ENSG00000134294

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256689 ENSG00000134294 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC38A2 protein_coding protein_coding 52.39777 11.32787 127.0059 3.077901 3.146454 3.485787 37.414019 10.37056 90.81931 3.230291 2.525994 3.129273 0.79672500 0.8814 0.7150667 -0.1663333 2.534235e-01 1.537724e-14 FALSE TRUE
ENST00000612232 ENSG00000134294 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC38A2 protein_coding protein_coding 52.39777 11.32787 127.0059 3.077901 3.146454 3.485787 6.448362 0.00000 12.47627 0.000000 1.306389 10.286127 0.07255417 0.0000 0.0981000 0.0981000 1.537724e-14 1.537724e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000134294 E001 178.2171979 1.426753988 0.251263141 0.48934346 12 46358188 46358480 293 - 1.922 2.506 1.955
ENSG00000134294 E002 964.1123148 1.990923580 0.408985016 0.63522679 12 46358481 46359384 904 - 2.693 3.116 1.409
ENSG00000134294 E003 1544.2542591 2.164346860 0.556337636 0.74073012 12 46359385 46360959 1575 - 2.925 3.204 0.926
ENSG00000134294 E004 307.7280546 1.666483098 0.578074831 0.75588957 12 46360960 46361110 151 - 2.242 2.418 0.588
ENSG00000134294 E005 173.4695532 1.479254954 0.584597925 0.76006502 12 46361111 46361117 7 - 1.997 2.159 0.544
ENSG00000134294 E006 277.4039254 1.639808312 0.607710563 0.77534620 12 46361118 46361209 92 - 2.203 2.341 0.461
ENSG00000134294 E007 16.6933656 0.071254963 0.110707921 0.30016846 12 46361853 46362283 431 - 1.053 0.893 -0.596
ENSG00000134294 E008 173.7056954 0.100261668 0.444122694 0.66148664 12 46362284 46362289 6 - 2.002 2.138 0.456
ENSG00000134294 E009 188.7765075 0.081094496 0.317616275 0.55757930 12 46362290 46362324 35 - 2.032 2.207 0.584
ENSG00000134294 E010 231.8272005 0.006224768 0.876088813 0.93926787 12 46362325 46362381 57 - 2.132 2.233 0.337
ENSG00000134294 E011 6.8343557 0.004397929 0.237020253 0.47310723 12 46362382 46362493 112 - 0.668 0.953 1.125
ENSG00000134294 E012 435.2027068 0.013021707 0.490763110 0.69451229 12 46362494 46362638 145 - 2.403 2.496 0.310
ENSG00000134294 E013 7.2191761 0.004581905 0.202702838 0.43294097 12 46362639 46362904 266 - 0.740 0.601 -0.588
ENSG00000134294 E014 423.2602522 0.030271519 0.329548101 0.56850579 12 46363021 46363114 94 - 2.394 2.461 0.223
ENSG00000134294 E015 297.8087855 0.028035949 0.325930454 0.56518398 12 46363115 46363145 31 - 2.243 2.301 0.192
ENSG00000134294 E016 449.1230360 0.032121626 0.175166812 0.39738376 12 46363726 46363826 101 - 2.424 2.444 0.064
ENSG00000134294 E017 355.6801961 0.030221196 0.137134733 0.34315610 12 46363924 46364003 80 - 2.324 2.334 0.033
ENSG00000134294 E018 309.1745952 0.025330725 0.150205421 0.36264369 12 46364389 46364441 53 - 2.262 2.292 0.100
ENSG00000134294 E019 426.7896130 0.032538623 0.106654606 0.29340383 12 46364442 46364556 115 - 2.404 2.406 0.008
ENSG00000134294 E020 9.3908174 0.006903147 0.002916317 0.02289997 12 46364557 46364641 85 - 0.849 0.300 -2.604
ENSG00000134294 E021 7.9340620 0.056707106 0.015765801 0.08097133 12 46364642 46364643 2 - 0.781 0.301 -2.333
ENSG00000134294 E022 324.0508936 0.040959105 0.164991253 0.38394577 12 46364644 46364702 59 - 2.284 2.298 0.048
ENSG00000134294 E023 4.7749573 0.084589170 0.126391995 0.32609284 12 46364703 46364832 130 - 0.605 0.301 -1.598
ENSG00000134294 E024 377.9457667 0.040205532 0.040477405 0.15596484 12 46365107 46365189 83 - 2.359 2.282 -0.255
ENSG00000134294 E025 13.6504941 0.183227487 0.233236736 0.46889494 12 46365190 46365307 118 - 0.975 0.769 -0.793
ENSG00000134294 E026 325.4627139 0.038643420 0.034544694 0.14033524 12 46366864 46366945 82 - 2.295 2.203 -0.307
ENSG00000134294 E027 330.9721589 0.033623768 0.089026518 0.26194253 12 46367076 46367168 93 - 2.297 2.266 -0.105
ENSG00000134294 E028 271.1908827 0.027304615 0.031661336 0.13222238 12 46367267 46367340 74 - 2.213 2.160 -0.179
ENSG00000134294 E029 15.1501472 0.062736628 0.135845061 0.34111405 12 46367341 46367410 70 - 1.010 0.845 -0.623
ENSG00000134294 E030 356.6848726 0.035476085 0.011625619 0.06491410 12 46370512 46370627 116 - 2.337 2.221 -0.388
ENSG00000134294 E031 199.5047197 0.039836430 0.016448421 0.08346242 12 46370776 46370798 23 - 2.088 1.955 -0.445
ENSG00000134294 E032 299.7776985 0.043836265 0.012120773 0.06693284 12 46370799 46370857 59 - 2.264 2.113 -0.506
ENSG00000134294 E033 2.0306702 0.011503825 0.750210258 0.86688139 12 46370858 46371177 320 - 0.332 0.476 0.791
ENSG00000134294 E034 401.6827285 0.047405694 0.027302044 0.11918755 12 46371178 46371379 202 - 2.388 2.269 -0.400
ENSG00000134294 E035 0.8745889 0.221775489 0.750571002   12 46371380 46371433 54 - 0.207 0.001 -8.545
ENSG00000134294 E036 0.4466850 0.021768165 1.000000000   12 46372321 46372508 188 - 0.118 0.001 -7.580
ENSG00000134294 E037 245.4500875 0.048794077 0.076855744 0.23851235 12 46372509 46372773 265 - 2.172 2.096 -0.255