ENSG00000132763

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000401061 ENSG00000132763 HEK293_OSMI2_6hA HEK293_TMG_6hB MMACHC protein_coding protein_coding 18.40759 24.21863 11.88764 3.095865 0.5840444 -1.026038 7.079693 9.785243 4.462231 1.3648464 0.1634681 -1.1310867 0.38425417 0.40336667 0.37836667 -0.025000000 9.128743e-01 2.282498e-10 FALSE TRUE
ENST00000477188 ENSG00000132763 HEK293_OSMI2_6hA HEK293_TMG_6hB MMACHC protein_coding processed_transcript 18.40759 24.21863 11.88764 3.095865 0.5840444 -1.026038 1.476365 0.000000 1.711820 0.0000000 0.6444894 7.4277905 0.08295833 0.00000000 0.13953333 0.139533333 2.282498e-10 2.282498e-10   FALSE
MSTRG.1078.1 ENSG00000132763 HEK293_OSMI2_6hA HEK293_TMG_6hB MMACHC protein_coding   18.40759 24.21863 11.88764 3.095865 0.5840444 -1.026038 1.353525 1.979657 1.040292 0.5079790 0.1158230 -0.9217294 0.07403333 0.07856667 0.08846667 0.009900000 9.377231e-01 2.282498e-10 FALSE TRUE
MSTRG.1078.2 ENSG00000132763 HEK293_OSMI2_6hA HEK293_TMG_6hB MMACHC protein_coding   18.40759 24.21863 11.88764 3.095865 0.5840444 -1.026038 4.989382 8.528259 2.678087 0.7836406 0.2466788 -1.6673620 0.26781250 0.35756667 0.22806667 -0.129500000 2.428563e-01 2.282498e-10 TRUE TRUE
MSTRG.1078.3 ENSG00000132763 HEK293_OSMI2_6hA HEK293_TMG_6hB MMACHC protein_coding   18.40759 24.21863 11.88764 3.095865 0.5840444 -1.026038 3.508628 3.925473 1.995208 0.6622966 0.4336970 -0.9727850 0.19094583 0.16046667 0.16553333 0.005066667 1.000000e+00 2.282498e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000132763 E001 8.590333 0.0038883749 9.868212e-05 0.001478734 1 45500243 45500299 57 + 1.197 0.761 -1.628
ENSG00000132763 E002 43.765056 0.0010612722 2.690669e-02 0.118022907 1 45500300 45500340 41 + 1.681 1.553 -0.435
ENSG00000132763 E003 106.185612 0.0004043611 2.690971e-02 0.118033110 1 45500341 45500413 73 + 2.027 1.944 -0.276
ENSG00000132763 E004 4.209748 0.0062563962 7.449690e-01 0.863655154 1 45507305 45507355 51 + 0.631 0.683 0.221
ENSG00000132763 E005 179.775410 0.0042206480 7.290969e-01 0.853668719 1 45507356 45507550 195 + 2.207 2.192 -0.049
ENSG00000132763 E006 173.501122 0.0030813537 2.514834e-01 0.489558981 1 45508212 45508364 153 + 2.148 2.192 0.149
ENSG00000132763 E007 291.318564 0.0010898088 3.155213e-02 0.131922014 1 45508796 45509347 552 + 2.360 2.419 0.195
ENSG00000132763 E008 54.762434 0.0013439770 4.482439e-02 0.167188312 1 45509348 45509432 85 + 1.593 1.711 0.399
ENSG00000132763 E009 58.489948 0.0006336032 1.352291e-02 0.072450429 1 45509433 45509508 76 + 1.605 1.742 0.463
ENSG00000132763 E010 265.756463 0.0002810269 3.048068e-01 0.545383237 1 45509509 45509974 466 + 2.342 2.368 0.085
ENSG00000132763 E011 267.315763 0.0002014040 6.645096e-02 0.217071609 1 45509975 45510528 554 + 2.396 2.354 -0.138
ENSG00000132763 E012 356.162031 0.0012663579 2.789392e-01 0.519007057 1 45510529 45513382 2854 + 2.509 2.486 -0.078