ENSG00000132359

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366401 ENSG00000132359 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1GAP2 protein_coding protein_coding 4.111476 4.802329 2.889014 0.1945374 0.2699873 -0.731173 0.2093065 0.6553161 0.09235546 0.10309580 0.09235546 -2.7004519 0.04895000 0.13840000 0.0390000 -0.09940000 3.656731e-01 4.554476e-05 FALSE TRUE
ENST00000574709 ENSG00000132359 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1GAP2 protein_coding processed_transcript 4.111476 4.802329 2.889014 0.1945374 0.2699873 -0.731173 0.5502974 0.7669700 0.00000000 0.22588937 0.00000000 -6.2797870 0.12649583 0.15806667 0.0000000 -0.15806667 4.554476e-05 4.554476e-05 FALSE TRUE
ENST00000575979 ENSG00000132359 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1GAP2 protein_coding retained_intron 4.111476 4.802329 2.889014 0.1945374 0.2699873 -0.731173 0.2648119 0.2607276 0.45794537 0.19769598 0.09894985 0.7894980 0.06817917 0.05323333 0.1562333 0.10300000 4.249549e-01 4.554476e-05 FALSE FALSE
ENST00000637138 ENSG00000132359 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1GAP2 protein_coding protein_coding 4.111476 4.802329 2.889014 0.1945374 0.2699873 -0.731173 0.2307836 0.3254758 0.00000000 0.12844403 0.00000000 -5.0681369 0.05111667 0.06720000 0.0000000 -0.06720000 1.926683e-02 4.554476e-05 FALSE TRUE
MSTRG.13422.10 ENSG00000132359 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1GAP2 protein_coding   4.111476 4.802329 2.889014 0.1945374 0.2699873 -0.731173 1.6983713 2.0726097 1.40046893 0.15239334 0.20073311 -0.5622176 0.41758333 0.43376667 0.4916000 0.05783333 8.939374e-01 4.554476e-05 FALSE TRUE
MSTRG.13422.9 ENSG00000132359 HEK293_OSMI2_6hA HEK293_TMG_6hB RAP1GAP2 protein_coding   4.111476 4.802329 2.889014 0.1945374 0.2699873 -0.731173 0.6348063 0.3683541 0.43789747 0.05208392 0.10243447 0.2434315 0.15661250 0.07726667 0.1517667 0.07450000 4.444528e-01 4.554476e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000132359 E001 2.3925011 0.1421960415 0.007543529 0.04722819 17 2755705 2755767 63 + 0.000 0.641 12.911
ENSG00000132359 E002 3.5762765 0.0068639111 0.013770835 0.07342847 17 2770329 2770445 117 + 0.290 0.731 2.206
ENSG00000132359 E003 0.0000000       17 2776613 2776720 108 +      
ENSG00000132359 E004 0.3337900 0.0275469004 0.566410815   17 2776887 2776947 61 + 0.169 0.086 -1.114
ENSG00000132359 E005 0.1723744 0.0319248134 1.000000000   17 2777056 2777278 223 + 0.000 0.086 11.643
ENSG00000132359 E006 0.0000000       17 2786466 2786499 34 +      
ENSG00000132359 E007 0.0000000       17 2796438 2796481 44 +      
ENSG00000132359 E008 0.0000000       17 2796482 2796571 90 +      
ENSG00000132359 E009 1.0536473 0.2552247173 0.541551162   17 2800515 2800550 36 + 0.169 0.329 1.251
ENSG00000132359 E010 2.3927565 0.0088305412 0.699199095 0.83506869 17 2905284 2905368 85 + 0.462 0.533 0.343
ENSG00000132359 E011 2.9290931 0.0077490456 0.396946586 0.62587967 17 2957759 2957794 36 + 0.462 0.609 0.692
ENSG00000132359 E012 0.9291287 0.0172671820 0.421340195   17 2962670 2962714 45 + 0.169 0.321 1.204
ENSG00000132359 E013 4.8450448 0.0060300774 0.088885821 0.26170295 17 2963430 2963462 33 + 0.528 0.797 1.151
ENSG00000132359 E014 10.7651811 0.0570795811 0.101188876 0.28393778 17 2963856 2964068 213 + 0.854 1.103 0.927
