ENSG00000135424

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257879 ENSG00000135424 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA7 protein_coding protein_coding 5.391925 6.877839 3.768153 1.945903 0.2588339 -0.8663701 0.9399922 2.0211373 0.3215495 0.1549688 0.3215495 -2.6149918 0.17010833 0.34716667 0.07876667 -0.26840000 0.2605620 0.025269 FALSE TRUE
ENST00000347027 ENSG00000135424 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA7 protein_coding protein_coding 5.391925 6.877839 3.768153 1.945903 0.2588339 -0.8663701 0.3490088 0.3156837 0.4748493 0.3156837 0.1681385 0.5740649 0.06838333 0.02933333 0.13350000 0.10416667 0.3767494 0.025269 FALSE TRUE
ENST00000553276 ENSG00000135424 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA7 protein_coding processed_transcript 5.391925 6.877839 3.768153 1.945903 0.2588339 -0.8663701 0.2923343 0.4431434 0.3549474 0.3581302 0.1352675 -0.3122789 0.05154167 0.04733333 0.09020000 0.04286667 0.7712397 0.025269   FALSE
ENST00000553737 ENSG00000135424 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA7 protein_coding retained_intron 5.391925 6.877839 3.768153 1.945903 0.2588339 -0.8663701 0.2851581 0.2545286 0.2736757 0.1292583 0.1040197 0.1008187 0.05463333 0.03833333 0.06976667 0.03143333 0.7825921 0.025269   FALSE
ENST00000553804 ENSG00000135424 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA7 protein_coding protein_coding 5.391925 6.877839 3.768153 1.945903 0.2588339 -0.8663701 0.3309023 0.3675945 0.1262331 0.1207611 0.1262331 -1.4707603 0.06395000 0.05663333 0.03880000 -0.01783333 0.7056504 0.025269 FALSE TRUE
ENST00000554543 ENSG00000135424 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA7 protein_coding retained_intron 5.391925 6.877839 3.768153 1.945903 0.2588339 -0.8663701 0.3352864 0.6071514 0.1905332 0.4789749 0.1905332 -1.6217836 0.05689583 0.06673333 0.05853333 -0.00820000 0.8399949 0.025269 FALSE FALSE
ENST00000557058 ENSG00000135424 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA7 protein_coding retained_intron 5.391925 6.877839 3.768153 1.945903 0.2588339 -0.8663701 0.3847124 0.3753415 0.2213800 0.2029459 0.1206752 -0.7358738 0.06757083 0.04820000 0.06036667 0.01216667 1.0000000 0.025269 FALSE TRUE
ENST00000688413 ENSG00000135424 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA7 protein_coding retained_intron 5.391925 6.877839 3.768153 1.945903 0.2588339 -0.8663701 0.7948494 0.7226379 0.9882239 0.2440491 0.1503441 0.4462631 0.15496667 0.10286667 0.26103333 0.15816667 0.0252690 0.025269 FALSE TRUE
ENST00000691846 ENSG00000135424 HEK293_OSMI2_6hA HEK293_TMG_6hB ITGA7 protein_coding nonsense_mediated_decay 5.391925 6.877839 3.768153 1.945903 0.2588339 -0.8663701 0.1222673 0.3054981 0.0000000 0.3054981 0.0000000 -4.9795592 0.02351250 0.06356667 0.00000000 -0.06356667 0.9717971 0.025269 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000135424 E001 0.2735028 0.027442404 0.432405418   12 55684568 55684571 4 - 0.192 0.074 -1.575
ENSG00000135424 E002 1.2028192 0.021492958 0.454442019   12 55684572 55684584 13 - 0.426 0.286 -0.841
ENSG00000135424 E003 2.6321953 0.008838383 0.601750864 0.77130043 12 55684585 55684600 16 - 0.578 0.486 -0.434
ENSG00000135424 E004 8.0079672 0.029539269 0.312582831 0.55290394 12 55684601 55684621 21 - 0.778 0.923 0.564
ENSG00000135424 E005 15.3682144 0.003234988 0.249482261 0.48732820 12 55684622 55684702 81 - 1.064 1.177 0.408
ENSG00000135424 E006 25.0695931 0.006350431 0.217679097 0.45062922 12 55684703 55684857 155 - 1.274 1.375 0.351
