ENSG00000134900

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376065 ENSG00000134900 HEK293_OSMI2_6hA HEK293_TMG_6hB TPP2 protein_coding protein_coding 10.69829 3.653138 18.34923 0.5311705 0.5557696 2.325353 1.4163688 0.7124025 0.7030747 0.71240249 0.70307468 -0.01874969 0.18778333 0.15146667 0.040300000 -0.111166667 9.079182e-01 3.227297e-05 FALSE TRUE
ENST00000482393 ENSG00000134900 HEK293_OSMI2_6hA HEK293_TMG_6hB TPP2 protein_coding processed_transcript 10.69829 3.653138 18.34923 0.5311705 0.5557696 2.325353 0.3498366 0.3628403 0.4934460 0.23102271 0.49344604 0.43327952 0.03842500 0.08920000 0.028300000 -0.060900000 5.778793e-01 3.227297e-05 FALSE TRUE
ENST00000490010 ENSG00000134900 HEK293_OSMI2_6hA HEK293_TMG_6hB TPP2 protein_coding processed_transcript 10.69829 3.653138 18.34923 0.5311705 0.5557696 2.325353 0.3609366 0.3684782 0.1570316 0.09987866 0.03707739 -1.18008894 0.07200833 0.10006667 0.008666667 -0.091400000 3.227297e-05 3.227297e-05 FALSE TRUE
ENST00000650757 ENSG00000134900 HEK293_OSMI2_6hA HEK293_TMG_6hB TPP2 protein_coding protein_coding 10.69829 3.653138 18.34923 0.5311705 0.5557696 2.325353 1.2286444 0.3092810 2.5799726 0.15655070 0.43539430 3.02003811 0.11292917 0.09866667 0.139633333 0.040966667 8.440339e-01 3.227297e-05 FALSE FALSE
ENST00000651448 ENSG00000134900 HEK293_OSMI2_6hA HEK293_TMG_6hB TPP2 protein_coding nonsense_mediated_decay 10.69829 3.653138 18.34923 0.5311705 0.5557696 2.325353 0.6964906 0.2297509 1.3260774 0.09204202 0.32676083 2.47839527 0.06131667 0.06823333 0.073100000 0.004866667 9.785654e-01 3.227297e-05 TRUE TRUE
MSTRG.9039.3 ENSG00000134900 HEK293_OSMI2_6hA HEK293_TMG_6hB TPP2 protein_coding   10.69829 3.653138 18.34923 0.5311705 0.5557696 2.325353 4.8925388 1.2844008 10.2310998 0.47650091 0.79613027 2.98401432 0.33553333 0.38550000 0.556066667 0.170566667 7.319492e-01 3.227297e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000134900 E001 3.6973627 0.0075494456 4.857847e-01 6.911184e-01 13 102596986 102596990 5 + 0.581 0.698 0.503
ENSG00000134900 E002 3.6973627 0.0075494456 4.857847e-01 6.911184e-01 13 102596991 102596991 1 + 0.581 0.698 0.503
ENSG00000134900 E003 12.4332516 0.0028518960 9.993573e-01 1.000000e+00 13 102596992 102597002 11 + 1.041 1.041 -0.003
ENSG00000134900 E004 20.7143754 0.0018559906 7.666473e-01 8.765836e-01 13 102597003 102597020 18 + 1.237 1.263 0.091
ENSG00000134900 E005 24.0384782 0.0016594974 9.405172e-01 9.725414e-01 13 102597021 102597032 12 + 1.302 1.308 0.018
ENSG00000134900 E006 26.4008591 0.0021964474 7.998910e-01 8.963075e-01 13 102597033 102597050 18 + 1.345 1.321 -0.081
ENSG00000134900 E007 42.3142640 0.0008870074 5.872211e-01 7.617725e-01 13 102597051 102597203 153 + 1.547 1.509 -0.130
ENSG00000134900 E008 42.9942189 0.0010845618 4.947370e-01 6.972545e-01 13 102604793 102604894 102 + 1.556 1.509 -0.163
