ENSG00000132376

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320345 ENSG00000132376 HEK293_OSMI2_6hA HEK293_TMG_6hB INPP5K protein_coding protein_coding 22.01584 30.36873 17.86127 3.410749 0.7137616 -0.765419 1.116417 1.475791 1.218617 0.5852011 0.08729112 -0.27419556 0.05138750 0.0454000 0.06806667 0.022666667 0.725457253 0.004813459 FALSE TRUE
ENST00000421807 ENSG00000132376 HEK293_OSMI2_6hA HEK293_TMG_6hB INPP5K protein_coding protein_coding 22.01584 30.36873 17.86127 3.410749 0.7137616 -0.765419 12.660922 18.364673 7.370203 2.6912515 0.12318175 -1.31598615 0.54380417 0.5997667 0.41376667 -0.186000000 0.004813459 0.004813459 FALSE TRUE
ENST00000481867 ENSG00000132376 HEK293_OSMI2_6hA HEK293_TMG_6hB INPP5K protein_coding retained_intron 22.01584 30.36873 17.86127 3.410749 0.7137616 -0.765419 1.269194 1.621085 1.530801 0.2334296 0.44266077 -0.08215105 0.06541667 0.0561000 0.08400000 0.027900000 0.768589167 0.004813459   FALSE
MSTRG.13360.5 ENSG00000132376 HEK293_OSMI2_6hA HEK293_TMG_6hB INPP5K protein_coding   22.01584 30.36873 17.86127 3.410749 0.7137616 -0.765419 2.700253 3.752734 2.147538 0.6519298 0.02307722 -0.80239504 0.13234583 0.1217000 0.12056667 -0.001133333 1.000000000 0.004813459 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000132376 E001 10.2698858 0.0099571285 0.6284401370 0.789573308 17 1494577 1494608 32 - 0.931 1.053 0.450
ENSG00000132376 E002 60.7146291 0.3248608816 0.1805395371 0.404659432 17 1494609 1494756 148 - 1.516 1.814 1.014
ENSG00000132376 E003 319.8626945 1.2323039537 0.4190638078 0.642906014 17 1494757 1495566 810 - 2.266 2.521 0.853
ENSG00000132376 E004 163.5526519 0.9303492027 0.3381631932 0.576394247 17 1495567 1495799 233 - 1.948 2.237 0.969
ENSG00000132376 E005 133.2265797 0.8859870031 0.3412267750 0.579195968 17 1495800 1495879 80 - 1.866 2.148 0.946
ENSG00000132376 E006 159.8770490 0.9417252712 0.3667558381 0.601303103 17 1496060 1496154 95 - 1.959 2.223 0.884
ENSG00000132376 E007 97.6741123 0.5260747937 0.2691433889 0.508904377 17 1496155 1496164 10 - 1.745 2.012 0.900
ENSG00000132376 E008 1.8396641 0.0107505069 0.9554575913 0.979597925 17 1496165 1496318 154 - 0.400 0.456 0.295
ENSG00000132376 E009 158.8665615 0.0086571962 0.0735457963 0.231863066 17 1496319 1496402 84 - 2.042 2.203 0.536
ENSG00000132376 E010 1.0425010 0.0173582530 0.6015468590   17 1496403 1496461 59 - 0.177 0.309 1.037
ENSG00000132376 E011 3.9040181 0.0066191262 0.0063300422 0.041352006 17 1496489 1496665 177 - 0.878 0.541 -1.405
ENSG00000132376 E012 184.9310935 0.0016997525 0.7855083539 0.887828304 17 1496666 1496803 138 - 2.182 2.245 0.212
ENSG00000132376 E013 4.2212221 0.0497000008 0.0485021024 0.176206494 17 1497758 1497935 178 - 0.848 0.572 -1.148
ENSG00000132376 E014 174.9847281 0.0012197876 0.1777375910 0.400758539 17 1497936 1498060 125 - 2.184 2.213 0.097
