ENSG00000135365

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000418153 ENSG00000135365 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF21A protein_coding protein_coding 6.093181 9.145857 6.635294 1.565925 0.09407268 -0.462362 0.1529514 0.1688849 0.47885340 0.04190553 0.13638537 1.4503703 0.02484583 0.02100000 0.072700000 0.05170000 0.252554248 0.008029376 FALSE TRUE
ENST00000532028 ENSG00000135365 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF21A protein_coding protein_coding 6.093181 9.145857 6.635294 1.565925 0.09407268 -0.462362 0.2284183 0.5978641 0.00000000 0.38140768 0.00000000 -5.9256770 0.03302917 0.05730000 0.000000000 -0.05730000 0.008029376 0.008029376 FALSE FALSE
ENST00000676320 ENSG00000135365 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF21A protein_coding protein_coding 6.093181 9.145857 6.635294 1.565925 0.09407268 -0.462362 1.4896048 2.2822239 1.12015322 0.19178387 0.06749500 -1.0202296 0.25302500 0.26076667 0.168833333 -0.09193333 0.409401099 0.008029376 FALSE TRUE
MSTRG.5442.19 ENSG00000135365 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF21A protein_coding   6.093181 9.145857 6.635294 1.565925 0.09407268 -0.462362 0.1359759 0.1237167 0.50364365 0.06241617 0.13889914 1.9415879 0.02136667 0.01520000 0.075900000 0.06070000 0.245054816 0.008029376 FALSE TRUE
MSTRG.5442.3 ENSG00000135365 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF21A protein_coding   6.093181 9.145857 6.635294 1.565925 0.09407268 -0.462362 0.2943905 0.2999324 0.03700657 0.26160659 0.03700657 -2.7210192 0.05114583 0.03176667 0.005666667 -0.02610000 0.811514171 0.008029376 FALSE TRUE
MSTRG.5442.6 ENSG00000135365 HEK293_OSMI2_6hA HEK293_TMG_6hB PHF21A protein_coding   6.093181 9.145857 6.635294 1.565925 0.09407268 -0.462362 1.2606020 2.4989692 1.68221919 0.53870666 0.11651922 -0.5681783 0.20073750 0.27123333 0.253733333 -0.01750000 0.955329818 0.008029376 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000135365 E001 0.0000000       11 45929319 45929322 4 -      
ENSG00000135365 E002 158.5088266 0.0077871088 6.513821e-05 0.00104437 11 45929323 45932565 3243 - 2.048 2.253 0.687
ENSG00000135365 E003 9.2277601 0.0039081736 6.750401e-01 0.81957569 11 45932566 45932578 13 - 0.952 1.009 0.210
ENSG00000135365 E004 8.3002087 0.0047668237 1.177983e-01 0.31220973 11 45932579 45932580 2 - 0.809 1.009 0.759
ENSG00000135365 E005 8.9240697 0.0038348715 1.751011e-01 0.39728234 11 45932581 45932595 15 - 0.862 1.030 0.628
ENSG00000135365 E006 14.0342001 0.0128021327 2.282048e-01 0.46317624 11 45932596 45932651 56 - 1.060 1.198 0.495
ENSG00000135365 E007 149.0521410 0.0003629893 2.403431e-02 0.10918586 11 45932652 45933480 829 - 2.108 2.186 0.259
ENSG00000135365 E008 70.4571200 0.0007998781 9.275598e-01 0.96584125 11 45933481 45933830 350 - 1.832 1.845 0.044
