ENSG00000131626

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253925 ENSG00000131626 HEK293_OSMI2_6hA HEK293_TMG_6hB PPFIA1 protein_coding protein_coding 21.70102 14.55782 32.77946 1.255551 0.5381512 1.170447 2.126769 1.6103687 3.2744143 1.06027624 0.2642212 1.0193139 0.11909167 0.11126667 0.09993333 -0.01133333 0.94210312 0.0001683013 FALSE TRUE
ENST00000389547 ENSG00000131626 HEK293_OSMI2_6hA HEK293_TMG_6hB PPFIA1 protein_coding protein_coding 21.70102 14.55782 32.77946 1.255551 0.5381512 1.170447 10.980060 7.0886591 17.0191197 1.20284137 1.0968896 1.2623854 0.47884167 0.48093333 0.52006667 0.03913333 0.91665460 0.0001683013 FALSE TRUE
ENST00000532793 ENSG00000131626 HEK293_OSMI2_6hA HEK293_TMG_6hB PPFIA1 protein_coding retained_intron 21.70102 14.55782 32.77946 1.255551 0.5381512 1.170447 1.062680 1.1360240 0.8178682 0.06494439 0.1473781 -0.4691644 0.05912917 0.07960000 0.02506667 -0.05453333 0.01207987 0.0001683013 FALSE TRUE
MSTRG.5871.1 ENSG00000131626 HEK293_OSMI2_6hA HEK293_TMG_6hB PPFIA1 protein_coding   21.70102 14.55782 32.77946 1.255551 0.5381512 1.170447 1.251393 1.3567125 0.8540272 0.73012569 0.8540272 -0.6615611 0.05782917 0.08553333 0.02583333 -0.05970000 0.61984315 0.0001683013 FALSE TRUE
MSTRG.5871.11 ENSG00000131626 HEK293_OSMI2_6hA HEK293_TMG_6hB PPFIA1 protein_coding   21.70102 14.55782 32.77946 1.255551 0.5381512 1.170447 1.791235 0.8917757 3.4672911 0.24774695 1.0544580 1.9471233 0.08805417 0.06116667 0.10643333 0.04526667 0.76342713 0.0001683013 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000131626 E001 0.0000000       11 70270681 70270689 9 +      
ENSG00000131626 E002 0.0000000       11 70270690 70270700 11 +      
ENSG00000131626 E003 1.1492389 0.0147029184 3.063393e-01   11 70270701 70270716 16 + 0.236 0.437 1.264
ENSG00000131626 E004 3.7926532 0.0066645798 7.342948e-02 2.316512e-01 11 70270717 70270772 56 + 0.532 0.822 1.229
ENSG00000131626 E005 18.8809459 0.0022730036 8.972861e-03 5.369836e-02 11 70270773 70270914 142 + 1.188 1.430 0.847
ENSG00000131626 E006 1.1661824 0.0697247204 6.453662e-01   11 70271212 70271219 8 + 0.344 0.272 -0.472
ENSG00000131626 E007 3.0346814 0.0430607454 7.670274e-01 8.768159e-01 11 70271220 70271281 62 + 0.589 0.560 -0.132
ENSG00000131626 E008 4.1897877 0.0065832420 4.857649e-01 6.911184e-01 11 70271282 70271319 38 + 0.726 0.650 -0.318
ENSG00000131626 E009 2.9135588 0.0107592462 1.357404e-02 7.266373e-02 11 70271907 70271921 15 + 0.685 0.271 -2.149
ENSG00000131626 E010 11.2003164 0.1754463495 2.549594e-01 4.935535e-01 11 70271922 70272172 251 + 1.132 0.915 -0.794
ENSG00000131626 E011 40.3936447 0.0055300185 7.334823e-01 8.563272e-01 11 70272173 70272227 55 + 1.580 1.644 0.217
ENSG00000131626 E012 140.6710242 0.0057655769 1.667119e-01 3.861522e-01 11 70272228 70272436 209 + 2.146 2.122 -0.079
ENSG00000131626 E013 0.1723744 0.0471130677 2.976330e-01   11 70322397 70322554 158 + 0.000 0.156 11.526
ENSG00000131626 E014 114.2477449 0.0120235167 4.659551e-01 6.772152e-01 11 70324402 70324503 102 + 2.054 2.039 -0.051
ENSG00000131626 E015 124.9433032 0.3284381528 4.680074e-01 6.787411e-01 11 70324847 70325011 165 + 2.055 2.130 0.251
