ENSG00000133275

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000255641 ENSG00000133275 HEK293_OSMI2_6hA HEK293_TMG_6hB CSNK1G2 protein_coding protein_coding 92.20734 138.517 55.33971 23.90829 2.102566 -1.323519 62.665331 102.693169 32.024920 22.642827 1.1351922 -1.6807634 0.6531333 0.72636667 0.58106667 -0.145300000 0.34079676 0.03486553 FALSE TRUE
ENST00000585959 ENSG00000133275 HEK293_OSMI2_6hA HEK293_TMG_6hB CSNK1G2 protein_coding protein_coding 92.20734 138.517 55.33971 23.90829 2.102566 -1.323519 13.024952 16.521661 13.028827 1.468562 1.0377585 -0.3424176 0.1610417 0.12483333 0.23470000 0.109866667 0.03486553 0.03486553 FALSE FALSE
ENST00000590106 ENSG00000133275 HEK293_OSMI2_6hA HEK293_TMG_6hB CSNK1G2 protein_coding retained_intron 92.20734 138.517 55.33971 23.90829 2.102566 -1.323519 5.185989 7.697807 3.770417 1.530887 0.1865695 -1.0277751 0.0610625 0.05986667 0.06853333 0.008666667 0.89904334 0.03486553 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000133275 E001 2.8035790 3.612138e-02 7.472682e-02 2.342604e-01 19 1941144 1941171 28 + 0.203 0.596 2.308
ENSG00000133275 E002 5.9022135 4.861320e-03 7.811805e-02 2.410709e-01 19 1941172 1941190 19 + 0.529 0.831 1.279
ENSG00000133275 E003 5.8303474 5.182567e-03 7.935975e-02 2.435333e-01 19 1941191 1941194 4 + 0.529 0.830 1.278
ENSG00000133275 E004 139.9466866 3.754079e-03 5.470704e-03 3.706864e-02 19 1941195 1941418 224 + 1.955 2.105 0.502
ENSG00000133275 E005 0.4929928 2.155509e-02 1.033205e-01   19 1942459 1942613 155 + 0.340 0.070 -2.761
ENSG00000133275 E006 0.4762370 2.176816e-02 6.404096e-01   19 1954621 1954632 12 + 0.202 0.130 -0.761
ENSG00000133275 E007 0.3453689 3.056784e-02 3.656741e-01   19 1954633 1954715 83 + 0.202 0.070 -1.757
ENSG00000133275 E008 0.3926045 2.704644e-01 6.995246e-01   19 1959238 1959303 66 + 0.001 0.177 8.236
ENSG00000133275 E009 5.2118739 5.200451e-03 4.936251e-01 6.963689e-01 19 1968791 1968905 115 + 0.803 0.716 -0.350
ENSG00000133275 E010 776.4278772 1.165709e-04 1.024020e-02 5.914635e-02 19 1969508 1969825 318 + 2.836 2.812 -0.082
ENSG00000133275 E011 564.1214249 1.239173e-04 2.233663e-01 4.573846e-01 19 1969826 1969959 134 + 2.686 2.679 -0.023
ENSG00000133275 E012 3.8745681 6.884838e-03 1.263310e-02 6.897700e-02 19 1974688 1974751 64 + 0.877 0.516 -1.521
ENSG00000133275 E013 393.5320258 1.473881e-04 1.042393e-01 2.892894e-01 19 1978305 1978345 41 + 2.539 2.520 -0.064
ENSG00000133275 E014 7.5629995 6.300356e-02 1.756222e-01 3.979545e-01 19 1978346 1978441 96 + 1.022 0.800 -0.841
ENSG00000133275 E015 346.3072382 1.648808e-04 1.774323e-02 8.814676e-02 19 1978442 1978452 11 + 2.499 2.460 -0.128
ENSG00000133275 E016 376.6373909 3.897367e-04 1.202018e-01 3.161760e-01 19 1978453 1978474 22 + 2.522 2.499 -0.076
ENSG00000133275 E017 422.8608680 6.736696e-04 4.612270e-03 3.253997e-02 19 1978475 1978511 37 + 2.595 2.542 -0.179
ENSG00000133275 E018 52.1134686 8.943677e-03 4.155021e-02 1.587657e-01 19 1978512 1978601 90 + 1.755 1.616 -0.471
ENSG00000133275 E019 280.2473184 1.211057e-03 7.902187e-04 8.200309e-03 19 1978602 1978603 2 + 2.442 2.353 -0.295
ENSG00000133275 E020 413.8556904 1.857816e-04 1.884218e-07 6.539618e-06 19 1978604 1978642 39 + 2.615 2.523 -0.307
ENSG00000133275 E021 691.7843689 1.464387e-04 9.377474e-06 1.983696e-04 19 1978643 1978750 108 + 2.811 2.753 -0.191
ENSG00000133275 E022 725.9882074 1.410780e-03 2.693599e-04 3.421098e-03 19 1978859 1978933 75 + 2.844 2.765 -0.262
ENSG00000133275 E023 1010.6379259 1.317085e-03 2.049642e-02 9.765918e-02 19 1978934 1979093 160 + 2.960 2.917 -0.144
ENSG00000133275 E024 36.3741789 5.221326e-02 8.433118e-01 9.212863e-01 19 1979094 1979162 69 + 1.512 1.495 -0.060
ENSG00000133275 E025 520.5315753 1.296782e-04 5.347312e-01 7.254558e-01 19 1979163 1979203 41 + 2.624 2.650 0.088
ENSG00000133275 E026 498.1657747 1.636785e-04 7.539367e-02 2.356588e-01 19 1979204 1979248 45 + 2.587 2.637 0.167
ENSG00000133275 E027 1.6888472 8.404302e-02 6.873430e-01 8.274071e-01 19 1979258 1979318 61 + 0.446 0.376 -0.383
ENSG00000133275 E028 434.5345278 7.271395e-04 4.803660e-01 6.873262e-01 19 1979319 1979333 15 + 2.568 2.561 -0.023
ENSG00000133275 E029 662.9631612 1.162409e-04 5.316626e-01 7.232109e-01 19 1979334 1979403 70 + 2.746 2.751 0.015
ENSG00000133275 E030 879.9540212 8.780613e-05 2.087209e-01 4.403013e-01 19 1979495 1979618 124 + 2.875 2.872 -0.011
ENSG00000133275 E031 506.4864720 1.518943e-04 9.311411e-01 9.676024e-01 19 1979619 1979643 25 + 2.621 2.638 0.056
ENSG00000133275 E032 773.2778177 1.096018e-04 7.778619e-02 2.403589e-01 19 1979752 1979835 84 + 2.784 2.826 0.140
ENSG00000133275 E033 13.2584059 2.805017e-03 8.810734e-01 9.418530e-01 19 1979836 1979910 75 + 1.068 1.098 0.110
ENSG00000133275 E034 822.3409811 1.022293e-04 5.745076e-02 1.970604e-01 19 1979911 1980017 107 + 2.809 2.852 0.143
ENSG00000133275 E035 1301.6844354 7.892655e-04 6.853895e-08 2.647144e-06 19 1980149 1980579 431 + 2.956 3.059 0.345
ENSG00000133275 E036 1593.1928798 3.815196e-03 2.130989e-06 5.518780e-05 19 1980580 1981481 902 + 3.000 3.154 0.512
ENSG00000133275 E037 3.5004550 9.120879e-03 5.471888e-05 9.000023e-04 19 1981714 1981776 63 + 0.969 0.380 -2.570