ENSG00000131759

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394089 ENSG00000131759 HEK293_OSMI2_6hA HEK293_TMG_6hB RARA protein_coding protein_coding 10.07671 13.77784 7.917413 2.055352 0.08213371 -0.7984747 6.906070 10.440195 4.456261 1.9606102 0.04905981 -1.2263905 0.6694875 0.7471 0.5630667 -0.1840333 0.081555667 0.002751006 FALSE TRUE
ENST00000475125 ENSG00000131759 HEK293_OSMI2_6hA HEK293_TMG_6hB RARA protein_coding protein_coding 10.07671 13.77784 7.917413 2.055352 0.08213371 -0.7984747 2.335775 2.287906 2.712629 0.1446599 0.07299306 0.2446806 0.2454583 0.1714 0.3427667 0.1713667 0.002751006 0.002751006 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000131759 E001 0.1779838 0.0617255417 0.154246915   17 40309180 40309191 12 + 0.189 0.000 -11.154
ENSG00000131759 E002 0.4868358 0.4491782207 0.209356526   17 40309192 40309286 95 + 0.325 0.074 -2.581
ENSG00000131759 E003 16.5299917 0.0236434210 0.015417098 0.07966462 17 40318281 40318284 4 + 0.933 1.255 1.166
ENSG00000131759 E004 54.3089526 0.3314754969 0.223750144 0.45793317 17 40318285 40318448 164 + 1.514 1.732 0.740
ENSG00000131759 E005 1.8257525 0.1088246822 0.209847752 0.44164745 17 40322991 40323259 269 + 0.570 0.335 -1.227
ENSG00000131759 E006 1.0894291 0.0579382387 0.645690940   17 40326475 40326551 77 + 0.189 0.294 0.830
ENSG00000131759 E007 167.4604714 0.0002929677 0.792633593 0.89194836 17 40330857 40331396 540 + 2.159 2.180 0.067
ENSG00000131759 E008 0.3447487 0.6755764365 0.962193518   17 40341388 40341615 228 + 0.000 0.144 10.648
ENSG00000131759 E009 0.6082027 0.8746176010 0.809626458   17 40342363 40342398 36 + 0.000 0.215 11.250
ENSG00000131759 E010 1.4466843 0.0128927639 0.308828781 0.54933448 17 40342399 40342706 308 + 0.188 0.404 1.497
ENSG00000131759 E011 1.9038954 0.0897301348 0.967546638 0.98568925 17 40342707 40342795 89 + 0.418 0.435 0.089
ENSG00000131759 E012 2.6301023 0.0092931592 0.481825073 0.68831454 17 40342796 40342867 72 + 0.420 0.566 0.717
ENSG00000131759 E013 0.0000000       17 40345241 40345316 76 +      
ENSG00000131759 E014 70.9241860 0.5116267909 0.418568821 0.64253387 17 40348316 40348464 149 + 1.714 1.825 0.373
ENSG00000131759 E015 85.6339165 0.6061780647 0.467570776 0.67844990 17 40349784 40349925 142 + 1.817 1.899 0.275
ENSG00000131759 E016 4.9446113 0.1659251880 0.057254198 0.19659777 17 40351387 40351531 145 + 0.967 0.591 -1.511
ENSG00000131759 E017 106.5485642 0.0009288956 0.242728919 0.47963422 17 40351910 40352070 161 + 1.992 1.972 -0.065
ENSG00000131759 E018 115.0763248 0.0003743890 0.005861401 0.03905676 17 40352331 40352507 177 + 2.061 1.992 -0.230
ENSG00000131759 E019 119.9536862 0.0130608005 0.403470058 0.63110854 17 40354302 40354506 205 + 2.037 2.022 -0.048
ENSG00000131759 E020 87.8845816 0.0071497855 0.796978019 0.89453125 17 40355263 40355421 159 + 1.855 1.906 0.172
ENSG00000131759 E021 286.4278556 0.0293166094 0.872827860 0.93751183 17 40356009 40357643 1635 + 2.378 2.407 0.096