ENSG00000134452

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000362091 ENSG00000134452 HEK293_OSMI2_6hA HEK293_TMG_6hB FBH1 protein_coding protein_coding 45.82133 52.30379 36.51378 3.913157 1.605068 -0.5183553 23.605642 29.4174719 20.6337841 4.0222284 0.09435397 -0.51145616 0.53379583 0.558166667 0.56740000 0.009233333 9.935463e-01 2.487775e-05 FALSE TRUE
ENST00000485290 ENSG00000134452 HEK293_OSMI2_6hA HEK293_TMG_6hB FBH1 protein_coding processed_transcript 45.82133 52.30379 36.51378 3.913157 1.605068 -0.5183553 2.982067 2.4728525 0.6337454 1.4106152 0.41513210 -1.94743640 0.05392083 0.043666667 0.01646667 -0.027200000 9.282580e-01 2.487775e-05 FALSE FALSE
MSTRG.3493.10 ENSG00000134452 HEK293_OSMI2_6hA HEK293_TMG_6hB FBH1 protein_coding   45.82133 52.30379 36.51378 3.913157 1.605068 -0.5183553 1.208364 0.3989592 2.1621091 0.1100045 0.05375752 2.40906761 0.02958333 0.007966667 0.05933333 0.051366667 2.487775e-05 2.487775e-05 FALSE TRUE
MSTRG.3493.3 ENSG00000134452 HEK293_OSMI2_6hA HEK293_TMG_6hB FBH1 protein_coding   45.82133 52.30379 36.51378 3.913157 1.605068 -0.5183553 3.113762 3.3997553 1.1884691 0.6910734 0.24977709 -1.50847550 0.06401250 0.064666667 0.03313333 -0.031533333 3.830823e-01 2.487775e-05   FALSE
MSTRG.3493.6 ENSG00000134452 HEK293_OSMI2_6hA HEK293_TMG_6hB FBH1 protein_coding   45.82133 52.30379 36.51378 3.913157 1.605068 -0.5183553 3.653662 2.7360643 2.8897809 1.1756173 0.65785071 0.07857847 0.06985000 0.054133333 0.07846667 0.024333333 7.917942e-01 2.487775e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000134452 E001 2.427798 0.0104978674 9.299886e-01 9.670126e-01 10 5890203 5890242 40 + 0.483 0.519 0.176
ENSG00000134452 E002 2.915802 0.0103651922 7.249246e-01 8.510575e-01 10 5890243 5890244 2 + 0.586 0.552 -0.155
ENSG00000134452 E003 4.380339 0.0654198878 6.952187e-01 8.324106e-01 10 5890245 5890247 3 + 0.630 0.738 0.452
ENSG00000134452 E004 45.610555 0.0008732127 3.024774e-05 5.436877e-04 10 5890248 5890279 32 + 1.464 1.736 0.926
ENSG00000134452 E005 71.600463 0.0005854151 6.189728e-02 2.070921e-01 10 5890280 5890346 67 + 1.770 1.883 0.382
ENSG00000134452 E006 14.458122 0.0029695324 4.647657e-03 3.272844e-02 10 5891019 5891116 98 + 1.304 1.079 -0.801
ENSG00000134452 E007 26.463910 0.0016714052 4.210177e-01 6.444561e-01 10 5893977 5894247 271 + 1.370 1.456 0.299
ENSG00000134452 E008 9.026593 0.0607479671 2.238890e-01 4.580804e-01 10 5894386 5894511 126 + 1.064 0.931 -0.491
ENSG00000134452 E009 11.526455 0.0039056837 3.685523e-01 6.028721e-01 10 5895056 5895187 132 + 1.122 1.059 -0.225
ENSG00000134452 E010 165.720511 0.0003241815 1.542853e-03 1.390943e-02 10 5903020 5903165 146 + 2.238 2.177 -0.203
ENSG00000134452 E011 92.206521 0.0005401344 6.469224e-06 1.440250e-04 10 5903166 5903175 10 + 2.031 1.889 -0.476
ENSG00000134452 E012 6.635749 0.0047762227 1.709038e-01 3.917323e-01 10 5905218 5905287 70 + 0.961 0.821 -0.537
ENSG00000134452 E013 497.444732 0.0016291113 3.801689e-02 1.496814e-01 10 5906037 5906505 469 + 2.689 2.676 -0.045
ENSG00000134452 E014 325.064013 0.0041865528 8.191617e-02 2.486016e-01 10 5906506 5906632 127 + 2.514 2.489 -0.086
ENSG00000134452 E015 305.204876 0.0036782114 2.343266e-01 4.700677e-01 10 5908925 5909055 131 + 2.475 2.469 -0.019
ENSG00000134452 E016 245.493600 0.0077082952 7.447762e-01 8.635367e-01 10 5909159 5909294 136 + 2.366 2.386 0.066
ENSG00000134452 E017 4.761967 0.2913593814 8.658058e-01 9.336424e-01 10 5909295 5909478 184 + 0.814 0.719 -0.381
