ENSG00000134775

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257209 ENSG00000134775 HEK293_OSMI2_6hA HEK293_TMG_6hB FHOD3 protein_coding protein_coding 6.256004 6.919537 4.801732 1.053161 0.03426738 -0.5262026 2.2191802 2.2595638 1.0800818 0.4780301 0.2989733 -1.057979 0.35830417 0.3288667 0.22513333 -0.10373333 6.931540e-01 1.417903e-15 FALSE TRUE
ENST00000359247 ENSG00000134775 HEK293_OSMI2_6hA HEK293_TMG_6hB FHOD3 protein_coding protein_coding 6.256004 6.919537 4.801732 1.053161 0.03426738 -0.5262026 1.2201953 0.7904214 2.1504881 0.5414932 0.3663600 1.432526 0.20768750 0.1105667 0.44816667 0.33760000 4.160962e-01 1.417903e-15 FALSE TRUE
ENST00000592128 ENSG00000134775 HEK293_OSMI2_6hA HEK293_TMG_6hB FHOD3 protein_coding protein_coding 6.256004 6.919537 4.801732 1.053161 0.03426738 -0.5262026 1.3712970 2.0830024 0.0000000 0.4351837 0.0000000 -7.709430 0.19713750 0.2954000 0.00000000 -0.29540000 1.417903e-15 1.417903e-15 FALSE TRUE
ENST00000592930 ENSG00000134775 HEK293_OSMI2_6hA HEK293_TMG_6hB FHOD3 protein_coding protein_coding 6.256004 6.919537 4.801732 1.053161 0.03426738 -0.5262026 0.3472039 0.8100660 0.3136270 0.4126624 0.3136270 -1.341408 0.05537083 0.1281667 0.06440000 -0.06376667 7.499991e-01 1.417903e-15 FALSE TRUE
MSTRG.15710.1 ENSG00000134775 HEK293_OSMI2_6hA HEK293_TMG_6hB FHOD3 protein_coding   6.256004 6.919537 4.801732 1.053161 0.03426738 -0.5262026 0.3356420 0.1436942 0.4217706 0.1436942 0.4217706 1.490203 0.05844583 0.0296000 0.08853333 0.05893333 9.929323e-01 1.417903e-15 FALSE TRUE
MSTRG.15710.8 ENSG00000134775 HEK293_OSMI2_6hA HEK293_TMG_6hB FHOD3 protein_coding   6.256004 6.919537 4.801732 1.053161 0.03426738 -0.5262026 0.1401751 0.0000000 0.6037937 0.0000000 0.3035900 5.939682 0.02651667 0.0000000 0.12520000 0.12520000 2.238775e-01 1.417903e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000134775 E001 0.1723744 0.0366136329 0.6786654378   18 36297701 36297709 9 + 0.000 0.106 11.732
ENSG00000134775 E002 0.3032425 0.0274424043 0.3246309245   18 36297710 36297712 3 + 0.000 0.191 12.734
ENSG00000134775 E003 0.3032425 0.0274424043 0.3246309245   18 36297713 36297713 1 + 0.000 0.191 12.734
ENSG00000134775 E004 0.3032425 0.0274424043 0.3246309245   18 36297714 36297716 3 + 0.000 0.191 12.734
ENSG00000134775 E005 2.8297635 0.6012037901 0.1929227042 0.420692781 18 36297717 36297750 34 + 0.250 0.726 2.476
ENSG00000134775 E006 4.7520646 0.0773009326 0.0033671426 0.025573268 18 36297751 36297794 44 + 0.329 0.931 2.736
ENSG00000134775 E007 5.5096268 0.0343059560 0.0102149556 0.059048758 18 36297795 36297834 40 + 0.513 0.962 1.853
ENSG00000134775 E008 4.2322329 0.0065970581 0.0500286091 0.179741231 18 36297835 36297835 1 + 0.513 0.833 1.364
ENSG00000134775 E009 16.7456845 0.0784239311 0.9055879432 0.954924658 18 36297836 36298000 165 + 1.212 1.272 0.213
ENSG00000134775 E010 23.0226171 0.0845656510 0.5015179873 0.701894556 18 36355539 36355645 107 + 1.419 1.346 -0.254
ENSG00000134775 E011 22.2899506 0.0016817841 0.5372895915 0.727189721 18 36372680 36372744 65 + 1.372 1.359 -0.045
ENSG00000134775 E012 27.4146512 0.0016037289 0.1690277776 0.389312704 18 36501932 36501999 68 + 1.482 1.423 -0.203
ENSG00000134775 E013 32.0076130 0.0041661314 0.0004934202 0.005613969 18 36512438 36512543 106 + 1.615 1.414 -0.688
ENSG00000134775 E014 0.0000000       18 36544551 36544687 137 +      