ENSG00000135365 E009 58.5603613 0.0008227749 1.653824e-01 0.38443153 11 45933831 45933984 154 - 1.710 1.786 0.259
ENSG00000135365 E010 28.2349837 0.0020873436 1.344461e-01 0.33879974 11 45933985 45934001 17 - 1.380 1.495 0.396
ENSG00000135365 E011 25.0918175 0.0037326678 2.996031e-01 0.54002831 11 45934002 45934004 3 - 1.349 1.436 0.304
ENSG00000135365 E012 35.9496830 0.0086387608 2.678242e-01 0.50744666 11 45934005 45934043 39 - 1.497 1.589 0.314
ENSG00000135365 E013 47.2867121 0.0277351209 4.443686e-01 0.66166900 11 45934044 45934132 89 - 1.610 1.700 0.305
ENSG00000135365 E014 49.0902896 0.0414472119 5.028308e-01 0.70272996 11 45934133 45934225 93 - 1.633 1.712 0.270
ENSG00000135365 E015 1.6470807 0.3058114756 2.808516e-02 0.12152225 11 45934226 45934585 360 - 0.000 0.559 14.471
ENSG00000135365 E016 3.5145996 0.0788689038 9.938399e-01 0.99855241 11 45934586 45935120 535 - 0.640 0.648 0.034
ENSG00000135365 E017 3.5457225 0.0600428204 1.803118e-01 0.40442569 11 45935121 45935157 37 - 0.779 0.567 -0.897
ENSG00000135365 E018 3.3738255 0.0075563398 3.171313e-01 0.55714536 11 45935158 45935246 89 - 0.715 0.572 -0.616
ENSG00000135365 E019 2.4600948 0.2185584225 5.079210e-01 0.70637346 11 45935247 45935635 389 - 0.635 0.469 -0.774
ENSG00000135365 E020 46.5598306 0.0127871387 7.855966e-01 0.88787678 11 45935636 45935693 58 - 1.639 1.671 0.109
ENSG00000135365 E021 45.7809584 0.0016605734 3.211329e-01 0.56066335 11 45935694 45935739 46 - 1.680 1.634 -0.156
ENSG00000135365 E022 55.0161373 0.0012314701 2.136081e-01 0.44589473 11 45936494 45936569 76 - 1.763 1.710 -0.180
ENSG00000135365 E023 2.3455209 0.0114994300 9.281569e-01 0.96608989 11 45936570 45938156 1587 - 0.490 0.511 0.100
ENSG00000135365 E024 51.2850520 0.0044511094 4.560768e-01 0.67031128 11 45938157 45938218 62 - 1.721 1.684 -0.124
ENSG00000135365 E025 58.3947607 0.0011061511 4.372846e-01 0.65667711 11 45938219 45938312 94 - 1.773 1.744 -0.097
ENSG00000135365 E026 9.7331432 0.0889368230 7.370194e-01 0.85859703 11 45938313 45939756 1444 - 1.051 0.982 -0.255
ENSG00000135365 E027 60.5808960 0.0006446153 9.744426e-01 0.98908606 11 45945840 45946003 164 - 1.769 1.777 0.027
ENSG00000135365 E028 0.9458845 0.0185386423 8.662181e-01   11 45946004 45946075 72 - 0.264 0.299 0.245
ENSG00000135365 E029 2.3260903 0.0092566086 2.146226e-02 0.10085303 11 45946076 45946098 23 - 0.715 0.350 -1.754
ENSG00000135365 E030 38.1528089 0.0011123266 3.573345e-01 0.59354849 11 45948886 45948946 61 - 1.601 1.557 -0.152
ENSG00000135365 E031 41.4673844 0.0013717232 9.492493e-02 0.27285190 11 45949402 45949481 80 - 1.669 1.585 -0.285
ENSG00000135365 E032 0.8787002 0.8383853225 6.525747e-01   11 45949482 45950205 724 - 0.366 0.179 -1.373
