838 E030 3.9996839 0.072271435 0.040325534 0.15554553 1 182825821 182827020 1200 + 0.481 0.857 1.611
ENSG00000135838 E031 21.1441536 0.002882584 0.701070242 0.83630946 1 182828724 182828900 177 + 1.332 1.361 0.102
ENSG00000135838 E032 36.3122672 0.002988355 0.665138408 0.81312889 1 182828901 182829494 594 + 1.585 1.560 -0.085
ENSG00000135838 E033 9.7743219 0.003693218 0.934148676 0.96920779 1 182829495 182829602 108 + 1.022 1.031 0.033
ENSG00000135838 E034 22.7255660 0.006134403 0.713160647 0.84378479 1 182829603 182830384 782 + 1.387 1.361 -0.092