ENSG00000135837

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367607 ENSG00000135837 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP350 protein_coding protein_coding 7.097347 3.719524 11.28264 0.8831726 0.4681287 1.59832 1.5176938 0.71275596 2.4855051 0.12002865 0.07887686 1.787751 0.18388333 0.204233333 0.22066667 0.01643333 9.468298e-01 1.118588e-09 FALSE TRUE
ENST00000417046 ENSG00000135837 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP350 protein_coding protein_coding 7.097347 3.719524 11.28264 0.8831726 0.4681287 1.59832 1.3344693 1.56903092 0.1734678 0.54685990 0.17346785 -3.105440 0.30881667 0.395466667 0.01463333 -0.38083333 8.280702e-03 1.118588e-09 FALSE TRUE
ENST00000429851 ENSG00000135837 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP350 protein_coding protein_coding 7.097347 3.719524 11.28264 0.8831726 0.4681287 1.59832 1.6905257 1.19155252 3.0942833 0.25632539 0.05578922 1.369361 0.25256667 0.325166667 0.27536667 -0.04980000 7.476587e-01 1.118588e-09 FALSE TRUE
MSTRG.2682.2 ENSG00000135837 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP350 protein_coding   7.097347 3.719524 11.28264 0.8831726 0.4681287 1.59832 0.8258627 0.03218466 0.9236266 0.03218466 0.46271531 4.468055 0.08104583 0.008233333 0.08450000 0.07626667 7.110935e-01 1.118588e-09 FALSE TRUE
MSTRG.2682.7 ENSG00000135837 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP350 protein_coding   7.097347 3.719524 11.28264 0.8831726 0.4681287 1.59832 0.2803261 0.00000000 1.3453758 0.00000000 0.44388263 7.082549 0.02545000 0.000000000 0.11990000 0.11990000 1.103511e-03 1.118588e-09 FALSE TRUE
MSTRG.2682.8 ENSG00000135837 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP350 protein_coding   7.097347 3.719524 11.28264 0.8831726 0.4681287 1.59832 0.8497347 0.00865023 1.6695550 0.00865023 0.05055440 6.492742 0.07799167 0.002200000 0.14810000 0.14590000 1.118588e-09 1.118588e-09 FALSE TRUE
MSTRG.2682.9 ENSG00000135837 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP350 protein_coding   7.097347 3.719524 11.28264 0.8831726 0.4681287 1.59832 0.2010474 0.00000000 1.1229075 0.00000000 0.67814155 6.823886 0.02137917 0.000000000 0.09596667 0.09596667 4.626104e-01 1.118588e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000135837 E001 1.0053869 0.0153787590 7.803939e-01   1 179954773 179954787 15 + 0.231 0.241 0.080
ENSG00000135837 E002 1.6488367 0.0115407859 3.416889e-01 5.794741e-01 1 179954788 179954792 5 + 0.355 0.241 -0.768
ENSG00000135837 E003 1.9411206 0.0102725856 6.749639e-01 8.195359e-01 1 179954793 179954808 16 + 0.381 0.395 0.078
ENSG00000135837 E004 1.9411206 0.0102725856 6.749639e-01 8.195359e-01 1 179954809 179954809 1 + 0.381 0.395 0.078
ENSG00000135837 E005 6.1746434 0.0101778029 7.638135e-01 8.749500e-01 1 179954810 179954939 130 + 0.705 0.885 0.713
ENSG00000135837 E006 9.8446421 0.0486088481 3.422045e-01 5.799241e-01 1 179954940 179955142 203 + 0.851 1.136 1.055
ENSG00000135837 E007 0.4644705 0.0217681645 4.836773e-03   1 179955245 179955256 12 + 0.000 0.508 15.927
ENSG00000135837 E008 0.8214337 0.0172671820 2.595984e-01   1 179955257 179955418 162 + 0.231 0.000 -11.901