ENSG00000135365 E033 29.7929931 0.0082888591 3.681363e-01 0.60250196 11 45950206 45950257 52 - 1.516 1.459 -0.195
ENSG00000135365 E034 1.0075998 0.0283686456 2.217041e-02   11 45951910 45953526 1617 - 0.491 0.097 -3.072
ENSG00000135365 E035 39.1899692 0.0067182224 3.963123e-01 0.62538745 11 45953527 45953625 99 - 1.619 1.575 -0.149
ENSG00000135365 E036 3.0403381 0.0687841907 4.413908e-01 0.65966282 11 45964503 45965314 812 - 0.677 0.543 -0.594
ENSG00000135365 E037 69.1227363 0.0091542370 1.209050e-01 0.31729391 11 45965315 45965608 294 - 1.883 1.798 -0.285
ENSG00000135365 E038 39.0480442 0.0012647104 1.889492e-02 0.09207105 11 45969815 45969901 87 - 1.661 1.536 -0.427
ENSG00000135365 E039 21.0078393 0.0046401073 1.743113e-01 0.39627936 11 45969902 45969904 3 - 1.381 1.278 -0.359
ENSG00000135365 E040 1.1957345 0.0178969476 7.472950e-01   11 45969905 45971115 1211 - 0.354 0.300 -0.337
ENSG00000135365 E041 28.7800329 0.0040709734 4.180208e-03 0.03016582 11 45971116 45971138 23 - 1.564 1.370 -0.665
ENSG00000135365 E042 51.0594351 0.0007824095 1.060344e-02 0.06069018 11 45971139 45971277 139 - 1.769 1.651 -0.401
ENSG00000135365 E043 38.7847792 0.0009478849 9.552223e-01 0.97955779 11 45971278 45971346 69 - 1.578 1.591 0.045
ENSG00000135365 E044 22.7675543 0.0015644676 7.161649e-01 0.84570808 11 45971347 45971347 1 - 1.341 1.378 0.127
ENSG00000135365 E045 25.9181627 0.0013720594 4.120864e-01 0.63765869 11 45971348 45971364 17 - 1.373 1.441 0.234
ENSG00000135365 E046 17.4122722 0.0018990330 8.663463e-02 0.25761770 11 45971365 45971367 3 - 1.146 1.304 0.559
ENSG00000135365 E047 0.3559677 0.4355193531 1.724184e-01   11 45971368 45971369 2 - 0.269 0.000 -12.922
ENSG00000135365 E048 0.6120945 0.0200006500 6.277664e-01   11 45977881 45979223 1343 - 0.152 0.242 0.829
ENSG00000135365 E049 0.3447487 0.6373012019 5.535656e-01   11 45979224 45979759 536 - 0.000 0.179 11.576
ENSG00000135365 E050 34.1936950 0.0021756112 7.579075e-01 0.87131508 11 45979760 45979815 56 - 1.543 1.534 -0.030
ENSG00000135365 E051 32.3148626 0.0013775815 4.836064e-01 0.68949806 11 45979816 45979862 47 - 1.532 1.499 -0.115
ENSG00000135365 E052 40.7914261 0.0043162959 9.514944e-01 0.97771975 11 45979863 45979966 104 - 1.601 1.618 0.058
ENSG00000135365 E053 0.1723744 0.0415515777 7.855266e-01   11 45979967 45981155 1189 - 0.000 0.097 12.222
ENSG00000135365 E054 0.0000000       11 46026811 46027078 268 -      
ENSG00000135365 E055 0.0000000       11 46047970 46048003 34 -      
ENSG00000135365 E056 1.6785765 0.0120431796 6.031163e-03 0.03987348 11 46048004 46049399 1396 - 0.639 0.175 -2.751
ENSG00000135365 E057 1.1117944 0.4635323681 8.014685e-01   11 46049400 46049497 98 - 0.362 0.253 -0.721
ENSG00000135365 E058 0.1779838 0.0337543381 2.903120e-01   11 46049616 46049737 122 - 0.152 0.000 -13.823
ENSG00000135365 E059 0.0000000       11 46050346 46050466 121 -      
