ENSG00000134444

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000587725 ENSG00000134444 HEK293_OSMI2_6hA HEK293_TMG_6hB RELCH protein_coding non_stop_decay 9.073371 2.550091 17.90538 0.4112326 1.402691 2.806931 2.6370942 0.7047233 5.144427 0.2438593 0.3233885 2.850355 0.2304917 0.27243333 0.28953333 0.0171 9.589665e-01 6.312998e-05 FALSE TRUE
ENST00000587764 ENSG00000134444 HEK293_OSMI2_6hA HEK293_TMG_6hB RELCH protein_coding processed_transcript 9.073371 2.550091 17.90538 0.4112326 1.402691 2.806931 2.2103189 0.4292632 3.743720 0.2769920 0.2703026 3.095163 0.2354208 0.14520000 0.20940000 0.0642 8.021497e-01 6.312998e-05 FALSE FALSE
ENST00000588446 ENSG00000134444 HEK293_OSMI2_6hA HEK293_TMG_6hB RELCH protein_coding non_stop_decay 9.073371 2.550091 17.90538 0.4112326 1.402691 2.806931 1.0626597 0.0000000 2.707369 0.0000000 0.5632895 8.086067 0.1094458 0.00000000 0.15470000 0.1547 6.312998e-05 6.312998e-05 FALSE FALSE
ENST00000591227 ENSG00000134444 HEK293_OSMI2_6hA HEK293_TMG_6hB RELCH protein_coding processed_transcript 9.073371 2.550091 17.90538 0.4112326 1.402691 2.806931 0.6483002 0.1921755 1.366277 0.1921755 0.7103165 2.767091 0.0811500 0.08716667 0.07166667 -0.0155 8.716346e-01 6.312998e-05 FALSE FALSE
ENST00000644646 ENSG00000134444 HEK293_OSMI2_6hA HEK293_TMG_6hB RELCH protein_coding protein_coding 9.073371 2.550091 17.90538 0.4112326 1.402691 2.806931 1.8958202 0.9456140 3.455714 0.1864859 0.1418777 1.858653 0.2747292 0.38353333 0.19423333 -0.1893 3.300994e-01 6.312998e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000134444 E001 0.1308682 0.0326491905 0.1055138010   18 62187255 62187257 3 + 0.000 0.216 10.472
ENSG00000134444 E002 0.4702677 0.0217681645 0.5720345861   18 62187258 62187273 16 + 0.122 0.216 0.991
ENSG00000134444 E003 4.8942125 0.0757687286 0.3093076044 0.549790617 18 62187274 62187290 17 + 0.659 0.860 0.813
ENSG00000134444 E004 72.4154984 0.0034291800 0.2265460302 0.461259429 18 62187291 62188031 741 + 1.787 1.719 -0.229
ENSG00000134444 E005 26.0602694 0.0017858000 0.0156492922 0.080536937 18 62211153 62211242 90 + 1.382 1.162 -0.774
ENSG00000134444 E006 0.4654660 0.0260366246 0.6326511117   18 62220860 62221036 177 + 0.172 0.000 -12.885
ENSG00000134444 E007 29.1105794 0.0011492135 0.0442721341 0.165787133 18 62221037 62221108 72 + 1.418 1.249 -0.590
ENSG00000134444 E008 25.2389895 0.0014807824 0.0305100497 0.128872234 18 62221219 62221274 56 + 1.361 1.162 -0.700
ENSG00000134444 E009 37.1924147 0.0009808754 0.0521537563 0.184749841 18 62221384 62221497 114 + 1.516 1.372 -0.498
ENSG00000134444 E010 55.2211119 0.0006511072 0.5816195233 0.758179647 18 62227289 62227492 204 + 1.664 1.632 -0.107
ENSG00000134444 E011 40.9843869 0.0012053840 0.2189903943 0.452241235 18 62227598 62227689 92 + 1.543 1.458 -0.293
ENSG00000134444 E012 39.7885514 0.0200565911 0.7180337042 0.847001964 18 62228305 62228384 80 + 1.519 1.500 -0.066
ENSG00000134444 E013 39.2627616 0.0341427800 0.9514361970 0.977694505 18 62228385 62228439 55 + 1.503 1.537 0.116
ENSG00000134444 E014 59.0657596 0.0008428258 0.4907092316 0.694484608 18 62228440 62228598 159 + 1.690 1.652 -0.131
ENSG00000134444 E015 38.1444551 0.0023287795 0.8835963768 0.943156554 18 62231194 62231269 76 + 1.505 1.495 -0.037
ENSG00000134444 E016 37.0686706 0.0010377928 0.5349356939 0.725601638 18 62232332 62232427 96 + 1.501 1.458 -0.149
ENSG00000134444 E017 0.1723744 0.0632662009 0.1059714105   18 62234880 62235407 528 + 0.000 0.216 12.916
ENSG00000134444 E018 46.9766285 0.0048361629 0.4041298277 0.631648825 18 62244764 62244876 113 + 1.603 1.545 -0.200
