ENSG00000132478

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000586527 ENSG00000132478 HEK293_OSMI2_6hA HEK293_TMG_6hB UNK protein_coding nonsense_mediated_decay 27.97816 28.72255 24.02625 2.998472 0.0221233 -0.2574738 12.65919 6.431954 13.917102 0.4901113 0.7148902 1.112325 0.4567542 0.2256667 0.5793333 0.3536667 2.695587e-10 9.844866e-20   FALSE
ENST00000589666 ENSG00000132478 HEK293_OSMI2_6hA HEK293_TMG_6hB UNK protein_coding protein_coding 27.97816 28.72255 24.02625 2.998472 0.0221233 -0.2574738 10.98413 18.407194 6.287385 2.2773110 0.2305497 -1.548229 0.3855958 0.6382000 0.2617000 -0.3765000 9.844866e-20 9.844866e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000132478 E001 0.0000000       17 75784740 75784780 41 +      
ENSG00000132478 E002 0.3040503 0.0244411696 5.091262e-02   17 75784781 75784805 25 + 0.305 0.000 -11.411
ENSG00000132478 E003 1.0135691 0.1384887962 1.008453e-01   17 75784806 75784817 12 + 0.480 0.151 -2.279
ENSG00000132478 E004 3.0615272 0.1179514239 7.447092e-02 2.337426e-01 17 75784818 75784841 24 + 0.813 0.426 -1.721
ENSG00000132478 E005 5.8728217 0.0862022305 1.240603e-01 3.221521e-01 17 75784842 75784848 7 + 1.001 0.690 -1.211
ENSG00000132478 E006 6.9749450 0.0823597736 1.811230e-01 4.054366e-01 17 75784849 75784854 6 + 1.042 0.772 -1.029
ENSG00000132478 E007 23.8007524 0.4730607427 9.650970e-01 9.844734e-01 17 75784855 75784861 7 + 1.477 1.292 -0.644
ENSG00000132478 E008 81.7347870 0.7604923094 6.453824e-01 8.004174e-01 17 75784862 75784984 123 + 1.903 1.860 -0.143
ENSG00000132478 E009 17.7276898 0.1244717794 7.915286e-02 2.431353e-01 17 75791760 75791770 11 + 1.480 1.078 -1.413
ENSG00000132478 E010 106.4050333 0.0005449129 4.328253e-69 4.593980e-65 17 75791771 75792019 249 + 2.332 1.710 -2.088
ENSG00000132478 E011 1.1073002 0.0206468821 4.403143e-01   17 75792020 75792165 146 + 0.403 0.259 -0.906
ENSG00000132478 E012 109.1614611 0.0038716484 7.502129e-49 2.275061e-45 17 75792313 75792478 166 + 2.354 1.689 -2.234
ENSG00000132478 E013 1.2018915 0.0855842377 4.823965e-01   17 75792479 75792636 158 + 0.403 0.262 -0.885
ENSG00000132478 E014 197.8991443 0.0044932789 3.110410e-55 1.288339e-51 17 75793443 75794198 756 + 2.598 1.969 -2.101
ENSG00000132478 E015 2.6589143 0.0382011165 1.373251e-01 3.434099e-01 17 75797257 75797397 141 + 0.305 0.588 1.497
ENSG00000132478 E016 6.7397331 0.0048106300 9.624223e-01 9.831903e-01 17 75808948 75809039 92 + 0.852 0.853 0.004
ENSG00000132478 E017 117.4217871 0.0004560797 5.183764e-02 1.840716e-01 17 75809760 75809930 171 + 1.985 2.050 0.218
ENSG00000132478 E018 70.6374875 0.0006035170 3.619959e-01 5.973456e-01 17 75809931 75809969 39 + 1.847 1.799 -0.162
ENSG00000132478 E019 85.6280831 0.0031837891 8.093964e-01 9.018234e-01 17 75812112 75812147 36 + 1.908 1.889 -0.064
ENSG00000132478 E020 138.8617123 0.0067716972 5.111978e-01 7.088716e-01 17 75812148 75812288 141 + 2.081 2.109 0.094
ENSG00000132478 E021 9.0813071 0.1555923423 5.082144e-02 1.816367e-01 17 75812289 75812360 72 + 1.206 0.810 -1.466
ENSG00000132478 E022 121.5686429 0.0094972733 5.990740e-01 7.696003e-01 17 75812455 75812585 131 + 2.025 2.049 0.080
ENSG00000132478 E023 100.6516552 0.0091756504 1.798390e-01 4.037598e-01 17 75813078 75813213 136 + 1.903 1.980 0.256
ENSG00000132478 E024 102.6001729 0.0006773627 6.935818e-01 8.314120e-01 17 75813761 75813878 118 + 1.965 1.974 0.033
ENSG00000132478 E025 93.5354307 0.0014445506 5.156310e-01 7.120403e-01 17 75815169 75815253 85 + 1.957 1.925 -0.109
ENSG00000132478 E026 124.3720267 0.0004224084 8.815875e-01 9.421653e-01 17 75816770 75816912 143 + 2.067 2.056 -0.037
ENSG00000132478 E027 148.7482129 0.0004393993 1.577456e-01 3.733271e-01 17 75817326 75817526 201 + 2.105 2.145 0.136
ENSG00000132478 E028 84.8458896 0.0018170397 3.437892e-02 1.399107e-01 17 75818103 75818168 66 + 1.821 1.915 0.318
ENSG00000132478 E029 126.6165494 0.0006339837 2.690988e-03 2.151764e-02 17 75818642 75818816 175 + 1.990 2.093 0.347
ENSG00000132478 E030 76.4292646 0.5890965373 3.133063e-01 5.535353e-01 17 75819684 75819738 55 + 1.701 1.889 0.633
ENSG00000132478 E031 84.0681164 0.5414170252 1.875879e-01 4.138845e-01 17 75819739 75819785 47 + 1.650 1.950 1.016
ENSG00000132478 E032 180.3703867 0.0999482627 2.523493e-02 1.129115e-01 17 75819920 75820108 189 + 1.993 2.276 0.947
ENSG00000132478 E033 149.1419250 0.0003791067 3.953858e-09 2.025508e-07 17 75822477 75822560 84 + 1.983 2.179 0.657
ENSG00000132478 E034 160.1124816 0.0004292145 3.225710e-12 3.043331e-10 17 75822561 75822658 98 + 1.990 2.220 0.771
ENSG00000132478 E035 202.6409232 0.0011344985 1.122550e-11 9.570020e-10 17 75823265 75823522 258 + 2.101 2.319 0.729
ENSG00000132478 E036 369.3924408 0.0030252241 2.725867e-04 3.454589e-03 17 75824262 75824969 708 + 2.442 2.552 0.365
ENSG00000132478 E037 224.2040947 0.0003642527 1.180455e-14 1.706114e-12 17 75824970 75825399 430 + 2.146 2.360 0.716
ENSG00000132478 E038 126.7831702 0.0004734928 5.213027e-08 2.070374e-06 17 75825400 75825799 400 + 1.916 2.114 0.665