ENSG00000132549

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357162 ENSG00000132549 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13B protein_coding protein_coding 2.769589 2.237743 4.187256 0.1651218 0.1133803 0.9009693 1.2141252 0.774507 1.8090096 0.1634888 0.10883507 1.2132949 0.41157917 0.3398333 0.4319667 0.09213333 7.440012e-01 1.415435e-05 FALSE TRUE
ENST00000493587 ENSG00000132549 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13B protein_coding retained_intron 2.769589 2.237743 4.187256 0.1651218 0.1133803 0.9009693 1.0484974 1.282378 0.9210200 0.0785363 0.09079037 -0.4731439 0.43578750 0.5753667 0.2197000 -0.35566667 1.415435e-05 1.415435e-05 FALSE TRUE
ENST00000682358 ENSG00000132549 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13B protein_coding retained_intron 2.769589 2.237743 4.187256 0.1651218 0.1133803 0.9009693 0.2251176 0.000000 0.7012396 0.0000000 0.16570188 6.1522638 0.06005833 0.0000000 0.1657000 0.16570000 4.055467e-05 1.415435e-05 TRUE TRUE
ENST00000683334 ENSG00000132549 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS13B protein_coding nonsense_mediated_decay 2.769589 2.237743 4.187256 0.1651218 0.1133803 0.9009693 0.1103303 0.000000 0.5228104 0.0000000 0.18167663 5.7355504 0.02800000 0.0000000 0.1274667 0.12746667 2.503034e-03 1.415435e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000132549 E001 0.1308682 0.0326491905 1.785237e-01   8 99013266 99013268 3 + 0.000 0.183 11.269
ENSG00000132549 E002 0.1308682 0.0326491905 1.785237e-01   8 99013269 99013271 3 + 0.000 0.183 14.035
ENSG00000132549 E003 0.0000000       8 99013272 99013273 2 +      
ENSG00000132549 E004 0.0000000       8 99013274 99013275 2 +      
ENSG00000132549 E005 0.0000000       8 99013276 99013295 20 +      
ENSG00000132549 E006 0.5255656 0.2782641547 7.860590e-01   8 99013296 99013306 11 + 0.145 0.187 0.440
ENSG00000132549 E007 0.5255656 0.2782641547 7.860590e-01   8 99013307 99013307 1 + 0.145 0.187 0.440
ENSG00000132549 E008 0.6869813 0.5507628121 9.192274e-01   8 99013308 99013310 3 + 0.203 0.189 -0.126
ENSG00000132549 E009 2.2557536 0.3892708458 6.447195e-01 7.999939e-01 8 99013311 99013347 37 + 0.525 0.320 -1.109
ENSG00000132549 E010 9.5409446 0.0031109950 1.247640e-03 1.177496e-02 8 99013760 99013935 176 + 1.060 0.619 -1.727
ENSG00000132549 E011 11.4459100 0.0287140472 2.606964e-04 3.328991e-03 8 99038423 99038566 144 + 1.143 0.563 -2.283
ENSG00000132549 E012 0.2027342 0.0361699591 1.772539e-01   8 99055926 99056040 115 + 0.000 0.184 14.018
ENSG00000132549 E013 10.1797599 0.0141462063 4.364501e-03 3.117267e-02 8 99096312 99096432 121 + 1.076 0.672 -1.562
ENSG00000132549 E014 6.9447251 0.0068338873 5.083402e-03 3.506981e-02 8 99102953 99103058 106 + 0.930 0.493 -1.833
ENSG00000132549 E015 5.1592231 0.0076646962 5.665262e-02 1.952059e-01 8 99103059 99103120 62 + 0.802 0.493 -1.339
ENSG00000132549 E016 10.0622337 0.0030967946 5.663179e-01 7.475427e-01 8 99111098 99111279 182 + 1.012 0.950 -0.231
