ENSG00000132485

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000254821 ENSG00000132485 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRANB2 protein_coding protein_coding 69.73151 21.72208 128.3382 1.389021 0.9536328 2.562165 27.742325 10.0440132 51.487324 1.4232899 1.0892241 2.3567260 0.41905833 0.45803333 0.40130000 -0.05673333 0.72599527 0.03675561 FALSE TRUE
ENST00000370920 ENSG00000132485 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRANB2 protein_coding protein_coding 69.73151 21.72208 128.3382 1.389021 0.9536328 2.562165 13.580522 3.5908422 24.016579 0.6055682 1.3560825 2.7382249 0.21692917 0.16373333 0.18703333 0.02330000 0.84073011 0.03675561 FALSE TRUE
ENST00000477096 ENSG00000132485 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRANB2 protein_coding processed_transcript 69.73151 21.72208 128.3382 1.389021 0.9536328 2.562165 8.998962 3.2964184 18.095049 0.6137449 0.9137458 2.4530509 0.13658333 0.15290000 0.14106667 -0.01183333 0.97770592 0.03675561   FALSE
ENST00000487510 ENSG00000132485 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRANB2 protein_coding processed_transcript 69.73151 21.72208 128.3382 1.389021 0.9536328 2.562165 5.583407 1.9706529 9.727527 0.6803245 1.0717921 2.2975793 0.08132500 0.09110000 0.07580000 -0.01530000 0.97884541 0.03675561   FALSE
ENST00000611683 ENSG00000132485 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRANB2 protein_coding protein_coding 69.73151 21.72208 128.3382 1.389021 0.9536328 2.562165 10.917186 0.9691151 21.540827 0.9691151 1.2142299 4.4601209 0.09980833 0.04826667 0.16776667 0.11950000 0.22538365 0.03675561 FALSE TRUE
MSTRG.1408.4 ENSG00000132485 HEK293_OSMI2_6hA HEK293_TMG_6hB ZRANB2 protein_coding   69.73151 21.72208 128.3382 1.389021 0.9536328 2.562165 2.803144 1.8104609 3.413948 0.1190920 0.8855911 0.9113569 0.04430417 0.08396667 0.02656667 -0.05740000 0.03675561 0.03675561 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000132485 E001 1.392022 0.0932635518 0.409996268 0.63600694 1 71063291 71063296 6 - 0.285 0.477 1.104
ENSG00000132485 E002 24.313151 0.0073363127 0.840712108 0.91984133 1 71063297 71063336 40 - 1.302 1.300 -0.006
ENSG00000132485 E003 2225.088236 0.0099402496 0.650312059 0.80378073 1 71063337 71065042 1706 - 3.241 3.244 0.011
ENSG00000132485 E004 176.109515 0.0003333237 0.323190004 0.56247985 1 71065043 71065053 11 - 2.135 2.186 0.170
ENSG00000132485 E005 181.368763 0.0004512804 0.643524192 0.79921880 1 71065054 71065086 33 - 2.151 2.184 0.111
ENSG00000132485 E006 292.171092 0.0139488104 0.271949061 0.51181600 1 71065087 71065137 51 - 2.346 2.425 0.263
ENSG00000132485 E007 228.655893 0.0107791064 0.082914341 0.25055665 1 71065678 71065718 41 - 2.233 2.345 0.372
ENSG00000132485 E008 188.211605 0.0167463716 0.168133352 0.38810463 1 71065719 71065748 30 - 2.151 2.252 0.338
ENSG00000132485 E009 141.873096 0.0306404153 0.277403811 0.51744459 1 71065749 71065752 4 - 2.031 2.127 0.321
ENSG00000132485 E010 354.276747 0.0224875921 0.689393907 0.82866283 1 71065753 71066775 1023 - 2.432 2.495 0.210
ENSG00000132485 E011 451.397843 1.8769520703 0.551914679 0.73764830 1 71066776 71066934 159 - 2.510 2.686 0.584
ENSG00000132485 E012 82.565117 1.3543307730 0.543737636 0.73174122 1 71066935 71067513 579 - 1.787 1.926 0.469
ENSG00000132485 E013 327.561234 0.0524486570 0.171150887 0.39205456 1 71069276 71069362 87 - 2.382 2.517 0.449
ENSG00000132485 E014 40.871894 0.0263362502 0.214008246 0.44636397 1 71069363 71069600 238 - 1.485 1.643 0.541
ENSG00000132485 E015 463.081308 0.0114656704 0.883164956 0.94293138 1 71070827 71070996 170 - 2.556 2.581 0.082
ENSG00000132485 E016 493.014505 0.0115672632 0.145554796 0.35572689 1 71072121 71072255 135 - 2.599 2.539 -0.199
ENSG00000132485 E017 447.905195 0.0075707815 0.054891065 0.19110093 1 71072472 71072548 77 - 2.559 2.487 -0.240
ENSG00000132485 E018 523.606376 0.0148923159 0.256626606 0.49541429 1 71076795 71076877 83 - 2.623 2.569 -0.178
ENSG00000132485 E019 588.039770 0.0099437819 0.107922205 0.29558855 1 71078457 71078565 109 - 2.675 2.610 -0.219
ENSG00000132485 E020 408.815707 0.0036332476 0.015311061 0.07923966 1 71078656 71078708 53 - 2.519 2.450 -0.230
ENSG00000132485 E021 345.419630 0.0037520003 0.008313977 0.05077214 1 71080940 71081289 350 - 2.448 2.365 -0.278