ENSG00000135424 E007 31.6091081 0.001760528 0.175845588 0.39825861 12 55684858 55685016 159 - 1.377 1.472 0.327
ENSG00000135424 E008 20.0279983 0.002482116 0.853438425 0.92684483 12 55685017 55685057 41 - 1.248 1.261 0.044
ENSG00000135424 E009 20.0355652 0.008102126 0.407144133 0.63385662 12 55685058 55685110 53 - 1.205 1.278 0.255
ENSG00000135424 E010 22.8561506 0.001751641 0.817167225 0.90651739 12 55685111 55685198 88 - 1.300 1.315 0.054
ENSG00000135424 E011 23.6888799 0.001612246 0.297805835 0.53827049 12 55685199 55685288 90 - 1.262 1.345 0.293
ENSG00000135424 E012 0.3337900 0.025162059 0.429753807   12 55686202 55686314 113 - 0.192 0.074 -1.573
ENSG00000135424 E013 29.8604095 0.003229384 0.050255193 0.18029211 12 55687971 55688096 126 - 1.312 1.463 0.523
ENSG00000135424 E014 24.0697221 0.001865396 0.304217976 0.54480088 12 55688202 55688300 99 - 1.275 1.356 0.283
ENSG00000135424 E015 24.6115937 0.001700687 0.029245352 0.12511420 12 55688844 55688957 114 - 1.205 1.387 0.637
ENSG00000135424 E016 1.3319518 0.013486940 0.379345043   12 55688958 55690915 1958 - 0.192 0.364 1.234
ENSG00000135424 E017 28.5650665 0.002654130 0.704928660 0.83866766 12 55692844 55692975 132 - 1.387 1.416 0.101
ENSG00000135424 E018 23.0759272 0.002054399 0.798236529 0.89529249 12 55693141 55693212 72 - 1.299 1.319 0.070
ENSG00000135424 E019 29.4448919 0.001251207 0.460441871 0.67345592 12 55693213 55693317 105 - 1.377 1.429 0.179
ENSG00000135424 E020 1.3155713 0.263359259 0.908896668   12 55693619 55694020 402 - 0.326 0.329 0.021
ENSG00000135424 E021 30.5355225 0.001140647 0.697178327 0.83369498 12 55694021 55694123 103 - 1.416 1.440 0.085
ENSG00000135424 E022 1.4809311 0.469356738 0.469231968 0.67955263 12 55694124 55694255 132 - 0.421 0.335 -0.493
ENSG00000135424 E023 27.1586291 0.001381880 0.395807154 0.62503263 12 55694256 55694330 75 - 1.334 1.397 0.218
ENSG00000135424 E024 26.5118259 0.001416946 0.854153696 0.92716487 12 55694443 55694522 80 - 1.367 1.377 0.036
ENSG00000135424 E025 26.8982082 0.002740201 0.612289008 0.77838064 12 55694615 55694695 81 - 1.356 1.391 0.120
ENSG00000135424 E026 0.7874895 0.276870876 0.217403675   12 55694696 55694777 82 - 0.428 0.137 -2.179
ENSG00000135424 E027 36.1847459 0.003427811 0.006103275 0.04022808 12 55694778 55694970 193 - 1.346 1.546 0.690
ENSG00000135424 E028 10.0600946 0.101181422 0.208617842 0.44020897 12 55694971 55695521 551 - 1.105 0.939 -0.612
ENSG00000135424 E029 15.8251021 0.002248522 0.471786681 0.68136699 12 55695522 55695553 32 - 1.220 1.149 -0.252
ENSG00000135424 E030 22.8715992 0.009230317 0.899270445 0.95147693 12 55695554 55695637 84 - 1.311 1.313 0.008
ENSG00000135424 E031 30.9331823 0.004748426 0.673805610 0.81881963 12 55696283 55696432 150 - 1.468 1.429 -0.134
ENSG00000135424 E032 34.6638318 0.059209826 0.634066870 0.79301787 12 55696899 55697050 152 - 1.468 1.495 0.093
ENSG00000135424 E033 15.1346318 0.150343866 0.659209941 0.80951183 12 55697051 55697068 18 - 1.132 1.150 0.065
ENSG00000135424 E034 17.0707536 0.033474200 0.977313266 0.99040860 12 55697216 55697277 62 - 1.208 1.191 -0.060
ENSG00000135424 E035 21.6635777 0.015316569 0.364960148 0.59990761 12 55697451 55697546 96 - 1.220 1.305 0.296
ENSG00000135424 E036 14.9046246 0.036856313 0.463686305 0.67561195 12 55697695 55697751 57 - 1.205 1.105 -0.356
ENSG00000135424 E037 10.3833972 0.006624223 0.089060711 0.26201960 12 55697752 55697758 7 - 1.122 0.930 -0.704
ENSG00000135424 E038 11.4568783 0.015195759 0.113130897 0.30440035 12 55697759 55697770 12 - 1.157 0.970 -0.681