ENSG00000135837 E009 4.2872931 0.0934195627 8.210267e-01 9.086191e-01 1 179986169 179986180 12 + 0.601 0.672 0.307
ENSG00000135837 E010 4.1093093 0.0724472017 8.662732e-01 9.339270e-01 1 179986181 179986181 1 + 0.584 0.673 0.384
ENSG00000135837 E011 12.5051964 0.0616998852 9.856232e-02 2.793090e-01 1 179986182 179986254 73 + 1.028 0.885 -0.533
ENSG00000135837 E012 1.3012550 0.0638751402 1.103506e-01   1 179987240 179987242 3 + 0.328 0.000 -12.582
ENSG00000135837 E013 13.6996139 0.0874826271 5.957016e-03 3.952638e-02 1 179987243 179987286 44 + 1.090 0.671 -1.614
ENSG00000135837 E014 15.3958808 0.0260877066 6.005657e-06 1.349429e-04 1 179990507 179990621 115 + 1.146 0.509 -2.547
ENSG00000135837 E015 25.4747279 0.0014711821 5.456443e-07 1.673220e-05 1 179992062 179992221 160 + 1.341 0.962 -1.359
ENSG00000135837 E016 53.8033216 0.0009233579 1.735289e-05 3.386097e-04 1 179996553 179996945 393 + 1.632 1.507 -0.427
ENSG00000135837 E017 36.5308230 0.0039454167 1.694514e-04 2.329157e-03 1 179996946 179997175 230 + 1.470 1.306 -0.567
ENSG00000135837 E018 20.2925717 0.0017882241 3.626236e-05 6.340797e-04 1 180003174 180003287 114 + 1.244 0.925 -1.158
ENSG00000135837 E019 19.2443774 0.0029466579 3.030736e-04 3.760969e-03 1 180006454 180006567 114 + 1.223 0.961 -0.945
ENSG00000135837 E020 28.5518840 0.0013327758 2.007841e-07 6.914977e-06 1 180011929 180012075 147 + 1.391 1.027 -1.291
ENSG00000135837 E021 30.7384032 0.0221537120 1.885045e-04 2.545920e-03 1 180013847 180013981 135 + 1.410 1.130 -0.985
ENSG00000135837 E022 72.6834774 0.0008326942 6.172566e-13 6.576183e-11 1 180013982 180014505 524 + 1.775 1.486 -0.982
ENSG00000135837 E023 33.6215736 0.0075009495 6.695718e-07 2.004737e-05 1 180015849 180015970 122 + 1.453 1.109 -1.210
ENSG00000135837 E024 127.5700805 0.0127484861 4.054927e-05 6.962085e-04 1 180019949 180021009 1061 + 1.997 1.876 -0.406
ENSG00000135837 E025 30.8367980 0.0059049175 2.868965e-02 1.234428e-01 1 180022698 180022848 151 + 1.379 1.338 -0.140
ENSG00000135837 E026 13.1677754 0.0210919526 1.054820e-01 2.914747e-01 1 180024419 180024430 12 + 1.041 0.961 -0.297
ENSG00000135837 E027 36.0329770 0.0010275276 9.540425e-05 1.437840e-03 1 180024431 180024582 152 + 1.466 1.307 -0.550
ENSG00000135837 E028 33.4741666 0.0026661985 8.306634e-04 8.529279e-03 1 180031320 180031494 175 + 1.433 1.307 -0.438
ENSG00000135837 E029 38.0751453 0.0136581589 4.511825e-02 1.679280e-01 1 180033862 180034082 221 + 1.468 1.441 -0.093
ENSG00000135837 E030 36.3306670 0.0315942361 8.611552e-02 2.566404e-01 1 180036926 180037089 164 + 1.451 1.414 -0.129
ENSG00000135837 E031 30.5332140 0.0089960277 1.911485e-02 9.285832e-02 1 180041138 180041202 65 + 1.382 1.321 -0.211
ENSG00000135837 E032 22.2535434 0.0049362378 2.678719e-02 1.176476e-01 1 180041203 180041248 46 + 1.249 1.179 -0.247
ENSG00000135837 E033 35.9646911 0.0023172679 2.008692e-02 9.618285e-02 1 180041662 180041802 141 + 1.442 1.418 -0.082
ENSG00000135837 E034 37.4405221 0.0032747113 5.163015e-02 1.835920e-01 1 180043056 180043192 137 + 1.455 1.465 0.032
ENSG00000135837 E035 28.6012752 0.0149227499 8.439397e-02 2.535073e-01 1 180044051 180044173 123 + 1.347 1.323 -0.084