ENSG00000134775 E015 30.2214884 0.0117624513 0.0119576642 0.066273503 18 36576451 36576545 95 + 1.574 1.403 -0.588
ENSG00000134775 E016 0.1723744 0.0366136329 0.6786654378   18 36594786 36594786 1 + 0.000 0.106 11.737
ENSG00000134775 E017 36.3394256 0.0017620459 0.0017396897 0.015292636 18 36594787 36594898 112 + 1.646 1.494 -0.520
ENSG00000134775 E018 37.8296619 0.0009769573 0.0017972753 0.015681996 18 36602674 36602768 95 + 1.660 1.516 -0.490
ENSG00000134775 E019 41.4981339 0.0011931483 0.0024118388 0.019759067 18 36611952 36612095 144 + 1.698 1.565 -0.452
ENSG00000134775 E020 45.0853095 0.0009068775 0.3754759959 0.608574712 18 36625511 36625749 239 + 1.667 1.653 -0.047
ENSG00000134775 E021 0.0000000       18 36649316 36649405 90 +      
ENSG00000134775 E022 0.1308682 0.0326491905 0.6811684524   18 36652570 36652929 360 + 0.000 0.106 11.732
ENSG00000134775 E023 0.0000000       18 36653342 36653416 75 +      
ENSG00000134775 E024 18.2824647 0.0074972367 0.2368060604 0.472902029 18 36658075 36658130 56 + 1.313 1.241 -0.251
ENSG00000134775 E025 17.3077971 0.0019828058 0.0277770706 0.120641044 18 36658131 36658188 58 + 1.336 1.188 -0.521
ENSG00000134775 E026 32.0761948 0.0011702233 0.0014766844 0.013452871 18 36681436 36681570 135 + 1.599 1.436 -0.558
ENSG00000134775 E027 12.4650873 0.0027344443 0.4002471320 0.628454905 18 36687128 36687178 51 + 1.151 1.102 -0.177
ENSG00000134775 E028 0.0000000       18 36692976 36693208 233 +      
ENSG00000134775 E029 54.0497857 0.0022687855 0.6506719284 0.803975305 18 36693209 36693423 215 + 1.729 1.737 0.026
ENSG00000134775 E030 77.5370598 0.0013071033 0.4105149168 0.636438197 18 36709095 36709391 297 + 1.892 1.890 -0.005
ENSG00000134775 E031 1.2910658 0.0132244994 0.3642561597   18 36709392 36711469 2078 + 0.243 0.425 1.144
ENSG00000134775 E032 103.0752351 0.0089392684 0.4149984625 0.639801253 18 36717832 36718511 680 + 2.018 2.005 -0.042
ENSG00000134775 E033 24.5948274 0.0014650686 0.1593524599 0.375795718 18 36718512 36718556 45 + 1.436 1.370 -0.230
ENSG00000134775 E034 41.2872463 0.0008977899 0.2437255039 0.480744706 18 36718557 36718715 159 + 1.642 1.611 -0.104
ENSG00000134775 E035 22.6434881 0.0022892550 0.8761581760 0.939288866 18 36730646 36730703 58 + 1.350 1.394 0.152
ENSG00000134775 E036 34.7556733 0.0013787803 0.7953701373 0.893617966 18 36730704 36730804 101 + 1.542 1.558 0.056
ENSG00000134775 E037 51.8573283 0.0011730114 0.3166817359 0.556663759 18 36740656 36740838 183 + 1.664 1.747 0.283
ENSG00000134775 E038 48.5446402 0.0012814844 0.3933622725 0.623035343 18 36742737 36742856 120 + 1.642 1.718 0.260
ENSG00000134775 E039 60.2173666 0.0006511177 0.4458762247 0.662685463 18 36744032 36744193 162 + 1.784 1.782 -0.006
ENSG00000134775 E040 63.0759949 0.0008651733 0.6386958447 0.796151152 18 36746945 36747135 191 + 1.764 1.819 0.183
ENSG00000134775 E041 59.5706533 0.0030553685 0.1187982169 0.313902470 18 36755119 36755311 193 + 1.701 1.816 0.387
ENSG00000134775 E042 0.3751086 0.0266210709 0.3219352061   18 36759118 36759141 24 + 0.000 0.192 12.740
ENSG00000134775 E043 43.9518800 0.0011522828 0.0004888843 0.005573938 18 36760608 36760782 175 + 1.503 1.731 0.778
ENSG00000134775 E044 47.3906158 0.0175147398 0.0023427596 0.019333032 18 36769265 36769426 162 + 1.499 1.779 0.953
ENSG00000134775 E045 106.2388936 0.3945259450 0.1138035583 0.305469774 18 36779448 36780220 773 + 1.762 2.147 1.294