ENSG00000135424 E039 17.6921547 0.002287756 0.206962681 0.43814385 12 55697771 55697822 52 - 1.287 1.172 -0.406
ENSG00000135424 E040 20.1742030 0.001834857 0.304534035 0.54512847 12 55697938 55698026 89 - 1.323 1.233 -0.316
ENSG00000135424 E041 0.3751086 0.024441170 0.694827967   12 55698027 55698162 136 - 0.000 0.138 9.684
ENSG00000135424 E042 16.0323299 0.002128924 0.167303114 0.38697262 12 55698383 55698423 41 - 1.261 1.132 -0.460
ENSG00000135424 E043 20.2209636 0.002592322 0.544080111 0.73199329 12 55698424 55698510 87 - 1.311 1.255 -0.196
ENSG00000135424 E044 14.7269273 0.002553915 0.275262180 0.51529316 12 55698511 55698522 12 - 1.220 1.113 -0.381
ENSG00000135424 E045 21.3925560 0.001879549 0.477359075 0.68527405 12 55698523 55698576 54 - 1.335 1.273 -0.214
ENSG00000135424 E046 26.9446282 0.002373680 0.210485944 0.44240336 12 55698710 55698857 148 - 1.452 1.356 -0.330
ENSG00000135424 E047 17.9069269 0.027208645 0.174893654 0.39701865 12 55698858 55698917 60 - 1.320 1.176 -0.509
ENSG00000135424 E048 2.7115374 0.009016584 0.056559818 0.19498504 12 55699511 55699571 61 - 0.737 0.429 -1.405
ENSG00000135424 E049 15.3387566 0.010642864 0.145019484 0.35494270 12 55699870 55699961 92 - 1.249 1.103 -0.520
ENSG00000135424 E050 8.2925457 0.004052563 0.063646003 0.21092745 12 55699962 55699977 16 - 1.064 0.844 -0.822
ENSG00000135424 E051 7.9778264 0.004506036 0.360443598 0.59605832 12 55699978 55699989 12 - 0.971 0.856 -0.435
ENSG00000135424 E052 6.9178271 0.078523553 0.386431175 0.61765194 12 55699990 55700261 272 - 0.914 0.814 -0.384
ENSG00000135424 E053 5.4020992 0.005699212 0.817634286 0.90672500 12 55700262 55700393 132 - 0.736 0.768 0.127
ENSG00000135424 E054 6.4364782 0.189492952 0.445054544 0.66216915 12 55700566 55700671 106 - 0.893 0.785 -0.421
ENSG00000135424 E055 8.4782514 0.298425143 0.412775356 0.63818644 12 55700672 55700775 104 - 0.977 0.897 -0.299
ENSG00000135424 E056 4.1750224 0.119473589 0.423367277 0.64614770 12 55700776 55700782 7 - 0.741 0.626 -0.484
ENSG00000135424 E057 6.5541748 0.117188718 0.330805942 0.56973219 12 55700783 55700898 116 - 0.921 0.783 -0.536
ENSG00000135424 E058 17.2818099 0.002106498 0.958756829 0.98128046 12 55700899 55700971 73 - 1.205 1.198 -0.025
ENSG00000135424 E059 11.3839550 0.003647471 0.865486490 0.93341660 12 55700972 55700996 25 - 1.020 1.038 0.066
ENSG00000135424 E060 20.2262961 0.008418441 0.972598948 0.98824987 12 55700997 55701133 137 - 1.262 1.266 0.015
ENSG00000135424 E061 12.3524134 0.003538987 0.438925476 0.65790515 12 55701134 55701154 21 - 0.996 1.081 0.313
ENSG00000135424 E062 0.0000000       12 55701379 55701416 38 -      
ENSG00000135424 E063 0.0000000       12 55702828 55702871 44 -      
ENSG00000135424 E064 16.8903054 0.001997124 0.609276020 0.77641602 12 55702872 55702951 80 - 1.157 1.203 0.164
ENSG00000135424 E065 0.1723744 0.032649190 1.000000000   12 55702952 55703050 99 - 0.000 0.075 8.682
ENSG00000135424 E066 20.2344614 0.002552170 0.422390963 0.64541750 12 55703051 55703178 128 - 1.323 1.251 -0.251
ENSG00000135424 E067 21.0557817 0.001647929 0.901166833 0.95245681 12 55707477 55707904 428 - 1.274 1.282 0.027
ENSG00000135424 E068 3.1199588 0.023918212 0.368915236 0.60314319 12 55712063 55712134 72 - 0.690 0.534 -0.688
ENSG00000135424 E069 0.0000000       12 55712135 55712256 122 -      
ENSG00000135424 E070 0.0000000       12 55712257 55712411 155 -      
ENSG00000135424 E071 2.8112945 0.088377283 0.302639266 0.54320254 12 55715919 55716043 125 - 0.689 0.483 -0.931
ENSG00000135424 E072 0.0000000       12 55716278 55716404 127 -