ENSG00000135164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331242 ENSG00000135164 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTF1 protein_coding protein_coding 22.7863 9.327304 50.18448 0.7302102 3.193552 2.426451 2.3835510 1.0906702 5.935882 0.5578281 0.8087236 2.4335086 0.09254167 0.12580000 0.11940000 -0.00640000 0.9490012984 6.85833e-08 FALSE TRUE
ENST00000454008 ENSG00000135164 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTF1 protein_coding protein_coding 22.7863 9.327304 50.18448 0.7302102 3.193552 2.426451 1.4202158 1.5547986 1.874929 0.2775801 0.5889584 0.2685334 0.11577500 0.17120000 0.03620000 -0.13500000 0.0264984744 6.85833e-08 FALSE TRUE
ENST00000488352 ENSG00000135164 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTF1 protein_coding retained_intron 22.7863 9.327304 50.18448 0.7302102 3.193552 2.426451 1.3431098 0.3821008 2.524920 0.0838695 0.2039018 2.6926440 0.05633333 0.04020000 0.05023333 0.01003333 0.8570968829 6.85833e-08 FALSE TRUE
ENST00000579677 ENSG00000135164 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTF1 protein_coding nonsense_mediated_decay 22.7863 9.327304 50.18448 0.7302102 3.193552 2.426451 0.5479682 0.9992848 0.000000 0.5115807 0.0000000 -6.6571895 0.03482500 0.09926667 0.00000000 -0.09926667 0.0744675366 6.85833e-08 FALSE TRUE
ENST00000580803 ENSG00000135164 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTF1 protein_coding retained_intron 22.7863 9.327304 50.18448 0.7302102 3.193552 2.426451 1.9872614 0.6851446 4.533092 0.2154939 0.3569928 2.7082896 0.07699583 0.07710000 0.09153333 0.01443333 0.8778232877 6.85833e-08 FALSE TRUE
ENST00000583751 ENSG00000135164 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTF1 protein_coding processed_transcript 22.7863 9.327304 50.18448 0.7302102 3.193552 2.426451 1.3765817 0.0000000 2.481905 0.0000000 0.8053022 7.9611052 0.07274583 0.00000000 0.04776667 0.04776667 0.0001181242 6.85833e-08   FALSE
MSTRG.30166.17 ENSG00000135164 HEK293_OSMI2_6hA HEK293_TMG_6hB DMTF1 protein_coding   22.7863 9.327304 50.18448 0.7302102 3.193552 2.426451 1.8284688 0.6398202 5.832103 0.3254412 0.5695985 3.1683753 0.06465833 0.07180000 0.11803333 0.04623333 0.8080684406 6.85833e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000135164 E001 0.1426347 0.0332053832 1.000000e+00   7 87152409 87152411 3 + 0.067 0.000 -7.270
ENSG00000135164 E002 0.3206185 0.0274424043 1.000000e+00   7 87152412 87152425 14 + 0.125 0.000 -10.633
ENSG00000135164 E003 0.4986023 0.0300268528 5.780752e-01   7 87152426 87152431 6 + 0.176 0.000 -11.190
ENSG00000135164 E004 0.8192208 0.0808568932 2.934808e-01   7 87152432 87152435 4 + 0.263 0.000 -11.674
ENSG00000135164 E005 3.2817888 0.0119246346 8.025165e-01 8.977331e-01 7 87152436 87152439 4 + 0.563 0.615 0.232
ENSG00000135164 E006 5.7392246 0.0050990294 1.060159e-01 2.923714e-01 7 87152440 87152447 8 + 0.698 0.930 0.914
ENSG00000135164 E007 7.6154936 0.0044295211 1.231387e-01 3.207133e-01 7 87152448 87152449 2 + 0.812 1.016 0.774
ENSG00000135164 E008 7.7934775 0.0046945228 1.452640e-01 3.552945e-01 7 87152450 87152451 2 + 0.823 1.016 0.731
ENSG00000135164 E009 8.4369273 0.0042773238 2.515105e-01 4.895855e-01 7 87152452 87152452 1 + 0.864 1.016 0.571
ENSG00000135164 E010 14.2763569 0.0144910970 2.456691e-01 4.831780e-01 7 87152453 87152464 12 + 1.074 1.218 0.516
ENSG00000135164 E011 28.3211653 0.0015127761 3.029266e-01 5.435000e-01 7 87152465 87152467 3 + 1.367 1.455 0.307
ENSG00000135164 E012 44.2055431 0.0084447479 3.567074e-01 5.931056e-01 7 87152468 87152497 30 + 1.556 1.641 0.287