ENSG00000132549 E017 0.1779838 0.0344655435 1.000000e+00   8 99113128 99114855 1728 + 0.078 0.000 -13.296
ENSG00000132549 E018 11.0134245 0.0031052458 3.128994e-01 5.532333e-01 8 99115700 99115874 175 + 1.060 0.950 -0.406
ENSG00000132549 E019 16.6930197 0.0023479423 7.439963e-04 7.811760e-03 8 99121177 99121445 269 + 1.274 0.923 -1.270
ENSG00000132549 E020 1.0045791 0.0153787590 2.498074e-01   8 99121446 99121762 317 + 0.202 0.412 1.416
ENSG00000132549 E021 13.5913922 0.0023793835 5.238406e-04 5.892183e-03 8 99134632 99134727 96 + 1.199 0.797 -1.491
ENSG00000132549 E022 14.7960376 0.0027634569 6.252515e-08 2.437046e-06 8 99135015 99135137 123 + 1.264 0.561 -2.720
ENSG00000132549 E023 13.8663224 0.0034116993 3.478871e-07 1.125277e-05 8 99135596 99135733 138 + 1.235 0.561 -2.618
ENSG00000132549 E024 12.8981222 0.0055741385 1.121925e-05 2.315477e-04 8 99136665 99136752 88 + 1.199 0.619 -2.227
ENSG00000132549 E025 0.1426347 0.0327369584 1.000000e+00   8 99136753 99137068 316 + 0.078 0.000 -13.305
ENSG00000132549 E026 13.0097570 0.0027725018 1.656236e-02 8.384016e-02 8 99142974 99143165 192 + 1.160 0.895 -0.973
ENSG00000132549 E027 12.4148124 0.0030888523 4.148005e-01 6.396784e-01 8 99147841 99148010 170 + 1.102 1.020 -0.298
ENSG00000132549 E028 0.0000000       8 99150754 99150822 69 +      
ENSG00000132549 E029 6.9410936 0.0043616288 7.407252e-02 2.328795e-01 8 99156549 99156628 80 + 0.919 0.671 -0.986
ENSG00000132549 E030 11.0707978 0.0048276738 9.251783e-02 2.684377e-01 8 99156629 99156743 115 + 1.088 0.895 -0.717
ENSG00000132549 E031 11.5071418 0.0315331290 1.175732e-01 3.117888e-01 8 99170039 99170163 125 + 1.112 0.893 -0.810
ENSG00000132549 E032 14.2831751 0.0021700248 1.773566e-03 1.552409e-02 8 99192876 99193057 182 + 1.210 0.865 -1.266
ENSG00000132549 E033 0.8483969 0.7213894895 1.000000e+00   8 99193058 99193385 328 + 0.254 0.191 -0.531
ENSG00000132549 E034 0.0000000       8 99236271 99236392 122 +      
ENSG00000132549 E035 0.1723744 0.0396647140 1.773578e-01   8 99240870 99241502 633 + 0.000 0.184 13.995
ENSG00000132549 E036 9.6661896 0.0379447968 3.449081e-01 5.824753e-01 8 99274198 99274332 135 + 1.026 0.891 -0.502
ENSG00000132549 E037 11.2607034 0.0114721428 1.559041e-01 3.707514e-01 8 99275081 99275208 128 + 1.089 0.922 -0.617
ENSG00000132549 E038 8.4738921 0.0052100542 2.660262e-01 5.054852e-01 8 99275209 99275254 46 + 0.969 0.832 -0.521
ENSG00000132549 E039 9.0843443 0.0035235920 8.304346e-02 2.508483e-01 8 99384208 99384317 110 + 1.012 0.797 -0.818
ENSG00000132549 E040 0.0000000       8 99389616 99389720 105 +      
ENSG00000132549 E041 2.0048746 0.0108647759 7.582448e-02 2.364229e-01 8 99391557 99391559 3 + 0.527 0.184 -2.169
ENSG00000132549 E042 7.9830836 0.0254385819 3.627081e-02 1.449810e-01 8 99391560 99391704 145 + 0.985 0.669 -1.238
ENSG00000132549 E043 0.4458772 0.0217681645 1.617727e-01   8 99391705 99392341 637 + 0.078 0.312 2.416
