ENSG00000132305

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000254636 ENSG00000132305 HEK293_OSMI2_6hA HEK293_TMG_6hB IMMT protein_coding protein_coding 78.9819 67.82345 83.24027 13.45546 4.015543 0.2954581 34.325764 26.392306 42.115705 4.0143797 1.7378573 0.6740369 0.4350875 0.39913333 0.50650000 0.10736667 0.17635831 0.01577446 FALSE TRUE
ENST00000410111 ENSG00000132305 HEK293_OSMI2_6hA HEK293_TMG_6hB IMMT protein_coding protein_coding 78.9819 67.82345 83.24027 13.45546 4.015543 0.2954581 12.510503 10.477191 15.544907 2.2041604 1.0778110 0.5687415 0.1590750 0.15380000 0.18636667 0.03256667 0.42443694 0.01577446 FALSE TRUE
ENST00000419070 ENSG00000132305 HEK293_OSMI2_6hA HEK293_TMG_6hB IMMT protein_coding protein_coding 78.9819 67.82345 83.24027 13.45546 4.015543 0.2954581 23.605676 25.414948 14.125674 6.9608100 1.8198124 -0.8469042 0.2960667 0.35990000 0.16836667 -0.19153333 0.01577446 0.01577446 FALSE TRUE
ENST00000449247 ENSG00000132305 HEK293_OSMI2_6hA HEK293_TMG_6hB IMMT protein_coding protein_coding 78.9819 67.82345 83.24027 13.45546 4.015543 0.2954581 5.527383 3.705685 6.605111 0.8438663 0.5512796 0.8321373 0.0702875 0.05553333 0.08023333 0.02470000 0.58949956 0.01577446 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000132305 E001 0.6901176 0.1637997059 2.941880e-01   2 86143691 86143895 205 - 0.110 0.322 1.931
ENSG00000132305 E002 0.0000000       2 86143896 86143898 3 -      
ENSG00000132305 E003 0.3751086 0.0313225392 1.800291e-01   2 86143899 86143931 33 - 0.000 0.236 11.796
ENSG00000132305 E004 1.7927182 0.1675281776 1.715186e-02 8.600898e-02 2 86143932 86143935 4 - 0.111 0.640 3.535
ENSG00000132305 E005 5.8575507 0.0049589232 4.295145e-08 1.739186e-06 2 86143936 86143939 4 - 0.272 1.109 3.771
ENSG00000132305 E006 1682.2918938 2.0467987942 4.387071e-01 6.577825e-01 2 86143940 86144881 942 - 3.030 3.381 1.167
ENSG00000132305 E007 551.5932179 0.0319145682 1.073659e-01 2.946161e-01 2 86146068 86146197 130 - 2.652 2.829 0.589
ENSG00000132305 E008 611.0833134 0.0001078611 4.269063e-02 1.617568e-01 2 86147702 86147833 132 - 2.745 2.836 0.304
ENSG00000132305 E009 898.4361494 0.0048381778 2.898477e-01 5.304289e-01 2 86151297 86151520 224 - 2.940 2.968 0.093
ENSG00000132305 E010 316.0372754 0.0072286244 8.593648e-02 2.563078e-01 2 86153560 86153574 15 - 2.505 2.494 -0.037
ENSG00000132305 E011 4.7269246 0.1811956075 3.614812e-01 5.969139e-01 2 86158376 86158476 101 - 0.815 0.667 -0.604
ENSG00000132305 E012 5.9310135 0.0891946287 7.673377e-01 8.769985e-01 2 86158477 86158591 115 - 0.792 0.881 0.343
ENSG00000132305 E013 577.6007466 0.0067325577 1.022751e-01 2.858664e-01 2 86158592 86158721 130 - 2.762 2.759 -0.010
ENSG00000132305 E014 8.1054480 0.1062633383 3.866145e-01 6.177880e-01 2 86159247 86159535 289 - 1.006 0.877 -0.483
ENSG00000132305 E015 557.9168597 0.0031966638 1.026593e-01 2.865345e-01 2 86159536 86159671 136 - 2.740 2.753 0.042
ENSG00000132305 E016 3.5699205 0.0073324685 5.093054e-01 7.074008e-01 2 86161952 86161975 24 - 0.678 0.627 -0.218
ENSG00000132305 E017 518.0083425 0.0039713478 9.575719e-03 5.630028e-02 2 86161976 86162079 104 - 2.725 2.699 -0.085
ENSG00000132305 E018 475.3880819 0.0034950283 9.776096e-04 9.737279e-03 2 86166508 86166644 137 - 2.696 2.651 -0.152
ENSG00000132305 E019 344.2214726 0.0074857134 1.421219e-03 1.304923e-02 2 86170749 86170790 42 - 2.572 2.487 -0.285
ENSG00000132305 E020 351.1581958 0.0050489720 5.272439e-04 5.926146e-03 2 86170791 86170841 51 - 2.575 2.504 -0.236
ENSG00000132305 E021 146.3781309 0.0020594576 4.890063e-05 8.164030e-04 2 86170842 86170844 3 - 2.204 2.119 -0.283
ENSG00000132305 E022 423.1297673 0.0063757348 5.666674e-04 6.280155e-03 2 86171208 86171309 102 - 2.660 2.581 -0.261
ENSG00000132305 E023 212.2596060 0.0051025920 2.726584e-03 2.172249e-02 2 86171310 86171312 3 - 2.354 2.293 -0.203
ENSG00000132305 E024 114.8276469 0.0004168646 5.344739e-04 5.988385e-03 2 86171313 86171345 33 - 2.088 2.032 -0.186
ENSG00000132305 E025 2.0939061 0.0101084220 4.902229e-01 6.941619e-01 2 86171346 86171381 36 - 0.521 0.447 -0.367
ENSG00000132305 E026 6.0194320 0.1148228057 3.725019e-01 6.060835e-01 2 86171382 86171577 196 - 0.898 0.779 -0.466
ENSG00000132305 E027 2.9606025 0.1211930938 3.846339e-01 6.161943e-01 2 86173508 86173649 142 - 0.650 0.504 -0.663
ENSG00000132305 E028 446.0726923 0.0072296353 4.869590e-03 3.392273e-02 2 86173650 86173761 112 - 2.676 2.614 -0.207
ENSG00000132305 E029 0.4702677 0.0215867929 6.120209e-01   2 86173762 86173762 1 - 0.199 0.133 -0.693
ENSG00000132305 E030 532.9418776 0.0062086087 7.391397e-02 2.325834e-01 2 86179433 86179622 190 - 2.731 2.720 -0.035
ENSG00000132305 E031 307.4919025 0.0071902869 1.959332e-01 4.244691e-01 2 86181299 86181372 74 - 2.487 2.491 0.014
ENSG00000132305 E032 0.0000000       2 86194922 86195002 81 -      
ENSG00000132305 E033 247.8325597 0.0085206254 2.834752e-01 5.239436e-01 2 86195338 86196258 921 - 2.390 2.402 0.038
ENSG00000132305 E034 0.8899192 1.4260815413 4.643499e-01   2 86196259 86196921 663 - 0.410 0.000 -12.642
ENSG00000132305 E035 0.1723744 0.0577013019 4.510701e-01   2 86199310 86199393 84 - 0.000 0.134 10.794