ENSG00000131558

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253861 ENSG00000131558 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC4 protein_coding protein_coding 20.18381 12.88086 20.22269 3.023202 0.9052076 0.6503393 15.306958 9.3316284 17.331657 2.3429017 0.6836076 0.8924958 0.75044583 0.71816667 0.8581333 0.13996667 0.03905117 0.03905117 FALSE TRUE
ENST00000466000 ENSG00000131558 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC4 protein_coding processed_transcript 20.18381 12.88086 20.22269 3.023202 0.9052076 0.6503393 2.019541 0.9560834 0.000000 0.6515228 0.0000000 -6.5940758 0.09447917 0.05776667 0.0000000 -0.05776667 0.19817416 0.03905117   FALSE
ENST00000481074 ENSG00000131558 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC4 protein_coding processed_transcript 20.18381 12.88086 20.22269 3.023202 0.9052076 0.6503393 2.275974 2.2555680 2.053746 0.1437130 0.2752906 -0.1346072 0.12581667 0.19230000 0.1008000 -0.09150000 0.27754275 0.03905117   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000131558 E001 0.1426347 0.0322741794 7.581567e-01   7 133253073 133253077 5 + 0.098 0.000 -8.863
ENSG00000131558 E002 12.7841738 0.0028077007 1.332009e-01 3.368363e-01 7 133253078 133253094 17 + 1.175 1.035 -0.504
ENSG00000131558 E003 22.9202311 0.0014959650 5.992459e-02 2.026399e-01 7 133253095 133253098 4 + 1.413 1.280 -0.464
ENSG00000131558 E004 64.9262646 0.0009184706 5.109275e-02 1.822908e-01 7 133253099 133253187 89 + 1.836 1.754 -0.276
ENSG00000131558 E005 2.9124390 0.2311469460 5.046132e-01 7.040391e-01 7 133253365 133253493 129 + 0.520 0.689 0.748
ENSG00000131558 E006 22.9308616 0.0289640633 4.357888e-03 3.114247e-02 7 133253540 133254018 479 + 1.228 1.529 1.044
ENSG00000131558 E007 108.2878051 0.0004488658 1.080270e-06 3.039846e-05 7 133274982 133275171 190 + 2.082 1.915 -0.562
ENSG00000131558 E008 98.0482262 0.0004253683 8.760651e-05 1.337674e-03 7 133288922 133289116 195 + 2.031 1.893 -0.465
ENSG00000131558 E009 104.9192549 0.0007821886 6.041418e-05 9.791675e-04 7 133305877 133306061 185 + 2.065 1.923 -0.475
ENSG00000131558 E010 96.8035873 0.0008112923 8.351112e-05 1.286476e-03 7 133317284 133317390 107 + 2.028 1.883 -0.487
ENSG00000131558 E011 83.9608576 0.0015013343 8.091862e-05 1.253589e-03 7 133356330 133356386 57 + 1.971 1.807 -0.552
ENSG00000131558 E012 125.1630176 0.0005567991 3.428321e-03 2.592429e-02 7 133356387 133356573 187 + 2.117 2.029 -0.297
ENSG00000131558 E013 101.3755536 0.0004735688 7.977038e-01 8.950497e-01 7 133374828 133375002 175 + 1.997 1.997 0.002
ENSG00000131558 E014 0.1426347 0.0322741794 7.581567e-01   7 133375003 133375028 26 + 0.098 0.000 -11.279
ENSG00000131558 E015 0.0000000       7 133396139 133396414 276 +      
ENSG00000131558 E016 0.0000000       7 133447300 133447369 70 +      
ENSG00000131558 E017 98.5807634 0.0004819950 1.954418e-01 4.239106e-01 7 133475328 133475473 146 + 1.998 1.960 -0.128
ENSG00000131558 E018 0.0000000       7 133478915 133479040 126 +      
ENSG00000131558 E019 0.0000000       7 133479306 133479402 97 +      
ENSG00000131558 E020 0.0000000       7 133479447 133479685 239 +      
ENSG00000131558 E021 79.1466474 0.0005301482 3.993064e-01 6.276916e-01 7 133480050 133480138 89 + 1.899 1.874 -0.085
ENSG00000131558 E022 0.9444795 0.0178381958 7.884888e-01   7 133480139 133481078 940 + 0.304 0.260 -0.311