ENSG00000132359 E015 8.1255388 0.0318219957 0.069394353 0.22355181 17 2965540 2965643 104 + 0.721 1.001 1.080
ENSG00000132359 E016 0.0000000       17 2975611 2975614 4 +      
ENSG00000132359 E017 11.3234670 0.0030123719 0.027619644 0.12017860 17 2975615 2975771 157 + 1.196 0.980 -0.783
ENSG00000132359 E018 5.4332197 0.0057432251 0.195834280 0.42439085 17 2975772 2975775 4 + 0.883 0.714 -0.672
ENSG00000132359 E019 19.2836507 0.0017827833 0.005658048 0.03802853 17 2980287 2980365 79 + 1.410 1.196 -0.748
ENSG00000132359 E020 15.1111599 0.0021152223 0.001087993 0.01058590 17 2981195 2981248 54 + 1.349 1.070 -0.992
ENSG00000132359 E021 21.6816095 0.0018119891 0.002290204 0.01898698 17 2984983 2985066 84 + 1.469 1.247 -0.774
ENSG00000132359 E022 19.2357502 0.0018629231 0.001773602 0.01552409 17 2991297 2991344 48 + 1.425 1.183 -0.846
ENSG00000132359 E023 18.7694609 0.0028486637 0.105244073 0.29109180 17 2991345 2991397 53 + 1.349 1.219 -0.455
ENSG00000132359 E024 27.9154347 0.0021278433 0.210696022 0.44263185 17 2995337 2995466 130 + 1.483 1.400 -0.286
ENSG00000132359 E025 29.1847478 0.0012720670 0.384160814 0.61572695 17 2998221 2998376 156 + 1.483 1.429 -0.186
ENSG00000132359 E026 0.1426347 0.0315937259 0.222983098   17 3005341 3005368 28 + 0.169 0.000 -13.719
ENSG00000132359 E027 18.5876093 0.0021514362 0.551628374 0.73744557 17 3005369 3005440 72 + 1.222 1.278 0.197
ENSG00000132359 E028 26.0923880 0.0219698889 0.834285029 0.91617011 17 3005955 3006041 87 + 1.379 1.403 0.083
ENSG00000132359 E029 25.3118085 0.0017550945 0.784546833 0.88726570 17 3008011 3008100 90 + 1.368 1.392 0.085
ENSG00000132359 E030 15.4926064 0.0026809597 0.615108801 0.78035586 17 3008101 3008145 45 + 1.155 1.207 0.184
ENSG00000132359 E031 22.9133744 0.0018809349 0.457674942 0.67155354 17 3018061 3018198 138 + 1.385 1.334 -0.177
ENSG00000132359 E032 22.6664783 0.0020764276 0.470007340 0.68009557 17 3020477 3020595 119 + 1.376 1.326 -0.177
ENSG00000132359 E033 27.0167492 0.0014622613 0.754474653 0.86939541 17 3026008 3026121 114 + 1.425 1.408 -0.062
ENSG00000132359 E034 1.7678657 0.0144673396 0.119931813 0.31574081 17 3026122 3026248 127 + 0.585 0.322 -1.377
ENSG00000132359 E035 21.2584672 0.0034739198 0.087606615 0.25927121 17 3026350 3026464 115 + 1.209 1.360 0.526
ENSG00000132359 E036 23.6631730 0.0014134552 0.227676980 0.46258600 17 3026944 3027070 127 + 1.290 1.388 0.341
ENSG00000132359 E037 21.1692832 0.0026666238 0.309974348 0.55044201 17 3030922 3030998 77 + 1.246 1.335 0.313
ENSG00000132359 E038 14.6631106 0.0021665098 0.618838583 0.78304642 17 3032411 3032449 39 + 1.125 1.177 0.185
ENSG00000132359 E039 0.7788594 0.0238181401 0.109868055   17 3033081 3033391 311 + 0.000 0.321 13.898
ENSG00000132359 E040 63.7304305 0.0117335488 0.489326896 0.69354901 17 3033392 3034212 821 + 1.734 1.792 0.193
ENSG00000132359 E041 10.0224899 0.0200193177 0.665146316 0.81313270 17 3034213 3034229 17 + 0.958 1.022 0.236
ENSG00000132359 E042 21.2874777 0.0158563475 0.639997871 0.79689092 17 3034230 3034400 171 + 1.278 1.330 0.181
ENSG00000132359 E043 26.0152153 0.0016793998 0.997543654 1.00000000 17 3034401 3034693 293 + 1.402 1.407 0.018
ENSG00000132359 E044 14.8283051 0.0703255547 0.267625222 0.50731137 17 3034694 3034751 58 + 1.268 1.127 -0.501
ENSG00000132359 E045 234.0239497 0.0004464416 0.012578238 0.06875480 17 3034752 3037741 2990 + 2.295 2.356 0.204