ENSG00000133226

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323848 ENSG00000133226 HEK293_OSMI2_6hA HEK293_TMG_6hB SRRM1 protein_coding protein_coding 65.55286 66.27352 77.11421 5.497591 2.590061 0.2185337 34.573243 39.672209 36.1486192 5.1312809 0.6257302 -0.1341528 0.54171250 0.59376667 0.46933333 -0.12443333 1.953649e-01 1.326758e-05 FALSE TRUE
ENST00000462710 ENSG00000133226 HEK293_OSMI2_6hA HEK293_TMG_6hB SRRM1 protein_coding retained_intron 65.55286 66.27352 77.11421 5.497591 2.590061 0.2185337 2.844258 0.920128 6.1433064 0.2210726 0.1958121 2.7258607 0.03990833 0.01466667 0.07970000 0.06503333 9.852016e-05 1.326758e-05   FALSE
ENST00000496882 ENSG00000133226 HEK293_OSMI2_6hA HEK293_TMG_6hB SRRM1 protein_coding processed_transcript 65.55286 66.27352 77.11421 5.497591 2.590061 0.2185337 2.512428 0.000000 5.3090358 0.0000000 2.6813125 9.0550209 0.03300000 0.00000000 0.06683333 0.06683333 2.853551e-01 1.326758e-05 FALSE FALSE
MSTRG.568.23 ENSG00000133226 HEK293_OSMI2_6hA HEK293_TMG_6hB SRRM1 protein_coding   65.55286 66.27352 77.11421 5.497591 2.590061 0.2185337 3.468625 2.865008 4.5177522 0.6430570 0.2425190 0.6552289 0.05103750 0.04446667 0.05886667 0.01440000 7.845179e-01 1.326758e-05 FALSE TRUE
MSTRG.568.6 ENSG00000133226 HEK293_OSMI2_6hA HEK293_TMG_6hB SRRM1 protein_coding   65.55286 66.27352 77.11421 5.497591 2.590061 0.2185337 4.008998 7.658274 4.8997450 2.5313605 2.5231780 -0.6432537 0.06147083 0.11393333 0.06210000 -0.05183333 8.329368e-01 1.326758e-05 FALSE TRUE
MSTRG.568.9 ENSG00000133226 HEK293_OSMI2_6hA HEK293_TMG_6hB SRRM1 protein_coding   65.55286 66.27352 77.11421 5.497591 2.590061 0.2185337 0.962301 4.390242 0.5565825 0.2140938 0.5565825 -2.9572250 0.01547083 0.06766667 0.00680000 -0.06086667 1.106135e-01 1.326758e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000133226 E001 0.0000000       1 24631716 24631777 62 +      
ENSG00000133226 E002 0.0000000       1 24633019 24633065 47 +      
ENSG00000133226 E003 0.0000000       1 24633066 24633099 34 +      
ENSG00000133226 E004 0.0000000       1 24635644 24635877 234 +      
ENSG00000133226 E005 0.0000000       1 24641231 24641392 162 +      
ENSG00000133226 E006 0.0000000       1 24643133 24643168 36 +      
ENSG00000133226 E007 0.2027342 0.0361890793 5.660761e-01   1 24643169 24643187 19 + 0.000 0.113 10.573
ENSG00000133226 E008 0.8395791 0.0170596310 2.731331e-02   1 24643188 24643189 2 + 0.000 0.396 12.932
ENSG00000133226 E009 1.0119535 0.0152806978 1.379654e-02   1 24643190 24643191 2 + 0.000 0.445 13.196
ENSG00000133226 E010 1.2736898 0.0131611292 3.761516e-03   1 24643192 24643192 1 + 0.000 0.529 13.608
ENSG00000133226 E011 1.2736898 0.0131611292 3.761516e-03   1 24643193 24643201 9 + 0.000 0.529 13.608
ENSG00000133226 E012 2.9049923 0.0091320969 1.328956e-05 2.686433e-04 1 24643202 24643213 12 + 0.000 0.783 14.701
ENSG00000133226 E013 3.5703595 0.0135074313 4.676883e-04 5.380316e-03 1 24643214 24643216 3 + 0.230 0.825 3.020
ENSG00000133226 E014 5.0861489 0.0639257809 3.911215e-02 1.524590e-01 1 24643217 24643240 24 + 0.538 0.902 1.507