ENSG00000135164 E013 52.9093028 0.0175623556 8.948939e-01 9.491817e-01 7 87152498 87152530 33 + 1.644 1.676 0.111
ENSG00000135164 E014 55.3624415 0.0110275298 9.559748e-01 9.798918e-01 7 87152531 87152545 15 + 1.665 1.685 0.068
ENSG00000135164 E015 44.4668151 0.0120807174 6.481458e-01 8.022951e-01 7 87152546 87152553 8 + 1.580 1.553 -0.094
ENSG00000135164 E016 42.1717024 0.0059908978 5.475454e-01 7.345024e-01 7 87152554 87152555 2 + 1.559 1.524 -0.119
ENSG00000135164 E017 0.8315845 0.0916316850 8.102316e-02   7 87152556 87152612 57 + 0.125 0.459 2.490
ENSG00000135164 E018 0.5227326 0.2242886149 1.329578e-01   7 87152613 87152628 16 + 0.067 0.355 2.920
ENSG00000135164 E019 0.3503582 0.0284011441 3.377142e-01   7 87152629 87152630 2 + 0.067 0.211 1.916
ENSG00000135164 E020 2.0336637 0.4289716823 4.230456e-01 6.458831e-01 7 87152631 87152791 161 + 0.305 0.689 1.934
ENSG00000135164 E021 1.3495154 0.2484492647 2.334883e-01   7 87152792 87152795 4 + 0.223 0.551 1.932
ENSG00000135164 E022 3.2249269 0.0306054215 4.078268e-01 6.343325e-01 7 87152796 87152944 149 + 0.522 0.678 0.696
ENSG00000135164 E023 4.4024711 0.0057018161 3.440362e-01 5.816583e-01 7 87154228 87154278 51 + 0.698 0.545 -0.671
ENSG00000135164 E024 29.0095074 0.0013056758 3.775033e-01 6.102514e-01 7 87154390 87154456 67 + 1.408 1.348 -0.208
ENSG00000135164 E025 36.8485798 0.0011521827 2.362084e-01 4.722028e-01 7 87154457 87154528 72 + 1.511 1.436 -0.257
ENSG00000135164 E026 5.2282356 0.0084805107 9.468836e-03 5.582067e-02 7 87155455 87155497 43 + 0.619 0.989 1.470
ENSG00000135164 E027 3.3372744 0.0068730785 7.944479e-01 8.929895e-01 7 87155498 87155559 62 + 0.583 0.545 -0.173
ENSG00000135164 E028 5.5139350 0.0231013103 2.555430e-01 4.941989e-01 7 87162798 87162881 84 + 0.685 0.863 0.715
ENSG00000135164 E029 8.8915708 0.0159268362 4.478877e-01 6.641429e-01 7 87162882 87163219 338 + 0.930 0.823 -0.408
ENSG00000135164 E030 3.9958873 0.0069844885 7.423123e-02 2.332114e-01 7 87163220 87163238 19 + 0.683 0.353 -1.609
ENSG00000135164 E031 12.5610468 0.0029239811 1.904896e-01 4.175762e-01 7 87163239 87163286 48 + 1.078 0.930 -0.546
ENSG00000135164 E032 13.8487525 0.0028274680 3.475779e-01 5.849911e-01 7 87163287 87163332 46 + 1.113 1.017 -0.349
ENSG00000135164 E033 12.3785824 0.0165406871 2.493825e-02 1.120334e-01 7 87163333 87163494 162 + 1.093 0.778 -1.185
ENSG00000135164 E034 105.6988896 0.0005085572 2.936551e-03 2.301735e-02 7 87163495 87163617 123 + 1.966 1.844 -0.408
ENSG00000135164 E035 1.8941925 0.0106637734 6.861905e-01 8.266247e-01 7 87164254 87164331 78 + 0.425 0.353 -0.407
ENSG00000135164 E036 81.2114225 0.0013421794 8.905604e-01 9.469709e-01 7 87164934 87165050 117 + 1.828 1.844 0.055
ENSG00000135164 E037 88.1926119 0.0005079415 2.797559e-02 1.211947e-01 7 87166483 87166605 123 + 1.885 1.791 -0.318
ENSG00000135164 E038 11.0915991 0.0066643529 4.450662e-01 6.621691e-01 7 87167957 87168043 87 + 1.019 0.931 -0.328
ENSG00000135164 E039 91.6447670 0.0007658473 1.079411e-03 1.052712e-02 7 87170995 87171089 95 + 1.911 1.763 -0.500
ENSG00000135164 E040 93.8944228 0.0004294012 5.931374e-04 6.518792e-03 7 87173535 87173649 115 + 1.920 1.768 -0.513
ENSG00000135164 E041 84.0252642 0.0099099574 2.170184e-01 4.499087e-01 7 87174593 87174669 77 + 1.860 1.774 -0.288
ENSG00000135164 E042 108.5506463 0.0008223101 3.520340e-01 5.890590e-01 7 87179545 87179702 158 + 1.962 1.932 -0.102
ENSG00000135164 E043 2.0687797 0.1632477700 8.520809e-01 9.262359e-01 7 87181196 87181308 113 + 0.425 0.459 0.175