ENSG00000132549 E044 0.1614157 0.0335292122 1.000000e+00   8 99424267 99424532 266 + 0.078 0.000 -13.301
ENSG00000132549 E045 0.0000000       8 99429570 99429647 78 +      
ENSG00000132549 E046 0.0000000       8 99431521 99431536 16 +      
ENSG00000132549 E047 7.6158428 0.0564940153 1.699260e-01 3.903765e-01 8 99431537 99431664 128 + 0.949 0.714 -0.918
ENSG00000132549 E048 12.0410888 0.0420063199 2.139629e-01 4.463148e-01 8 99442401 99442635 235 + 1.117 0.943 -0.637
ENSG00000132549 E049 0.0000000       8 99442636 99442836 201 +      
ENSG00000132549 E050 0.0000000       8 99444120 99444261 142 +      
ENSG00000132549 E051 14.1277580 0.0071343014 2.500820e-01 4.880070e-01 8 99467414 99467634 221 + 1.161 1.041 -0.430
ENSG00000132549 E052 15.7763752 0.0024490302 3.288510e-02 1.357374e-01 8 99481599 99481802 204 + 1.231 1.020 -0.757
ENSG00000132549 E053 15.0529449 0.0025817403 1.809539e-03 1.576309e-02 8 99501687 99501858 172 + 1.231 0.895 -1.226
ENSG00000132549 E054 0.0000000       8 99502030 99502835 806 +      
ENSG00000132549 E055 7.8129464 0.0044200225 2.983196e-01 5.387633e-01 8 99502836 99502950 115 + 0.930 0.797 -0.512
ENSG00000132549 E056 6.2448981 0.0049698091 6.665028e-01 8.139979e-01 8 99507137 99507203 67 + 0.802 0.864 0.244
ENSG00000132549 E057 1.4534769 0.0125660078 7.034499e-01 8.378230e-01 8 99507770 99507911 142 + 0.339 0.412 0.417
ENSG00000132549 E058 21.2689286 0.0102055265 8.918762e-02 2.622705e-01 8 99511104 99511512 409 + 1.342 1.181 -0.566
ENSG00000132549 E059 10.4696450 0.0289119937 4.230336e-02 1.607142e-01 8 99520899 99521010 112 + 1.083 0.794 -1.088
ENSG00000132549 E060 15.5183743 0.0300985226 3.894922e-01 6.200614e-01 8 99556450 99556653 204 + 1.205 1.110 -0.338
ENSG00000132549 E061 12.4602806 0.0028211756 3.414688e-01 5.793538e-01 8 99575658 99575784 127 + 1.116 1.020 -0.347
ENSG00000132549 E062 12.8762416 0.0106135961 2.159103e-01 4.485203e-01 8 99577490 99577633 144 + 1.135 0.997 -0.502
ENSG00000132549 E063 0.1614157 0.0335292122 1.000000e+00   8 99577634 99577785 152 + 0.078 0.000 -13.301
ENSG00000132549 E064 23.7280285 0.0015903315 5.427523e-03 3.684515e-02 8 99641811 99642266 456 + 1.400 1.167 -0.815
ENSG00000132549 E065 13.7154696 0.0024922767 1.468340e-03 1.339338e-02 8 99642267 99642498 232 + 1.194 0.832 -1.334
ENSG00000132549 E066 13.0718457 0.0025102801 1.414495e-02 7.493801e-02 8 99661354 99661491 138 + 1.165 0.895 -0.993
ENSG00000132549 E067 25.5809067 0.0015402130 8.030081e-04 8.306996e-03 8 99699525 99699932 408 + 1.442 1.167 -0.962
ENSG00000132549 E068 19.5166491 0.0022034044 1.087047e-01 2.969416e-01 8 99717171 99717373 203 + 1.305 1.167 -0.487
ENSG00000132549 E069 18.9618941 0.0019749665 2.485484e-02 1.117859e-01 8 99720345 99720552 208 + 1.304 1.100 -0.724
ENSG00000132549 E070 7.1172039 0.0040967802 9.693732e-01 9.865337e-01 8 99720863 99720867 5 + 0.865 0.865 0.000
ENSG00000132549 E071 18.2527011 0.0021672623 1.338765e-01 3.378752e-01 8 99720868 99721047 180 + 1.269 1.135 -0.475
