ENSG00000131507

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253814 ENSG00000131507 HEK293_OSMI2_6hA HEK293_TMG_6hB NDFIP1 protein_coding protein_coding 66.39169 41.3224 75.6206 2.180169 2.348979 0.8716971 24.74001 12.03695 33.33990 1.475249 0.8127106 1.4690149 0.3626250 0.2891667 0.4411333 0.1519667 0.005904567 0.002334762 FALSE TRUE
MSTRG.27076.3 ENSG00000131507 HEK293_OSMI2_6hA HEK293_TMG_6hB NDFIP1 protein_coding   66.39169 41.3224 75.6206 2.180169 2.348979 0.8716971 41.06760 28.94501 41.47315 0.830273 1.8238226 0.5187125 0.6289958 0.7023000 0.5480333 -0.1542667 0.002334762 0.002334762 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000131507 E001 3.4850028 0.0833128306 4.594034e-01 6.727404e-01 5 142108775 142108778 4 + 0.598 0.740 0.602
ENSG00000131507 E002 6.3927079 0.0392874146 8.408035e-01 9.198821e-01 5 142108779 142108787 9 + 0.857 0.883 0.101
ENSG00000131507 E003 176.1574265 0.0026287672 4.480246e-10 2.774795e-08 5 142108788 142109037 250 + 2.140 2.357 0.727
ENSG00000131507 E004 296.7290515 0.0008773740 2.409494e-06 6.140501e-05 5 142131808 142131895 88 + 2.415 2.524 0.362
ENSG00000131507 E005 0.0000000       5 142131896 142132106 211 +      
ENSG00000131507 E006 574.2680723 0.0011173285 1.577113e-01 3.732753e-01 5 142132212 142132342 131 + 2.737 2.760 0.078
ENSG00000131507 E007 0.7547291 0.0193874923 3.011161e-01   5 142134034 142134068 35 + 0.175 0.354 1.344
ENSG00000131507 E008 575.5950631 0.0001911753 3.428177e-02 1.396257e-01 5 142135730 142135817 88 + 2.736 2.762 0.087
ENSG00000131507 E009 608.7139530 0.0002050805 1.113118e-04 1.634526e-03 5 142137734 142137858 125 + 2.748 2.800 0.172
ENSG00000131507 E010 1.1168538 0.0234338764 7.451130e-01   5 142137859 142138192 334 + 0.299 0.354 0.346
ENSG00000131507 E011 426.0827452 0.0010498590 1.245458e-02 6.826562e-02 5 142140563 142140609 47 + 2.595 2.645 0.168
ENSG00000131507 E012 346.5225127 0.0046587294 5.411138e-01 7.298412e-01 5 142140610 142140629 20 + 2.518 2.538 0.068
ENSG00000131507 E013 7.9419456 0.0039754399 2.410349e-01 4.777449e-01 5 142142978 142144570 1593 + 0.985 0.838 -0.559
ENSG00000131507 E014 516.7799957 0.0009452115 4.420336e-01 6.600934e-01 5 142144571 142144676 106 + 2.694 2.705 0.037
ENSG00000131507 E015 1343.0901062 0.0004406481 4.084153e-36 5.214910e-33 5 142151731 142154440 2710 + 3.165 3.012 -0.508
ENSG00000131507 E016 0.3393995 0.0274424043 3.913362e-01   5 142168987 142169032 46 + 0.175 0.000 -9.620