ENSG00000132024

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318003 ENSG00000132024 HEK293_OSMI2_6hA HEK293_TMG_6hB CC2D1A protein_coding protein_coding 32.09198 52.32855 20.15298 5.424013 1.259985 -1.376165 6.9992236 14.1082969 2.063059 2.3986338 0.5023941 -2.7677327 0.21342917 0.26626667 0.10603333 -0.1602333333 1.224593e-01 1.157868e-13 FALSE  
ENST00000585896 ENSG00000132024 HEK293_OSMI2_6hA HEK293_TMG_6hB CC2D1A protein_coding retained_intron 32.09198 52.32855 20.15298 5.424013 1.259985 -1.376165 1.6971104 2.5481390 1.579389 0.5596860 0.1662321 -0.6866222 0.05828333 0.05170000 0.07800000 0.0263000000 6.249956e-01 1.157868e-13 FALSE  
ENST00000587508 ENSG00000132024 HEK293_OSMI2_6hA HEK293_TMG_6hB CC2D1A protein_coding protein_coding 32.09198 52.32855 20.15298 5.424013 1.259985 -1.376165 5.7950416 8.5348480 1.157132 1.3814649 0.7258539 -2.8720866 0.14540833 0.16166667 0.05410000 -0.1075666667 5.831289e-01 1.157868e-13 FALSE  
ENST00000588932 ENSG00000132024 HEK293_OSMI2_6hA HEK293_TMG_6hB CC2D1A protein_coding retained_intron 32.09198 52.32855 20.15298 5.424013 1.259985 -1.376165 0.7070221 0.5918463 1.473206 0.5918463 0.8153533 1.3012520 0.03065833 0.01363333 0.06940000 0.0557666667 5.897913e-01 1.157868e-13 FALSE  
ENST00000589224 ENSG00000132024 HEK293_OSMI2_6hA HEK293_TMG_6hB CC2D1A protein_coding retained_intron 32.09198 52.32855 20.15298 5.424013 1.259985 -1.376165 0.5210453 0.0000000 1.182538 0.0000000 0.1877598 6.8978914 0.02582500 0.00000000 0.06016667 0.0601666667 1.157868e-13 1.157868e-13 FALSE  
ENST00000589606 ENSG00000132024 HEK293_OSMI2_6hA HEK293_TMG_6hB CC2D1A protein_coding protein_coding 32.09198 52.32855 20.15298 5.424013 1.259985 -1.376165 0.2694521 0.0000000 1.478608 0.0000000 0.7667267 7.2178196 0.01477917 0.00000000 0.07810000 0.0781000000 1.885662e-01 1.157868e-13 FALSE  
ENST00000589679 ENSG00000132024 HEK293_OSMI2_6hA HEK293_TMG_6hB CC2D1A protein_coding retained_intron 32.09198 52.32855 20.15298 5.424013 1.259985 -1.376165 2.7183717 4.5215430 3.163407 0.2456519 0.5014234 -0.5139696 0.09131667 0.08760000 0.15516667 0.0675666667 6.848369e-02 1.157868e-13 FALSE  
MSTRG.16574.3 ENSG00000132024 HEK293_OSMI2_6hA HEK293_TMG_6hB CC2D1A protein_coding   32.09198 52.32855 20.15298 5.424013 1.259985 -1.376165 5.7782397 10.0690347 3.925019 1.9418158 1.4236363 -1.3569151 0.18754583 0.18913333 0.18820000 -0.0009333333 9.830383e-01 1.157868e-13 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000132024 E001 1.404558 0.0125553922 9.076311e-02 2.651403e-01 19 13906201 13906202 2 + 0.000 0.390 11.297
ENSG00000132024 E002 3.445961 0.0072036566 3.487513e-03 2.626430e-02 19 13906203 13906213 11 + 0.000 0.659 12.577
ENSG00000132024 E003 32.284317 0.0323069293 2.986276e-06 7.405641e-05 19 13906214 13906255 42 + 0.829 1.509 2.444
ENSG00000132024 E004 44.731284 0.1843794283 1.730743e-02 8.658164e-02 19 13906256 13906283 28 + 1.126 1.630 1.752
ENSG00000132024 E005 103.547192 0.4969490342 1.367485e-01 3.425329e-01 19 13906284 13906441 158 + 1.581 1.977 1.338