ENSG00000133226 E015 7.7107143 0.0040520995 2.126620e-03 1.791686e-02 1 24643241 24643261 21 + 0.686 1.069 1.478
ENSG00000133226 E016 10.0485010 0.0033971831 8.545624e-02 2.554422e-01 1 24643262 24643271 10 + 0.922 1.111 0.696
ENSG00000133226 E017 9.7572126 0.0041458189 3.187801e-01 5.585485e-01 1 24643272 24643274 3 + 0.957 1.069 0.414
ENSG00000133226 E018 18.3966303 0.0018496520 2.720001e-01 5.118609e-01 1 24643275 24643287 13 + 1.233 1.327 0.330
ENSG00000133226 E019 30.1904646 0.0016704780 3.188850e-01 5.586199e-01 1 24643288 24643292 5 + 1.446 1.517 0.243
ENSG00000133226 E020 32.3677927 0.0030822294 1.872788e-01 4.134449e-01 1 24643293 24643298 6 + 1.462 1.555 0.318
ENSG00000133226 E021 44.0021889 0.0011559912 6.991873e-01 8.350645e-01 1 24643299 24643301 3 + 1.633 1.660 0.090
ENSG00000133226 E022 47.8016099 0.0022182272 3.710820e-01 6.047910e-01 1 24643302 24643304 3 + 1.654 1.708 0.184
ENSG00000133226 E023 52.2067558 0.0015956732 7.788302e-01 8.840481e-01 1 24643305 24643307 3 + 1.711 1.730 0.066
ENSG00000133226 E024 239.2705735 0.0002792376 8.931094e-01 9.482074e-01 1 24643308 24643347 40 + 2.372 2.381 0.029
ENSG00000133226 E025 1.4325327 0.2170212975 5.584448e-01 7.421822e-01 1 24643559 24643732 174 + 0.316 0.438 0.699
ENSG00000133226 E026 353.5596215 0.0001803979 2.900474e-01 5.306292e-01 1 24645984 24646073 90 + 2.555 2.540 -0.050
ENSG00000133226 E027 448.2215899 0.0001678320 3.372211e-03 2.559917e-02 1 24646667 24646789 123 + 2.673 2.628 -0.151
ENSG00000133226 E028 19.0732726 0.0018453035 1.551194e-19 4.276435e-17 1 24646790 24647078 289 + 1.569 0.760 -2.920
ENSG00000133226 E029 59.9414302 0.0420401233 3.019785e-06 7.475640e-05 1 24647079 24647208 130 + 1.990 1.479 -1.729
ENSG00000133226 E030 98.4115258 0.0768924081 4.673034e-09 2.363982e-07 1 24647209 24648023 815 + 2.267 1.441 -2.789
ENSG00000133226 E031 44.9008565 0.0841118405 2.457668e-06 6.254586e-05 1 24648024 24648166 143 + 1.911 1.207 -2.412
ENSG00000133226 E032 70.5311374 0.0586403909 1.479681e-08 6.684860e-07 1 24648167 24648533 367 + 2.106 1.390 -2.427
ENSG00000133226 E033 31.3292981 0.0298763362 1.363590e-10 9.409545e-09 1 24648534 24648617 84 + 1.755 1.051 -2.449
ENSG00000133226 E034 48.1369169 0.0433687212 1.508137e-09 8.511679e-08 1 24648618 24648858 241 + 1.939 1.232 -2.419
ENSG00000133226 E035 447.8037182 0.0001617258 6.779829e-01 8.214334e-01 1 24648859 24649029 171 + 2.652 2.651 -0.004
ENSG00000133226 E036 213.0251096 0.0005045011 6.966694e-01 8.334264e-01 1 24649971 24649987 17 + 2.321 2.337 0.053
ENSG00000133226 E037 363.5766646 0.0001577534 8.218556e-01 9.090256e-01 1 24649988 24650086 99 + 2.554 2.565 0.034
ENSG00000133226 E038 3.9797735 0.3213950362 1.765158e-01 3.991271e-01 1 24650565 24650627 63 + 0.828 0.534 -1.242
ENSG00000133226 E039 342.5547334 0.0011195438 2.868882e-01 5.276104e-01 1 24651409 24651498 90 + 2.544 2.523 -0.069
ENSG00000133226 E040 243.4912301 0.0028127707 2.446873e-01 4.818415e-01 1 24651499 24651519 21 + 2.403 2.369 -0.112
ENSG00000133226 E041 372.8239161 0.0049895769 4.036853e-01 6.313026e-01 1 24651520 24651612 93 + 2.583 2.559 -0.079