ENSG00000131558 E023 0.1614157 0.0336564724 7.578417e-01   7 133484040 133484197 158 + 0.098 0.000 -11.266
ENSG00000131558 E024 0.0000000       7 133551599 133551752 154 +      
ENSG00000131558 E025 0.0000000       7 133576462 133576631 170 +      
ENSG00000131558 E026 0.0000000       7 133576632 133576699 68 +      
ENSG00000131558 E027 0.0000000       7 133576700 133576761 62 +      
ENSG00000131558 E028 0.0000000       7 133576762 133576804 43 +      
ENSG00000131558 E029 0.0000000       7 133576805 133576872 68 +      
ENSG00000131558 E030 0.0000000       7 133601838 133602010 173 +      
ENSG00000131558 E031 84.4590622 0.0006513746 1.381233e-01 3.446512e-01 7 133630045 133630141 97 + 1.935 1.886 -0.165
ENSG00000131558 E032 0.5067846 0.0217681645 8.692970e-01   7 133630142 133630198 57 + 0.178 0.149 -0.306
ENSG00000131558 E033 0.0000000       7 133768097 133768441 345 +      
ENSG00000131558 E034 0.0000000       7 133771307 133771487 181 +      
ENSG00000131558 E035 128.8258874 0.0003934481 2.181183e-01 4.511755e-01 7 133817325 133817544 220 + 2.110 2.080 -0.099
ENSG00000131558 E036 0.3206185 0.0274424043 3.638794e-01   7 133895063 133895195 133 + 0.178 0.000 -12.319
ENSG00000131558 E037 105.4067628 0.0005320693 7.376174e-02 2.323024e-01 7 133895599 133895735 137 + 2.034 1.979 -0.185
ENSG00000131558 E038 0.3453689 0.0260548870 7.373034e-01   7 133895736 133895736 1 + 0.098 0.149 0.695
ENSG00000131558 E039 110.8165470 0.0052636843 5.088472e-01 7.070370e-01 7 133917583 133917738 156 + 2.047 2.019 -0.094
ENSG00000131558 E040 0.0000000       7 133930441 133930713 273 +      
ENSG00000131558 E041 131.2946098 0.0003504529 5.903693e-01 7.639600e-01 7 133937891 133938069 179 + 2.096 2.123 0.090
ENSG00000131558 E042 91.5148741 0.0015374461 2.612642e-01 5.003007e-01 7 133997492 133997574 83 + 1.928 1.985 0.191
ENSG00000131558 E043 47.5943114 0.0008772380 8.662519e-02 2.576177e-01 7 133997575 133997576 2 + 1.632 1.731 0.336
ENSG00000131558 E044 66.2323048 0.0007527487 5.641944e-02 1.946117e-01 7 133997577 133997633 57 + 1.774 1.869 0.322
ENSG00000131558 E045 0.3040503 0.0274424043 3.643548e-01   7 133997634 133997634 1 + 0.178 0.000 -12.319
ENSG00000131558 E046 101.6337828 0.0027492943 2.250103e-03 1.873226e-02 7 134004912 134005090 179 + 1.933 2.075 0.479
ENSG00000131558 E047 113.0727891 0.0004262419 7.423627e-04 7.799929e-03 7 134007676 134007835 160 + 1.988 2.112 0.416
ENSG00000131558 E048 0.3393995 0.0274424043 3.632635e-01   7 134007836 134007939 104 + 0.179 0.000 -12.321
ENSG00000131558 E049 0.0000000       7 134009868 134009968 101 +      
ENSG00000131558 E050 0.1779838 0.0353918930 7.576220e-01   7 134009969 134010203 235 + 0.098 0.000 -11.250
ENSG00000131558 E051 0.0000000       7 134010204 134010291 88 +      
ENSG00000131558 E052 65.0092085 0.0009722953 1.525247e-01 3.659724e-01 7 134064291 134064317 27 + 1.772 1.847 0.252
ENSG00000131558 E053 155.1703355 0.0004662161 5.255984e-03 3.596676e-02 7 134064318 134064586 269 + 2.141 2.232 0.305
ENSG00000131558 E054 426.8818556 0.0016364940 2.847922e-09 1.509968e-07 7 134064587 134065761 1175 + 2.549 2.703 0.512
ENSG00000131558 E055 0.7132229 0.1793197871 4.642568e-01   7 134065797 134065950 154 + 0.178 0.341 1.229
ENSG00000131558 E056 1.5020137 0.7663384708 7.675717e-01 8.771665e-01 7 134066260 134066589 330 + 0.420 0.337 -0.480