ENSG00000132549 E072 17.6503249 0.0020712212 2.006880e-01 4.305863e-01 8 99766774 99766970 197 + 1.250 1.135 -0.409
ENSG00000132549 E073 17.2314109 0.0116730240 8.671518e-01 9.344115e-01 8 99776775 99776956 182 + 1.224 1.211 -0.049
ENSG00000132549 E074 28.6280103 0.0203902373 6.159238e-01 7.809533e-01 8 99778682 99779031 350 + 1.413 1.462 0.171
ENSG00000132549 E075 19.0748732 0.0195247504 6.850753e-01 8.259433e-01 8 99784315 99784476 162 + 1.271 1.227 -0.154
ENSG00000132549 E076 19.2790458 0.0017667550 3.765032e-02 1.487263e-01 8 99809375 99809530 156 + 1.304 1.118 -0.660
ENSG00000132549 E077 26.0036610 0.0022403988 6.745940e-01 8.192708e-01 8 99817540 99817803 264 + 1.392 1.364 -0.097
ENSG00000132549 E078 14.4500572 0.0896454364 9.201666e-01 9.622849e-01 8 99818451 99818534 84 + 1.143 1.144 0.002
ENSG00000132549 E079 22.2181302 0.0708653427 7.097878e-01 8.416615e-01 8 99818713 99818888 176 + 1.304 1.353 0.174
ENSG00000132549 E080 20.9606288 0.0135681159 3.220399e-01 5.614564e-01 8 99819412 99819582 171 + 1.269 1.364 0.330
ENSG00000132549 E081 18.3351458 0.0141823641 1.286083e-01 3.296470e-01 8 99819921 99820122 202 + 1.189 1.345 0.548
ENSG00000132549 E082 21.5966396 0.0018061974 2.101117e-01 4.419899e-01 8 99821294 99821482 189 + 1.278 1.383 0.365
ENSG00000132549 E083 18.2458271 0.0023539932 8.653918e-02 2.574910e-01 8 99823832 99823978 147 + 1.194 1.344 0.527
ENSG00000132549 E084 21.7626202 0.0218646369 2.789776e-01 5.190558e-01 8 99832369 99832652 284 + 1.275 1.398 0.429
ENSG00000132549 E085 20.7050533 0.0021858273 9.922777e-02 2.804273e-01 8 99835197 99835324 128 + 1.245 1.384 0.482
ENSG00000132549 E086 28.9757944 0.0020776323 1.496220e-01 3.617183e-01 8 99835539 99835738 200 + 1.393 1.499 0.365
ENSG00000132549 E087 20.8677695 0.0020918557 4.659410e-01 6.772152e-01 8 99848776 99848894 119 + 1.269 1.334 0.225
ENSG00000132549 E088 67.0962152 0.0010827269 1.201769e-05 2.457411e-04 8 99853451 99854256 806 + 1.724 1.928 0.689
ENSG00000132549 E089 0.2027342 0.0361699591 1.772539e-01   8 99854410 99854519 110 + 0.000 0.184 14.018
ENSG00000132549 E090 23.8963868 0.0179769776 2.010436e-01 4.310234e-01 8 99859304 99859480 177 + 1.316 1.454 0.475
ENSG00000132549 E091 25.3132022 0.0047422374 3.844994e-02 1.507488e-01 8 99861776 99861946 171 + 1.326 1.490 0.570
ENSG00000132549 E092 4.3169448 0.0621425267 8.472695e-02 2.542031e-01 8 99868057 99868288 232 + 0.577 0.868 1.200
ENSG00000132549 E093 30.7611003 0.0184324228 7.607152e-02 2.368881e-01 8 99868289 99868465 177 + 1.404 1.561 0.540
ENSG00000132549 E094 21.7954060 0.0584358873 1.116369e-01 3.017719e-01 8 99870785 99870887 103 + 1.243 1.447 0.711
ENSG00000132549 E095 25.0586262 0.0662900943 9.658664e-01 9.848355e-01 8 99870888 99871447 560 + 1.368 1.371 0.009
ENSG00000132549 E096 40.5092601 0.0047634760 2.679038e-02 1.176586e-01 8 99871448 99871697 250 + 1.521 1.667 0.499
ENSG00000132549 E097 173.8852258 0.0004030032 5.672282e-39 8.837468e-36 8 99875418 99877613 2196 + 2.065 2.415 1.167