ENSG00000133858

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378743 ENSG00000133858 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFC3H1 protein_coding protein_coding 10.60963 6.016017 19.04252 0.3541635 0.4814845 1.660705 6.4258890 4.2673643 11.107632 0.7209765 0.6662013 1.378056 0.60140417 0.70323333 0.58306667 -0.12016667 0.6873401884 0.0003051131 FALSE TRUE
ENST00000550963 ENSG00000133858 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFC3H1 protein_coding retained_intron 10.60963 6.016017 19.04252 0.3541635 0.4814845 1.660705 1.5504067 0.8620983 2.313337 0.1120604 0.2429194 1.413636 0.18205417 0.14523333 0.12100000 -0.02423333 0.8612126314 0.0003051131   FALSE
ENST00000551487 ENSG00000133858 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFC3H1 protein_coding retained_intron 10.60963 6.016017 19.04252 0.3541635 0.4814845 1.660705 0.6074419 0.3380138 1.404365 0.0733086 0.1807501 2.022937 0.05214167 0.05683333 0.07336667 0.01653333 0.8124174199 0.0003051131   FALSE
ENST00000552994 ENSG00000133858 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFC3H1 protein_coding nonsense_mediated_decay 10.60963 6.016017 19.04252 0.3541635 0.4814845 1.660705 1.0302336 0.3549042 2.300445 0.1342467 0.3714374 2.662581 0.09218333 0.06100000 0.12110000 0.06010000 0.5026950126 0.0003051131 TRUE TRUE
MSTRG.7662.3 ENSG00000133858 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFC3H1 protein_coding   10.60963 6.016017 19.04252 0.3541635 0.4814845 1.660705 0.6249983 0.0000000 1.308498 0.0000000 0.4502417 7.042751 0.04000417 0.00000000 0.06993333 0.06993333 0.0003051131 0.0003051131 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000133858 E001 0.4466850 0.0226990380 3.250176e-01   12 71609599 71609697 99 - 0.194 0.000 -11.215
ENSG00000133858 E002 104.7547669 1.2712114723 2.581443e-01 4.968683e-01 12 71609698 71610109 412 - 1.764 2.284 1.744
ENSG00000133858 E003 114.7988306 1.3247663924 2.944000e-01 5.349901e-01 12 71610110 71610387 278 - 1.823 2.305 1.614
ENSG00000133858 E004 95.7536067 1.2815603497 3.381023e-01 5.763763e-01 12 71610388 71610565 178 - 1.775 2.197 1.415
ENSG00000133858 E005 15.5311362 0.6597118505 7.123770e-01 8.432742e-01 12 71610566 71610694 129 - 1.140 1.232 0.329
ENSG00000133858 E006 63.8610536 0.8968012780 2.629115e-01 5.021341e-01 12 71610695 71610757 63 - 1.601 2.025 1.432
ENSG00000133858 E007 55.8489932 0.8712883861 2.835320e-01 5.239817e-01 12 71611058 71611097 40 - 1.556 1.954 1.348
ENSG00000133858 E008 27.0233303 0.8014332595 7.190205e-01 8.475772e-01 12 71611098 71611555 458 - 1.381 1.423 0.143
ENSG00000133858 E009 17.5821019 0.7642175006 9.280294e-01 9.660353e-01 12 71611556 71611785 230 - 1.222 1.196 -0.093
ENSG00000133858 E010 76.5068683 0.4072465214 1.524025e-01 3.658126e-01 12 71611786 71611887 102 - 1.692 2.087 1.331
ENSG00000133858 E011 55.9544565 0.1667089342 7.131778e-02 2.274057e-01 12 71613335 71613366 32 - 1.567 1.945 1.280
ENSG00000133858 E012 59.6051722 0.0600148972 1.053300e-02 6.038368e-02 12 71613367 71613435 69 - 1.593 1.974 1.290
ENSG00000133858 E013 8.3907868 0.0317930988 9.065929e-01 9.553988e-01 12 71613436 71613748 313 - 0.902 0.969 0.252
ENSG00000133858 E014 95.4658687 0.0100778001 1.258784e-02 6.878958e-02 12 71614535 71614700 166 - 1.854 2.093 0.803
ENSG00000133858 E015 83.0533925 0.0033525270 3.627360e-01 5.979390e-01 12 71614834 71614938 105 - 1.829 1.971 0.476
ENSG00000133858 E016 1.2493376 0.0135764344 3.536349e-02   12 71614939 71615070 132 - 0.399 0.000 -12.624
ENSG00000133858 E017 1.0159857 0.1514351543 1.103686e-01   12 71615071 71615205 135 - 0.332 0.000 -12.230
ENSG00000133858 E018 88.7065756 0.0149361707 4.823730e-01 6.886357e-01 12 71615206 71615316 111 - 1.855 1.996 0.473
ENSG00000133858 E019 74.7755868 0.0179591034 1.439895e-01 3.533732e-01 12 71619315 71619409 95 - 1.758 1.967 0.705
ENSG00000133858 E020 90.2856801 0.0114011145 5.432101e-02 1.898256e-01 12 71619926 71620124 199 - 1.835 2.057 0.748