ENSG00000135837 E036 34.8727051 0.0011299420 9.132860e-02 2.661375e-01 1 180048536 180048705 170 + 1.424 1.454 0.102
ENSG00000135837 E037 0.5067846 0.0217681645 6.157521e-01   1 180052224 180052316 93 + 0.107 0.241 1.404
ENSG00000135837 E038 46.7968878 0.0127820372 2.883668e-02 1.238963e-01 1 180052970 180053166 197 + 1.557 1.526 -0.105
ENSG00000135837 E039 46.9856763 0.0067176324 9.145917e-02 2.663945e-01 1 180053750 180053934 185 + 1.548 1.580 0.108
ENSG00000135837 E040 28.5666923 0.0015478707 2.381156e-01 4.744627e-01 1 180054415 180054502 88 + 1.335 1.393 0.202
ENSG00000135837 E041 36.9406032 0.0035476500 5.838962e-01 7.595540e-01 1 180062220 180062366 147 + 1.429 1.545 0.400
ENSG00000135837 E042 37.0650282 0.0037679148 1.566746e-01 3.717872e-01 1 180065115 180065272 158 + 1.447 1.496 0.169
ENSG00000135837 E043 0.4929928 0.0230370432 6.170512e-01   1 180073819 180073908 90 + 0.107 0.241 1.402
ENSG00000135837 E044 48.9357678 0.0115358847 3.173806e-03 2.445434e-02 1 180075022 180075221 200 + 1.584 1.494 -0.308
ENSG00000135837 E045 44.2911817 0.0082991595 5.253538e-02 1.855675e-01 1 180078463 180078674 212 + 1.528 1.534 0.022
ENSG00000135837 E046 35.5195629 0.0105223983 4.227243e-01 6.456803e-01 1 180080517 180080661 145 + 1.416 1.507 0.311
ENSG00000135837 E047 43.4749732 0.0156721908 6.312795e-01 7.912398e-01 1 180084018 180084178 161 + 1.495 1.615 0.407
ENSG00000135837 E048 0.1426347 0.0318611564 1.000000e+00   1 180084179 180084280 102 + 0.057 0.000 -9.576
ENSG00000135837 E049 0.4514866 0.0244411696 6.221349e-01   1 180085580 180085603 24 + 0.107 0.241 1.398
ENSG00000135837 E050 0.9279113 0.0157274184 5.088450e-01   1 180085604 180085928 325 + 0.193 0.395 1.400
ENSG00000135837 E051 0.1308682 0.0307844772 1.198119e-01   1 180087165 180087288 124 + 0.000 0.240 14.341
ENSG00000135837 E052 36.8270364 0.0010228797 5.900024e-03 3.924944e-02 1 180087578 180087717 140 + 1.459 1.406 -0.183
ENSG00000135837 E053 33.0085152 0.0011236259 1.291861e-01 3.304728e-01 1 180090714 180090796 83 + 1.403 1.442 0.137
ENSG00000135837 E054 197.7317699 0.0062838947 7.631243e-02 2.373685e-01 1 180092614 180093713 1100 + 2.153 2.235 0.273
ENSG00000135837 E055 178.0939719 0.0150905471 4.213064e-01 6.446012e-01 1 180093714 180094616 903 + 2.077 2.301 0.749
ENSG00000135837 E056 0.1426347 0.0318611564 1.000000e+00   1 180095147 180095198 52 + 0.057 0.000 -9.576
ENSG00000135837 E057 108.5416372 0.0118617471 5.495123e-02 1.912331e-01 1 180095523 180095930 408 + 1.845 2.135 0.973
ENSG00000135837 E058 55.6794257 0.0205797414 1.815476e-02 8.954156e-02 1 180096038 180096184 147 + 1.536 1.905 1.249
ENSG00000135837 E059 49.5989007 0.0013911456 8.433423e-05 1.296920e-03 1 180098863 180098985 123 + 1.491 1.867 1.276
ENSG00000135837 E060 49.6403021 0.8391946744 2.423533e-01 4.791856e-01 1 180110997 180111195 199 + 1.455 1.928 1.608
ENSG00000135837 E061 119.4214193 1.3912699778 3.687283e-01 6.029885e-01 1 180111196 180112436 1241 + 1.837 2.288 1.512
ENSG00000135837 E062 317.9281091 1.6905488583 2.724447e-01 5.122994e-01 1 180112437 180114875 2439 + 2.196 2.806 2.035