ENSG00000134452 E018 310.699759 0.0064155598 5.560764e-01 7.405587e-01 10 5910938 5911128 191 + 2.472 2.484 0.040
ENSG00000134452 E019 152.263179 0.0002904343 1.446601e-01 3.544201e-01 10 5913747 5913783 37 + 2.174 2.161 -0.045
ENSG00000134452 E020 203.556604 0.0002915381 8.336034e-05 1.284677e-03 10 5913784 5913839 56 + 2.337 2.266 -0.239
ENSG00000134452 E021 248.069502 0.0003024325 1.951212e-07 6.744467e-06 10 5914178 5914269 92 + 2.434 2.341 -0.309
ENSG00000134452 E022 331.307480 0.0023411778 2.440476e-04 3.153861e-03 10 5915403 5915571 169 + 2.549 2.476 -0.245
ENSG00000134452 E023 24.687356 0.0232522550 2.499822e-01 4.879074e-01 10 5915572 5915944 373 + 1.440 1.365 -0.260
ENSG00000134452 E024 424.742309 0.0034218179 4.069917e-03 2.956698e-02 10 5916234 5916456 223 + 2.646 2.592 -0.178
ENSG00000134452 E025 8.431813 0.0849597058 3.247701e-01 5.640135e-01 10 5917062 5917419 358 + 0.799 1.036 0.896
ENSG00000134452 E026 268.149386 0.0002512757 8.510824e-02 2.548146e-01 10 5917420 5917507 88 + 2.417 2.408 -0.029
ENSG00000134452 E027 240.603524 0.0004734041 3.196916e-01 5.594413e-01 10 5917590 5917676 87 + 2.359 2.366 0.021
ENSG00000134452 E028 291.364629 0.0010484504 6.148174e-01 7.801510e-01 10 5918342 5918478 137 + 2.416 2.463 0.158
ENSG00000134452 E029 264.303719 0.0024272556 6.850878e-02 2.217590e-01 10 5921258 5921345 88 + 2.419 2.397 -0.075
ENSG00000134452 E030 159.968106 0.0020040489 7.179960e-02 2.284041e-01 10 5921346 5921353 8 + 2.206 2.175 -0.102
ENSG00000134452 E031 157.203664 0.0030950196 1.158111e-01 3.088764e-01 10 5921354 5921357 4 + 2.197 2.170 -0.091
ENSG00000134452 E032 342.301462 0.0008402077 7.579917e-01 8.713151e-01 10 5921448 5921569 122 + 2.501 2.527 0.085
ENSG00000134452 E033 2.118224 0.1191819355 2.712998e-01 5.112740e-01 10 5923571 5923620 50 + 0.586 0.405 -0.891
ENSG00000134452 E034 286.779222 0.0008369813 3.091658e-01 5.496703e-01 10 5923621 5923696 76 + 2.436 2.443 0.023
ENSG00000134452 E035 13.291265 0.1287606497 8.893636e-01 9.463841e-01 10 5923697 5924310 614 + 1.078 1.177 0.357
ENSG00000134452 E036 400.256108 0.0018976202 2.484065e-01 4.862207e-01 10 5924311 5924508 198 + 2.543 2.611 0.227
ENSG00000134452 E037 5.927373 0.0273038597 5.883868e-01 7.626149e-01 10 5924751 5924801 51 + 0.852 0.806 -0.180
ENSG00000134452 E038 3.780872 0.4133189093 7.989076e-01 8.956489e-01 10 5925264 5925366 103 + 0.483 0.753 1.191
ENSG00000134452 E039 181.549319 0.0010662500 7.898810e-03 4.886029e-02 10 5925367 5925410 44 + 2.167 2.283 0.387
ENSG00000134452 E040 224.956013 0.0017696225 1.144773e-04 1.672045e-03 10 5925411 5925492 82 + 2.236 2.391 0.520
ENSG00000134452 E041 247.897057 0.0253971139 1.627737e-02 8.280725e-02 10 5927435 5927541 107 + 2.238 2.453 0.718
ENSG00000134452 E042 1.986243 0.2172626917 6.259931e-01 7.879396e-01 10 5928336 5928673 338 + 0.414 0.514 0.512
ENSG00000134452 E043 1.446252 0.0134577390 8.438785e-02 2.535073e-01 10 5929375 5929866 492 + 0.148 0.483 2.325
ENSG00000134452 E044 243.816578 1.2933919977 3.597319e-01 5.955831e-01 10 5936456 5936587 132 + 2.136 2.476 1.136
ENSG00000134452 E045 5.548807 0.0437644435 7.292452e-01 8.537984e-01 10 5936633 5936730 98 + 0.767 0.837 0.278
ENSG00000134452 E046 227.451873 1.2537402046 3.343347e-01 5.729106e-01 10 5937110 5937205 96 + 2.089 2.451 1.210
ENSG00000134452 E047 265.918227 1.3340896700 3.747154e-01 6.079029e-01 10 5937206 5937594 389 + 2.183 2.511 1.094