ENSG00000132382

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000254718 ENSG00000132382 HEK293_OSMI2_6hA HEK293_TMG_6hB MYBBP1A protein_coding protein_coding 112.8694 169.4304 62.9125 24.95479 2.376974 -1.42913 77.25281 126.959010 45.2146289 23.577189 1.3468203 -1.489296 0.68433333 0.73910000 0.719133333 -0.01996667 9.257517e-01 5.809575e-09 FALSE TRUE
ENST00000571368 ENSG00000132382 HEK293_OSMI2_6hA HEK293_TMG_6hB MYBBP1A protein_coding retained_intron 112.8694 169.4304 62.9125 24.95479 2.376974 -1.42913 11.59909 5.089334 0.4715797 2.240465 0.1605454 -3.404462 0.07301667 0.03250000 0.007333333 -0.02516667 6.379979e-01 5.809575e-09 FALSE TRUE
ENST00000574547 ENSG00000132382 HEK293_OSMI2_6hA HEK293_TMG_6hB MYBBP1A protein_coding retained_intron 112.8694 169.4304 62.9125 24.95479 2.376974 -1.42913 2.13272 13.605543 0.0000000 5.189825 0.0000000 -10.411039 0.01310833 0.07396667 0.000000000 -0.07396667 5.809575e-09 5.809575e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000132382 E001 6.512112 2.410504e-01 9.332346e-01 9.687778e-01 17 4536947 4536979 33 - 0.835 0.814 -0.082
ENSG00000132382 E002 41.324318 5.271686e-01 7.717009e-01 8.796242e-01 17 4537488 4538896 1409 - 1.613 1.535 -0.266
ENSG00000132382 E003 4.526185 2.035663e-02 1.684337e-01 3.884745e-01 17 4538897 4538901 5 - 0.834 0.625 -0.854
ENSG00000132382 E004 3.764678 9.567411e-03 4.285205e-01 6.499298e-01 17 4538902 4538903 2 - 0.706 0.586 -0.516
ENSG00000132382 E005 5.008629 5.801661e-03 7.179609e-01 8.469530e-01 17 4538904 4538905 2 - 0.753 0.708 -0.187
ENSG00000132382 E006 52.185756 3.177418e-01 1.188442e-01 3.139775e-01 17 4538906 4538943 38 - 1.383 1.709 1.115
ENSG00000132382 E007 117.694191 6.138365e-01 2.291152e-01 4.640828e-01 17 4538944 4538975 32 - 1.753 2.053 1.011
ENSG00000132382 E008 1031.293066 4.806914e-03 6.866990e-06 1.514313e-04 17 4538976 4539362 387 - 2.803 2.973 0.568
ENSG00000132382 E009 546.304364 1.895742e-04 1.092922e-01 2.979483e-01 17 4539363 4539438 76 - 2.636 2.678 0.138
ENSG00000132382 E010 788.431153 9.324624e-05 5.413485e-01 7.300253e-01 17 4539439 4539522 84 - 2.810 2.830 0.067
ENSG00000132382 E011 841.951596 2.170945e-04 5.813229e-02 1.985879e-01 17 4539523 4539621 99 - 2.822 2.863 0.137
ENSG00000132382 E012 1653.648170 5.160620e-04 3.296476e-02 1.359572e-01 17 4539622 4539967 346 - 3.113 3.154 0.136
ENSG00000132382 E013 648.530954 6.464031e-04 7.888550e-01 8.898007e-01 17 4540348 4540395 48 - 2.727 2.742 0.050
ENSG00000132382 E014 624.197958 1.079140e-04 8.648607e-01 9.330616e-01 17 4540396 4540435 40 - 2.714 2.728 0.046
ENSG00000132382 E015 625.215885 1.138074e-04 9.570101e-01 9.803730e-01 17 4540436 4540484 49 - 2.716 2.728 0.039
ENSG00000132382 E016 870.842719 4.874994e-04 5.716781e-01 7.514540e-01 17 4541463 4541564 102 - 2.854 2.874 0.066
ENSG00000132382 E017 71.894541 1.012944e-01 4.615225e-01 6.742120e-01 17 4541565 4541783 219 - 1.862 1.765 -0.325
ENSG00000132382 E018 982.776058 1.215606e-03 7.157609e-01 8.454309e-01 17 4541784 4541891 108 - 2.908 2.924 0.053
ENSG00000132382 E019 136.758099 8.462402e-02 5.636145e-01 7.458419e-01 17 4541892 4542423 532 - 2.109 2.051 -0.194
ENSG00000132382 E020 743.409192 2.586617e-03 2.582262e-01 4.969657e-01 17 4542464 4542532 69 - 2.766 2.807 0.136
ENSG00000132382 E021 877.862679 1.010429e-04 8.245837e-04 8.477956e-03 17 4542616 4542741 126 - 2.826 2.886 0.202
ENSG00000132382 E022 629.886540 1.093242e-04 3.144814e-04 3.876193e-03 17 4542913 4542999 87 - 2.671 2.746 0.247
