ENSG00000134243

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256637 ENSG00000134243 HEK293_OSMI2_6hA HEK293_TMG_6hB SORT1 protein_coding protein_coding 20.22324 14.78387 21.64001 2.306499 0.7134113 0.5493687 14.057752 11.893265 15.0938763 1.8208618 0.6785163 0.3435615 0.7067458 0.8049000 0.69696667 -0.1079333 5.190128e-02 2.771542e-32 FALSE TRUE
ENST00000538502 ENSG00000134243 HEK293_OSMI2_6hA HEK293_TMG_6hB SORT1 protein_coding protein_coding 20.22324 14.78387 21.64001 2.306499 0.7134113 0.5493687 1.683794 2.633243 0.6458908 0.4419689 0.3631222 -2.0107816 0.1033833 0.1789667 0.03096667 -0.1480000 3.067476e-01 2.771542e-32 FALSE TRUE
MSTRG.1749.3 ENSG00000134243 HEK293_OSMI2_6hA HEK293_TMG_6hB SORT1 protein_coding   20.22324 14.78387 21.64001 2.306499 0.7134113 0.5493687 4.197275 0.000000 5.7190002 0.0000000 0.3707118 9.1621396 0.1745250 0.0000000 0.26370000 0.2637000 2.771542e-32 2.771542e-32 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000134243 E001 0.3807181 2.926432e-02 9.277262e-01   1 109309568 109309574 7 - 0.115 0.129 0.189
ENSG00000134243 E002 1620.6324680 7.866317e-05 1.126168e-39 1.787376e-36 1 109309575 109313630 4056 - 3.152 3.256 0.348
ENSG00000134243 E003 53.4194913 8.277982e-03 7.385516e-01 8.595801e-01 1 109313631 109313654 24 - 1.725 1.746 0.073
ENSG00000134243 E004 88.4156213 4.552502e-03 4.871486e-02 1.766205e-01 1 109313655 109313800 146 - 1.900 1.998 0.331
ENSG00000134243 E005 143.3062011 5.139809e-04 1.373323e-02 7.329408e-02 1 109313801 109314057 257 - 2.113 2.191 0.261
ENSG00000134243 E006 127.6001454 3.483643e-04 2.035857e-01 4.340329e-01 1 109314261 109314384 124 - 2.084 2.126 0.141
ENSG00000134243 E007 145.5883063 3.391919e-04 2.154673e-01 4.480008e-01 1 109314672 109314778 107 - 2.141 2.180 0.131
ENSG00000134243 E008 172.8094397 2.416386e-03 7.685561e-01 8.777598e-01 1 109316850 109316958 109 - 2.225 2.242 0.059
ENSG00000134243 E009 158.7738631 4.606341e-04 3.046557e-01 5.452314e-01 1 109317853 109317969 117 - 2.181 2.214 0.108
ENSG00000134243 E010 204.5769552 2.614310e-04 5.774568e-01 7.554145e-01 1 109322932 109323121 190 - 2.299 2.315 0.054
ENSG00000134243 E011 200.4509608 2.299986e-04 7.886328e-01 8.897159e-01 1 109324899 109325089 191 - 2.294 2.302 0.029
ENSG00000134243 E012 0.1779838 3.428079e-02 5.454696e-01   1 109326806 109326991 186 - 0.115 0.000 -10.894
ENSG00000134243 E013 158.2133827 2.881274e-04 1.495842e-01 3.616475e-01 1 109326992 109327160 169 - 2.217 2.178 -0.132
ENSG00000134243 E014 124.3021172 3.903589e-04 7.459334e-03 4.683401e-02 1 109327499 109327601 103 - 2.134 2.049 -0.285
ENSG00000134243 E015 148.3367789 3.245657e-04 1.677350e-02 8.463369e-02 1 109336240 109336346 107 - 2.201 2.132 -0.231
ENSG00000134243 E016 175.5783586 2.729600e-04 1.266725e-02 6.911513e-02 1 109340724 109340879 156 - 2.272 2.206 -0.220
ENSG00000134243 E017 161.7178928 3.602556e-04 1.552110e-03 1.397879e-02 1 109342014 109342158 145 - 2.246 2.157 -0.298
ENSG00000134243 E018 172.2117768 3.478931e-04 3.133596e-07 1.025350e-05 1 109345751 109345878 128 - 2.296 2.154 -0.472
ENSG00000134243 E019 60.3668316 6.569071e-04 1.216345e-02 6.712051e-02 1 109345879 109345881 3 - 1.833 1.719 -0.387
ENSG00000134243 E020 131.7494256 3.359250e-04 1.009835e-05 2.114329e-04 1 109347483 109347532 50 - 2.179 2.041 -0.461
ENSG00000134243 E021 98.5986937 4.773963e-04 8.954553e-03 5.361628e-02 1 109350929 109350946 18 - 2.037 1.944 -0.314
ENSG00000134243 E022 118.0552695 3.874233e-04 2.272304e-03 1.887637e-02 1 109350947 109351002 56 - 2.118 2.018 -0.334
ENSG00000134243 E023 130.4961069 1.655923e-03 2.676719e-03 2.143685e-02 1 109354367 109354484 118 - 2.165 2.059 -0.354
ENSG00000134243 E024 108.5941816 4.258241e-04 3.081535e-08 1.291818e-06 1 109354485 109354531 47 - 2.117 1.924 -0.646
ENSG00000134243 E025 114.2233792 5.239272e-04 5.139590e-06 1.179487e-04 1 109355367 109355440 74 - 2.124 1.969 -0.521
ENSG00000134243 E026 82.5547110 5.169446e-04 4.319304e-04 5.048642e-03 1 109355441 109355469 29 - 1.975 1.836 -0.468
ENSG00000134243 E027 1.6533103 6.937937e-02 3.489944e-02 1.413371e-01 1 109366783 109367407 625 - 0.205 0.607 2.334
ENSG00000134243 E028 94.5238751 5.214883e-04 2.989983e-04 3.719366e-03 1 109367408 109367481 74 - 2.035 1.901 -0.450
ENSG00000134243 E029 0.0000000       1 109368478 109368808 331 -      
ENSG00000134243 E030 64.4255879 3.251491e-03 4.704676e-02 1.726515e-01 1 109369530 109369589 60 - 1.858 1.758 -0.338
ENSG00000134243 E031 0.0000000       1 109389775 109389899 125 -      
ENSG00000134243 E032 0.3393995 2.744240e-02 2.359077e-01   1 109392591 109393026 436 - 0.206 0.000 -11.994
ENSG00000134243 E033 0.1779838 3.428079e-02 5.454696e-01   1 109393027 109393357 331 - 0.115 0.000 -10.894
ENSG00000134243 E034 0.5481031 2.168682e-01 5.521612e-01   1 109397207 109397293 87 - 0.114 0.233 1.241
ENSG00000134243 E035 0.0000000       1 109397294 109397340 47 -      
ENSG00000134243 E036 47.9436115 7.787703e-04 5.482162e-01 7.350587e-01 1 109397587 109397946 360 - 1.669 1.701 0.110