ENSG00000132466

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330838 ENSG00000132466 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD17 protein_coding protein_coding 26.22049 25.72624 34.0482 7.850853 1.323737 0.4042005 6.656512 8.0038232 9.908590 2.4576812 0.4602060 0.307644292 0.25467917 0.31113333 0.29176667 -0.01936667 0.894739899 1.395404e-07 FALSE TRUE
ENST00000358602 ENSG00000132466 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD17 protein_coding protein_coding 26.22049 25.72624 34.0482 7.850853 1.323737 0.4042005 1.908128 2.3124110 1.750686 0.8710539 0.2307715 -0.399485986 0.07995833 0.08520000 0.05116667 -0.03403333 0.298864395 1.395404e-07 FALSE TRUE
ENST00000509867 ENSG00000132466 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD17 protein_coding protein_coding 26.22049 25.72624 34.0482 7.850853 1.323737 0.4042005 5.423247 3.1411461 8.926850 0.5057690 0.5553754 1.503889768 0.19012500 0.14433333 0.26170000 0.11736667 0.227395575 1.395404e-07 FALSE TRUE
ENST00000510127 ENSG00000132466 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD17 protein_coding processed_transcript 26.22049 25.72624 34.0482 7.850853 1.323737 0.4042005 1.973314 3.6693170 0.000000 1.8357657 0.0000000 -8.523294170 0.09041250 0.10986667 0.00000000 -0.10986667 0.181883578 1.395404e-07   FALSE
ENST00000558247 ENSG00000132466 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD17 protein_coding protein_coding 26.22049 25.72624 34.0482 7.850853 1.323737 0.4042005 6.120348 6.8813141 6.843752 2.2065680 0.1390509 -0.007885195 0.24013750 0.26226667 0.20190000 -0.06036667 0.341990018 1.395404e-07 FALSE TRUE
MSTRG.25018.12 ENSG00000132466 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD17 protein_coding   26.22049 25.72624 34.0482 7.850853 1.323737 0.4042005 1.845145 0.4734103 2.606253 0.1393872 0.5684759 2.436181766 0.06245000 0.01916667 0.07546667 0.05630000 0.003846046 1.395404e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000132466 E001 93.2294606 0.0135450975 3.901682e-04 4.635479e-03 4 73073376 73075237 1862 - 1.824 2.100 0.929
ENSG00000132466 E002 199.0105783 0.0043135768 7.738990e-09 3.727335e-07 4 73075238 73075685 448 - 2.158 2.425 0.891
ENSG00000132466 E003 138.1980647 0.0034207870 7.153672e-13 7.525758e-11 4 73075686 73075781 96 - 1.962 2.290 1.097
ENSG00000132466 E004 202.1736298 0.0021915044 2.775720e-14 3.826146e-12 4 73075782 73075855 74 - 2.155 2.437 0.942
ENSG00000132466 E005 592.2952330 0.0016796308 3.056806e-33 3.224322e-30 4 73075856 73076290 435 - 2.600 2.916 1.050
ENSG00000132466 E006 258.8473752 0.0001854918 7.789242e-28 5.399153e-25 4 73076940 73077104 165 - 2.273 2.539 0.885
ENSG00000132466 E007 126.0970507 0.0004361848 3.026632e-09 1.592292e-07 4 73077355 73077368 14 - 1.992 2.205 0.711
ENSG00000132466 E008 327.3717421 0.0002094676 1.283625e-21 4.531996e-19 4 73077369 73077533 165 - 2.405 2.617 0.709
ENSG00000132466 E009 392.3545127 0.0001735536 8.435057e-30 6.570948e-27 4 73078642 73078890 249 - 2.476 2.705 0.760
ENSG00000132466 E010 0.1723744 0.1337247094 3.982003e-01   4 73080721 73080810 90 - 0.000 0.135 9.364
ENSG00000132466 E011 242.1743583 0.0002530029 4.544983e-20 1.363680e-17 4 73085249 73085365 117 - 2.263 2.498 0.782
ENSG00000132466 E012 196.0969848 0.0020388346 2.416683e-11 1.945985e-09 4 73085366 73085446 81 - 2.169 2.405 0.787
ENSG00000132466 E013 1412.6278628 0.0013185035 3.881473e-06 9.263117e-05 4 73090667 73092300 1634 - 3.099 3.199 0.333
ENSG00000132466 E014 212.0695164 0.0002506138 7.979340e-01 8.951509e-01 4 73094079 73094228 150 - 2.314 2.339 0.082
ENSG00000132466 E015 213.9454741 0.0002661213 8.088114e-01 9.014865e-01 4 73097117 73097272 156 - 2.327 2.339 0.042
ENSG00000132466 E016 379.0700079 0.0057543766 7.932194e-01 8.923054e-01 4 73098073 73098520 448 - 2.581 2.574 -0.025
ENSG00000132466 E017 1.7249545 0.0129946010 2.345921e-01 4.703795e-01 4 73100861 73101007 147 - 0.518 0.319 -1.083
ENSG00000132466 E018 3.2916161 0.0124963021 3.869470e-01 6.180808e-01 4 73101008 73101173 166 - 0.675 0.549 -0.556
ENSG00000132466 E019 106.9870008 0.0095403331 4.615948e-01 6.742712e-01 4 73102376 73102462 87 - 2.011 2.059 0.163