ENSG00000133226 E042 291.7675349 0.0040682131 8.291248e-01 9.133125e-01 1 24652434 24652496 63 + 2.463 2.464 0.000
ENSG00000133226 E043 323.1764766 0.0019678006 2.448515e-01 4.820418e-01 1 24652497 24652628 132 + 2.486 2.526 0.135
ENSG00000133226 E044 163.0674577 0.0003125048 9.366883e-01 9.705442e-01 1 24652913 24652927 15 + 2.211 2.215 0.012
ENSG00000133226 E045 334.8030983 0.0009425960 5.951866e-01 7.671365e-01 1 24652928 24653032 105 + 2.527 2.520 -0.023
ENSG00000133226 E046 3.3634298 0.0075046637 5.806181e-02 1.984349e-01 1 24654306 24654343 38 + 0.771 0.489 -1.235
ENSG00000133226 E047 149.1104896 0.0021782282 1.164184e-01 3.098468e-01 1 24654855 24654857 3 + 2.202 2.150 -0.173
ENSG00000133226 E048 482.1404857 0.0001577607 3.072226e-03 2.384637e-02 1 24654858 24655010 153 + 2.706 2.663 -0.145
ENSG00000133226 E049 294.5512777 0.0004261125 1.878911e-01 4.142742e-01 1 24655011 24655021 11 + 2.482 2.459 -0.078
ENSG00000133226 E050 344.4254697 0.0001952164 2.583471e-02 1.147674e-01 1 24655022 24655053 32 + 2.556 2.518 -0.127
ENSG00000133226 E051 431.3004734 0.0005502900 5.357616e-02 1.880470e-01 1 24655054 24655123 70 + 2.652 2.620 -0.109
ENSG00000133226 E052 178.5011204 0.0003273982 3.522031e-02 1.421561e-01 1 24655124 24655129 6 + 2.282 2.230 -0.172
ENSG00000133226 E053 377.3440973 0.0012396317 4.731436e-01 6.822445e-01 1 24660719 24660799 81 + 2.584 2.573 -0.038
ENSG00000133226 E054 2.4942130 0.0090187691 3.319384e-02 1.365703e-01 1 24660800 24660975 176 + 0.686 0.341 -1.693
ENSG00000133226 E055 163.3794950 0.0011233587 4.251154e-01 6.473496e-01 1 24661310 24661312 3 + 2.227 2.208 -0.063
ENSG00000133226 E056 364.8937369 0.0002164414 5.882059e-01 7.624937e-01 1 24661313 24661396 84 + 2.552 2.569 0.054
ENSG00000133226 E057 408.3433276 0.0001539003 1.532906e-01 3.670447e-01 1 24662660 24662804 145 + 2.591 2.623 0.105
ENSG00000133226 E058 5.9590745 0.0068852094 5.319900e-02 1.872612e-01 1 24662805 24663068 264 + 0.957 0.713 -0.950
ENSG00000133226 E059 84.3855835 0.0018573227 6.796274e-01 8.224698e-01 1 24663183 24663224 42 + 1.933 1.919 -0.044
ENSG00000133226 E060 4.6615754 0.2328787902 3.804650e-01 6.125842e-01 1 24666555 24666814 260 + 0.837 0.666 -0.690
ENSG00000133226 E061 363.4601168 0.0001400645 4.329573e-02 1.633289e-01 1 24666815 24666925 111 + 2.534 2.578 0.148
ENSG00000133226 E062 1013.7466025 0.0007597413 1.088840e-01 2.972090e-01 1 24669123 24669582 460 + 2.987 3.020 0.109
ENSG00000133226 E063 212.5004911 0.0002068986 5.775576e-01 7.554948e-01 1 24669583 24669587 5 + 2.317 2.336 0.065
ENSG00000133226 E064 18.9833085 0.1380530594 2.823029e-02 1.219514e-01 1 24669588 24670119 532 + 1.460 1.092 -1.293
ENSG00000133226 E065 557.5304098 0.0022370170 3.837483e-03 2.822892e-02 1 24670120 24670315 196 + 2.698 2.781 0.278
ENSG00000133226 E066 562.5437589 0.0040308902 4.762292e-03 3.334076e-02 1 24671386 24671595 210 + 2.691 2.793 0.337
ENSG00000133226 E067 1701.6160706 0.0020994563 1.405627e-09 7.967547e-08 1 24672182 24673281 1100 + 3.148 3.286 0.459