ENSG00000132024 E006 79.159327 0.0990803916 3.542597e-02 1.426916e-01 19 13906442 13906501 60 + 1.547 1.854 1.040
ENSG00000132024 E007 166.108633 0.0010981269 7.057646e-01 8.392036e-01 19 13909823 13909958 136 + 2.118 2.132 0.048
ENSG00000132024 E008 212.711469 0.0006304297 8.059974e-02 2.460443e-01 19 13912323 13912438 116 + 2.277 2.223 -0.181
ENSG00000132024 E009 182.197267 0.0003547150 2.627475e-02 1.161298e-01 19 13912528 13912593 66 + 2.222 2.151 -0.235
ENSG00000132024 E010 173.014401 0.0013208855 3.745418e-02 1.481720e-01 19 13913168 13913252 85 + 2.203 2.128 -0.253
ENSG00000132024 E011 133.295948 0.0035603933 5.758524e-01 7.542786e-01 19 13913253 13913302 50 + 2.052 2.025 -0.092
ENSG00000132024 E012 222.393664 0.0003233459 1.649894e-01 3.839458e-01 19 13913404 13913638 235 + 2.287 2.248 -0.131
ENSG00000132024 E013 2.741897 0.0132611926 1.601307e-02 8.186244e-02 19 13915291 13916547 1257 + 0.788 0.391 -1.816
ENSG00000132024 E014 146.879480 0.0004650652 6.684471e-01 8.151786e-01 19 13918070 13918194 125 + 2.088 2.074 -0.048
ENSG00000132024 E015 57.107699 0.0093692116 5.770658e-01 7.551807e-01 19 13918504 13918506 3 + 1.703 1.666 -0.125
ENSG00000132024 E016 101.898392 0.0005532260 9.114255e-01 9.579130e-01 19 13918507 13918576 70 + 1.923 1.920 -0.011
ENSG00000132024 E017 106.283070 0.0017304120 3.630743e-01 5.982105e-01 19 13918746 13918817 72 + 1.971 1.929 -0.141
ENSG00000132024 E018 156.053708 0.0003130620 8.838721e-01 9.432846e-01 19 13918912 13919042 131 + 2.108 2.104 -0.012
ENSG00000132024 E019 119.855432 0.0034199129 8.308850e-01 9.142788e-01 19 13919130 13919202 73 + 1.979 1.991 0.039
ENSG00000132024 E020 37.194264 0.0348269864 2.505141e-03 2.036138e-02 19 13919694 13919817 124 + 1.731 1.394 -1.151
ENSG00000132024 E021 92.534754 0.0004937465 4.246334e-03 3.052898e-02 19 13919818 13919826 9 + 1.974 1.852 -0.410
ENSG00000132024 E022 172.052719 0.0002697334 3.108396e-03 2.406661e-02 19 13919827 13919939 113 + 2.217 2.123 -0.314
ENSG00000132024 E023 65.770281 0.0079526428 6.423059e-03 4.179236e-02 19 13919940 13919951 12 + 1.867 1.684 -0.618
ENSG00000132024 E024 49.582218 0.0810487399 3.042043e-02 1.286120e-01 19 13919952 13920276 325 + 1.831 1.527 -1.031
ENSG00000132024 E025 26.978450 0.0931859463 2.714707e-01 5.113611e-01 19 13920277 13920401 125 + 1.474 1.314 -0.553
ENSG00000132024 E026 9.484060 0.0559647188 4.286457e-01 6.500446e-01 19 13920402 13920403 2 + 1.027 0.904 -0.461
ENSG00000132024 E027 25.906905 0.1128521732 2.171209e-01 4.499923e-01 19 13920404 13920501 98 + 1.482 1.290 -0.666
ENSG00000132024 E028 24.578267 0.1447193334 1.305837e-01 3.327146e-01 19 13920502 13920556 55 + 1.541 1.232 -1.071
ENSG00000132024 E029 74.203086 0.0072812076 3.935358e-01 6.231796e-01 19 13920557 13920559 3 + 1.827 1.767 -0.205
ENSG00000132024 E030 168.685752 0.0002502494 1.358416e-01 3.411141e-01 19 13920560 13920668 109 + 2.174 2.126 -0.160
