ENSG00000132128

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343304 ENSG00000132128 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC41 protein_coding protein_coding 55.64219 85.6792 23.71802 16.73974 0.5764689 -1.852522 7.412744 13.57444 0.00000 2.081242 0.0000000 -10.40774 0.1030458 0.1620000 0.0000000 -0.1620 8.026712e-30 8.026712e-30 FALSE TRUE
ENST00000615587 ENSG00000132128 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC41 protein_coding protein_coding 55.64219 85.6792 23.71802 16.73974 0.5764689 -1.852522 41.435762 64.47794 20.01524 14.132071 0.7532896 -1.68721 0.7610833 0.7430667 0.8433667 0.1003 1.232619e-01 8.026712e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000132128 E001 0.5233527 0.0209415228 6.148132e-02   1 46261196 46261404 209 - 0.381 0.060 -3.235
ENSG00000132128 E002 1.4013017 0.2310693374 9.794611e-02 0.2781847696 1 46267495 46267677 183 - 0.584 0.207 -2.218
ENSG00000132128 E003 37.9619735 0.0799306833 9.118649e-01 0.9581029339 1 46277462 46278400 939 - 1.493 1.467 -0.089
ENSG00000132128 E004 5.5546834 0.0175470258 6.380135e-01 0.7957328336 1 46278401 46278402 2 - 0.654 0.725 0.295
ENSG00000132128 E005 6.1921485 0.0049949654 7.635342e-01 0.8747855976 1 46278403 46278403 1 - 0.717 0.759 0.172
ENSG00000132128 E006 634.9354682 0.0096568899 1.472588e-01 0.3583928888 1 46278404 46278731 328 - 2.631 2.690 0.198
ENSG00000132128 E007 936.1627089 0.0010636833 6.929978e-04 0.0073840485 1 46278732 46279011 280 - 2.794 2.860 0.219
ENSG00000132128 E008 424.8446466 0.0034647002 2.941770e-04 0.0036706844 1 46279012 46279084 73 - 2.394 2.526 0.440
ENSG00000132128 E009 373.6066634 0.0022868966 5.933660e-06 0.0001336435 1 46279182 46279257 76 - 2.320 2.473 0.510
ENSG00000132128 E010 34.0819517 0.0555002602 3.144874e-01 0.5547197672 1 46279258 46279491 234 - 1.555 1.392 -0.561
ENSG00000132128 E011 566.3627373 0.0018195328 7.895834e-02 0.2427485174 1 46279492 46279614 123 - 2.594 2.638 0.147
ENSG00000132128 E012 479.0877292 0.0001701630 6.311623e-01 0.7911564275 1 46280192 46280290 99 - 2.574 2.559 -0.049
ENSG00000132128 E013 489.6098888 0.0001971272 2.341895e-01 0.4699535603 1 46280396 46280560 165 - 2.554 2.574 0.069
ENSG00000132128 E014 727.9457222 0.0001769175 6.925610e-01 0.8307454870 1 46281125 46281385 261 - 2.742 2.743 0.004
ENSG00000132128 E015 26.9418677 0.0017031273 2.427764e-02 0.1099588720 1 46284167 46284430 264 - 1.474 1.287 -0.647
ENSG00000132128 E016 44.9616987 0.0224257902 7.314701e-04 0.0077088523 1 46285005 46285361 357 - 1.791 1.461 -1.124
ENSG00000132128 E017 1966.8298036 0.0007211279 4.592456e-06 0.0001069681 1 46285362 46286499 1138 - 3.229 3.159 -0.234
ENSG00000132128 E018 18.2597512 0.1574848539 4.571557e-04 0.0052881648 1 46296742 46297562 821 - 1.668 0.912 -2.667
ENSG00000132128 E019 383.6906853 0.0029870656 1.945150e-03 0.0166994215 1 46297563 46297633 71 - 2.555 2.439 -0.385
ENSG00000132128 E020 334.7098165 0.0002699363 1.073300e-01 0.2945602973 1 46298284 46298370 87 - 2.444 2.398 -0.151
ENSG00000132128 E021 63.2637255 0.1921554755 3.969584e-02 0.1539383133 1 46298371 46300780 2410 - 1.991 1.585 -1.371
ENSG00000132128 E022 251.0291010 0.0004965967 3.913977e-03 0.0286637317 1 46303124 46303616 493 - 2.211 2.298 0.290