ENSG00000133104

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000491805 ENSG00000133104 HEK293_OSMI2_6hA HEK293_TMG_6hB SPART protein_coding processed_transcript 26.68082 9.394681 44.42863 1.007766 3.765095 2.240363 3.569236 1.484014 5.865715 0.7428433 2.0343866 1.975570 0.1178792 0.16090000 0.1273000 -0.0336000 0.993971572 0.003874482 FALSE TRUE
ENST00000494062 ENSG00000133104 HEK293_OSMI2_6hA HEK293_TMG_6hB SPART protein_coding protein_coding 26.68082 9.394681 44.42863 1.007766 3.765095 2.240363 13.092203 5.839963 21.420289 1.1681882 0.7152599 1.873152 0.5546792 0.61983333 0.4875333 -0.1323000 0.755390598 0.003874482 FALSE TRUE
ENST00000494703 ENSG00000133104 HEK293_OSMI2_6hA HEK293_TMG_6hB SPART protein_coding processed_transcript 26.68082 9.394681 44.42863 1.007766 3.765095 2.240363 6.622435 0.916601 12.947848 0.3287326 1.1225894 3.805734 0.1901917 0.09403333 0.2919667 0.1979333 0.003874482 0.003874482 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000133104 E001 0.0000000       13 36301638 36301639 2 -      
ENSG00000133104 E002 0.0000000       13 36301640 36301651 12 -      
ENSG00000133104 E003 26.5733318 0.0224489176 8.233733e-01 9.098835e-01 13 36301652 36303185 1534 - 1.365 1.408 0.149
ENSG00000133104 E004 15.7116103 0.0278528836 6.946198e-01 8.320620e-01 13 36303186 36303601 416 - 1.137 1.211 0.265
ENSG00000133104 E005 217.3428032 0.0130339704 7.129607e-04 7.550237e-03 13 36303602 36304321 720 - 2.205 2.420 0.718
ENSG00000133104 E006 174.5267860 0.0004130473 2.483828e-01 4.861936e-01 13 36304322 36304450 129 - 2.161 2.208 0.157
ENSG00000133104 E007 104.1579658 0.0005294921 3.874618e-01 6.184494e-01 13 36304451 36304456 6 - 1.941 1.987 0.154
ENSG00000133104 E008 214.7134820 0.0005602071 8.001506e-01 8.964023e-01 13 36304457 36304632 176 - 2.260 2.278 0.062
ENSG00000133104 E009 0.6190593 0.0225223369 9.514858e-01   13 36308419 36308444 26 - 0.184 0.202 0.172
ENSG00000133104 E010 0.7319543 0.2348138489 3.270605e-01   13 36312142 36312144 3 - 0.269 0.000 -11.165
ENSG00000133104 E011 135.2385669 0.0030474722 3.061275e-01 5.467820e-01 13 36312145 36312235 91 - 2.051 2.102 0.174
ENSG00000133104 E012 146.0250890 0.0028543515 7.707236e-01 8.790923e-01 13 36312319 36312477 159 - 2.092 2.113 0.073
ENSG00000133104 E013 1.7185372 0.1505530136 6.954289e-02 2.238633e-01 13 36312478 36312584 107 - 0.272 0.657 2.023
ENSG00000133104 E014 3.5648586 0.1386922007 3.712590e-02 1.472506e-01 13 36313968 36314082 115 - 0.462 0.885 1.813
ENSG00000133104 E015 0.1723744 0.0428226858 1.357000e-01   13 36314222 36314226 5 - 0.000 0.202 12.330
ENSG00000133104 E016 218.2443050 0.0002424633 9.808824e-02 2.784208e-01 13 36314227 36314421 195 - 2.277 2.242 -0.116
ENSG00000133104 E017 0.6901176 0.1229954424 3.825712e-02   13 36314422 36314441 20 - 0.070 0.448 3.366
ENSG00000133104 E018 2.1483962 0.0100865876 1.962682e-02 9.464151e-02 13 36325923 36326574 652 - 0.313 0.712 1.978
ENSG00000133104 E019 194.2629240 0.0003224621 2.045949e-02 9.752959e-02 13 36326575 36326698 124 - 2.230 2.172 -0.196
ENSG00000133104 E020 128.0406183 0.0050509845 7.667255e-01 8.766479e-01 13 36329362 36329391 30 - 2.038 2.031 -0.021
ENSG00000133104 E021 179.7708291 0.0008657336 8.762888e-01 9.393755e-01 13 36329392 36329517 126 - 2.182 2.187 0.019
ENSG00000133104 E022 174.0133249 0.0002890525 3.696732e-02 1.468333e-01 13 36331399 36331596 198 - 2.151 2.226 0.248
ENSG00000133104 E023 161.7546011 0.0007785673 2.954265e-01 5.359047e-01 13 36335021 36335232 212 - 2.126 2.172 0.154
ENSG00000133104 E024 224.9902080 0.0007682392 1.029700e-03 1.014073e-02 13 36335233 36335580 348 - 2.303 2.216 -0.293
ENSG00000133104 E025 190.9401388 0.0036020610 7.001463e-06 1.538772e-04 13 36335581 36335832 252 - 2.248 2.070 -0.596
ENSG00000133104 E026 9.9134603 0.0032700838 1.443301e-02 7.600886e-02 13 36336287 36336358 72 - 0.885 1.165 1.030
ENSG00000133104 E027 0.9121510 0.0387176036 1.656736e-01   13 36345525 36345634 110 - 0.312 0.000 -11.448
ENSG00000133104 E028 10.9908691 0.0029286788 2.884408e-01 5.291571e-01 13 36346225 36346313 89 - 0.982 1.109 0.462
ENSG00000133104 E029 8.6264267 0.0197886722 3.010860e-01 5.415422e-01 13 36346314 36346581 268 - 0.893 1.041 0.549
ENSG00000133104 E030 68.9730075 0.0006083480 1.286612e-08 5.884631e-07 13 36346582 36346914 333 - 1.832 1.518 -1.065
ENSG00000133104 E031 0.1779838 0.0357535526 1.000000e+00   13 36368874 36368990 117 - 0.070 0.000 -8.870
ENSG00000133104 E032 0.7119354 1.1218272299 9.277151e-01   13 36370089 36370180 92 - 0.244 0.000 -11.008