ENSG00000132024 E031 204.689069 0.0013481552 1.955711e-01 4.240504e-01 19 13920750 13920922 173 + 2.254 2.212 -0.140
ENSG00000132024 E032 30.243002 0.1202745738 9.027104e-03 5.394503e-02 19 13920923 13923179 2257 + 1.704 1.274 -1.477
ENSG00000132024 E033 3.042416 0.2775457273 3.417172e-01 5.794741e-01 19 13923328 13923332 5 + 0.730 0.462 -1.206
ENSG00000132024 E034 197.487625 0.0009761126 3.867846e-01 6.179444e-01 19 13923333 13923455 123 + 2.227 2.200 -0.090
ENSG00000132024 E035 162.197796 0.0003074039 8.508788e-01 9.255386e-01 19 13923548 13923578 31 + 2.114 2.122 0.028
ENSG00000132024 E036 160.184824 0.0002642579 9.126985e-01 9.584471e-01 19 13923579 13923606 28 + 2.116 2.114 -0.007
ENSG00000132024 E037 247.209684 0.0001958233 9.494470e-01 9.767778e-01 19 13923695 13923811 117 + 2.301 2.301 -0.002
ENSG00000132024 E038 249.366818 0.0002027985 3.508954e-01 5.880854e-01 19 13926517 13926590 74 + 2.324 2.300 -0.081
ENSG00000132024 E039 240.708188 0.0002387123 1.393049e-01 3.464476e-01 19 13926667 13926725 59 + 2.322 2.282 -0.133
ENSG00000132024 E040 235.149334 0.0002276334 4.883217e-02 1.768533e-01 19 13926821 13926872 52 + 2.322 2.268 -0.180
ENSG00000132024 E041 290.178771 0.0003459379 4.880634e-02 1.768004e-01 19 13926978 13927077 100 + 2.409 2.359 -0.168
ENSG00000132024 E042 14.088763 0.1835258426 3.068118e-01 5.474342e-01 19 13927078 13927174 97 + 1.218 1.046 -0.617
ENSG00000132024 E043 267.581417 0.0003101128 9.100411e-01 9.571812e-01 19 13927175 13927265 91 + 2.336 2.333 -0.009
ENSG00000132024 E044 38.510270 0.1618887754 3.992541e-02 1.545049e-01 19 13927266 13927892 627 + 1.757 1.405 -1.200
ENSG00000132024 E045 230.825312 0.0002355121 8.670387e-04 8.825842e-03 19 13927893 13927990 98 + 2.189 2.291 0.343
ENSG00000132024 E046 143.355943 0.0051006991 1.102031e-01 2.993255e-01 19 13927991 13928030 40 + 1.995 2.079 0.285
ENSG00000132024 E047 7.615225 0.0866526048 1.830761e-01 4.079212e-01 19 13928031 13928123 93 + 0.626 0.882 1.039
ENSG00000132024 E048 85.905927 0.0005174104 2.754497e-02 1.199213e-01 19 13928124 13928126 3 + 1.755 1.866 0.376
ENSG00000132024 E049 163.047773 0.0003778767 1.695489e-02 8.529074e-02 19 13928127 13928188 62 + 2.050 2.137 0.294
ENSG00000132024 E050 180.046242 0.0002446854 7.208157e-02 2.289813e-01 19 13929379 13929442 64 + 2.114 2.176 0.207
ENSG00000132024 E051 218.139089 0.0002074224 1.030973e-03 1.014856e-02 19 13929534 13929642 109 + 2.163 2.266 0.346
ENSG00000132024 E052 93.611743 0.0004191086 1.419402e-01 3.503540e-01 19 13929643 13929644 2 + 1.827 1.897 0.236
ENSG00000132024 E053 107.354030 0.0004097474 1.419169e-02 7.510458e-02 19 13929645 13929660 16 + 1.851 1.962 0.373
ENSG00000132024 E054 152.741045 0.0025097831 1.256673e-03 1.183815e-02 19 13930078 13930154 77 + 1.971 2.117 0.491
ENSG00000132024 E055 129.656482 0.0003979212 1.415358e-05 2.833105e-04 19 13930242 13930289 48 + 1.870 2.055 0.622
ENSG00000132024 E056 319.287480 0.0015591629 1.899574e-05 3.659157e-04 19 13930375 13930879 505 + 2.298 2.436 0.460