ENSG00000131653

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326181 ENSG00000131653 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAF7 protein_coding protein_coding 45.99544 65.88515 35.89786 10.69196 2.206413 -0.8758726 28.526573 46.039770 18.447652 6.8315691 0.4613297 -1.318974907 0.5987583 0.70273333 0.51863333 -0.18410000 0.0280931 0.0280931 FALSE TRUE
ENST00000569686 ENSG00000131653 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAF7 protein_coding retained_intron 45.99544 65.88515 35.89786 10.69196 2.206413 -0.8758726 2.151449 1.487863 2.506432 1.0314510 1.9353592 0.748473705 0.0503000 0.01903333 0.06486667 0.04583333 0.9351446 0.0280931 FALSE FALSE
ENST00000570169 ENSG00000131653 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAF7 protein_coding retained_intron 45.99544 65.88515 35.89786 10.69196 2.206413 -0.8758726 4.307301 3.699582 3.718587 0.8239382 0.2890387 0.007372108 0.1033125 0.06196667 0.10380000 0.04183333 0.5707446 0.0280931 FALSE FALSE
MSTRG.11844.4 ENSG00000131653 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAF7 protein_coding   45.99544 65.88515 35.89786 10.69196 2.206413 -0.8758726 6.392238 8.888387 5.949399 2.8575087 0.7219017 -0.578377078 0.1434375 0.12633333 0.16713333 0.04080000 0.7800696 0.0280931 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000131653 E001 0.7567544 0.0199541751 7.536324e-01   16 2155503 2155571 69 + 0.183 0.253 0.591
ENSG00000131653 E002 5.6780098 0.0307799284 7.979153e-01 0.8951465858 16 2155698 2155777 80 + 0.797 0.785 -0.049
ENSG00000131653 E003 5.9515126 0.0198538658 6.905269e-01 0.8294186018 16 2155778 2155781 4 + 0.831 0.800 -0.125
ENSG00000131653 E004 47.9921770 0.0008069655 9.404814e-01 0.9725364029 16 2155782 2155803 22 + 1.628 1.653 0.087
ENSG00000131653 E005 99.5301238 0.0004572628 3.336180e-02 0.1370635653 16 2155804 2155828 25 + 1.875 1.985 0.369
ENSG00000131653 E006 116.6859044 0.0004010110 9.186519e-02 0.2671419438 16 2155829 2155858 30 + 1.962 2.048 0.286
ENSG00000131653 E007 1.1715316 0.4887748652 3.946077e-01   16 2163542 2163799 258 + 0.411 0.260 -0.948
ENSG00000131653 E008 252.5084925 0.0002493480 1.489630e-01 0.3607928498 16 2163883 2164001 119 + 2.370 2.355 -0.051
ENSG00000131653 E009 11.7083561 0.0028536216 1.542812e-01 0.3683786565 16 2165857 2165878 22 + 1.149 1.022 -0.461
ENSG00000131653 E010 248.6401756 0.0002927065 4.875702e-05 0.0008141656 16 2165879 2165936 58 + 2.408 2.327 -0.271
ENSG00000131653 E011 321.8709814 0.0021775842 3.958458e-04 0.0046902319 16 2168077 2168168 92 + 2.524 2.434 -0.299
ENSG00000131653 E012 31.1515147 0.0204525762 1.058141e-03 0.0103541779 16 2168169 2168515 347 + 1.646 1.351 -1.011
ENSG00000131653 E013 353.8826284 0.0032574845 8.997472e-02 0.2637391213 16 2170614 2170730 117 + 2.530 2.490 -0.133
ENSG00000131653 E014 349.4004020 0.0003054617 8.443342e-03 0.0513509887 16 2171264 2171356 93 + 2.523 2.485 -0.126
ENSG00000131653 E015 2.8900712 0.1674593371 1.258562e-01 0.3252487122 16 2171357 2171382 26 + 0.766 0.417 -1.584
ENSG00000131653 E016 249.2062320 0.0002318325 1.193228e-01 0.3147621414 16 2171572 2171605 34 + 2.364 2.345 -0.063
ENSG00000131653 E017 478.2199566 0.0002780336 7.928827e-02 0.2433883038 16 2172191 2172374 184 + 2.643 2.631 -0.042
ENSG00000131653 E018 517.3929750 0.0001365185 1.305328e-02 0.0706577899 16 2172465 2172593 129 + 2.685 2.662 -0.075
ENSG00000131653 E019 245.7538891 0.0003181302 1.396117e-02 0.0741888580 16 2172594 2172599 6 + 2.376 2.333 -0.144
ENSG00000131653 E020 716.8926287 0.0005524316 1.231637e-03 0.0116610128 16 2173182 2173399 218 + 2.836 2.797 -0.129
ENSG00000131653 E021 311.2350284 0.0001795888 5.883071e-02 0.2001328008 16 2173481 2173512 32 + 2.462 2.440 -0.073
ENSG00000131653 E022 335.5310780 0.0002635754 4.798613e-01 0.6869961661 16 2173513 2173554 42 + 2.477 2.482 0.017
ENSG00000131653 E023 340.3911632 0.0003755311 2.636611e-01 0.5029340136 16 2173788 2173836 49 + 2.490 2.485 -0.017
ENSG00000131653 E024 481.5460640 0.0002051756 8.084864e-02 0.2465160474 16 2173921 2174048 128 + 2.644 2.633 -0.039
ENSG00000131653 E025 367.5095327 0.0035401603 7.302619e-01 0.8543880123 16 2174251 2174333 83 + 2.491 2.523 0.107
ENSG00000131653 E026 304.1726910 0.0050843908 4.433487e-01 0.6609670687 16 2175111 2175150 40 + 2.398 2.445 0.154
ENSG00000131653 E027 8.3711188 0.1366440425 3.130088e-01 0.5533103417 16 2175151 2175219 69 + 1.045 0.864 -0.674
ENSG00000131653 E028 473.0338919 0.0017446823 8.679029e-01 0.9348294218 16 2175301 2175417 117 + 2.617 2.629 0.039
ENSG00000131653 E029 549.2961119 0.0002860155 8.616004e-01 0.9312006707 16 2175500 2175622 123 + 2.675 2.699 0.079
ENSG00000131653 E030 607.4196056 0.0002504276 2.888837e-01 0.5294698883 16 2175834 2175953 120 + 2.707 2.746 0.131
ENSG00000131653 E031 589.5505445 0.0004710198 2.410662e-01 0.4777688380 16 2176049 2176180 132 + 2.691 2.734 0.144
ENSG00000131653 E032 398.8149181 0.0005136838 2.135178e-01 0.4458173395 16 2176265 2176384 120 + 2.518 2.567 0.165
ENSG00000131653 E033 384.8664120 0.0013660643 5.627556e-03 0.0378745471 16 2176560 2176787 228 + 2.465 2.562 0.320
ENSG00000131653 E034 517.5380537 0.0169113481 5.382971e-02 0.1886873047 16 2176788 2177323 536 + 2.567 2.695 0.427
ENSG00000131653 E035 168.0656509 1.0669242344 3.598844e-01 0.5956815298 16 2177324 2177436 113 + 1.963 2.235 0.912
ENSG00000131653 E036 529.1972037 1.4953818045 4.435644e-01 0.6611033203 16 2177437 2178635 1199 + 2.469 2.729 0.867