ENSG00000131626 E016 105.8553405 0.0663540766 8.526892e-01 9.265227e-01 11 70325500 70325574 75 + 2.009 2.019 0.032
ENSG00000131626 E017 111.9741991 0.0024236377 1.129922e-01 3.041429e-01 11 70326262 70326343 82 + 2.051 2.020 -0.105
ENSG00000131626 E018 82.5698646 0.0014561482 3.660197e-02 1.458505e-01 11 70326344 70326363 20 + 1.927 1.872 -0.186
ENSG00000131626 E019 209.4430186 0.0003494799 5.828191e-07 1.775674e-05 11 70326597 70326818 222 + 2.342 2.246 -0.320
ENSG00000131626 E020 0.1308682 0.0326491905 2.992298e-01   11 70327554 70327714 161 + 0.000 0.156 11.521
ENSG00000131626 E021 0.3559677 0.6872138254 5.634301e-01   11 70329893 70330172 280 + 0.176 0.000 -10.912
ENSG00000131626 E022 171.5814815 0.0015473803 2.865299e-05 5.184802e-04 11 70330173 70330319 147 + 2.256 2.153 -0.343
ENSG00000131626 E023 153.7913964 0.0055719914 5.075624e-02 1.814801e-01 11 70331960 70332094 135 + 2.191 2.143 -0.163
ENSG00000131626 E024 0.0000000       11 70333022 70333096 75 +      
ENSG00000131626 E025 126.9762366 0.0028840368 3.058800e-01 5.465469e-01 11 70333470 70333553 84 + 2.095 2.092 -0.009
ENSG00000131626 E026 0.6316833 0.0326751640 6.003955e-01   11 70334352 70334632 281 + 0.236 0.156 -0.741
ENSG00000131626 E027 111.0436917 0.0099610507 4.741585e-01 6.829476e-01 11 70335563 70335612 50 + 2.038 2.035 -0.009
ENSG00000131626 E028 129.8846377 0.0127409809 3.718025e-03 2.757112e-02 11 70335613 70335694 82 + 2.150 2.003 -0.490
ENSG00000131626 E029 94.1306921 0.0125588742 3.083319e-02 1.298518e-01 11 70337365 70337396 32 + 1.998 1.892 -0.356
ENSG00000131626 E030 104.5855193 0.0057462842 1.459376e-02 7.657264e-02 11 70337397 70337427 31 + 2.039 1.951 -0.296
ENSG00000131626 E031 122.1439809 0.0004027003 7.476213e-05 1.173196e-03 11 70338374 70338434 61 + 2.110 2.010 -0.335
ENSG00000131626 E032 79.7570694 0.0005504487 1.158317e-02 6.474523e-02 11 70338435 70338453 19 + 1.919 1.849 -0.234
ENSG00000131626 E033 134.8338684 0.0022451744 2.266202e-02 1.048275e-01 11 70339171 70339306 136 + 2.136 2.086 -0.168
ENSG00000131626 E034 0.3337900 0.0365770447 7.063046e-01   11 70339307 70339311 5 + 0.094 0.156 0.851
ENSG00000131626 E035 0.0000000       11 70340977 70340995 19 +      
ENSG00000131626 E036 0.0000000       11 70340996 70341006 11 +      
ENSG00000131626 E037 0.0000000       11 70341007 70341097 91 +      
ENSG00000131626 E038 0.5767453 0.0196771105 1.345727e-01   11 70341873 70342143 271 + 0.093 0.361 2.432
ENSG00000131626 E039 97.8829908 0.0078480685 9.689993e-01 9.863303e-01 11 70343669 70343750 82 + 1.965 2.001 0.122
ENSG00000131626 E040 131.8444653 0.0069259560 5.101187e-01 7.080498e-01 11 70343751 70343892 142 + 2.104 2.110 0.020
ENSG00000131626 E041 0.0000000       11 70345915 70346009 95 +      
ENSG00000131626 E042 157.9613586 0.0025018946 4.796664e-01 6.868792e-01 11 70348189 70348374 186 + 2.163 2.225 0.210
ENSG00000131626 E043 89.8377955 0.0063308409 8.102796e-01 9.023755e-01 11 70348375 70348420 46 + 1.924 1.973 0.164
ENSG00000131626 E044 30.8519352 0.0103793207 1.180811e-01 3.127285e-01 11 70349923 70350039 117 + 1.426 1.585 0.544
ENSG00000131626 E045 3.7206851 0.0070982523 6.967416e-01 8.334730e-01 11 70350994 70351023 30 + 0.640 0.726 0.362
