ENSG00000133466

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337843 ENSG00000133466 HEK293_OSMI2_6hA HEK293_TMG_6hB C1QTNF6 protein_coding protein_coding 3.624026 4.949766 1.600228 0.6909112 0.125879 -1.623007 0.4296926 1.02866764 0.00000000 0.14915168 0.00000000 -6.6985903 0.10542500 0.21150000 0.00000000 -0.211500000 6.992860e-06 6.99286e-06 FALSE TRUE
ENST00000467564 ENSG00000133466 HEK293_OSMI2_6hA HEK293_TMG_6hB C1QTNF6 protein_coding processed_transcript 3.624026 4.949766 1.600228 0.6909112 0.125879 -1.623007 0.1970289 0.22459006 0.05811966 0.22459006 0.05811966 -1.7839987 0.05099583 0.03593333 0.04166667 0.005733333 9.644516e-01 6.99286e-06   FALSE
ENST00000470655 ENSG00000133466 HEK293_OSMI2_6hA HEK293_TMG_6hB C1QTNF6 protein_coding processed_transcript 3.624026 4.949766 1.600228 0.6909112 0.125879 -1.623007 0.5054192 0.66787678 0.31317434 0.19510071 0.06186488 -1.0687104 0.14552083 0.12923333 0.19210000 0.062866667 7.124358e-01 6.99286e-06 FALSE TRUE
ENST00000493023 ENSG00000133466 HEK293_OSMI2_6hA HEK293_TMG_6hB C1QTNF6 protein_coding retained_intron 3.624026 4.949766 1.600228 0.6909112 0.125879 -1.623007 0.5212140 0.53492011 0.21493631 0.07313582 0.04127082 -1.2765282 0.14181667 0.11420000 0.13416667 0.019966667 9.096745e-01 6.99286e-06 FALSE TRUE
ENST00000497071 ENSG00000133466 HEK293_OSMI2_6hA HEK293_TMG_6hB C1QTNF6 protein_coding processed_transcript 3.624026 4.949766 1.600228 0.6909112 0.125879 -1.623007 0.2796857 0.09512705 0.19010438 0.09512705 0.09703729 0.9286188 0.08529583 0.02020000 0.11323333 0.093033333 5.835430e-01 6.99286e-06   FALSE
MSTRG.22066.10 ENSG00000133466 HEK293_OSMI2_6hA HEK293_TMG_6hB C1QTNF6 protein_coding   3.624026 4.949766 1.600228 0.6909112 0.125879 -1.623007 0.1789881 0.15086063 0.25970622 0.15086063 0.08036185 0.7455775 0.05777083 0.03206667 0.16860000 0.136533333 3.017711e-01 6.99286e-06 FALSE TRUE
MSTRG.22066.4 ENSG00000133466 HEK293_OSMI2_6hA HEK293_TMG_6hB C1QTNF6 protein_coding   3.624026 4.949766 1.600228 0.6909112 0.125879 -1.623007 0.5647407 0.68149461 0.30261922 0.12865910 0.02217194 -1.1453116 0.16312083 0.13603333 0.19196667 0.055933333 7.306129e-01 6.99286e-06 FALSE TRUE
MSTRG.22066.6 ENSG00000133466 HEK293_OSMI2_6hA HEK293_TMG_6hB C1QTNF6 protein_coding   3.624026 4.949766 1.600228 0.6909112 0.125879 -1.623007 0.3474102 0.70653329 0.06233519 0.05894196 0.03260815 -3.3082641 0.08695833 0.14880000 0.04163333 -0.107166667 2.186745e-01 6.99286e-06 FALSE TRUE
MSTRG.22066.8 ENSG00000133466 HEK293_OSMI2_6hA HEK293_TMG_6hB C1QTNF6 protein_coding   3.624026 4.949766 1.600228 0.6909112 0.125879 -1.623007 0.4990221 0.81119139 0.17931411 0.21562179 0.13045134 -2.1169366 0.13652917 0.16226667 0.10400000 -0.058266667 7.932884e-01 6.99286e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000133466 E001 0.1308682 0.0316735986 1.0000000000   22 37180166 37180166 1 - 0.000 0.066 7.660
ENSG00000133466 E002 0.1308682 0.0316735986 1.0000000000   22 37180167 37180170 4 - 0.000 0.066 9.871
ENSG00000133466 E003 2.3329466 0.0092386388 0.5619588759 0.744656020 22 37180171 37180202 32 - 0.357 0.472 0.626
