ENSG00000134480

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256897 ENSG00000134480 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNH protein_coding protein_coding 31.72585 11.94449 45.602 1.226149 1.888359 1.93186 22.999863 7.6457995 33.5100433 1.5062188 2.9294680 2.1303991 0.6799833 0.6301 0.73256667 0.10246667 0.750016042 0.000615154 FALSE  
ENST00000504115 ENSG00000134480 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNH protein_coding retained_intron 31.72585 11.94449 45.602 1.226149 1.888359 1.93186 3.305168 1.1034502 3.5092577 0.5644628 1.9811789 1.6602341 0.1226708 0.0988 0.07890000 -0.01990000 0.993124810 0.000615154 FALSE  
ENST00000645953 ENSG00000134480 HEK293_OSMI2_6hA HEK293_TMG_6hB CCNH protein_coding nonsense_mediated_decay 31.72585 11.94449 45.602 1.226149 1.888359 1.93186 0.711318 0.9116283 0.7654645 0.0534135 0.3016788 -0.2491244 0.0361125 0.0779 0.01683333 -0.06106667 0.009590994 0.000615154 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000134480 E001 10.1110712 0.008866031 7.071786e-10 4.239153e-08 5 87318416 87318897 482 - 0.696 1.383 2.547
ENSG00000134480 E002 2.2151709 0.009676551 7.330460e-01 8.560171e-01 5 87365059 87365115 57 - 0.447 0.520 0.363
ENSG00000134480 E003 3.0253856 0.071717095 5.132774e-01 7.104384e-01 5 87365116 87365218 103 - 0.522 0.653 0.589
ENSG00000134480 E004 0.9396778 0.017267182 6.522900e-01   5 87366246 87366296 51 - 0.279 0.198 -0.637
ENSG00000134480 E005 0.6190593 0.020157950 1.000000e+00   5 87376253 87376255 3 - 0.187 0.198 0.100
ENSG00000134480 E006 3.5781730 0.087700709 8.407603e-02 2.529191e-01 5 87376256 87376518 263 - 0.518 0.832 1.334
ENSG00000134480 E007 5.5883444 0.081395022 3.190238e-01 5.587333e-01 5 87376519 87377180 662 - 0.721 0.920 0.783
ENSG00000134480 E008 1.2397840 0.015073090 4.012432e-01   5 87389255 87389324 70 - 0.354 0.198 -1.126
ENSG00000134480 E009 26.1571236 0.044926822 9.442374e-01 9.744658e-01 5 87391494 87392706 1213 - 1.362 1.392 0.102
ENSG00000134480 E010 7.4045611 0.035728614 5.645435e-01 7.464668e-01 5 87392707 87392769 63 - 0.843 0.954 0.423
ENSG00000134480 E011 21.4451189 0.001516782 5.608827e-03 3.777394e-02 5 87392770 87392904 135 - 1.222 1.458 0.824
ENSG00000134480 E012 21.2591172 0.057073668 8.878539e-01 9.454708e-01 5 87392905 87393416 512 - 1.282 1.278 -0.014
ENSG00000134480 E013 23.9004880 0.114100917 5.727862e-01 7.522408e-01 5 87393417 87394273 857 - 1.345 1.279 -0.230
ENSG00000134480 E014 2.7906286 0.009269506 9.230984e-01 9.638316e-01 5 87394274 87394279 6 - 0.524 0.521 -0.016
ENSG00000134480 E015 8.6519578 0.040562833 4.023851e-01 6.303020e-01 5 87394280 87394325 46 - 0.876 1.016 0.526
ENSG00000134480 E016 47.7484829 0.010593976 7.382110e-01 8.593957e-01 5 87394326 87394404 79 - 1.622 1.618 -0.014
ENSG00000134480 E017 107.8182303 0.002092309 2.138590e-01 4.461938e-01 5 87394405 87394484 80 - 1.979 1.945 -0.111
ENSG00000134480 E018 14.9914200 0.012971838 1.197818e-02 6.634890e-02 5 87394485 87395043 559 - 1.193 0.900 -1.070
ENSG00000134480 E019 148.9309688 0.000396180 1.146221e-01 3.068471e-01 5 87395044 87395104 61 - 2.118 2.086 -0.108
ENSG00000134480 E020 210.4141601 0.003244153 6.672312e-01 8.144505e-01 5 87399394 87399505 112 - 2.257 2.263 0.020
ENSG00000134480 E021 161.0760167 0.003299872 1.365491e-01 3.421922e-01 5 87401702 87401772 71 - 2.153 2.114 -0.130
ENSG00000134480 E022 0.2852693 0.241642705 8.633539e-01   5 87401773 87401774 2 - 0.132 0.001 -7.683
ENSG00000134480 E023 0.4231520 0.066699455 1.414167e-01   5 87404842 87404843 2 - 0.072 0.332 2.669
ENSG00000134480 E024 223.4268753 0.004699016 9.012137e-01 9.524767e-01 5 87404844 87405007 164 - 2.278 2.305 0.091
ENSG00000134480 E025 123.4778925 0.005839669 4.933797e-01 6.961983e-01 5 87407976 87408006 31 - 2.031 2.019 -0.041
ENSG00000134480 E026 125.0558813 0.006496018 6.408953e-01 7.974579e-01 5 87408007 87408037 31 - 2.035 2.035 -0.001
ENSG00000134480 E027 191.6856700 0.002424999 1.168526e-01 3.105761e-01 5 87408038 87408186 149 - 2.228 2.194 -0.113
ENSG00000134480 E028 0.4161375 0.088717226 7.233491e-01   5 87409073 87409087 15 - 0.133 0.197 0.683
ENSG00000134480 E029 1.6236384 0.012174208 2.909902e-01 5.315866e-01 5 87409088 87409129 42 - 0.318 0.520 1.099
ENSG00000134480 E030 1.6489069 0.018027261 1.981432e-01 4.272815e-01 5 87409130 87409289 160 - 0.446 0.198 -1.637
ENSG00000134480 E031 120.7436245 0.005079713 9.964940e-02 2.811340e-01 5 87409290 87409363 74 - 2.038 1.978 -0.202
ENSG00000134480 E032 147.7139854 0.061161079 4.339390e-01 6.541570e-01 5 87411224 87411346 123 - 2.086 2.165 0.267
ENSG00000134480 E033 4.9524252 0.212636591 8.077171e-02 2.463756e-01 5 87412435 87412677 243 - 0.583 0.977 1.586
ENSG00000134480 E034 144.5871257 1.506315343 4.990742e-01 7.001615e-01 5 87412678 87412930 253 - 2.043 2.232 0.633