ENSG00000134759

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358232 ENSG00000134759 HEK293_OSMI2_6hA HEK293_TMG_6hB ELP2 protein_coding protein_coding 93.62505 34.60116 172.2498 9.467481 4.402793 2.315277 9.472391 5.180394 12.90816 1.417428 0.3319259 1.315484 0.1213333 0.1493667 0.07496667 -0.074400000 8.566453e-07 8.566453e-07 FALSE TRUE
ENST00000535093 ENSG00000134759 HEK293_OSMI2_6hA HEK293_TMG_6hB ELP2 protein_coding processed_transcript 93.62505 34.60116 172.2498 9.467481 4.402793 2.315277 19.742079 7.432804 36.49656 2.448698 0.8176483 2.294238 0.2087875 0.2034667 0.21190000 0.008433333 9.690629e-01 8.566453e-07 FALSE FALSE
ENST00000540135 ENSG00000134759 HEK293_OSMI2_6hA HEK293_TMG_6hB ELP2 protein_coding processed_transcript 93.62505 34.60116 172.2498 9.467481 4.402793 2.315277 13.334105 3.432544 31.02542 1.030661 0.4914122 3.172369 0.1107500 0.1016333 0.18023333 0.078600000 1.286150e-01 8.566453e-07 FALSE TRUE
ENST00000542050 ENSG00000134759 HEK293_OSMI2_6hA HEK293_TMG_6hB ELP2 protein_coding processed_transcript 93.62505 34.60116 172.2498 9.467481 4.402793 2.315277 11.880353 4.370499 21.21829 1.607472 0.7163380 2.276821 0.1306083 0.1201667 0.12316667 0.003000000 9.944374e-01 8.566453e-07 FALSE TRUE
ENST00000543439 ENSG00000134759 HEK293_OSMI2_6hA HEK293_TMG_6hB ELP2 protein_coding processed_transcript 93.62505 34.60116 172.2498 9.467481 4.402793 2.315277 16.277787 5.080605 31.30055 1.749363 3.0007628 2.620740 0.1498958 0.1388333 0.18103333 0.042200000 6.019650e-01 8.566453e-07 FALSE FALSE
ENST00000543861 ENSG00000134759 HEK293_OSMI2_6hA HEK293_TMG_6hB ELP2 protein_coding processed_transcript 93.62505 34.60116 172.2498 9.467481 4.402793 2.315277 11.166188 4.948504 17.24454 1.374823 1.6256073 1.798999 0.1364625 0.1425667 0.10003333 -0.042533333 3.508491e-01 8.566453e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000134759 E001 0.6953672 0.2346611924 3.566335e-01   18 36129444 36129497 54 + 0.244 0.000 -10.492
ENSG00000134759 E002 8.5252259 0.1084718162 3.683417e-03 2.738623e-02 18 36129554 36129879 326 + 1.012 0.331 -3.024
ENSG00000134759 E003 2.9526645 0.0081927964 3.744620e-01 6.077010e-01 18 36129880 36129890 11 + 0.576 0.431 -0.705
ENSG00000134759 E004 2.8100298 0.0084810370 4.449127e-01 6.620844e-01 18 36129891 36129893 3 + 0.554 0.431 -0.605
ENSG00000134759 E005 2.6320460 0.0085671661 5.266394e-01 7.195831e-01 18 36129894 36129894 1 + 0.531 0.431 -0.498
ENSG00000134759 E006 2.9714455 0.0084547455 3.743177e-01 6.076169e-01 18 36129895 36129897 3 + 0.576 0.431 -0.705
ENSG00000134759 E007 2.9526645 0.0081927964 3.744620e-01 6.077010e-01 18 36129898 36129898 1 + 0.576 0.431 -0.705
ENSG00000134759 E008 2.9526645 0.0081927964 3.744620e-01 6.077010e-01 18 36129899 36129900 2 + 0.576 0.431 -0.705
ENSG00000134759 E009 2.7912488 0.0086746146 4.459579e-01 6.627072e-01 18 36129901 36129901 1 + 0.554 0.431 -0.605
ENSG00000134759 E010 2.6298331 0.0091744894 5.281673e-01 7.207308e-01 18 36129902 36129902 1 + 0.531 0.431 -0.498
