ENSG00000135108

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330622 ENSG00000135108 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXO21 protein_coding protein_coding 18.1164 8.66636 27.64959 1.307532 1.119909 1.672618 6.286632 2.731489 9.785158 0.3464857 0.3853019 1.837109 0.3145375 0.3178000 0.3543000 0.0365000 7.801556e-01 5.819091e-18 FALSE TRUE
ENST00000622495 ENSG00000135108 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXO21 protein_coding protein_coding 18.1164 8.66636 27.64959 1.307532 1.119909 1.672618 8.656010 5.460771 11.060877 1.1582447 0.3519470 1.016954 0.5513375 0.6177333 0.4011000 -0.2166333 2.621401e-02 5.819091e-18 FALSE TRUE
MSTRG.8106.4 ENSG00000135108 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXO21 protein_coding   18.1164 8.66636 27.64959 1.307532 1.119909 1.672618 2.494021 0.000000 6.082051 0.0000000 0.7874981 9.250784 0.0916875 0.0000000 0.2188667 0.2188667 5.819091e-18 5.819091e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000135108 E001 480.5663197 1.703535143 0.42053953 0.64406042 12 117141991 117145048 3058 - 2.525 2.840 1.049
ENSG00000135108 E002 41.3163312 0.616084770 0.34748959 0.58491732 12 117145049 117145067 19 - 1.509 1.737 0.777
ENSG00000135108 E003 293.0577674 1.557179798 0.49398840 0.69669225 12 117145068 117145915 848 - 2.349 2.580 0.773
ENSG00000135108 E004 183.2696861 1.400411054 0.50533329 0.70452857 12 117145916 117146277 362 - 2.163 2.354 0.639
ENSG00000135108 E005 1.5753550 0.157444389 0.47856853 0.68611710 12 117154250 117154302 53 - 0.317 0.531 1.155
ENSG00000135108 E006 4.9733083 0.084591025 0.01951720 0.09424673 12 117155054 117155615 562 - 0.548 1.027 1.931
ENSG00000135108 E007 117.1270794 0.004301866 0.16255104 0.38055013 12 117155791 117155948 158 - 1.993 2.133 0.468
ENSG00000135108 E008 139.7647954 0.024242169 0.21321186 0.44549778 12 117157873 117158063 191 - 2.112 2.117 0.017
ENSG00000135108 E009 17.9147159 0.048270167 0.15590030 0.37074760 12 117158064 117158084 21 - 1.272 1.169 -0.363
ENSG00000135108 E010 135.9504339 0.037728171 0.14011857 0.34769534 12 117165485 117165617 133 - 2.115 2.073 -0.142
ENSG00000135108 E011 162.3960670 0.046538979 0.08558233 0.25566157 12 117166898 117167077 180 - 2.201 2.125 -0.255
ENSG00000135108 E012 75.9375322 0.040625751 0.09929329 0.28055311 12 117172471 117172509 39 - 1.874 1.802 -0.244
ENSG00000135108 E013 114.3855193 0.039001901 0.03507530 0.14176490 12 117172510 117172607 98 - 2.059 1.949 -0.367
ENSG00000135108 E014 142.7827776 0.031734379 0.02132838 0.10040609 12 117174205 117174341 137 - 2.151 2.053 -0.329
ENSG00000135108 E015 60.6047849 0.015823266 0.08402621 0.25283691 12 117174651 117174654 4 - 1.765 1.733 -0.109
ENSG00000135108 E016 150.6632932 0.022130779 0.10051361 0.28271097 12 117174655 117174797 143 - 2.153 2.132 -0.067
ENSG00000135108 E017 130.1058236 0.030877494 0.04761198 0.17407847 12 117177520 117177641 122 - 2.105 2.033 -0.243
ENSG00000135108 E018 0.1426347 0.030988297 0.87723208   12 117184785 117184810 26 - 0.084 0.000 -9.377
ENSG00000135108 E019 102.2570507 0.038134480 0.05777776 0.19784814 12 117186477 117186571 95 - 2.007 1.916 -0.305
ENSG00000135108 E020 0.8192208 0.351698961 0.14460720   12 117188759 117188793 35 - 0.317 0.000 -11.714
ENSG00000135108 E021 0.3393995 0.027770096 0.43802748   12 117188794 117189226 433 - 0.154 0.000 -10.380
ENSG00000135108 E022 94.1156520 0.023468274 0.05513580 0.19165937 12 117189227 117189362 136 - 1.961 1.903 -0.194
ENSG00000135108 E023 66.6151596 0.028856176 0.97162130 0.98770647 12 117190218 117190470 253 - 1.764 1.863 0.336