ENSG00000134644

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257075 ENSG00000134644 HEK293_OSMI2_6hA HEK293_TMG_6hB PUM1 protein_coding protein_coding 38.2536 25.20956 56.50593 5.77866 1.935149 1.164114 13.477405 11.1331087 21.6050353 2.3351821 2.0755746 0.9558834 0.33631667 0.44593333 0.38356667 -0.06236667 7.535674e-01 1.524016e-14 FALSE TRUE
ENST00000373747 ENSG00000134644 HEK293_OSMI2_6hA HEK293_TMG_6hB PUM1 protein_coding protein_coding 38.2536 25.20956 56.50593 5.77866 1.935149 1.164114 6.310087 7.8939542 6.1559010 2.0125011 0.7529315 -0.3582629 0.22393333 0.30896667 0.10833333 -0.20063333 4.993502e-05 1.524016e-14 FALSE TRUE
ENST00000424085 ENSG00000134644 HEK293_OSMI2_6hA HEK293_TMG_6hB PUM1 protein_coding protein_coding 38.2536 25.20956 56.50593 5.77866 1.935149 1.164114 2.153622 1.1070421 0.6146882 0.6337343 0.1489034 -0.8384754 0.09377917 0.03683333 0.01103333 -0.02580000 4.621341e-01 1.524016e-14 FALSE TRUE
ENST00000440538 ENSG00000134644 HEK293_OSMI2_6hA HEK293_TMG_6hB PUM1 protein_coding protein_coding 38.2536 25.20956 56.50593 5.77866 1.935149 1.164114 6.100549 0.5109079 12.6774286 0.5109079 1.1425320 4.6062275 0.11142083 0.03546667 0.22356667 0.18810000 1.456140e-01 1.524016e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000134644 E001 365.0262155 1.5104870357 0.355556418 0.59219171 1 30931506 30931813 308 - 2.347 2.764 1.391
ENSG00000134644 E002 346.3010613 1.4618419876 0.300142601 0.54057245 1 30931814 30932058 245 - 2.282 2.768 1.618
ENSG00000134644 E003 557.5721537 1.6479021649 0.363400885 0.59847775 1 30932059 30932834 776 - 2.529 2.949 1.399
ENSG00000134644 E004 76.3532125 0.6978405854 0.173204765 0.39478703 1 30932835 30932843 9 - 1.661 2.097 1.470
ENSG00000134644 E005 67.5176227 0.6403697182 0.144076611 0.35351050 1 30932844 30932849 6 - 1.590 2.056 1.576
ENSG00000134644 E006 170.5559648 1.2607372880 0.340006867 0.57795314 1 30932850 30932954 105 - 2.040 2.419 1.267
ENSG00000134644 E007 218.5544900 1.3696968776 0.395194655 0.62451744 1 30932955 30933079 125 - 2.175 2.505 1.100
ENSG00000134644 E008 379.9395366 1.5942497182 0.502721172 0.70263626 1 30933080 30933304 225 - 2.462 2.700 0.792
ENSG00000134644 E009 204.0431935 1.3781420016 0.461190221 0.67396905 1 30933305 30933342 38 - 2.186 2.438 0.842
ENSG00000134644 E010 234.9193486 1.4349709820 0.493951272 0.69667223 1 30936643 30936721 79 - 2.256 2.489 0.778
ENSG00000134644 E011 116.9140115 1.2069178018 0.508791300 0.70701038 1 30936722 30936723 2 - 1.975 2.167 0.644
ENSG00000134644 E012 229.8324230 1.4311703238 0.495995955 0.69822294 1 30936724 30936835 112 - 2.252 2.474 0.742
ENSG00000134644 E013 248.7894968 1.4678775865 0.526752445 0.71965600 1 30941151 30941272 122 - 2.298 2.495 0.657
ENSG00000134644 E014 3.6564334 0.0532222063 0.281635517 0.52197654 1 30941922 30941997 76 - 0.557 0.796 1.010
ENSG00000134644 E015 254.7489940 1.4780743832 0.524828568 0.71836460 1 30941998 30942123 126 - 2.309 2.506 0.658
ENSG00000134644 E016 223.9203507 0.0292079451 0.532468775 0.72386888 1 30945346 30945400 55 - 2.292 2.405 0.376
ENSG00000134644 E017 283.3857489 0.0001702546 0.442991352 0.66074709 1 30945401 30945483 83 - 2.411 2.497 0.287
ENSG00000134644 E018 71.8290604 0.0045660313 0.079608701 0.24405607 1 30950127 30950132 6 - 1.844 1.852 0.026
ENSG00000134644 E019 336.9153593 0.0062524370 0.182649374 0.40748407 1 30950133 30950261 129 - 2.492 2.548 0.188
ENSG00000134644 E020 279.9423689 0.0102772870 0.117099518 0.31099773 1 30952234 30952363 130 - 2.421 2.452 0.104
ENSG00000134644 E021 224.2836370 0.0203276496 0.288918385 0.52949590 1 30953714 30953818 105 - 2.325 2.353 0.093
ENSG00000134644 E022 270.6859754 0.0211433551 0.369080604 0.60330900 1 30953819 30953981 163 - 2.403 2.441 0.128
ENSG00000134644 E023 330.2651016 0.0164696508 0.129803252 0.33153503 1 30964674 30964887 214 - 2.499 2.512 0.045
ENSG00000134644 E024 135.2119369 0.0271079355 0.300491124 0.54095920 1 30964888 30964910 23 - 2.110 2.134 0.079
