ENSG00000135454

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341156 ENSG00000135454 HEK293_OSMI2_6hA HEK293_TMG_6hB B4GALNT1 protein_coding protein_coding 4.596153 7.43929 3.764075 0.3617391 0.1316575 -0.9809798 1.9905387 2.8526433 2.0061335 0.19063739 0.10225735 -0.5057567 0.45498333 0.38376667 0.53370000 0.14993333 1.678425e-01 7.780712e-16 FALSE TRUE
ENST00000547741 ENSG00000135454 HEK293_OSMI2_6hA HEK293_TMG_6hB B4GALNT1 protein_coding protein_coding 4.596153 7.43929 3.764075 0.3617391 0.1316575 -0.9809798 0.4991792 0.9452237 0.1943770 0.10307780 0.05097065 -2.2246058 0.09994583 0.12786667 0.05083333 -0.07703333 1.684240e-01 7.780712e-16 FALSE FALSE
ENST00000550764 ENSG00000135454 HEK293_OSMI2_6hA HEK293_TMG_6hB B4GALNT1 protein_coding protein_coding 4.596153 7.43929 3.764075 0.3617391 0.1316575 -0.9809798 0.6742727 1.7403169 0.0000000 0.24438849 0.00000000 -7.4514723 0.13527500 0.23180000 0.00000000 -0.23180000 8.126118e-12 7.780712e-16 FALSE TRUE
ENST00000552350 ENSG00000135454 HEK293_OSMI2_6hA HEK293_TMG_6hB B4GALNT1 protein_coding protein_coding 4.596153 7.43929 3.764075 0.3617391 0.1316575 -0.9809798 0.3479449 0.0000000 0.7274256 0.00000000 0.03369060 6.2044257 0.07973333 0.00000000 0.19316667 0.19316667 7.780712e-16 7.780712e-16 FALSE TRUE
ENST00000552468 ENSG00000135454 HEK293_OSMI2_6hA HEK293_TMG_6hB B4GALNT1 protein_coding retained_intron 4.596153 7.43929 3.764075 0.3617391 0.1316575 -0.9809798 0.2924237 0.4146090 0.3515051 0.06296902 0.11128159 -0.2321189 0.07063750 0.05673333 0.09413333 0.03740000 7.948363e-01 7.780712e-16 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000135454 E001 0.3032425 0.024441170 0.564815844   12 57623409 57623409 1 - 0.000 0.154 14.009
ENSG00000135454 E002 194.8814700 0.750746706 0.555288704 0.73996770 12 57623410 57626171 2762 - 2.194 2.277 0.278
ENSG00000135454 E003 34.5221558 0.001215503 0.001602198 0.01434545 12 57626172 57626427 256 - 1.624 1.448 -0.603
ENSG00000135454 E004 19.5966688 0.001730450 0.030200348 0.12793319 12 57626428 57626475 48 - 1.380 1.224 -0.546
ENSG00000135454 E005 54.1136428 0.000842672 0.014746343 0.07713505 12 57626476 57626940 465 - 1.776 1.673 -0.347
ENSG00000135454 E006 11.5465208 0.003056368 0.176737907 0.39942355 12 57626941 57626961 21 - 1.152 1.032 -0.433
ENSG00000135454 E007 33.0718338 0.001187019 0.924314489 0.96450232 12 57627618 57627858 241 - 1.489 1.500 0.038
ENSG00000135454 E008 7.0240611 0.004702561 0.597866447 0.76886330 12 57627859 57627891 33 - 0.895 0.843 -0.199
ENSG00000135454 E009 7.6686669 0.090046896 0.630139293 0.79047508 12 57627892 57628121 230 - 0.925 0.880 -0.167
ENSG00000135454 E010 20.9563827 0.001947096 0.471539106 0.68122247 12 57628122 57628166 45 - 1.246 1.323 0.268
ENSG00000135454 E011 26.4663173 0.001757623 0.415077891 0.63985633 12 57628167 57628262 96 - 1.343 1.421 0.270
ENSG00000135454 E012 2.4871755 0.028716842 0.180279565 0.40439683 12 57628263 57628397 135 - 0.647 0.432 -1.010
