ENSG00000132507

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336458 ENSG00000132507 HEK293_OSMI2_6hA HEK293_TMG_6hB EIF5A protein_coding protein_coding 1887.695 2646.5 1175.256 607.8849 48.62949 -1.171103 1198.23846 1597.73112 746.4647 397.996560 62.88796 -1.097868 0.61397917 0.59786667 0.6328000 0.03493333 8.713447e-01 1.707745e-08 FALSE TRUE
ENST00000573714 ENSG00000132507 HEK293_OSMI2_6hA HEK293_TMG_6hB EIF5A protein_coding protein_coding 1887.695 2646.5 1175.256 607.8849 48.62949 -1.171103 70.04538 39.77029 183.8611 4.061778 25.01235 2.208569 0.05692917 0.01706667 0.1562000 0.13913333 1.707745e-08 1.707745e-08 FALSE TRUE
MSTRG.13559.15 ENSG00000132507 HEK293_OSMI2_6hA HEK293_TMG_6hB EIF5A protein_coding   1887.695 2646.5 1175.256 607.8849 48.62949 -1.171103 454.65219 766.56606 152.3045 191.113237 30.39336 -2.331376 0.23944583 0.28893333 0.1320333 -0.15690000 9.421291e-02 1.707745e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000132507 E001 8.509857e-01 0.122080707 0.077465366   17 7306800 7306937 138 + 0.456 0.127 -2.454
ENSG00000132507 E002 9.958333e-01 0.072564058 0.026564930   17 7306938 7306978 41 + 0.540 0.127 -2.862
ENSG00000132507 E003 1.232819e+00 0.371590109 0.052499035   17 7306979 7306984 6 + 0.617 0.170 -2.706
ENSG00000132507 E004 1.375454e+00 0.098223055 0.007843495   17 7306985 7306985 1 + 0.672 0.176 -2.892
ENSG00000132507 E005 1.375454e+00 0.098223055 0.007843495   17 7306986 7306987 2 + 0.672 0.176 -2.892
ENSG00000132507 E006 1.435063e+01 0.044567778 0.164000747 0.38263311 17 7306988 7306998 11 + 1.245 1.053 -0.688
ENSG00000132507 E007 8.376351e+01 0.033278266 0.242658913 0.47955993 17 7306999 7307113 115 + 1.932 1.815 -0.397
ENSG00000132507 E008 4.717429e+01 0.076728503 0.498883249 0.70001859 17 7307114 7307115 2 + 1.667 1.578 -0.304
ENSG00000132507 E009 1.391989e+01 0.048673276 0.765479063 0.87593628 17 7307116 7307238 123 + 1.059 1.110 0.184
ENSG00000132507 E010 1.124793e+01 0.003376521 0.478564283 0.68611681 17 7307239 7307325 87 + 1.081 0.999 -0.302
ENSG00000132507 E011 4.712069e+01 0.321040778 0.474506574 0.68319504 17 7307326 7307350 25 + 1.136 1.670 1.853
ENSG00000132507 E012 7.558954e+00 0.029385068 0.340079823 0.57800776 17 7307351 7307409 59 + 0.724 0.875 0.597
ENSG00000132507 E013 1.745074e+01 0.639778760 0.405089041 0.63235655 17 7307410 7307448 39 + 0.683 1.256 2.160
ENSG00000132507 E014 2.962846e+02 0.054986518 0.253244805 0.49147812 17 7307540 7307581 42 + 2.244 2.418 0.582
ENSG00000132507 E015 3.638465e+02 0.073430738 0.402389143 0.63030196 17 7307582 7307591 10 + 2.354 2.503 0.497
ENSG00000132507 E016 4.785915e+02 0.082275335 0.541782706 0.73035471 17 7307592 7307601 10 + 2.497 2.617 0.397
ENSG00000132507 E017 5.499798e+02 0.083162825 0.853625604 0.92689742 17 7307602 7307609 8 + 2.608 2.666 0.191
ENSG00000132507 E018 1.186667e+03 0.100128556 0.432949784 0.65343924 17 7307610 7307627 18 + 2.868 3.015 0.487
ENSG00000132507 E019 1.130696e+03 0.100627345 0.480017865 0.68709867 17 7307628 7307630 3 + 2.858 2.992 0.445
ENSG00000132507 E020 1.562995e+03 0.094679136 0.440934302 0.65941145 17 7307631 7307647 17 + 2.991 3.133 0.473
ENSG00000132507 E021 6.950485e+03 0.062177248 0.507559021 0.70606152 17 7307648 7307752 105 + 3.789 3.745 -0.146
ENSG00000132507 E022 4.224598e+00 0.051454201 0.987899598 0.99580268 17 7307828 7307888 61 + 0.670 0.656 -0.060
ENSG00000132507 E023 3.909771e+01 0.094127851 0.012798984 0.06961635 17 7307974 7307992 19 + 1.129 1.582 1.580
ENSG00000132507 E024 2.600149e+02 0.054729800 0.522027773 0.71632495 17 7307993 7308113 121 + 2.251 2.349 0.326
ENSG00000132507 E025 1.713357e+01 0.008760315 0.787210951 0.88887679 17 7308114 7308133 20 + 1.162 1.190 0.101
ENSG00000132507 E026 4.489018e+01 0.066246677 0.634214231 0.79308431 17 7308371 7308480 110 + 1.512 1.591 0.271
ENSG00000132507 E027 5.731685e+01 0.049828790 0.439590900 0.65836417 17 7308481 7308575 95 + 1.745 1.660 -0.288
ENSG00000132507 E028 5.940304e+01 0.086420812 0.106838304 0.29374739 17 7309597 7309614 18 + 1.869 1.633 -0.800
ENSG00000132507 E029 1.667806e+04 0.020193993 0.165450619 0.38450428 17 7309615 7309800 186 + 4.178 4.122 -0.186
ENSG00000132507 E030 1.621202e+02 0.245956918 0.048994607 0.17721856 17 7309801 7310453 653 + 2.415 1.998 -1.393
ENSG00000132507 E031 1.644479e+04 0.034424120 0.696733800 0.83347251 17 7311018 7311122 105 + 4.139 4.126 -0.043
ENSG00000132507 E032 2.010125e+04 2.415508010 0.654822558 0.80662052 17 7311350 7311481 132 + 4.183 4.224 0.137
ENSG00000132507 E033 2.016913e+02 1.183695267 0.923678037 0.96420805 17 7311482 7311577 96 + 2.442 2.134 -1.027
ENSG00000132507 E034 1.300162e+04 0.076819008 0.340586867 0.57855104 17 7311578 7311651 74 + 3.994 4.035 0.136
ENSG00000132507 E035 1.058806e+03 0.019871538 0.361519299 0.59691875 17 7311784 7311821 38 + 2.976 2.927 -0.162
ENSG00000132507 E036 2.829552e+04 0.029327720 0.666423680 0.81394776 17 7311822 7312566 745 + 4.361 4.365 0.014