ENSG00000132376 E015 81.3996569 0.0054347481 0.2012235410 0.431254379 17 1498061 1498078 18 - 1.870 1.878 0.028
ENSG00000132376 E016 101.6137149 0.0004339344 0.1115693890 0.301651344 17 1498079 1498122 44 - 1.965 1.975 0.035
ENSG00000132376 E017 0.3447487 0.6466276636 0.8927209451   17 1498123 1498201 79 - 0.000 0.153 10.646
ENSG00000132376 E018 81.8122285 0.0005335776 0.0003875126 0.004609733 17 1506980 1506992 13 - 1.933 1.855 -0.263
ENSG00000132376 E019 135.6721905 0.0057871825 0.1649257211 0.383894580 17 1506993 1507085 93 - 2.091 2.095 0.014
ENSG00000132376 E020 69.9863022 0.0156995720 0.4918290488 0.695215493 17 1507086 1507089 4 - 1.795 1.816 0.071
ENSG00000132376 E021 13.1486335 0.0837514795 0.0046787867 0.032896379 17 1507090 1507705 616 - 1.344 0.957 -1.386
ENSG00000132376 E022 83.7422992 0.0147682188 0.4643820748 0.676144219 17 1508115 1508129 15 - 1.871 1.894 0.076
ENSG00000132376 E023 136.5740599 0.0110632309 0.1318955703 0.334801672 17 1508130 1508226 97 - 2.106 2.091 -0.052
ENSG00000132376 E024 12.3900098 0.0321866130 0.0130345875 0.070593106 17 1508227 1508500 274 - 1.256 1.003 -0.907
ENSG00000132376 E025 2.9876856 0.0073852107 0.0472830756 0.173226771 17 1508977 1509167 191 - 0.743 0.486 -1.136
ENSG00000132376 E026 5.2842403 0.0140339990 0.1657237596 0.384755329 17 1509168 1509177 10 - 0.848 0.711 -0.548
ENSG00000132376 E027 133.6276335 0.0162731626 0.0407911195 0.156761038 17 1509178 1509249 72 - 2.129 2.066 -0.211
ENSG00000132376 E028 127.7389068 0.0098421951 0.0262391439 0.116047893 17 1509250 1509340 91 - 2.102 2.051 -0.170
ENSG00000132376 E029 65.7342982 0.0047507031 0.0224048415 0.103918102 17 1509341 1509353 13 - 1.823 1.766 -0.190
ENSG00000132376 E030 74.5819229 0.0009990413 0.0052204040 0.035785285 17 1509683 1509714 32 - 1.878 1.824 -0.182
ENSG00000132376 E031 118.1032418 0.0218571867 0.3273129491 0.566414658 17 1509715 1509799 85 - 2.030 2.034 0.016
ENSG00000132376 E032 0.3559677 0.7979207515 0.1446255973   17 1510421 1510513 93 - 0.312 0.000 -13.280
ENSG00000132376 E033 109.7896395 0.0203940349 0.2290552903 0.464026251 17 1513453 1513554 102 - 2.010 1.998 -0.039
ENSG00000132376 E034 51.4515746 0.0189224458 0.3164222191 0.556443725 17 1513555 1513561 7 - 1.682 1.681 -0.003
ENSG00000132376 E035 114.2174064 0.0181870879 0.4264033141 0.648322545 17 1513872 1513979 108 - 2.001 2.027 0.089
ENSG00000132376 E036 5.0283036 0.0074827781 0.1542154195 0.368293140 17 1515427 1515568 142 - 0.848 0.709 -0.552
ENSG00000132376 E037 5.9783402 0.0788174529 0.0253953563 0.113427324 17 1515569 1515585 17 - 1.004 0.714 -1.122
ENSG00000132376 E038 0.1426347 0.0313933360 0.1613804404   17 1515586 1515701 116 - 0.177 0.000 -12.221
ENSG00000132376 E039 22.1071858 0.0024498992 0.0013385752 0.012449797 17 1515888 1516118 231 - 1.443 1.263 -0.625
ENSG00000132376 E040 89.9878767 0.0145907985 0.5881480993 0.762439311 17 1516456 1516742 287 - 1.827 1.948 0.407