ENSG00000134987

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000505303 ENSG00000134987 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR36 protein_coding retained_intron 13.45119 2.358851 28.52697 0.5548944 0.7642561 3.590573 1.8657260 0.01978317 4.297799 0.01978317 0.4981590 7.176310 0.08101667 0.0070000 0.1499333 0.14293333 1.687568e-05 1.687568e-05 FALSE TRUE
ENST00000513710 ENSG00000134987 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR36 protein_coding protein_coding 13.45119 2.358851 28.52697 0.5548944 0.7642561 3.590573 9.8259271 1.72699427 20.635189 0.44379166 0.9156632 3.571141 0.77213333 0.7344667 0.7228333 -0.01163333 9.738145e-01 1.687568e-05 FALSE TRUE
MSTRG.26730.1 ENSG00000134987 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR36 protein_coding   13.45119 2.358851 28.52697 0.5548944 0.7642561 3.590573 0.8916945 0.57842271 1.403474 0.23496642 0.5528487 1.264321 0.09343750 0.2316667 0.0503000 -0.18136667 1.278804e-01 1.687568e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000134987 E001 12.5186334 0.0142299154 0.7920518862 0.891631477 5 111092321 111092346 26 + 0.913 0.960 0.177
ENSG00000134987 E002 12.9889010 0.0149054469 0.9595275414 0.981671190 5 111092347 111092347 1 + 0.924 1.006 0.304
ENSG00000134987 E003 100.4703872 0.0112917510 0.0820312877 0.248811780 5 111092348 111092618 271 + 1.779 1.745 -0.115
ENSG00000134987 E004 42.6778486 0.0181547430 0.3196977175 0.559446298 5 111094920 111094947 28 + 1.415 1.418 0.010
ENSG00000134987 E005 7.6589596 0.1188557299 0.3641616317 0.599143770 5 111094948 111095209 262 + 0.748 0.603 -0.614
ENSG00000134987 E006 0.9475002 0.0161368731 0.6242735578   5 111097007 111097078 72 + 0.208 0.001 -8.405
ENSG00000134987 E007 73.1975063 0.0257396946 0.1756196182 0.397953811 5 111097079 111097179 101 + 1.644 1.631 -0.045
ENSG00000134987 E008 86.3629661 0.0261871684 0.0980717662 0.278383365 5 111098722 111098839 118 + 1.717 1.668 -0.166
ENSG00000134987 E009 83.0983979 0.0262012826 0.3472113119 0.584706083 5 111100589 111100721 133 + 1.694 1.706 0.039
ENSG00000134987 E010 53.5191856 0.0203655063 0.2035046816 0.433942837 5 111102345 111102399 55 + 1.511 1.481 -0.105
ENSG00000134987 E011 97.6666113 0.0147583399 0.1221444193 0.319255800 5 111103786 111103918 133 + 1.766 1.737 -0.100
ENSG00000134987 E012 129.0131455 0.0111867592 0.0020055746 0.017104896 5 111104177 111104352 176 + 1.894 1.759 -0.454
ENSG00000134987 E013 113.8227600 0.0101322226 0.0769449313 0.238675734 5 111104697 111104817 121 + 1.833 1.808 -0.082
ENSG00000134987 E014 87.6446008 0.0182958419 0.2733907462 0.513255599 5 111105295 111105360 66 + 1.718 1.732 0.050
ENSG00000134987 E015 91.6474636 0.0156678756 0.3536002603 0.590503255 5 111106057 111106143 87 + 1.734 1.759 0.084
ENSG00000134987 E016 131.7475854 0.0204224854 0.6009072730 0.770812568 5 111107294 111107439 146 + 1.887 1.940 0.178
ENSG00000134987 E017 108.0788645 0.0137503348 0.7180074556 0.846994534 5 111110189 111110303 115 + 1.801 1.871 0.239
ENSG00000134987 E018 136.3308324 0.0130447522 0.2645355382 0.503770282 5 111110788 111110953 166 + 1.905 1.926 0.069
ENSG00000134987 E019 112.1064650 0.0197828665 0.5902239137 0.763899886 5 111111170 111111278 109 + 1.817 1.876 0.199
ENSG00000134987 E020 1.3447864 0.0143589514 1.0000000000   5 111111279 111111552 274 + 0.235 0.304 0.499
ENSG00000134987 E021 87.5725356 0.0151502183 0.8646227679 0.932935372 5 111113074 111113153 80 + 1.706 1.817 0.376
ENSG00000134987 E022 112.3937580 0.0165401348 0.9725160292 0.988234320 5 111119013 111119120 108 + 1.814 1.907 0.312
ENSG00000134987 E023 117.5689933 0.0137497090 0.0988997318 0.279865297 5 111120496 111120593 98 + 1.846 1.811 -0.119
ENSG00000134987 E024 55.6820313 0.0081161613 0.0947623215 0.272538603 5 111120996 111121001 6 + 1.532 1.481 -0.172
ENSG00000134987 E025 115.6164586 0.0005497928 0.0001190983 0.001727948 5 111121002 111121141 140 + 1.849 1.722 -0.431
ENSG00000134987 E026 110.9655572 0.0004653421 0.0299680659 0.127247978 5 111123805 111123924 120 + 1.824 1.798 -0.085
ENSG00000134987 E027 95.3951989 0.0024744307 0.0482125573 0.175492469 5 111124108 111124189 82 + 1.758 1.730 -0.094
ENSG00000134987 E028 135.0542200 0.0079081670 0.3412713206 0.579222531 5 111125608 111125795 188 + 1.889 2.031 0.477
ENSG00000134987 E029 672.3347094 0.9293560481 0.2748440831 0.514856675 5 111126734 111130502 3769 + 2.551 2.879 1.091