ENSG00000134900 E009 30.5528398 0.0013945243 7.648876e-01 8.755718e-01 13 102604895 102604921 27 + 1.410 1.385 -0.085
ENSG00000134900 E010 2.9930845 0.0081191046 3.340198e-08 1.388938e-06 13 102607632 102608022 391 + 0.211 1.040 3.993
ENSG00000134900 E011 47.7684900 0.0009930404 1.758900e-01 3.983167e-01 13 102614101 102614196 96 + 1.608 1.518 -0.309
ENSG00000134900 E012 58.6782133 0.0007803441 2.356828e-01 4.716184e-01 13 102616396 102616500 105 + 1.690 1.619 -0.242
ENSG00000134900 E013 1.7502025 0.3541906774 7.662050e-01 8.763331e-01 13 102616956 102617051 96 + 0.360 0.461 0.551
ENSG00000134900 E014 64.3373345 0.0007424662 8.719455e-01 9.369715e-01 13 102618722 102618846 125 + 1.716 1.723 0.026
ENSG00000134900 E015 76.6015073 0.0045881195 5.269454e-01 7.198145e-01 13 102622877 102623040 164 + 1.798 1.755 -0.147
ENSG00000134900 E016 0.1426347 0.0318491999 1.000000e+00   13 102626900 102627011 112 + 0.063 0.000 -9.802
ENSG00000134900 E017 67.3719799 0.0047508804 7.558887e-01 8.701510e-01 13 102627012 102627145 134 + 1.739 1.713 -0.089
ENSG00000134900 E018 36.7527406 0.0013392595 5.924482e-01 7.652157e-01 13 102627146 102627166 21 + 1.483 1.441 -0.143
ENSG00000134900 E019 41.9493221 0.0012635965 6.358769e-01 7.941937e-01 13 102627848 102627924 77 + 1.536 1.500 -0.121
ENSG00000134900 E020 46.8682597 0.0010352706 4.878053e-01 6.925251e-01 13 102629482 102629609 128 + 1.589 1.543 -0.158
ENSG00000134900 E021 45.3718355 0.0007997362 1.200567e-01 3.159374e-01 13 102630096 102630195 100 + 1.588 1.481 -0.364
ENSG00000134900 E022 0.6659874 0.0234327182 7.550245e-01   13 102631280 102631532 253 + 0.167 0.222 0.509
ENSG00000134900 E023 65.8064092 0.0017137581 8.225104e-02 2.492166e-01 13 102633950 102634098 149 + 1.743 1.639 -0.352
ENSG00000134900 E024 58.5665587 0.0008706283 1.954325e-01 4.239068e-01 13 102635587 102635702 116 + 1.690 1.612 -0.266
ENSG00000134900 E025 59.1599215 0.0018620659 1.538204e-02 7.951978e-02 13 102636224 102636392 169 + 1.706 1.551 -0.527
ENSG00000134900 E026 63.0161405 0.0026173000 2.082135e-01 4.396888e-01 13 102637082 102637239 158 + 1.719 1.639 -0.272
ENSG00000134900 E027 45.8494883 0.0052697481 5.285050e-01 7.209832e-01 13 102638239 102638315 77 + 1.563 1.604 0.140
ENSG00000134900 E028 38.0290339 0.0011166452 6.711035e-01 8.170427e-01 13 102640270 102640295 26 + 1.489 1.518 0.097
ENSG00000134900 E029 55.9592364 0.0007324999 2.292721e-01 4.642937e-01 13 102640296 102640376 81 + 1.672 1.598 -0.252
ENSG00000134900 E030 75.0905831 0.0192228256 2.562740e-01 4.950632e-01 13 102643222 102643376 155 + 1.800 1.713 -0.294
ENSG00000134900 E031 64.2242780 0.0081000164 6.681583e-01 8.150020e-01 13 102644557 102644673 117 + 1.712 1.741 0.100
ENSG00000134900 E032 61.4690333 0.0010774044 4.787634e-01 6.862932e-01 13 102644909 102645009 101 + 1.694 1.734 0.134
