ENSG00000132824

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000255175 ENSG00000132824 HEK293_OSMI2_6hA HEK293_TMG_6hB SERINC3 protein_coding protein_coding 51.76182 35.63299 62.68175 1.499 2.831199 0.8146571 9.373044 10.274791 9.6993664 0.2393503 1.5395754 -0.08306337 0.18199583 0.28893333 0.1553333 -0.133600000 0.04449492 0.04449492 FALSE TRUE
ENST00000342374 ENSG00000132824 HEK293_OSMI2_6hA HEK293_TMG_6hB SERINC3 protein_coding protein_coding 51.76182 35.63299 62.68175 1.499 2.831199 0.8146571 22.403593 15.213881 32.7692104 2.6466115 1.4228721 1.10644490 0.43150000 0.43060000 0.5236333 0.093033333 0.77397223 0.04449492 FALSE TRUE
ENST00000411544 ENSG00000132824 HEK293_OSMI2_6hA HEK293_TMG_6hB SERINC3 protein_coding protein_coding 51.76182 35.63299 62.68175 1.499 2.831199 0.8146571 3.109960 0.697745 0.5837776 0.6977450 0.5837776 -0.25330689 0.07524167 0.02136667 0.0086000 -0.012766667 0.99922356 0.04449492 FALSE TRUE
MSTRG.20745.8 ENSG00000132824 HEK293_OSMI2_6hA HEK293_TMG_6hB SERINC3 protein_coding   51.76182 35.63299 62.68175 1.499 2.831199 0.8146571 9.023177 6.000006 9.8614384 1.8138091 0.3922396 0.71589398 0.17790417 0.16506667 0.1585000 -0.006566667 1.00000000 0.04449492 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000132824 E001 1.7081285 0.0115858357 9.364522e-01 9.704476e-01 20 44479825 44480543 719 - 0.411 0.413 0.012
ENSG00000132824 E002 1.3661562 0.3152459852 6.605650e-01   20 44484931 44485720 790 - 0.419 0.254 -1.030
ENSG00000132824 E003 0.5363366 0.0420684788 3.572347e-02   20 44485721 44485764 44 - 0.000 0.341 11.483
ENSG00000132824 E004 1.3354050 0.0919626290 2.253588e-01   20 44494885 44494924 40 - 0.252 0.477 1.346
ENSG00000132824 E005 1.6009132 0.0111019574 9.368015e-01 9.706319e-01 20 44496221 44496221 1 - 0.411 0.413 0.010
ENSG00000132824 E006 1.9215317 0.0099655944 7.029115e-01 8.374235e-01 20 44496222 44496223 2 - 0.491 0.413 -0.405
ENSG00000132824 E007 2.2854940 0.0106144306 7.579043e-01 8.713151e-01 20 44496224 44496229 6 - 0.491 0.529 0.181
ENSG00000132824 E008 2.4882282 0.0206836702 5.507259e-01 7.368540e-01 20 44496230 44496230 1 - 0.491 0.578 0.406
ENSG00000132824 E009 13.4190230 0.0034211957 1.615727e-03 1.443309e-02 20 44496231 44496288 58 - 1.019 1.293 0.982
ENSG00000132824 E010 29.9743446 0.0044327963 3.386743e-08 1.405540e-06 20 44496289 44496355 67 - 1.293 1.662 1.270
ENSG00000132824 E011 781.0045559 0.0121910944 4.392630e-01 6.581609e-01 20 44497441 44498923 1483 - 2.905 2.853 -0.172
ENSG00000132824 E012 364.4413432 0.0261493730 8.515999e-02 2.548976e-01 20 44498924 44499231 308 - 2.606 2.465 -0.471
ENSG00000132824 E013 183.7356228 0.0158089491 1.200540e-01 3.159353e-01 20 44499232 44499304 73 - 2.300 2.186 -0.381
ENSG00000132824 E014 818.5515733 0.0019645933 4.987984e-01 6.999573e-01 20 44499305 44500156 852 - 2.916 2.885 -0.103
ENSG00000132824 E015 297.3952071 0.0006961932 2.215225e-02 1.031154e-01 20 44500157 44500257 101 - 2.493 2.419 -0.247
ENSG00000132824 E016 429.4650514 0.0003079330 3.321983e-01 5.710185e-01 20 44500258 44500434 177 - 2.626 2.625 -0.004
ENSG00000132824 E017 538.3014499 0.0001587188 1.032836e-03 1.016218e-02 20 44501073 44501300 228 - 2.709 2.741 0.108
ENSG00000132824 E018 7.5904856 0.0056706044 2.204892e-01 4.540885e-01 20 44502358 44502437 80 - 0.985 0.817 -0.638
ENSG00000132824 E019 9.1505104 0.0357345757 4.934819e-01 6.962548e-01 20 44502438 44502581 144 - 1.047 0.932 -0.424
ENSG00000132824 E020 475.5864101 0.0010008079 2.960156e-02 1.261582e-01 20 44503815 44503995 181 - 2.656 2.686 0.098
ENSG00000132824 E021 301.3424401 0.0028582792 2.944162e-01 5.349943e-01 20 44504801 44504891 91 - 2.464 2.481 0.058
ENSG00000132824 E022 350.8330523 0.0006268091 5.357953e-02 1.880549e-01 20 44506827 44506996 170 - 2.527 2.551 0.079
ENSG00000132824 E023 313.1213801 0.0002046396 1.803683e-03 1.572740e-02 20 44509891 44510028 138 - 2.468 2.513 0.151
ENSG00000132824 E024 281.5496542 0.0002310301 2.345582e-01 4.703662e-01 20 44511289 44511368 80 - 2.438 2.445 0.023
ENSG00000132824 E025 490.3599000 0.0008517392 4.514978e-01 6.667113e-01 20 44512801 44512994 194 - 2.695 2.662 -0.110
ENSG00000132824 E026 1.4506439 0.0148952066 7.337796e-01 8.564966e-01 20 44513559 44513614 56 - 0.364 0.413 0.274
ENSG00000132824 E027 219.6982346 0.0031790031 2.091499e-01 4.408780e-01 20 44513879 44513892 14 - 2.357 2.296 -0.203
ENSG00000132824 E028 429.6782855 0.0057424499 8.678763e-01 9.348143e-01 20 44513893 44514040 148 - 2.627 2.622 -0.016
ENSG00000132824 E029 1.3212534 0.0992147405 9.364306e-01   20 44519312 44519414 103 - 0.367 0.339 -0.165
ENSG00000132824 E030 267.8739905 0.0064835984 8.617278e-01 9.312498e-01 20 44521913 44522087 175 - 2.422 2.418 -0.014