ENSG00000133858 E021 75.6642233 0.0042649996 1.250005e-01 3.237350e-01 12 71620210 71620315 106 - 1.780 1.960 0.606
ENSG00000133858 E022 107.0162820 0.0110443101 5.904415e-01 7.640125e-01 12 71623360 71623597 238 - 1.940 2.073 0.444
ENSG00000133858 E023 82.5278588 0.0127481596 6.628938e-01 8.116962e-01 12 71624104 71624292 189 - 1.829 1.955 0.422
ENSG00000133858 E024 101.4565156 0.0089017412 4.636060e-01 6.755355e-01 12 71626260 71626446 187 - 1.941 1.995 0.181
ENSG00000133858 E025 105.9453719 0.0083639186 4.460836e-01 6.627926e-01 12 71627751 71627934 184 - 1.959 2.012 0.179
ENSG00000133858 E026 88.5092920 0.0063907088 3.227167e-01 5.620975e-01 12 71628918 71629037 120 - 1.885 1.931 0.152
ENSG00000133858 E027 77.3425699 0.0011667200 5.357326e-01 7.261241e-01 12 71629609 71629710 102 - 1.820 1.887 0.227
ENSG00000133858 E028 79.9765848 0.0043021295 1.567757e-01 3.719284e-01 12 71630600 71630721 122 - 1.846 1.867 0.072
ENSG00000133858 E029 80.0627011 0.0046538749 3.266859e-02 1.351328e-01 12 71630823 71630954 132 - 1.857 1.834 -0.075
ENSG00000133858 E030 68.2445286 0.0062162900 8.592394e-02 2.562898e-01 12 71631778 71631887 110 - 1.785 1.775 -0.036
ENSG00000133858 E031 99.6350092 0.0090412926 6.548016e-02 2.149796e-01 12 71631972 71632222 251 - 1.951 1.935 -0.056
ENSG00000133858 E032 104.7857828 0.0050512301 2.616275e-02 1.158066e-01 12 71632223 71632514 292 - 1.974 1.956 -0.058
ENSG00000133858 E033 64.2932238 0.0057659961 1.438601e-01 3.531986e-01 12 71632886 71633017 132 - 1.757 1.765 0.027
ENSG00000133858 E034 0.7007164 0.6677403801 5.631743e-01   12 71633018 71633091 74 - 0.143 0.329 1.535
ENSG00000133858 E035 60.0207268 0.0033230084 1.550319e-03 1.396414e-02 12 71633264 71633438 175 - 1.752 1.664 -0.297
ENSG00000133858 E036 65.4490402 0.0008076685 2.947602e-05 5.314478e-04 12 71634155 71634304 150 - 1.795 1.676 -0.406
ENSG00000133858 E037 62.0247781 0.0118007626 2.108274e-03 1.779402e-02 12 71634704 71634825 122 - 1.774 1.638 -0.462
ENSG00000133858 E038 57.4549172 0.0164113500 1.038449e-01 2.886009e-01 12 71635443 71635580 138 - 1.720 1.680 -0.137
ENSG00000133858 E039 76.1417162 0.0196097919 8.419163e-02 2.531715e-01 12 71636490 71636654 165 - 1.843 1.792 -0.170
ENSG00000133858 E040 94.2426670 0.0503718728 2.858000e-02 1.230895e-01 12 71636850 71637059 210 - 1.958 1.803 -0.522
ENSG00000133858 E041 61.6707303 0.0265675367 6.542964e-03 4.242796e-02 12 71638418 71638515 98 - 1.779 1.616 -0.553
ENSG00000133858 E042 64.0714582 0.0024279566 2.791225e-06 6.981064e-05 12 71642436 71642559 124 - 1.797 1.627 -0.577
ENSG00000133858 E043 103.1619725 0.0049868426 9.228048e-07 2.648082e-05 12 71644095 71644318 224 - 1.998 1.830 -0.565
ENSG00000133858 E044 53.7598895 0.0054769577 7.742236e-05 1.207133e-03 12 71644877 71644913 37 - 1.719 1.547 -0.585
ENSG00000133858 E045 81.3640345 0.0039455241 2.189880e-07 7.467709e-06 12 71644914 71645075 162 - 1.901 1.705 -0.661
ENSG00000133858 E046 44.4244267 0.0067966665 1.051205e-06 2.967400e-05 12 71647749 71647813 65 - 1.657 1.374 -0.972
ENSG00000133858 E047 0.4812263 0.0217681645 1.946586e-01   12 71656343 71656563 221 - 0.075 0.323 2.549
ENSG00000133858 E048 0.4341107 0.0244411696 1.454926e-02   12 71656564 71656882 319 - 0.000 0.424 14.273
ENSG00000133858 E049 0.1308682 0.0326491905 2.046251e-01   12 71656883 71656884 2 - 0.000 0.191 12.689
ENSG00000133858 E050 110.6110261 0.0089947604 1.183076e-10 8.268048e-09 12 71656885 71657301 417 - 2.053 1.742 -1.047
ENSG00000133858 E051 1.0767030 0.3950947421 9.565939e-01   12 71660289 71660370 82 - 0.282 0.327 0.300
ENSG00000133858 E052 0.7970432 0.0172106460 6.303763e-01   12 71660371 71660427 57 - 0.244 0.191 -0.448
ENSG00000133858 E053 0.1614157 0.0334199048 1.000000e+00   12 71662985 71663012 28 - 0.075 0.000 -9.625
ENSG00000133858 E054 102.9363521 0.0052386762 7.733387e-05 1.206307e-03 12 71663013 71663858 846 - 1.988 1.875 -0.379
ENSG00000133858 E055 0.0000000       12 71667521 71667725 205 -