ENSG00000135164 E044 58.8190342 0.0007412882 5.666224e-01 7.477195e-01 7 87181309 87181341 33 + 1.698 1.675 -0.076
ENSG00000135164 E045 11.7036101 0.0079083740 5.699094e-02 1.960375e-01 7 87182017 87182055 39 + 1.066 0.822 -0.919
ENSG00000135164 E046 39.5951571 0.0016184340 8.870923e-01 9.451577e-01 7 87182056 87182197 142 + 1.522 1.542 0.068
ENSG00000135164 E047 22.7068038 0.0016108851 1.349996e-01 3.397036e-01 7 87182198 87182227 30 + 1.262 1.395 0.463
ENSG00000135164 E048 59.2271832 0.0006474624 2.412798e-01 4.780138e-01 7 87182228 87182246 19 + 1.677 1.749 0.246
ENSG00000135164 E049 91.6360805 0.0004993091 2.410368e-01 4.777449e-01 7 87182247 87182337 91 + 1.889 1.845 -0.148
ENSG00000135164 E050 151.4056489 0.0003337465 4.300001e-01 6.510852e-01 7 87184397 87184625 229 + 2.101 2.084 -0.059
ENSG00000135164 E051 1.5089785 0.0753126560 4.656448e-01 6.770624e-01 7 87184820 87184848 29 + 0.369 0.212 -1.092
ENSG00000135164 E052 1.4868009 0.0124720551 9.501564e-01 9.771401e-01 7 87184849 87184892 44 + 0.335 0.353 0.109
ENSG00000135164 E053 1.4702327 0.0126067714 9.501415e-01 9.771401e-01 7 87184893 87185020 128 + 0.335 0.353 0.109
ENSG00000135164 E054 116.9212262 0.0004443110 3.106579e-01 5.511524e-01 7 87185829 87185980 152 + 1.994 1.963 -0.103
ENSG00000135164 E055 10.9539455 0.0451076217 5.167394e-02 1.836823e-01 7 87185981 87185995 15 + 1.056 0.729 -1.251
ENSG00000135164 E056 167.4687542 0.0170806007 8.622956e-02 2.568721e-01 7 87185996 87188038 2043 + 2.161 2.057 -0.350
ENSG00000135164 E057 21.7419845 0.0018329672 8.639186e-01 9.325768e-01 7 87188039 87188091 53 + 1.274 1.268 -0.020
ENSG00000135164 E058 43.2637029 0.0010730144 4.240024e-01 6.465375e-01 7 87188092 87188092 1 + 1.569 1.526 -0.147
ENSG00000135164 E059 90.2288752 0.0004189011 8.543758e-01 9.272633e-01 7 87188093 87188197 105 + 1.871 1.889 0.061
ENSG00000135164 E060 91.3123525 0.0059753209 8.653041e-01 9.333372e-01 7 87188198 87188301 104 + 1.882 1.878 -0.016
ENSG00000135164 E061 91.8665800 0.0060082694 3.509791e-01 5.881101e-01 7 87190945 87191027 83 + 1.893 1.844 -0.167
ENSG00000135164 E062 27.8374546 0.0015465623 6.744299e-02 2.193376e-01 7 87192477 87193197 721 + 1.400 1.253 -0.510
ENSG00000135164 E063 103.7658814 0.0004513060 6.047180e-01 7.733292e-01 7 87193198 87193300 103 + 1.938 1.926 -0.040
ENSG00000135164 E064 79.6426380 0.0005439332 4.084794e-01 6.348653e-01 7 87193301 87193353 53 + 1.811 1.860 0.164
ENSG00000135164 E065 19.3654366 0.0021041167 6.888241e-03 4.413105e-02 7 87193354 87193493 140 + 1.270 0.990 -1.004
ENSG00000135164 E066 179.0693669 0.0002628673 6.310558e-01 7.910754e-01 7 87193725 87193953 229 + 2.165 2.191 0.084
ENSG00000135164 E067 144.9654318 0.0003054793 1.511631e-01 3.640228e-01 7 87193954 87194102 149 + 2.067 2.126 0.200
ENSG00000135164 E068 18.7950987 0.0020543222 8.678235e-01 9.347735e-01 7 87194103 87194683 581 + 1.212 1.238 0.091
ENSG00000135164 E069 134.9068136 0.0003881333 7.452560e-02 2.338732e-01 7 87194684 87194828 145 + 2.030 2.104 0.247
ENSG00000135164 E070 11.8878046 0.1617977638 7.659274e-01 8.761896e-01 7 87194829 87195030 202 + 1.002 1.103 0.365
ENSG00000135164 E071 127.7033441 0.0015505683 6.998691e-02 2.247870e-01 7 87195031 87195125 95 + 2.005 2.086 0.273
ENSG00000135164 E072 450.9405858 0.0035500026 1.216860e-06 3.366195e-05 7 87195126 87196337 1212 + 2.533 2.683 0.500
ENSG00000135164 E073 0.6151152 0.4817220275 7.868664e-01   7 87201198 87201226 29 + 0.176 0.207 0.281
ENSG00000135164 E074 4.8131166 0.0054152423 5.239507e-01 7.177800e-01 7 87202180 87202690 511 + 0.712 0.616 -0.407