ENSG00000135365 E060 0.6260739 0.1201125500 6.167305e-01   11 46075033 46076753 1721 - 0.264 0.175 -0.761
ENSG00000135365 E061 31.8427350 0.0012851494 7.780380e-01 0.88353245 11 46076754 46076819 66 - 1.488 1.516 0.096
ENSG00000135365 E062 0.4929928 0.0210903116 3.027377e-01   11 46076820 46076840 21 - 0.264 0.096 -1.751
ENSG00000135365 E063 20.9962105 0.0015396156 2.713574e-01 0.51130714 11 46079134 46079140 7 - 1.373 1.299 -0.259
ENSG00000135365 E064 23.6624519 0.0015036775 5.380868e-01 0.72771191 11 46079141 46079166 26 - 1.396 1.360 -0.125
ENSG00000135365 E065 0.0000000       11 46082424 46083554 1131 -      
ENSG00000135365 E066 0.0000000       11 46083555 46083611 57 -      
ENSG00000135365 E067 20.4078007 0.0017169248 7.080494e-01 0.84054655 11 46084166 46084185 20 - 1.324 1.304 -0.070
ENSG00000135365 E068 20.5152584 0.0017250554 9.553021e-01 0.97955945 11 46084186 46084192 7 - 1.307 1.320 0.047
ENSG00000135365 E069 40.9140650 0.0014506557 2.747722e-01 0.51475617 11 46084193 46084302 110 - 1.640 1.588 -0.177
ENSG00000135365 E070 10.6476893 0.0035950850 6.731133e-01 0.81830114 11 46090455 46090506 52 - 1.075 1.039 -0.129
ENSG00000135365 E071 11.2720277 0.0034134541 8.889015e-01 0.94611913 11 46090507 46090566 60 - 1.075 1.068 -0.024
ENSG00000135365 E072 0.1426347 0.0319859221 2.907720e-01   11 46090567 46090581 15 - 0.152 0.000 -13.840
ENSG00000135365 E073 26.5779866 0.0014037447 2.686996e-01 0.50837660 11 46092183 46092223 41 - 1.469 1.404 -0.226
ENSG00000135365 E074 0.3032425 0.0274424043 3.910873e-01   11 46092224 46092224 1 - 0.000 0.175 13.299
ENSG00000135365 E075 0.1779838 0.0337543381 2.903120e-01   11 46112043 46112093 51 - 0.152 0.000 -13.823
ENSG00000135365 E076 5.2340516 0.0135303595 4.808340e-01 0.68763764 11 46117922 46118064 143 - 0.715 0.825 0.440
ENSG00000135365 E077 2.4925296 0.0665252991 4.278757e-01 0.64939503 11 46118065 46118114 50 - 0.429 0.594 0.796
ENSG00000135365 E078 1.0067919 0.0160148633 5.138552e-01   11 46118115 46118137 23 - 0.354 0.242 -0.752
ENSG00000135365 E079 0.7982606 0.0170578233 4.254019e-01   11 46118138 46118145 8 - 0.152 0.300 1.247
ENSG00000135365 E080 5.7238355 0.0057106247 6.846233e-01 0.82568962 11 46118742 46118800 59 - 0.780 0.842 0.245
ENSG00000135365 E081 0.8018448 0.0182038477 2.996667e-01   11 46118801 46118803 3 - 0.353 0.175 -1.339
ENSG00000135365 E082 7.1551920 0.0043496440 6.529129e-01 0.80533861 11 46119724 46119862 139 - 0.862 0.927 0.246
ENSG00000135365 E083 0.3336024 0.0244411696 3.911821e-01   11 46120389 46120540 152 - 0.000 0.175 13.323
ENSG00000135365 E084 0.6957271 0.0187068199 5.978091e-01   11 46120746 46120934 189 - 0.264 0.176 -0.749
ENSG00000135365 E085 21.6084271 0.0020385893 1.127643e-02 0.06350722 11 46120935 46121454 520 - 1.450 1.270 -0.626