ENSG00000134759 E011 14.5143282 0.0130371625 7.328004e-01 8.558544e-01 18 36129903 36129916 14 + 1.136 1.111 -0.090
ENSG00000134759 E012 16.6264181 0.0165873586 4.695230e-01 6.797010e-01 18 36129917 36129917 1 + 1.201 1.131 -0.250
ENSG00000134759 E013 23.6393939 0.0071529236 1.047979e-01 2.902947e-01 18 36129918 36129919 2 + 1.360 1.227 -0.467
ENSG00000134759 E014 39.0162340 0.0067329364 1.126273e-03 1.086436e-02 18 36129920 36129923 4 + 1.589 1.341 -0.853
ENSG00000134759 E015 39.7739838 0.0028956061 3.419900e-04 4.159405e-03 18 36129924 36129924 1 + 1.597 1.352 -0.844
ENSG00000134759 E016 204.9002970 0.0002495553 2.365207e-05 4.408104e-04 18 36129925 36130071 147 + 2.276 2.174 -0.341
ENSG00000134759 E017 221.9020644 0.0002743273 8.159001e-07 2.382370e-05 18 36133238 36133316 79 + 2.315 2.195 -0.400
ENSG00000134759 E018 209.6679826 0.0003602854 2.296747e-06 5.889181e-05 18 36136307 36136377 71 + 2.290 2.170 -0.402
ENSG00000134759 E019 0.0000000       18 36136378 36136632 255 +      
ENSG00000134759 E020 0.0000000       18 36137174 36137183 10 +      
ENSG00000134759 E021 0.0000000       18 36137184 36137235 52 +      
ENSG00000134759 E022 0.8627522 0.0172671820 7.981446e-01   18 36138095 36138269 175 + 0.240 0.195 -0.384
ENSG00000134759 E023 129.1683540 0.0003394378 7.486362e-04 7.849818e-03 18 36138270 36138294 25 + 2.077 1.974 -0.346
ENSG00000134759 E024 242.9125908 0.0003193876 2.923988e-04 3.652791e-03 18 36138295 36138426 132 + 2.346 2.270 -0.255
ENSG00000134759 E025 1.6723468 0.5940378694 7.624613e-01 8.740673e-01 18 36138427 36138641 215 + 0.327 0.523 1.054
ENSG00000134759 E026 126.2035543 0.0018581194 3.907296e-02 1.523718e-01 18 36138795 36138806 12 + 2.061 1.998 -0.212
ENSG00000134759 E027 187.0574247 0.0003351661 5.179835e-04 5.839453e-03 18 36138807 36138872 66 + 2.235 2.151 -0.281
ENSG00000134759 E028 6.5364924 0.1012836674 1.136347e-01 3.052068e-01 18 36139419 36139613 195 + 0.732 1.010 1.074
ENSG00000134759 E029 1.0517650 0.1552355714 8.063459e-01   18 36139662 36139760 99 + 0.281 0.327 0.303
ENSG00000134759 E030 209.2437200 0.0016601523 5.962044e-04 6.546568e-03 18 36141137 36141201 65 + 2.285 2.193 -0.309
ENSG00000134759 E031 1.5149479 0.1526539727 9.217592e-01 9.631531e-01 18 36141373 36141422 50 + 0.361 0.332 -0.179
ENSG00000134759 E032 235.7717575 0.0023374228 7.324905e-03 4.619494e-02 18 36142281 36142347 67 + 2.332 2.263 -0.228
ENSG00000134759 E033 3.2871244 0.0084752786 6.745479e-01 8.192365e-01 18 36142348 36142349 2 + 0.554 0.642 0.391
ENSG00000134759 E034 321.1401809 0.0002607109 1.093417e-03 1.062467e-02 18 36142826 36142966 141 + 2.461 2.407 -0.178
ENSG00000134759 E035 260.2173081 0.0001996006 1.521904e-03 1.376316e-02 18 36144939 36145034 96 + 2.370 2.312 -0.194
ENSG00000134759 E036 1.5631088 0.4557335692 5.851507e-01 7.604143e-01 18 36145035 36145358 324 + 0.406 0.196 -1.441