ENSG00000134900 E033 39.6664428 0.1107548371 4.032209e-01 6.308828e-01 13 102645010 102646293 1284 + 1.531 1.412 -0.408
ENSG00000134900 E034 61.2214462 0.0006733731 7.336052e-01 8.563998e-01 13 102646294 102646390 97 + 1.694 1.712 0.061
ENSG00000134900 E035 75.1368573 0.0007183708 7.579006e-01 8.713151e-01 13 102647207 102647344 138 + 1.783 1.765 -0.058
ENSG00000134900 E036 64.7640289 0.0045098446 6.052674e-01 7.737021e-01 13 102648907 102648992 86 + 1.709 1.735 0.087
ENSG00000134900 E037 54.7772818 0.0009485136 4.530699e-01 6.680005e-01 13 102648993 102649054 62 + 1.636 1.678 0.143
ENSG00000134900 E038 70.7120028 0.0043393836 1.856399e-01 4.113830e-01 13 102649055 102649151 97 + 1.738 1.809 0.240
ENSG00000134900 E039 1.4129662 0.0371903275 1.163180e-01 3.096539e-01 13 102649152 102649407 256 + 0.381 0.000 -12.896
ENSG00000134900 E040 68.3678236 0.0033638877 2.890064e-01 5.295463e-01 13 102649408 102649486 79 + 1.729 1.785 0.191
ENSG00000134900 E041 0.5008152 0.0372444441 6.897572e-01   13 102651339 102651358 20 + 0.167 0.000 -11.374
ENSG00000134900 E042 7.3179147 0.0103219731 1.770907e-01 3.998881e-01 13 102651359 102651397 39 + 0.800 0.983 0.699
ENSG00000134900 E043 0.1723744 0.0359544690 9.503903e-02   13 102654942 102655007 66 + 0.000 0.222 13.014
ENSG00000134900 E044 1.6586277 0.0173496353 9.390562e-01 9.718355e-01 13 102656679 102656811 133 + 0.353 0.367 0.085
ENSG00000134900 E045 1.0207874 0.8089420919 8.248155e-01   13 102656942 102656981 40 + 0.264 0.214 -0.390
ENSG00000134900 E046 0.7310763 0.0245403703 1.641902e-01   13 102656982 102657055 74 + 0.118 0.368 2.091
ENSG00000134900 E047 98.0276527 0.0005796929 7.510436e-01 8.674129e-01 13 102657056 102657207 152 + 1.894 1.908 0.045
ENSG00000134900 E048 80.7693811 0.0007253703 2.419374e-01 4.787329e-01 13 102663648 102663744 97 + 1.806 1.862 0.189
ENSG00000134900 E049 98.1012832 0.0013681336 7.122017e-01 8.432036e-01 13 102664795 102664925 131 + 1.897 1.914 0.057
ENSG00000134900 E050 6.0326940 0.0333568335 9.812075e-01 9.923805e-01 13 102664926 102664936 11 + 0.759 0.751 -0.030
ENSG00000134900 E051 4.5317236 0.0064468057 1.324961e-01 3.357481e-01 13 102667758 102667883 126 + 0.616 0.844 0.934
ENSG00000134900 E052 0.7366858 0.6115460832 6.467387e-01   13 102673836 102674282 447 + 0.173 0.229 0.499
ENSG00000134900 E053 108.8261639 0.0022237887 8.992703e-01 9.514769e-01 13 102674283 102674490 208 + 1.946 1.940 -0.019
ENSG00000134900 E054 70.6516627 0.0005551101 3.051765e-01 5.457736e-01 13 102676296 102676415 120 + 1.747 1.798 0.173
ENSG00000134900 E055 153.7836332 0.0003795559 8.053820e-04 8.326072e-03 13 102678227 102679467 1241 + 2.065 2.176 0.373
ENSG00000134900 E056 1.5143277 0.6077469755 6.050417e-01 7.735568e-01 13 102679468 102679958 491 + 0.292 0.485 1.099
ENSG00000134900 E057 0.1308682 0.0326491905 9.604191e-02   13 102683795 102683846 52 + 0.000 0.221 13.035