ENSG00000131626 E046 1.4396852 0.0136968632 7.945581e-01 8.930680e-01 11 70354203 70354300 98 + 0.388 0.362 -0.151
ENSG00000131626 E047 74.0643875 0.0076508523 7.661166e-01 8.763056e-01 11 70354301 70354321 21 + 1.840 1.892 0.176
ENSG00000131626 E048 153.1691481 0.0138501456 5.740375e-01 7.530680e-01 11 70354322 70354452 131 + 2.172 2.171 -0.005
ENSG00000131626 E049 125.7209176 0.0026388998 4.923846e-01 6.955956e-01 11 70355639 70355703 65 + 2.084 2.094 0.033
ENSG00000131626 E050 162.8506256 0.0063542143 4.845929e-01 6.902364e-01 11 70355704 70355811 108 + 2.196 2.201 0.019
ENSG00000131626 E051 154.0744134 0.0140536707 5.458236e-01 7.333280e-01 11 70356161 70356254 94 + 2.171 2.176 0.020
ENSG00000131626 E052 119.1561912 0.0138770051 6.639385e-01 8.123404e-01 11 70362095 70362134 40 + 2.056 2.074 0.060
ENSG00000131626 E053 114.6945121 0.0115143568 7.857155e-01 8.879450e-01 11 70362135 70362176 42 + 2.036 2.063 0.090
ENSG00000131626 E054 201.8401565 0.0034083107 1.760926e-02 8.767611e-02 11 70362288 70362488 201 + 2.243 2.367 0.416
ENSG00000131626 E055 10.9493138 0.0170289536 2.249722e-04 2.947270e-03 11 70362489 70362795 307 + 0.831 1.286 1.667
ENSG00000131626 E056 3.2000232 0.0091237941 1.703181e-02 8.558894e-02 11 70364342 70365372 1031 + 0.429 0.821 1.739
ENSG00000131626 E057 5.0318897 0.0178890588 6.834180e-01 8.248529e-01 11 70365373 70365435 63 + 0.727 0.821 0.375
ENSG00000131626 E058 1.8084491 0.0121093633 2.705912e-01 5.105335e-01 11 70365436 70365940 505 + 0.343 0.556 1.110
ENSG00000131626 E059 0.4950181 0.0217681645 3.162511e-01   11 70365941 70365967 27 + 0.094 0.271 1.849
ENSG00000131626 E060 1.5845327 0.0209126474 6.313197e-01 7.912398e-01 11 70367506 70367629 124 + 0.428 0.361 -0.373
ENSG00000131626 E061 3.6468680 0.5960262289 5.418956e-01 7.304228e-01 11 70371327 70372211 885 + 0.433 0.883 1.957
ENSG00000131626 E062 5.3338969 0.0096921577 8.014523e-02 2.451018e-01 11 70372212 70372214 3 + 0.684 0.944 1.023
ENSG00000131626 E063 194.1711635 0.2053815592 1.740431e-01 3.959293e-01 11 70372215 70372390 176 + 2.180 2.401 0.736
ENSG00000131626 E064 143.9244899 0.9761848220 3.897242e-01 6.202475e-01 11 70372477 70372574 98 + 2.050 2.272 0.742
ENSG00000131626 E065 1.8633847 0.2042721040 4.926378e-01 6.957507e-01 11 70374660 70374829 170 + 0.384 0.554 0.861
ENSG00000131626 E066 204.2284831 1.4751967131 4.596572e-01 6.728710e-01 11 70374918 70375093 176 + 2.193 2.431 0.794
ENSG00000131626 E067 146.1931488 0.1093434835 1.980255e-01 4.271579e-01 11 70376532 70376600 69 + 2.079 2.256 0.592
ENSG00000131626 E068 126.7561607 0.0089462327 1.302390e-01 3.321813e-01 11 70378030 70378077 48 + 2.046 2.162 0.388
ENSG00000131626 E069 177.4742917 0.0003301872 4.653059e-01 6.767780e-01 11 70378078 70378195 118 + 2.217 2.273 0.188
ENSG00000131626 E070 24.9844402 0.0498133696 7.579879e-02 2.363639e-01 11 70378196 70378580 385 + 1.285 1.539 0.877
ENSG00000131626 E071 129.8024010 0.0004344465 2.723969e-01 5.122409e-01 11 70382088 70382158 71 + 2.101 2.101 -0.001
ENSG00000131626 E072 561.7022330 0.0122847972 3.886329e-01 6.193727e-01 11 70383003 70386577 3575 + 2.698 2.788 0.298