ENSG00000135655

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000280377 ENSG00000135655 HEK293_OSMI2_6hA HEK293_TMG_6hB USP15 protein_coding protein_coding 18.47316 4.420894 38.61738 0.4906575 2.300007 3.123954 1.2433452 0.2052804 2.243745 0.1411535 0.2474113 3.3880351 0.07217917 0.04153333 0.05890000 0.01736667 7.934288e-01 8.141327e-06 FALSE TRUE
ENST00000312635 ENSG00000135655 HEK293_OSMI2_6hA HEK293_TMG_6hB USP15 protein_coding protein_coding 18.47316 4.420894 38.61738 0.4906575 2.300007 3.123954 2.3248296 1.8518217 2.001036 0.5449010 0.1761022 0.1112239 0.27572083 0.39956667 0.05183333 -0.34773333 8.141327e-06 8.141327e-06 FALSE TRUE
ENST00000353364 ENSG00000135655 HEK293_OSMI2_6hA HEK293_TMG_6hB USP15 protein_coding protein_coding 18.47316 4.420894 38.61738 0.4906575 2.300007 3.123954 0.6481838 0.2630279 1.782725 0.1336633 0.3170279 2.7150339 0.05006250 0.06413333 0.04586667 -0.01826667 1.000000e+00 8.141327e-06 FALSE TRUE
ENST00000549415 ENSG00000135655 HEK293_OSMI2_6hA HEK293_TMG_6hB USP15 protein_coding protein_coding 18.47316 4.420894 38.61738 0.4906575 2.300007 3.123954 2.6894193 0.3945070 6.163961 0.3041361 1.5049530 3.9319598 0.11603333 0.08513333 0.15630000 0.07116667 7.026364e-01 8.141327e-06 FALSE TRUE
MSTRG.7547.3 ENSG00000135655 HEK293_OSMI2_6hA HEK293_TMG_6hB USP15 protein_coding   18.47316 4.420894 38.61738 0.4906575 2.300007 3.123954 5.8996631 0.8297197 13.804638 0.1248514 0.5632455 4.0401462 0.26218333 0.18863333 0.35836667 0.16973333 5.653691e-03 8.141327e-06 TRUE TRUE
MSTRG.7547.6 ENSG00000135655 HEK293_OSMI2_6hA HEK293_TMG_6hB USP15 protein_coding   18.47316 4.420894 38.61738 0.4906575 2.300007 3.123954 4.3474396 0.4987586 11.032866 0.2496007 0.6460705 4.4399896 0.14297500 0.12433333 0.28593333 0.16160000 6.183558e-01 8.141327e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000135655 E001 0.0000000       12 62260338 62260355 18 +      
ENSG00000135655 E002 0.0000000       12 62260356 62260358 3 +      
ENSG00000135655 E003 0.0000000       12 62260359 62260363 5 +      
ENSG00000135655 E004 0.9452873 0.0163912095 5.097400e-01   12 62260364 62260372 9 + 0.230 0.000 -10.506
ENSG00000135655 E005 6.3261821 0.0207788204 6.540827e-01 8.061478e-01 12 62260373 62260396 24 + 0.716 0.659 -0.237
ENSG00000135655 E006 6.3261821 0.0207788204 6.540827e-01 8.061478e-01 12 62260397 62260398 2 + 0.716 0.659 -0.237
ENSG00000135655 E007 9.7379833 0.0037108006 1.399041e-01 3.473275e-01 12 62260399 62260403 5 + 0.883 0.660 -0.895
ENSG00000135655 E008 10.7186198 0.0046065505 8.609977e-02 2.566160e-01 12 62260404 62260406 3 + 0.921 0.660 -1.040
ENSG00000135655 E009 11.8418910 0.0087329104 5.080191e-02 1.815898e-01 12 62260407 62260407 1 + 0.962 0.660 -1.195
ENSG00000135655 E010 36.2838373 0.0012863440 4.330272e-01 6.535121e-01 12 62260408 62260427 20 + 1.390 1.351 -0.134
ENSG00000135655 E011 80.9814916 0.0004685309 7.494485e-01 8.664374e-01 12 62260428 62260503 76 + 1.721 1.771 0.171
ENSG00000135655 E012 0.0000000       12 62278628 62278714 87 +      
ENSG00000135655 E013 125.2906031 0.0003532347 9.608100e-01 9.823222e-01 12 62294179 62294306 128 + 1.909 1.938 0.100
ENSG00000135655 E014 0.1779838 0.0352363283 7.758412e-01   12 62294307 62294640 334 + 0.048 0.000 -9.826
ENSG00000135655 E015 136.8249629 0.0002924474 4.114971e-01 6.371987e-01 12 62302790 62302920 131 + 1.952 1.947 -0.016
ENSG00000135655 E016 1.2611538 0.0156815290 3.379499e-01   12 62302921 62303586 666 + 0.230 0.445 1.349
ENSG00000135655 E017 1.5573818 0.0121989077 1.450405e-01 3.549678e-01 12 62304673 62304896 224 + 0.259 0.565 1.715
ENSG00000135655 E018 4.2630903 0.1242994404 4.243028e-01 6.468140e-01 12 62305595 62306058 464 + 0.541 0.739 0.856
ENSG00000135655 E019 0.1426347 0.0318933218 7.741144e-01   12 62312286 62312309 24 + 0.048 0.000 -9.845