ENSG00000134444 E019 43.7446480 0.0119106031 0.7101651132 0.841877854 18 62252664 62252754 91 + 1.568 1.536 -0.111
ENSG00000134444 E020 0.7765309 0.6238941242 0.8217703446   18 62254692 62254711 20 + 0.218 0.210 -0.068
ENSG00000134444 E021 41.9434344 0.0013765690 0.8318917537 0.914924152 18 62255407 62255478 72 + 1.539 1.554 0.050
ENSG00000134444 E022 50.0325605 0.0007629622 0.7031914084 0.837643777 18 62257948 62258088 141 + 1.620 1.598 -0.076
ENSG00000134444 E023 54.8490531 0.0007461739 0.6122515004 0.778350438 18 62258512 62258676 165 + 1.651 1.681 0.101
ENSG00000134444 E024 43.4570379 0.0008765507 0.3685309178 0.602845670 18 62261511 62261610 100 + 1.547 1.605 0.197
ENSG00000134444 E025 32.8956004 0.0010966967 0.8113579188 0.903041963 18 62261611 62261658 48 + 1.439 1.458 0.063
ENSG00000134444 E026 52.4149515 0.0008494601 0.5831175854 0.759045480 18 62263989 62264145 157 + 1.630 1.663 0.112
ENSG00000134444 E027 37.2357727 0.0012908424 0.3431629692 0.580829678 18 62264729 62264852 124 + 1.506 1.438 -0.234
ENSG00000134444 E028 36.8226018 0.0047824258 0.1597775048 0.376453333 18 62266701 62266749 49 + 1.506 1.395 -0.385
ENSG00000134444 E029 0.0000000       18 62268515 62268868 354 +      
ENSG00000134444 E030 24.4107735 0.0020983317 0.0534870305 0.187857479 18 62268869 62268880 12 + 1.343 1.162 -0.636
ENSG00000134444 E031 37.2299250 0.0011676106 0.1432150486 0.352271972 18 62268881 62268948 68 + 1.512 1.406 -0.366
ENSG00000134444 E032 0.7035494 0.0313227900 0.8100954176   18 62269411 62269512 102 + 0.172 0.216 0.411
ENSG00000134444 E033 52.2924067 0.0012896384 0.8511950641 0.925692893 18 62273980 62274086 107 + 1.632 1.645 0.043
ENSG00000134444 E034 50.6498856 0.0009188244 0.5249509029 0.718450925 18 62275374 62275473 100 + 1.612 1.651 0.133
ENSG00000134444 E035 1.7335847 0.0117847106 0.0548299693 0.190944117 18 62275474 62275572 99 + 0.444 0.000 -14.669
ENSG00000134444 E036 2.6708620 0.0109682546 0.3707471420 0.604526086 18 62277596 62277655 60 + 0.534 0.359 -0.910
ENSG00000134444 E037 52.8460912 0.0019826906 0.2946297044 0.535189863 18 62279774 62279856 83 + 1.624 1.688 0.217
ENSG00000134444 E038 2.1716395 0.0180829503 0.8898410470 0.946601579 18 62280326 62280359 34 + 0.443 0.467 0.123
ENSG00000134444 E039 7.5008364 0.0084386641 0.9477402924 0.976186182 18 62280360 62280442 83 + 0.844 0.833 -0.043
ENSG00000134444 E040 42.9248934 0.0013623163 0.1302523148 0.332193859 18 62280646 62280709 64 + 1.529 1.626 0.331
ENSG00000134444 E041 29.2658207 0.0016358348 0.5328534306 0.724088341 18 62282306 62282315 10 + 1.379 1.428 0.169
ENSG00000134444 E042 27.4173406 0.0071064300 0.7798020569 0.884584032 18 62282316 62282319 4 + 1.360 1.384 0.084
ENSG00000134444 E043 62.4299185 0.0023514679 0.4376427424 0.656966597 18 62282320 62282442 123 + 1.702 1.746 0.150
ENSG00000134444 E044 30.6622519 0.0027391445 0.6395425446 0.796634318 18 62282443 62282444 2 + 1.421 1.383 -0.129
ENSG00000134444 E045 1.4029310 0.0466447333 0.5129530377 0.710209934 18 62284239 62284361 123 + 0.359 0.216 -0.998
ENSG00000134444 E046 3.8887741 0.0137096468 0.9289127115 0.966494603 18 62285449 62285973 525 + 0.610 0.625 0.069
ENSG00000134444 E047 56.6257157 0.0050716514 0.6642224196 0.812516648 18 62287351 62287467 117 + 1.668 1.697 0.097
ENSG00000134444 E048 52.5209569 0.0012706416 0.4715402684 0.681222474 18 62291543 62291631 89 + 1.632 1.675 0.147
ENSG00000134444 E049 51.3508683 0.0032921474 0.2093309597 0.441079105 18 62298790 62298860 71 + 1.614 1.692 0.265
ENSG00000134444 E050 186.8668162 0.0007390499 0.0002446989 0.003161316 18 62305414 62310249 4836 + 2.155 2.268 0.377