ENSG00000132164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000254488 ENSG00000132164 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC6A11 protein_coding protein_coding 5.0288 4.876651 5.180361 0.3168324 0.2722474 0.08698885 2.7954838 3.5786559 2.3248877 0.12382329 0.08657500 -0.6200904 0.57870417 0.73686667 0.45280000 -0.28406667 0.00211755 0.00211755 FALSE TRUE
ENST00000454147 ENSG00000132164 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC6A11 protein_coding protein_coding 5.0288 4.876651 5.180361 0.3168324 0.2722474 0.08698885 0.4688335 0.2823504 0.6433493 0.03770519 0.05234293 1.1601560 0.09472083 0.05876667 0.12590000 0.06713333 0.26578252 0.00211755 FALSE TRUE
ENST00000464828 ENSG00000132164 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC6A11 protein_coding retained_intron 5.0288 4.876651 5.180361 0.3168324 0.2722474 0.08698885 0.3238982 0.4421534 0.3048030 0.02423451 0.04345252 -0.5223630 0.06655833 0.09080000 0.05946667 -0.03133333 0.63180333 0.00211755 FALSE TRUE
MSTRG.22459.2 ENSG00000132164 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC6A11 protein_coding   5.0288 4.876651 5.180361 0.3168324 0.2722474 0.08698885 0.8456152 0.3376178 1.0358865 0.16980136 0.38142728 1.5891525 0.15245417 0.06606667 0.19970000 0.13363333 0.64492878 0.00211755 FALSE TRUE
MSTRG.22459.4 ENSG00000132164 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC6A11 protein_coding   5.0288 4.876651 5.180361 0.3168324 0.2722474 0.08698885 0.3850913 0.1923033 0.8714343 0.11747861 0.48581794 2.1233335 0.07056250 0.03766667 0.16216667 0.12450000 0.82621004 0.00211755 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000132164 E001 0.5283420 0.3255933005 4.871430e-01   3 10816184 10816200 17 + 0.248 0.107 -1.463
ENSG00000132164 E002 0.5283420 0.3255933005 4.871430e-01   3 10816201 10816205 5 + 0.248 0.107 -1.463
ENSG00000132164 E003 0.7063259 0.6092774040 4.523601e-01   3 10816206 10816227 22 + 0.338 0.107 -2.073
ENSG00000132164 E004 0.3503582 0.0269188595 8.156663e-01   3 10816228 10816234 7 + 0.139 0.106 -0.447
ENSG00000132164 E005 5.8249639 0.0067056040 4.098594e-01 6.358856e-01 3 10816235 10816398 164 + 0.771 0.882 0.434
ENSG00000132164 E006 17.8377633 0.0044519249 6.190238e-02 2.070969e-01 3 10816399 10816521 123 + 1.358 1.208 -0.526
ENSG00000132164 E007 35.9558353 0.0010493543 1.623558e-03 1.448704e-02 3 10819465 10819599 135 + 1.657 1.481 -0.601
ENSG00000132164 E008 45.1929107 0.0009008838 4.478990e-05 7.575296e-04 3 10819712 10819852 141 + 1.768 1.564 -0.693
ENSG00000132164 E009 31.4545890 0.0016750145 9.273197e-02 2.688477e-01 3 10823302 10823392 91 + 1.565 1.465 -0.343
ENSG00000132164 E010 24.5379668 0.0038690368 4.762066e-07 1.483052e-05 3 10823393 10825498 2106 + 1.570 1.203 -1.274
ENSG00000132164 E011 38.0863817 0.0036644699 2.952065e-01 5.357104e-01 3 10844214 10844346 133 + 1.623 1.563 -0.204
ENSG00000132164 E012 34.0660696 0.0011554499 3.697891e-01 6.038418e-01 3 10874961 10875095 135 + 1.566 1.516 -0.170
ENSG00000132164 E013 30.5871757 0.0015773548 3.592507e-01 5.952508e-01 3 10912090 10912193 104 + 1.524 1.469 -0.186
ENSG00000132164 E014 30.4186595 0.0012691240 9.881404e-02 2.797190e-01 3 10918329 10918453 125 + 1.547 1.448 -0.340
ENSG00000132164 E015 6.2286408 0.0934470063 6.842702e-02 2.215578e-01 3 10923919 10924084 166 + 1.015 0.688 -1.272
ENSG00000132164 E016 26.5538569 0.0017907250 6.267265e-01 7.883389e-01 3 10926004 10926116 113 + 1.455 1.426 -0.099
ENSG00000132164 E017 32.1144162 0.0137733019 6.174097e-01 7.820335e-01 3 10929202 10929339 138 + 1.483 1.530 0.161
ENSG00000132164 E018 29.7797595 0.0020147082 9.843207e-01 9.940097e-01 3 10933151 10933253 103 + 1.477 1.482 0.017
ENSG00000132164 E019 2.7852411 0.0076920693 5.720949e-01 7.517807e-01 3 10933966 10934065 100 + 0.513 0.607 0.429
ENSG00000132164 E020 31.0710140 0.0015228273 6.414701e-02 2.120045e-01 3 10934066 10934166 101 + 1.419 1.541 0.421
ENSG00000132164 E021 37.5082355 0.0120412401 2.006026e-01 4.304696e-01 3 10935029 10935199 171 + 1.513 1.613 0.343
ENSG00000132164 E022 1.9456619 0.0100989605 5.887174e-01 7.627995e-01 3 10935200 10935397 198 + 0.513 0.425 -0.446
ENSG00000132164 E023 41.7554439 0.0051553562 6.543757e-02 2.148855e-01 3 10938250 10938447 198 + 1.547 1.666 0.405
ENSG00000132164 E024 72.8309587 0.0037902844 2.131594e-02 1.003671e-01 3 10938448 10939098 651 + 1.788 1.903 0.389
ENSG00000132164 E025 75.5832869 0.0008926357 2.826953e-05 5.124150e-04 3 10939099 10939947 849 + 1.760 1.939 0.602
ENSG00000132164 E026 53.8498331 0.0033066522 2.580787e-05 4.739155e-04 3 10939948 10940714 767 + 1.583 1.818 0.797
ENSG00000132164 E027 0.0000000       3 10941034 10941136 103 +      
ENSG00000132164 E028 0.8631121 0.1970360160 8.841210e-01   3 10945582 10945673 92 + 0.241 0.268 0.200