ENSG00000135655 E020 153.2061916 0.0003246015 5.138284e-02 1.830268e-01 12 62314790 62314916 127 + 2.005 1.952 -0.180
ENSG00000135655 E021 0.1426347 0.0318933218 7.741144e-01   12 62314917 62315073 157 + 0.048 0.000 -9.845
ENSG00000135655 E022 0.1426347 0.0318933218 7.741144e-01   12 62321461 62321463 3 + 0.048 0.000 -9.845
ENSG00000135655 E023 126.5114222 0.0013528682 2.368740e-01 4.729666e-01 12 62321464 62321609 146 + 1.921 1.895 -0.088
ENSG00000135655 E024 78.1361612 0.0005480522 3.439998e-01 5.816201e-01 12 62325872 62325933 62 + 1.717 1.692 -0.085
ENSG00000135655 E025 0.3503582 0.0334973223 1.551291e-01   12 62327661 62327781 121 + 0.048 0.277 2.939
ENSG00000135655 E026 0.0000000       12 62328293 62328405 113 +      
ENSG00000135655 E027 69.6753316 0.0387901048 2.287613e-17 4.731904e-15 12 62335166 62336690 1525 + 1.389 2.315 3.130
ENSG00000135655 E028 34.1243619 0.0011107905 2.126080e-02 1.001851e-01 12 62349221 62349307 87 + 1.383 1.185 -0.697
ENSG00000135655 E029 0.0000000       12 62355011 62355074 64 +      
ENSG00000135655 E030 81.9433378 0.0081718851 5.053460e-02 1.809123e-01 12 62355331 62355427 97 + 1.744 1.623 -0.410
ENSG00000135655 E031 71.2495477 0.0126029542 9.242539e-02 2.682565e-01 12 62355428 62355475 48 + 1.683 1.565 -0.404
ENSG00000135655 E032 2.9952860 0.0084761968 6.593578e-01 8.095821e-01 12 62374390 62374535 146 + 0.457 0.566 0.525
ENSG00000135655 E033 0.2735028 0.0274424043 1.555151e-01   12 62381135 62381200 66 + 0.048 0.277 2.938
ENSG00000135655 E034 119.1386037 0.0017018899 1.445273e-03 1.322773e-02 12 62381490 62381663 174 + 1.905 1.758 -0.496
ENSG00000135655 E035 105.0381569 0.0003999810 6.927877e-02 2.233447e-01 12 62383840 62383998 159 + 1.843 1.778 -0.221
ENSG00000135655 E036 1.9896413 0.0136672381 2.379543e-01 4.742302e-01 12 62383999 62384077 79 + 0.312 0.566 1.353
ENSG00000135655 E037 115.4402082 0.0025862976 2.776518e-01 5.177238e-01 12 62384078 62384302 225 + 1.883 1.854 -0.097
ENSG00000135655 E038 77.7378579 0.0005446913 1.328739e-02 7.159187e-02 12 62389431 62389514 84 + 1.724 1.596 -0.435
ENSG00000135655 E039 89.0420043 0.0004266992 1.105331e-02 6.259105e-02 12 62389605 62389699 95 + 1.780 1.660 -0.408
ENSG00000135655 E040 143.0491297 0.0003013223 3.235419e-02 1.342507e-01 12 62389797 62389988 192 + 1.977 1.911 -0.222
ENSG00000135655 E041 133.8918247 0.0003656172 4.872931e-04 5.561022e-03 12 62390864 62390979 116 + 1.956 1.815 -0.476
ENSG00000135655 E042 202.6349939 0.0004529793 2.502542e-02 1.122914e-01 12 62391157 62391429 273 + 2.126 2.072 -0.182
ENSG00000135655 E043 70.9960073 0.0188173387 7.102840e-01 8.419718e-01 12 62391816 62391886 71 + 1.663 1.734 0.241
ENSG00000135655 E044 82.5094980 0.0031140628 2.910043e-01 5.315952e-01 12 62392272 62392361 90 + 1.725 1.820 0.320
ENSG00000135655 E045 53.3282309 0.0050089344 2.016538e-01 4.316965e-01 12 62392362 62392387 26 + 1.536 1.659 0.421
ENSG00000135655 E046 55.4573315 0.0087245158 2.282534e-01 4.631859e-01 12 62393053 62393074 22 + 1.549 1.669 0.409
ENSG00000135655 E047 104.0820819 0.0062313186 4.498846e-01 6.656104e-01 12 62393075 62393202 128 + 1.824 1.897 0.246
ENSG00000135655 E048 0.7860845 0.0170557048 6.575506e-01   12 62396284 62396294 11 + 0.199 0.000 -12.200
ENSG00000135655 E049 103.4303318 0.0017091954 4.995013e-01 7.004355e-01 12 62396295 62396398 104 + 1.832 1.826 -0.018
ENSG00000135655 E050 0.5173834 0.0488096071 1.000000e+00   12 62401158 62401186 29 + 0.131 0.000 -11.310
ENSG00000135655 E051 98.4924171 0.0004099098 1.273913e-01 3.277228e-01 12 62401187 62401275 89 + 1.797 1.906 0.367
ENSG00000135655 E052 288.5645037 0.0004166118 1.459859e-03 1.333309e-02 12 62404193 62416389 12197 + 2.255 2.381 0.418
ENSG00000135655 E053 0.0000000       12 62417098 62417431 334 +