ENSG00000132382 E023 615.037841 3.468931e-04 1.008856e-03 9.980600e-03 17 4543000 4543124 125 - 2.660 2.735 0.250
ENSG00000132382 E024 376.051003 1.142596e-03 9.900882e-03 5.771255e-02 17 4543125 4543165 41 - 2.440 2.523 0.279
ENSG00000132382 E025 10.580519 2.196580e-01 9.330124e-01 9.686579e-01 17 4543166 4543299 134 - 1.008 0.997 -0.042
ENSG00000132382 E026 747.196712 2.213333e-03 1.252736e-01 3.242298e-01 17 4544489 4544646 158 - 2.758 2.812 0.181
ENSG00000132382 E027 1.482221 1.228959e-02 9.604816e-01 9.820979e-01 17 4544647 4544695 49 - 0.337 0.352 0.092
ENSG00000132382 E028 867.613083 1.477441e-03 5.867629e-01 7.614400e-01 17 4544751 4544901 151 - 2.847 2.870 0.078
ENSG00000132382 E029 490.982274 1.291055e-03 8.801268e-01 9.412973e-01 17 4544902 4544921 20 - 2.608 2.622 0.048
ENSG00000132382 E030 430.930686 5.319418e-04 6.967990e-01 8.334980e-01 17 4545026 4545031 6 - 2.549 2.569 0.068
ENSG00000132382 E031 1029.987798 2.434792e-04 5.208869e-02 1.846053e-01 17 4545032 4545175 144 - 2.956 2.938 -0.059
ENSG00000132382 E032 20.818267 1.544005e-01 1.186552e-01 3.136490e-01 17 4545176 4545258 83 - 1.467 1.186 -0.983
ENSG00000132382 E033 863.370033 1.275092e-04 9.394533e-07 2.689947e-05 17 4545259 4545345 87 - 2.912 2.851 -0.202
ENSG00000132382 E034 933.265882 9.059309e-05 1.162770e-05 2.387150e-04 17 4545610 4545761 152 - 2.937 2.887 -0.166
ENSG00000132382 E035 632.940365 4.095062e-04 5.209368e-01 7.155279e-01 17 4545846 4545942 97 - 2.712 2.735 0.078
ENSG00000132382 E036 23.518369 1.332695e-01 2.645218e-02 1.166378e-01 17 4547685 4547957 273 - 1.579 1.195 -1.330
ENSG00000132382 E037 618.844356 1.511033e-04 9.325757e-01 9.684515e-01 17 4547958 4548057 100 - 2.713 2.723 0.031
ENSG00000132382 E038 415.936920 1.623960e-04 9.837527e-02 2.789313e-01 17 4548143 4548153 11 - 2.567 2.544 -0.079
ENSG00000132382 E039 888.465486 4.215881e-04 3.288194e-03 2.512196e-02 17 4548154 4548310 157 - 2.908 2.867 -0.136
ENSG00000132382 E040 884.880412 1.158616e-04 1.392670e-06 3.790181e-05 17 4548524 4548649 126 - 2.920 2.861 -0.196
ENSG00000132382 E041 856.249010 4.964948e-04 2.860969e-03 2.256762e-02 17 4549332 4549442 111 - 2.892 2.849 -0.145
ENSG00000132382 E042 1263.776430 7.827883e-05 4.294144e-03 3.080485e-02 17 4550058 4550353 296 - 3.049 3.025 -0.079
ENSG00000132382 E043 580.692298 1.073300e-04 9.094701e-01 9.568657e-01 17 4551880 4551997 118 - 2.688 2.697 0.030
ENSG00000132382 E044 416.442697 1.323479e-04 2.442494e-01 4.813648e-01 17 4552125 4552182 58 - 2.561 2.547 -0.043
ENSG00000132382 E045 627.928460 9.883007e-05 6.131067e-05 9.913321e-04 17 4552183 4552292 110 - 2.770 2.714 -0.185
ENSG00000132382 E046 8.931697 1.487436e-01 8.596815e-01 9.301865e-01 17 4552440 4552450 11 - 0.981 0.912 -0.258
ENSG00000132382 E047 791.765983 5.946953e-04 9.830118e-07 2.799348e-05 17 4552451 4552626 176 - 2.886 2.806 -0.268
ENSG00000132382 E048 545.079627 1.921305e-03 8.413248e-04 8.621549e-03 17 4553810 4553917 108 - 2.724 2.642 -0.275
ENSG00000132382 E049 3.708930 1.471772e-01 9.772861e-01 9.904081e-01 17 4553918 4554018 101 - 0.595 0.601 0.027
ENSG00000132382 E050 400.661352 1.662912e-03 1.091101e-03 1.060884e-02 17 4554019 4554093 75 - 2.592 2.508 -0.282
ENSG00000132382 E051 466.029187 2.874058e-03 1.481336e-01 3.596573e-01 17 4554195 4554278 84 - 2.626 2.586 -0.135
ENSG00000132382 E052 578.517200 4.595754e-02 4.645165e-01 6.762433e-01 17 4554861 4554956 96 - 2.643 2.701 0.192
ENSG00000132382 E053 745.546808 1.624462e+00 5.633680e-01 7.456440e-01 17 4555127 4555458 332 - 2.684 2.827 0.475