ENSG00000134644 E025 145.9619838 0.0176057438 0.488476898 0.69297842 1 30965982 30966015 34 - 2.127 2.194 0.222
ENSG00000134644 E026 222.1759370 0.0110369172 0.204532759 0.43529512 1 30966016 30966146 131 - 2.320 2.358 0.127
ENSG00000134644 E027 136.1955725 0.0126602686 0.062443125 0.20823735 1 30966147 30966197 51 - 2.128 2.114 -0.049
ENSG00000134644 E028 96.7141619 0.0116845660 0.018044648 0.08918499 1 30966198 30966278 81 - 1.993 1.947 -0.156
ENSG00000134644 E029 1.6597954 0.0130138519 0.166323017 0.38567745 1 30966279 30966380 102 - 0.464 0.272 -1.131
ENSG00000134644 E030 5.5023537 0.4530894861 0.487695299 0.69244976 1 30967099 30967166 68 - 0.797 0.800 0.010
ENSG00000134644 E031 125.7422911 0.0180067543 0.022754641 0.10513567 1 30967167 30967224 58 - 2.108 2.044 -0.215
ENSG00000134644 E032 146.9139521 0.0226170819 0.046040742 0.17013615 1 30967225 30967310 86 - 2.169 2.124 -0.151
ENSG00000134644 E033 1.2768645 0.2979330748 0.200960262   1 30968297 30968353 57 - 0.425 0.158 -1.922
ENSG00000134644 E034 177.7776275 0.0307491813 0.088084366 0.26017935 1 30968354 30968492 139 - 2.249 2.211 -0.125
ENSG00000134644 E035 1.4999570 0.0230724555 0.027615954 0.12016563 1 30969211 30969276 66 - 0.169 0.608 2.681
ENSG00000134644 E036 0.3751086 0.0441409415 0.120220423   1 30974649 30974650 2 - 0.000 0.273 13.115
ENSG00000134644 E037 188.8089955 0.0232342479 0.063524593 0.21064835 1 30974651 30974802 152 - 2.272 2.242 -0.100
ENSG00000134644 E038 0.3040503 0.0244411696 0.332417128   1 30974803 30974859 57 - 0.169 0.000 -11.408
ENSG00000134644 E039 147.5244771 0.0207759027 0.093385408 0.27002831 1 30980062 30980163 102 - 2.161 2.144 -0.058
ENSG00000134644 E040 37.9950014 0.0219207760 0.076475906 0.23768975 1 30980164 30980166 3 - 1.597 1.534 -0.218
ENSG00000134644 E041 3.8933197 0.0082500109 0.353658644 0.59056416 1 30980167 30980178 12 - 0.704 0.651 -0.225
ENSG00000134644 E042 91.7760993 0.0255969361 0.127519107 0.32792255 1 30981312 30981337 26 - 1.959 1.938 -0.070
ENSG00000134644 E043 127.6752017 0.0232694091 0.051306600 0.18286268 1 30981338 30981405 68 - 2.109 2.065 -0.144
ENSG00000134644 E044 0.8405746 0.0205108634 0.977713307   1 30981917 30982145 229 - 0.235 0.273 0.286
ENSG00000134644 E045 153.6686534 0.0173491152 0.006534396 0.04238825 1 30992390 30992440 51 - 2.199 2.123 -0.253
ENSG00000134644 E046 300.0454367 0.0183374895 0.005415118 0.03677564 1 30992441 30992660 220 - 2.488 2.409 -0.264
ENSG00000134644 E047 313.2791362 0.0141225081 0.003759467 0.02779064 1 30995054 30995181 128 - 2.504 2.434 -0.235
ENSG00000134644 E048 226.5336272 0.0192151426 0.003667956 0.02730595 1 30995182 30995220 39 - 2.374 2.271 -0.343
ENSG00000134644 E049 351.1456257 0.0167757408 0.002956405 0.02313986 1 31005853 31006031 179 - 2.559 2.471 -0.293
ENSG00000134644 E050 262.6262527 0.0254147392 0.012298018 0.06763281 1 31006994 31007099 106 - 2.436 2.338 -0.329
ENSG00000134644 E051 106.1510143 0.0316534325 0.040186071 0.15516823 1 31007100 31007102 3 - 2.043 1.952 -0.305
ENSG00000134644 E052 0.1614157 0.0330229631 0.693242604   1 31028758 31028795 38 - 0.093 0.000 -10.410
ENSG00000134644 E053 220.6943046 0.0280238624 0.014536342 0.07638720 1 31028796 31028864 69 - 2.360 2.267 -0.311
ENSG00000134644 E054 2.8636597 0.2017568152 0.869661291 0.93566185 1 31055313 31055380 68 - 0.565 0.599 0.150
ENSG00000134644 E055 210.7354035 0.0272390921 0.017933214 0.08881944 1 31059204 31059278 75 - 2.339 2.250 -0.299
ENSG00000134644 E056 133.7650355 0.0230997541 0.009477744 0.05586156 1 31059279 31059298 20 - 2.146 2.047 -0.333
ENSG00000134644 E057 331.8331392 0.0204296853 0.007046544 0.04484748 1 31059299 31059577 279 - 2.532 2.451 -0.272
ENSG00000134644 E058 0.1426347 0.0318677249 0.693829536   1 31061667 31061916 250 - 0.093 0.000 -10.408
ENSG00000134644 E059 119.0714075 0.0211793236 0.098747119 0.27959894 1 31065616 31065688 73 - 2.066 2.054 -0.042
ENSG00000134644 E060 35.1299223 0.0137936779 0.454526672 0.66914437 1 31065689 31065991 303 - 1.522 1.570 0.166