ENSG00000133466 E004 12.3000503 0.0033083212 0.0486438621 0.176476108 22 37180203 37180332 130 - 0.828 1.083 0.956
ENSG00000133466 E005 32.2542664 0.0020569621 0.0074319827 0.046714101 22 37180333 37180648 316 - 1.244 1.467 0.775
ENSG00000133466 E006 24.2135609 0.0017389803 0.0001486666 0.002082228 22 37180649 37180749 101 - 0.967 1.361 1.407
ENSG00000133466 E007 24.6733880 0.0014376695 0.0403361680 0.155575542 22 37180750 37180867 118 - 1.157 1.348 0.671
ENSG00000133466 E008 68.2319647 0.0009075028 0.0014797024 0.013470971 22 37180868 37182151 1284 - 1.600 1.775 0.594
ENSG00000133466 E009 16.4865711 0.0041926496 0.1881210005 0.414560459 22 37182152 37182173 22 - 1.023 1.170 0.529
ENSG00000133466 E010 42.7567118 0.0141428555 0.0432174783 0.163128666 22 37182174 37182582 409 - 1.400 1.575 0.600
ENSG00000133466 E011 19.7243278 0.1522025238 0.3914091950 0.621542257 22 37182583 37182735 153 - 1.107 1.252 0.516
ENSG00000133466 E012 1.3151960 0.0131512192 0.1143962381   22 37182736 37182827 92 - 0.000 0.363 12.652
ENSG00000133466 E013 1.0348663 0.0234608306 0.8386213474   22 37184337 37184437 101 - 0.214 0.260 0.370
ENSG00000133466 E014 21.1382148 0.0024344448 0.5502729296 0.736491596 22 37185218 37185455 238 - 1.211 1.271 0.210
ENSG00000133466 E015 3.7802665 0.0075509412 0.1145869767 0.306801585 22 37185456 37185870 415 - 0.785 0.538 -1.053
ENSG00000133466 E016 1.9528487 0.0111749022 0.7468488033 0.864814955 22 37185871 37186046 176 - 0.356 0.421 0.364
ENSG00000133466 E017 1.0657940 0.0550712299 0.1937727284   22 37188163 37188476 314 - 0.464 0.217 -1.562
ENSG00000133466 E018 3.8964128 0.0441651803 0.3217356009 0.561213934 22 37190553 37190677 125 - 0.735 0.580 -0.665
ENSG00000133466 E019 11.8436127 0.0033245602 0.7767705624 0.882772030 22 37190865 37190928 64 - 1.048 1.020 -0.102
ENSG00000133466 E020 11.0202942 0.0027683858 0.3513385980 0.588500629 22 37191672 37191737 66 - 1.072 0.971 -0.374
ENSG00000133466 E021 11.5744702 0.0030594186 0.0006981579 0.007429242 22 37195381 37195458 78 - 1.260 0.914 -1.256
ENSG00000133466 E022 7.1147372 0.0045571687 0.0015953120 0.014292080 22 37195459 37195473 15 - 1.095 0.707 -1.485
ENSG00000133466 E023 7.9844886 0.0044634201 0.0177924154 0.088331668 22 37195474 37195512 39 - 1.073 0.784 -1.092
ENSG00000133466 E024 56.1166190 0.0012382639 0.0013922315 0.012841939 22 37195513 37197602 2090 - 1.784 1.624 -0.543
ENSG00000133466 E025 15.0379928 0.0028870100 0.0919146216 0.267253652 22 37197603 37197684 82 - 1.244 1.083 -0.574
ENSG00000133466 E026 23.3529510 0.0036075460 0.0095890504 0.056347450 22 37197685 37197841 157 - 1.453 1.251 -0.702
ENSG00000133466 E027 10.5285478 0.0045029869 0.4288476942 0.650240192 22 37197842 37197861 20 - 1.049 0.962 -0.318
ENSG00000133466 E028 24.7503915 0.0307486068 0.1215367082 0.318279410 22 37197862 37198301 440 - 1.424 1.287 -0.475
ENSG00000133466 E029 7.5519029 0.0045624964 0.2084799806 0.440039471 22 37199269 37199323 55 - 0.967 0.806 -0.616
ENSG00000133466 E030 7.9850858 0.0044987760 0.2723764466 0.512234726 22 37199324 37199407 84 - 0.967 0.828 -0.530