ENSG00000134759 E037 275.7393515 0.0004925370 7.592959e-04 7.936109e-03 18 36145948 36146048 101 + 2.395 2.330 -0.220
ENSG00000134759 E038 327.7849619 0.0001728330 1.724417e-01 3.937581e-01 18 36146250 36146381 132 + 2.458 2.451 -0.023
ENSG00000134759 E039 313.3647000 0.0002156767 1.269818e-02 6.923439e-02 18 36154850 36154930 81 + 2.446 2.411 -0.117
ENSG00000134759 E040 297.2255553 0.0002134597 2.755543e-01 5.156297e-01 18 36154931 36154999 69 + 2.415 2.413 -0.007
ENSG00000134759 E041 389.6630884 0.0010555987 5.211960e-01 7.156921e-01 18 36156466 36156654 189 + 2.530 2.540 0.034
ENSG00000134759 E042 0.1779838 0.0369463035 1.000000e+00   18 36158503 36158614 112 + 0.074 0.000 -8.345
ENSG00000134759 E043 206.5760195 0.0002760169 6.944313e-01 8.319659e-01 18 36158835 36158904 70 + 2.249 2.284 0.118
ENSG00000134759 E044 139.3341383 0.0003259930 9.491064e-01 9.766597e-01 18 36159735 36159757 23 + 2.080 2.101 0.071
ENSG00000134759 E045 234.3260048 0.0002661333 1.347732e-01 3.393368e-01 18 36159758 36159830 73 + 2.294 2.357 0.210
ENSG00000134759 E046 3.0412888 0.0193069389 6.783820e-01 8.217131e-01 18 36159957 36159957 1 + 0.553 0.641 0.392
ENSG00000134759 E047 234.9205067 0.0002685538 9.451529e-02 2.721132e-01 18 36159958 36160015 58 + 2.294 2.362 0.227
ENSG00000134759 E048 230.7843913 0.0002335161 4.996883e-02 1.795986e-01 18 36160932 36161004 73 + 2.284 2.360 0.252
ENSG00000134759 E049 244.1598348 0.0002515458 1.081462e-01 2.959491e-01 18 36164475 36164531 57 + 2.312 2.377 0.219
ENSG00000134759 E050 371.5404235 0.0031534513 3.629356e-01 5.980769e-01 18 36164532 36164667 136 + 2.495 2.554 0.198
ENSG00000134759 E051 56.8902781 0.1720594602 3.673738e-01 6.018746e-01 18 36164668 36165225 558 + 1.735 1.582 -0.521
ENSG00000134759 E052 16.1900683 0.0566704414 8.966923e-01 9.501785e-01 18 36166889 36166965 77 + 1.182 1.162 -0.071
ENSG00000134759 E053 18.4288716 0.0561128063 6.605263e-01 8.102904e-01 18 36166966 36167047 82 + 1.214 1.277 0.219
ENSG00000134759 E054 17.3061870 0.0029423227 8.955306e-01 9.494962e-01 18 36167048 36167100 53 + 1.202 1.210 0.028
ENSG00000134759 E055 270.9741917 0.0018740821 2.766232e-01 5.165995e-01 18 36167101 36167152 52 + 2.358 2.419 0.203
ENSG00000134759 E056 164.0692610 0.0004327410 7.893693e-01 8.901089e-01 18 36167153 36167155 3 + 2.148 2.181 0.109
ENSG00000134759 E057 277.3084660 0.0002549670 2.381097e-01 4.744564e-01 18 36167156 36167222 67 + 2.370 2.423 0.177
ENSG00000134759 E058 12.3744998 0.2062145128 1.158274e-01 3.088936e-01 18 36169936 36170062 127 + 0.926 1.333 1.468
ENSG00000134759 E059 360.8128829 0.0002111195 6.867558e-04 7.329035e-03 18 36170063 36170196 134 + 2.473 2.568 0.317
ENSG00000134759 E060 9.8353668 0.1382174318 2.346601e-03 1.935626e-02 18 36170879 36171046 168 + 0.722 1.340 2.286
ENSG00000134759 E061 341.4883351 0.0005025250 9.466576e-04 9.476788e-03 18 36171047 36171160 114 + 2.448 2.548 0.333
ENSG00000134759 E062 867.5527312 0.0067574112 1.997163e-08 8.759405e-07 18 36174485 36180557 6073 + 2.810 3.031 0.733