ENSG00000134152

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256544 ENSG00000134152 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNBL1 protein_coding protein_coding 15.99585 3.197974 32.86105 0.5920468 0.9079511 3.357083 2.5380804 0.3887135 4.488565 0.07880774 0.1431526 3.496041 0.21220417 0.1423000 0.13663333 -0.005666667 0.9667614219 0.0001648654 FALSE TRUE
ENST00000559462 ENSG00000134152 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNBL1 protein_coding protein_coding 15.99585 3.197974 32.86105 0.5920468 0.9079511 3.357083 0.5615829 0.0000000 2.211865 0.00000000 0.5487382 7.795628 0.01945833 0.0000000 0.06810000 0.068100000 0.0014805689 0.0001648654   FALSE
ENST00000559760 ENSG00000134152 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNBL1 protein_coding protein_coding 15.99585 3.197974 32.86105 0.5920468 0.9079511 3.357083 1.6574860 0.4109805 3.631470 0.18610430 0.3044343 3.112696 0.09565417 0.1275667 0.11070000 -0.016866667 0.9817222020 0.0001648654 FALSE TRUE
ENST00000560310 ENSG00000134152 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNBL1 protein_coding protein_coding 15.99585 3.197974 32.86105 0.5920468 0.9079511 3.357083 1.2467238 0.0000000 1.553496 0.00000000 1.5534957 7.288631 0.05200000 0.0000000 0.04553333 0.045533333 1.0000000000 0.0001648654 FALSE FALSE
ENST00000560671 ENSG00000134152 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNBL1 protein_coding retained_intron 15.99585 3.197974 32.86105 0.5920468 0.9079511 3.357083 2.0149896 0.3882681 4.294056 0.11129470 0.6121624 3.433885 0.09620417 0.1241667 0.12993333 0.005766667 0.9704078886 0.0001648654 FALSE TRUE
ENST00000561270 ENSG00000134152 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNBL1 protein_coding protein_coding 15.99585 3.197974 32.86105 0.5920468 0.9079511 3.357083 0.4290149 0.0000000 1.794306 0.00000000 0.1643267 7.495300 0.02615000 0.0000000 0.05476667 0.054766667 0.0001648654 0.0001648654 FALSE TRUE
ENST00000561371 ENSG00000134152 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNBL1 protein_coding protein_coding 15.99585 3.197974 32.86105 0.5920468 0.9079511 3.357083 1.0574759 0.4586994 1.833293 0.26220451 0.2579268 1.975551 0.08907083 0.1195333 0.05610000 -0.063433333 0.8525623693 0.0001648654 FALSE FALSE
MSTRG.10431.2 ENSG00000134152 HEK293_OSMI2_6hA HEK293_TMG_6hB KATNBL1 protein_coding   15.99585 3.197974 32.86105 0.5920468 0.9079511 3.357083 4.7683463 1.0265951 10.035262 0.20538660 0.2458352 3.276591 0.29144167 0.3255000 0.30560000 -0.019900000 0.9738971341 0.0001648654 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000134152 E001 50.3240271 0.0007394652 0.2401783959 0.476777236 15 34140674 34141886 1213 - 1.507 1.415 -0.315
ENSG00000134152 E002 19.7491635 0.0028093883 0.8942465674 0.948827488 15 34141887 34141961 75 - 1.110 1.131 0.074
ENSG00000134152 E003 29.4102400 0.0013369112 0.9777822598 0.990686849 15 34141962 34142035 74 - 1.277 1.285 0.028
ENSG00000134152 E004 44.7349751 0.0009551591 0.9360983984 0.970276294 15 34142036 34142090 55 - 1.449 1.461 0.041
ENSG00000134152 E005 112.0334397 0.0003891476 0.1256639036 0.324903264 15 34142091 34142371 281 - 1.832 1.913 0.272
ENSG00000134152 E006 13.2404200 0.0464233983 0.0030911467 0.023964748 15 34142669 34143024 356 - 0.886 1.321 1.574
