ENSG00000131459

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253778 ENSG00000131459 HEK293_OSMI2_6hA HEK293_TMG_6hB GFPT2 protein_coding protein_coding 9.209801 7.82653 8.077385 0.2213583 0.3766337 0.04545847 6.6824209 6.002045 5.6462050 0.4404833 0.1961582 -0.08802146 0.7325167 0.7650000 0.7018333 -0.06316667 0.7918159236 0.0001859245 FALSE  
ENST00000518158 ENSG00000131459 HEK293_OSMI2_6hA HEK293_TMG_6hB GFPT2 protein_coding retained_intron 9.209801 7.82653 8.077385 0.2213583 0.3766337 0.04545847 0.2272313 0.000000 0.4847023 0.0000000 0.1865920 5.62848856 0.0219250 0.0000000 0.0584000 0.05840000 0.0001859245 0.0001859245 FALSE  
MSTRG.27454.2 ENSG00000131459 HEK293_OSMI2_6hA HEK293_TMG_6hB GFPT2 protein_coding   9.209801 7.82653 8.077385 0.2213583 0.3766337 0.04545847 1.9171419 1.265182 1.5903771 0.2386734 0.2113161 0.32770927 0.2032000 0.1634667 0.1961333 0.03266667 0.8703956169 0.0001859245 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000131459 E001 29.4612689 0.0012139339 0.0190365498 0.092595044 5 180300698 180300789 92 - 1.387 1.541 0.530
ENSG00000131459 E002 200.2811438 0.0005180832 0.0001144222 0.001671386 5 180300790 180301608 819 - 2.242 2.340 0.325
ENSG00000131459 E003 49.2553406 0.0119117192 0.1189100745 0.314064281 5 180302423 180302584 162 - 1.625 1.742 0.397
ENSG00000131459 E004 61.2412056 0.0006625208 0.0480544792 0.175121393 5 180304772 180304939 168 - 1.736 1.826 0.305
ENSG00000131459 E005 52.5090491 0.0009481542 0.6378518749 0.795633361 5 180307176 180307303 128 - 1.736 1.714 -0.073
ENSG00000131459 E006 49.4035772 0.0007285274 0.4559720240 0.670231594 5 180312430 180312544 115 - 1.718 1.683 -0.121
ENSG00000131459 E007 58.8319808 0.0006246292 0.1107743523 0.300264214 5 180313807 180313964 158 - 1.730 1.804 0.251
ENSG00000131459 E008 57.2033663 0.0007324796 0.9584401091 0.981104841 5 180316341 180316461 121 - 1.760 1.763 0.012
ENSG00000131459 E009 53.6234400 0.0007705464 0.0501549753 0.180058100 5 180316764 180316861 98 - 1.780 1.688 -0.313
ENSG00000131459 E010 54.5967894 0.0029104647 0.3406259474 0.578580658 5 180316963 180317058 96 - 1.764 1.715 -0.166
ENSG00000131459 E011 1.7507501 0.0160966542 0.2524645753 0.490561913 5 180318619 180318792 174 - 0.537 0.341 -1.036
ENSG00000131459 E012 28.0972906 0.0155580421 0.8864951537 0.944856936 5 180318793 180318808 16 - 1.465 1.451 -0.048
ENSG00000131459 E013 36.3706284 0.0013005079 0.0466788716 0.171765422 5 180318809 180318843 35 - 1.622 1.506 -0.394
ENSG00000131459 E014 52.2072061 0.0008547213 0.0775168580 0.239887793 5 180318844 180318956 113 - 1.762 1.678 -0.287
ENSG00000131459 E015 42.9380696 0.0027150420 0.0382308896 0.150188169 5 180324188 180324305 118 - 1.700 1.584 -0.396
ENSG00000131459 E016 0.0000000       5 180324306 180324486 181 -      
ENSG00000131459 E017 40.4698899 0.0009672552 0.7737760779 0.880984298 5 180324816 180324895 80 - 1.621 1.606 -0.050
ENSG00000131459 E018 36.5899702 0.0013139298 0.7089361140 0.841125503 5 180328277 180328338 62 - 1.583 1.563 -0.070
ENSG00000131459 E019 54.0257967 0.0006938234 0.2480720543 0.485932217 5 180330700 180330834 135 - 1.765 1.711 -0.182
ENSG00000131459 E020 2.9871675 0.0074984551 0.0393827926 0.153176069 5 180330835 180330934 100 - 0.379 0.714 1.582
ENSG00000131459 E021 1.3164518 0.0136968632 0.1013051265   5 180331412 180331494 83 - 0.491 0.203 -1.812
ENSG00000131459 E022 35.3651855 0.0011950623 0.1099186293 0.298885157 5 180331495 180331553 59 - 1.603 1.510 -0.318
ENSG00000131459 E023 0.0000000       5 180331554 180331648 95 -      
ENSG00000131459 E024 35.4160991 0.0013911741 0.2611495284 0.500182667 5 180335828 180335868 41 - 1.515 1.583 0.233
ENSG00000131459 E025 44.4212888 0.0010466756 0.4521394877 0.667272242 5 180335869 180335953 85 - 1.676 1.637 -0.131
ENSG00000131459 E026 0.8346052 0.1425453457 0.1671410521   5 180335954 180336478 525 - 0.381 0.114 -2.230
ENSG00000131459 E027 48.1333255 0.0010739722 0.1057309614 0.291898445 5 180336479 180336577 99 - 1.733 1.652 -0.274
ENSG00000131459 E028 40.1655886 0.0070289524 0.6226024898 0.785578154 5 180338493 180338572 80 - 1.632 1.601 -0.105
ENSG00000131459 E029 22.7190083 0.0073048351 0.2810848912 0.521345981 5 180338573 180338600 28 - 1.423 1.338 -0.292
ENSG00000131459 E030 0.1723744 0.0321673600 0.5592534267   5 180352372 180352900 529 - 0.000 0.113 9.172
ENSG00000131459 E031 30.5637093 0.0014471145 0.3189800684 0.558700326 5 180353211 180353350 140 - 1.461 1.525 0.221