ENSG00000134318

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315872 ENSG00000134318 HEK293_OSMI2_6hA HEK293_TMG_6hB ROCK2 protein_coding protein_coding 8.317423 3.073689 15.38876 0.4434487 0.5483365 2.320085 4.554835 2.89499390 7.293205 0.55612983 0.4319976 1.329995 0.7188667 0.92593333 0.4731333 -0.4528 0.005326201 0.005326201 FALSE TRUE
MSTRG.17960.2 ENSG00000134318 HEK293_OSMI2_6hA HEK293_TMG_6hB ROCK2 protein_coding   8.317423 3.073689 15.38876 0.4434487 0.5483365 2.320085 3.307292 0.06120226 7.298180 0.06120226 0.1661771 6.681445 0.2327167 0.02793333 0.4747333 0.4468 0.006815284 0.005326201 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000134318 E001 363.4688253 1.7394531853 0.3064666016 0.547114057 2 11179759 11182974 3216 - 2.301 2.816 1.714
ENSG00000134318 E002 34.3197349 0.7516036788 0.3229836957 0.562287901 2 11182975 11183121 147 - 1.362 1.695 1.140
ENSG00000134318 E003 61.2213493 0.9127412645 0.3233447015 0.562683862 2 11183122 11183330 209 - 1.601 1.948 1.174
ENSG00000134318 E004 45.2836301 0.8464127390 0.3341557788 0.572731039 2 11183331 11183440 110 - 1.481 1.805 1.101
ENSG00000134318 E005 3.0473756 0.0074769714 0.3945115024 0.623971646 2 11184666 11184769 104 - 0.480 0.700 0.988
ENSG00000134318 E006 68.5614622 0.0260752015 0.2910280886 0.531606282 2 11192148 11192361 214 - 1.703 1.880 0.599
ENSG00000134318 E007 94.0688227 0.0005924157 0.2871439051 0.527927847 2 11192451 11192675 225 - 1.843 1.994 0.508
ENSG00000134318 E008 50.1341377 0.0158593679 0.7983015180 0.895318193 2 11192676 11192712 37 - 1.579 1.712 0.453
ENSG00000134318 E009 62.7746834 0.0222943919 0.9711651160 0.987422234 2 11193779 11193857 79 - 1.678 1.796 0.400
ENSG00000134318 E010 0.6246688 0.0191972953 0.3353901561   2 11193910 11194255 346 - 0.210 0.000 -11.335
ENSG00000134318 E011 60.3869541 0.0046154649 0.8006625342 0.896677688 2 11194256 11194344 89 - 1.659 1.782 0.418
ENSG00000134318 E012 55.8242004 0.0013630315 0.5779950614 0.755826001 2 11194955 11195025 71 - 1.624 1.762 0.466
ENSG00000134318 E013 0.4646582 0.0217681645 0.1093965845   2 11195026 11195210 185 - 0.063 0.368 3.100
ENSG00000134318 E014 86.1627111 0.0027944255 0.8471903951 0.923413334 2 11197180 11197348 169 - 1.819 1.916 0.327
ENSG00000134318 E015 97.9162866 0.0030914577 0.9761938467 0.989871903 2 11197526 11197705 180 - 1.872 1.979 0.360
ENSG00000134318 E016 68.1818600 0.0046252589 0.7400570047 0.860477079 2 11198491 11198585 95 - 1.720 1.809 0.300
ENSG00000134318 E017 70.7759451 0.0078497776 0.6627461212 0.811595534 2 11198681 11198774 94 - 1.736 1.815 0.267
ENSG00000134318 E018 99.2439470 0.0065692583 0.0584850134 0.199379713 2 11200957 11201143 187 - 1.898 1.896 -0.009
ENSG00000134318 E019 65.2032791 0.0090852555 0.0379531884 0.149498395 2 11201310 11201413 104 - 1.726 1.686 -0.138
ENSG00000134318 E020 58.6411930 0.0155023121 0.0121701335 0.067150841 2 11202052 11202121 70 - 1.693 1.589 -0.354
ENSG00000134318 E021 89.5563253 0.0136168098 0.0258195735 0.114734381 2 11207726 11207910 185 - 1.866 1.814 -0.173
ENSG00000134318 E022 72.9675437 0.0022673347 0.0036264618 0.027081334 2 11208287 11208447 161 - 1.779 1.725 -0.185