ENSG00000134152 E007 15.0514511 0.0022565192 0.1613392667 0.378735371 15 34144964 34145252 289 - 0.985 1.161 0.640
ENSG00000134152 E008 66.5268268 0.0009121002 0.0597354628 0.202185504 15 34145398 34145491 94 - 1.607 1.732 0.423
ENSG00000134152 E009 3.4805062 0.0078152663 0.0013100400 0.012235998 15 34145492 34145855 364 - 0.400 0.939 2.344
ENSG00000134152 E010 12.2370243 0.3559896499 0.9423656341 0.973451089 15 34146070 34146659 590 - 0.893 1.142 0.919
ENSG00000134152 E011 4.0216668 0.0325796845 0.3896158536 0.620191338 15 34146660 34146760 101 - 0.515 0.686 0.765
ENSG00000134152 E012 71.6970993 0.0006693095 0.4338342140 0.654110018 15 34146761 34146850 90 - 1.645 1.700 0.187
ENSG00000134152 E013 8.5064785 0.0797511735 0.7149909240 0.844942855 15 34146851 34147199 349 - 0.777 0.833 0.219
ENSG00000134152 E014 36.1822993 0.0013136420 0.3710433579 0.604765069 15 34147200 34147202 3 - 1.367 1.286 -0.284
ENSG00000134152 E015 46.8481830 0.0016732971 0.5795568500 0.756883347 15 34147203 34147229 27 - 1.473 1.431 -0.144
ENSG00000134152 E016 52.0021289 0.0009371211 0.5297090743 0.721853118 15 34147230 34147289 60 - 1.520 1.475 -0.152
ENSG00000134152 E017 49.7798291 0.0007539245 0.7366586563 0.858371126 15 34147380 34147430 51 - 1.497 1.475 -0.073
ENSG00000134152 E018 3.3900537 0.1543926826 0.6189720592 0.783083832 15 34148390 34148542 153 - 0.480 0.589 0.515
ENSG00000134152 E019 2.7971161 0.0152484410 0.4929033235 0.695885896 15 34148543 34148631 89 - 0.452 0.293 -0.929
ENSG00000134152 E020 38.4744448 0.0009368547 0.7450538409 0.863691011 15 34148632 34148652 21 - 1.389 1.364 -0.083
ENSG00000134152 E021 37.1767039 0.0010400240 0.5671432766 0.748110364 15 34148653 34148655 3 - 1.375 1.327 -0.167
ENSG00000134152 E022 37.5574219 0.0010573501 0.6953756921 0.832479639 15 34148656 34148657 2 - 1.377 1.346 -0.107
ENSG00000134152 E023 70.1769847 0.0005587322 0.9967895567 1.000000000 15 34148658 34148750 93 - 1.641 1.646 0.020
ENSG00000134152 E024 96.7126994 0.0006050529 0.1189462584 0.314134806 15 34152790 34152973 184 - 1.787 1.700 -0.295
ENSG00000134152 E025 49.4535296 0.0008715354 0.0559560452 0.193551888 15 34152974 34153004 31 - 1.507 1.346 -0.556
ENSG00000134152 E026 59.7697487 0.0008996030 0.2775289472 0.517591084 15 34153005 34153069 65 - 1.579 1.503 -0.263
ENSG00000134152 E027 47.3518067 0.0010206839 0.4038884054 0.631416768 15 34154644 34154684 41 - 1.480 1.415 -0.222
ENSG00000134152 E028 0.1614157 0.0325405346 0.6443828385   15 34154685 34154785 101 - 0.045 0.000 -9.189
ENSG00000134152 E029 0.0000000       15 34154786 34154831 46 -      
ENSG00000134152 E030 74.3196570 0.0044365886 0.1705339166 0.391163625 15 34163560 34163690 131 - 1.672 1.575 -0.331
ENSG00000134152 E031 0.1614157 0.0325405346 0.6443828385   15 34165930 34166115 186 - 0.045 0.000 -9.189
ENSG00000134152 E032 2.9297671 0.0108432392 0.0995285599 0.280908071 15 34177821 34177999 179 - 0.470 0.000 -13.079
ENSG00000134152 E033 0.3228314 0.3705924263 1.0000000000   15 34198260 34198331 72 - 0.085 0.000 -9.623
ENSG00000134152 E034 0.1723744 0.0324155087 0.0337515443   15 34199579 34199840 262 - 0.000 0.293 13.432
ENSG00000134152 E035 3.5936909 0.0068139080 0.0002092381 0.002775823 15 34208517 34209950 1434 - 0.381 0.985 2.624
ENSG00000134152 E036 47.7660487 0.0072314664 0.7832401157 0.886541303 15 34209951 34210096 146 - 1.479 1.460 -0.065