ENSG00000135454 E013 1.3607344 0.237753009 0.036663439   12 57628398 57628451 54 - 0.601 0.155 -2.799
ENSG00000135454 E014 5.3640776 0.032872185 0.101579786 0.28463923 12 57628452 57628712 261 - 0.922 0.699 -0.879
ENSG00000135454 E015 39.3333699 0.001154705 0.663932569 0.81234036 12 57628713 57628903 191 - 1.576 1.568 -0.029
ENSG00000135454 E016 3.7129418 0.007195455 0.192889775 0.42066993 12 57628904 57629047 144 - 0.471 0.702 1.045
ENSG00000135454 E017 28.3632843 0.001632608 0.570476320 0.75059463 12 57629048 57629146 99 - 1.389 1.447 0.202
ENSG00000135454 E018 3.0071316 0.069640687 0.251879448 0.48993132 12 57629147 57629174 28 - 0.693 0.498 -0.871
ENSG00000135454 E019 4.8509299 0.047999683 0.139420537 0.34663876 12 57629175 57629328 154 - 0.870 0.646 -0.907
ENSG00000135454 E020 1.1438171 0.015002549 0.461138546   12 57629329 57629343 15 - 0.392 0.268 -0.785
ENSG00000135454 E021 45.1814512 0.006768416 0.888908406 0.94611913 12 57629344 57630151 808 - 1.609 1.637 0.096
ENSG00000135454 E022 55.4553568 0.010788470 0.871071332 0.93651956 12 57630152 57630332 181 - 1.691 1.724 0.111
ENSG00000135454 E023 25.7570249 0.012389680 0.900717017 0.95222437 12 57630478 57630506 29 - 1.382 1.391 0.033
ENSG00000135454 E024 24.4741260 0.001748539 0.462359283 0.67477398 12 57630507 57630518 12 - 1.313 1.388 0.258
ENSG00000135454 E025 21.5653730 0.024002810 0.963798880 0.98379065 12 57630980 57630996 17 - 1.304 1.319 0.049
ENSG00000135454 E026 33.0498012 0.001649127 0.343540874 0.58119706 12 57630997 57631086 90 - 1.430 1.512 0.281
ENSG00000135454 E027 3.3088835 0.032585092 0.772809949 0.88035649 12 57631087 57631087 1 - 0.538 0.603 0.296
ENSG00000135454 E028 4.4398188 0.150975496 0.667832783 0.81483315 12 57631128 57631156 29 - 0.600 0.721 0.515
ENSG00000135454 E029 4.8154798 0.109224687 0.147980646 0.35944900 12 57631157 57631199 43 - 0.473 0.795 1.409
ENSG00000135454 E030 15.6800559 0.007821470 0.854173855 0.92717489 12 57631200 57631221 22 - 1.154 1.190 0.130
ENSG00000135454 E031 15.3588172 0.017622474 0.532819905 0.72406016 12 57631222 57631254 33 - 1.107 1.196 0.318
ENSG00000135454 E032 18.8422491 0.065218493 0.660383186 0.81018511 12 57631255 57631338 84 - 1.203 1.280 0.271
ENSG00000135454 E033 13.5262378 0.003317087 0.457103031 0.67110810 12 57631339 57631364 26 - 1.052 1.146 0.337
ENSG00000135454 E034 26.8136922 0.032591602 0.381836629 0.61377015 12 57631915 57632133 219 - 1.315 1.435 0.416
ENSG00000135454 E035 2.0936458 0.012267047 0.496829146 0.69877027 12 57632134 57632540 407 - 0.537 0.432 -0.521
ENSG00000135454 E036 1.1969022 0.033392690 0.478168818   12 57632541 57632581 41 - 0.392 0.269 -0.774
ENSG00000135454 E037 0.6081007 0.019619055 0.003681894   12 57632582 57632771 190 - 0.471 0.000 -17.447
ENSG00000135454 E038 24.7919939 0.011892547 0.123795541 0.32172329 12 57632772 57633239 468 - 1.257 1.415 0.548