ENSG00000134318 E023 69.3585017 0.0005697186 0.0466881280 0.171784595 2 11211681 11211840 160 - 1.749 1.752 0.009
ENSG00000134318 E024 57.9941745 0.0008893733 0.2603124030 0.499271916 2 11214357 11214463 107 - 1.661 1.703 0.142
ENSG00000134318 E025 82.4054572 0.0020744316 0.0003638488 0.004376364 2 11214840 11215086 247 - 1.835 1.752 -0.282
ENSG00000134318 E026 35.9269791 0.0010810976 0.0001324593 0.001891729 2 11215321 11215359 39 - 1.503 1.309 -0.670
ENSG00000134318 E027 38.8409456 0.0009712057 0.0169237548 0.085171966 2 11215360 11215412 53 - 1.517 1.453 -0.220
ENSG00000134318 E028 64.0904861 0.0006450517 0.0217489489 0.101757445 2 11215510 11215645 136 - 1.722 1.703 -0.064
ENSG00000134318 E029 48.8915894 0.0009809163 0.0175023391 0.087297337 2 11216158 11216206 49 - 1.606 1.561 -0.153
ENSG00000134318 E030 54.0731100 0.0031035083 0.0209159229 0.099063052 2 11217090 11217169 80 - 1.648 1.606 -0.142
ENSG00000134318 E031 0.8323924 0.0175827784 0.9018672459   2 11217776 11218314 539 - 0.210 0.222 0.101
ENSG00000134318 E032 0.3228314 0.3538038281 1.0000000000   2 11218315 11218454 140 - 0.118 0.000 -10.342
ENSG00000134318 E033 29.3933705 0.0069410147 0.0198639475 0.095400315 2 11218455 11218466 12 - 1.401 1.295 -0.370
ENSG00000134318 E034 35.3344288 0.0074428301 0.0140983491 0.074740087 2 11218966 11219026 61 - 1.477 1.375 -0.354
ENSG00000134318 E035 62.4165122 0.0075046964 0.0014213125 0.013049227 2 11221198 11221326 129 - 1.722 1.605 -0.399
ENSG00000134318 E036 44.7631755 0.0191517224 0.0376182025 0.148623581 2 11221327 11221357 31 - 1.577 1.489 -0.302
ENSG00000134318 E037 57.2537148 0.0165535637 0.0580784001 0.198467646 2 11222083 11222174 92 - 1.676 1.623 -0.178
ENSG00000134318 E038 57.4344163 0.0049164564 0.0023828591 0.019580674 2 11224322 11224460 139 - 1.685 1.584 -0.343
ENSG00000134318 E039 67.8119515 0.0031435830 0.0013196977 0.012306591 2 11227254 11227398 145 - 1.753 1.666 -0.293
ENSG00000134318 E040 0.1779838 0.0453459615 1.0000000000   2 11234204 11234670 467 - 0.063 0.000 -9.338
ENSG00000134318 E041 75.3829535 0.0184124833 0.0049774640 0.034502954 2 11235702 11235883 182 - 1.805 1.671 -0.453
ENSG00000134318 E042 40.6797879 0.0026152361 0.0011817063 0.011293402 2 11235884 11235962 79 - 1.545 1.410 -0.466
ENSG00000134318 E043 43.0818997 0.0015287277 0.0005857111 0.006453881 2 11249661 11249798 138 - 1.570 1.432 -0.472
ENSG00000134318 E044 27.9053192 0.0273508349 0.0105775959 0.060571859 2 11286539 11286639 101 - 1.393 1.195 -0.695
ENSG00000134318 E045 19.1070333 0.0085102844 0.0031223485 0.024149780 2 11287655 11287736 82 - 1.244 1.014 -0.824
ENSG00000134318 E046 0.1426347 0.0317821261 1.0000000000   2 11287737 11287737 1 - 0.063 0.000 -9.334
ENSG00000134318 E047 0.1779838 0.0453459615 1.0000000000   2 11288350 11288403 54 - 0.063 0.000 -9.338
ENSG00000134318 E048 25.0700905 0.0136724766 0.6130364530 0.778980961 2 11343996 11344636 641 - 1.308 1.371 0.219
ENSG00000134318 E049 0.0000000       2 11345274 11345316 43 -      
ENSG00000134318 E050 0.0000000       2 11348168 11348330 163 -