ENSG00000132466 E020 102.7257184 0.0161701001 6.842677e-01 8.254574e-01 4 73102463 73102547 85 - 1.994 2.044 0.169
ENSG00000132466 E021 2.0871813 0.3797727574 7.243533e-01 8.507565e-01 4 73102548 73102779 232 - 0.436 0.521 0.425
ENSG00000132466 E022 1.1665423 0.3954615774 5.786367e-01   4 73104003 73104080 78 - 0.266 0.399 0.831
ENSG00000132466 E023 6.7902789 0.3061976548 8.427668e-01 9.209937e-01 4 73112879 73112894 16 - 0.947 0.810 -0.527
ENSG00000132466 E024 20.2790905 0.6447878733 9.185874e-01 9.614920e-01 4 73112895 73113079 185 - 1.387 1.237 -0.524
ENSG00000132466 E025 7.9911252 0.3447661438 9.126031e-01 9.584181e-01 4 73113080 73113083 4 - 0.983 0.910 -0.273
ENSG00000132466 E026 29.5793267 0.7592252818 8.384363e-01 9.185615e-01 4 73113084 73113311 228 - 1.537 1.407 -0.445
ENSG00000132466 E027 147.7235884 0.0050773903 3.161835e-02 1.321079e-01 4 73113792 73113908 117 - 2.205 2.132 -0.245
ENSG00000132466 E028 153.5999307 0.0031188384 2.002097e-03 1.708210e-02 4 73115821 73115916 96 - 2.233 2.133 -0.334
ENSG00000132466 E029 215.6881749 0.0036699167 2.701984e-02 1.183572e-01 4 73118688 73118850 163 - 2.363 2.298 -0.218
ENSG00000132466 E030 238.6939959 0.0002034065 2.281845e-06 5.859818e-05 4 73120162 73120337 176 - 2.417 2.324 -0.311
ENSG00000132466 E031 261.2657397 0.0020233597 3.599474e-05 6.301139e-04 4 73120881 73121094 214 - 2.462 2.351 -0.370
ENSG00000132466 E032 232.8451844 0.0002012201 1.889162e-14 2.660226e-12 4 73121617 73121759 143 - 2.434 2.267 -0.557
ENSG00000132466 E033 234.3327995 0.0002068344 3.317311e-13 3.728363e-11 4 73124913 73125058 146 - 2.433 2.275 -0.525
ENSG00000132466 E034 217.3302149 0.0003674650 3.290874e-14 4.460225e-12 4 73125201 73125312 112 - 2.408 2.229 -0.597
ENSG00000132466 E035 203.4203089 0.0006091512 1.295210e-09 7.413428e-08 4 73135117 73135262 146 - 2.371 2.222 -0.498
ENSG00000132466 E036 55.7074707 0.0296899023 1.494837e-02 7.789394e-02 4 73135263 73135265 3 - 1.835 1.635 -0.678
ENSG00000132466 E037 263.0950917 0.0010254581 5.855782e-09 2.886637e-07 4 73139531 73140283 753 - 2.478 2.341 -0.457
ENSG00000132466 E038 126.1703230 0.0003126894 6.992389e-06 1.537375e-04 4 73141741 73141792 52 - 2.156 2.028 -0.427
ENSG00000132466 E039 125.5259976 0.0004903377 4.759905e-06 1.102635e-04 4 73141793 73141843 51 - 2.153 2.019 -0.449
ENSG00000132466 E040 177.1390208 0.0003570378 1.569449e-13 1.873004e-11 4 73142242 73142385 144 - 2.325 2.135 -0.635
ENSG00000132466 E041 145.2191912 0.0003977758 1.307774e-09 7.477784e-08 4 73142640 73142767 128 - 2.234 2.066 -0.564
ENSG00000132466 E042 117.5757535 0.0004413131 7.408572e-08 2.837496e-06 4 73144745 73144832 88 - 2.140 1.975 -0.555
ENSG00000132466 E043 135.0929986 0.0006311245 5.834511e-06 1.318124e-04 4 73146764 73146873 110 - 2.187 2.058 -0.434
ENSG00000132466 E044 181.5633149 0.0002743481 1.186357e-13 1.454662e-11 4 73147241 73147432 192 - 2.334 2.147 -0.625
ENSG00000132466 E045 208.5240716 0.0002710992 1.542142e-17 3.290090e-15 4 73148813 73149050 238 - 2.400 2.196 -0.681
ENSG00000132466 E046 127.1637991 0.0003600031 2.514231e-10 1.640946e-08 4 73151430 73151524 95 - 2.182 1.993 -0.634
ENSG00000132466 E047 191.8446907 0.0040360923 1.998070e-09 1.100968e-07 4 73153880 73154113 234 - 2.375 2.144 -0.774
ENSG00000132466 E048 181.9015270 0.0021936837 8.757269e-11 6.285654e-09 4 73155631 73155778 148 - 2.346 2.133 -0.713
ENSG00000132466 E049 184.2273141 0.0005267724 2.260742e-17 4.693472e-15 4 73156019 73156166 148 - 2.356 2.130 -0.753
ENSG00000132466 E050 151.7110277 0.0003775388 3.592444e-11 2.790849e-09 4 73161192 73161348 157 - 2.258 2.076 -0.607
ENSG00000132466 E051 0.0000000       4 73168929 73169090 162 -      
ENSG00000132466 E052 116.3357663 0.0003988484 2.518160e-10 1.642879e-08 4 73177380 73177533 154 - 2.148 1.949 -0.666
ENSG00000132466 E053 3.2677392 0.2230657193 4.673073e-01 6.782692e-01 4 73222974 73223114 141 - 0.712 0.493 -0.974
ENSG00000132466 E054 44.2682532 0.0010534536 2.030998e-05 3.871045e-04 4 73258276 73258284 9 - 1.739 1.521 -0.740
ENSG00000132466 E055 106.0293902 0.0107534073 5.716470e-02 1.963807e-01 4 73258285 73258839 555 - 2.068 1.978 -0.300