ENSG00000131381

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253699 ENSG00000131381 HEK293_OSMI2_6hA HEK293_TMG_6hB RBSN protein_coding protein_coding 16.066 14.93941 18.56447 1.74859 0.6782372 0.3132325 12.5620258 12.9064877 13.415672 1.7516894 0.5082187 0.05578048 0.7891042 0.86010000 0.7225667 -0.13753333 0.01773061 0.008452158 FALSE TRUE
ENST00000449050 ENSG00000131381 HEK293_OSMI2_6hA HEK293_TMG_6hB RBSN protein_coding protein_coding 16.066 14.93941 18.56447 1.74859 0.6782372 0.3132325 0.9080379 0.4300385 0.826569 0.1055084 0.2252544 0.92685484 0.0572125 0.02823333 0.0438000 0.01556667 0.77364908 0.008452158   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000131381 E001 150.284398 0.8820972876 0.241613074 0.47839496 3 15070073 15070272 200 - 1.906 2.363 1.528
ENSG00000131381 E002 246.716849 1.0909800026 0.279891452 0.51996987 3 15070273 15070470 198 - 2.127 2.575 1.496
ENSG00000131381 E003 1072.185445 1.7324532499 0.436792660 0.65629232 3 15070471 15073604 3134 - 2.834 3.179 1.148
ENSG00000131381 E004 201.636013 1.1319362285 0.467600183 0.67844990 3 15073605 15073991 387 - 2.170 2.422 0.841
ENSG00000131381 E005 181.193536 1.0986134874 0.478768985 0.68629441 3 15073992 15074459 468 - 2.132 2.370 0.793
ENSG00000131381 E006 91.762992 0.6277756721 0.434129788 0.65434072 3 15074460 15074625 166 - 1.859 2.063 0.687
ENSG00000131381 E007 116.644094 0.9583001674 0.554800533 0.73963677 3 15074626 15074904 279 - 1.986 2.148 0.544
ENSG00000131381 E008 39.812737 0.4001556690 0.720477925 0.84852369 3 15074905 15074930 26 - 1.579 1.643 0.217
ENSG00000131381 E009 5.019214 0.0561244159 0.169163328 0.38946117 3 15075047 15075116 70 - 0.838 0.716 -0.486
ENSG00000131381 E010 5.452084 0.2559724227 0.772391731 0.88008079 3 15075290 15075417 128 - 0.793 0.839 0.182
ENSG00000131381 E011 85.624785 0.6331100554 0.550704599 0.73684388 3 15075606 15075710 105 - 1.872 2.001 0.433
ENSG00000131381 E012 98.910666 0.0005678078 0.006703800 0.04321677 3 15077062 15077164 103 - 1.973 2.033 0.200
ENSG00000131381 E013 70.365022 0.0217752145 0.074870417 0.23455862 3 15078075 15078109 35 - 1.829 1.878 0.167
ENSG00000131381 E014 79.646627 0.0512045381 0.207295919 0.43857545 3 15078110 15078156 47 - 1.874 1.938 0.218
ENSG00000131381 E015 54.209706 0.0693459273 0.298249651 0.53873843 3 15078157 15078161 5 - 1.706 1.775 0.234
ENSG00000131381 E016 91.080601 0.0901920558 0.144937931 0.35486504 3 15080732 15080802 71 - 1.967 1.959 -0.027
ENSG00000131381 E017 1.480384 0.2979595097 0.807732249 0.90085582 3 15081055 15081334 280 - 0.344 0.439 0.532
ENSG00000131381 E018 1.039856 1.1091024781 0.806852015   3 15081432 15081560 129 - 0.117 0.449 2.554
ENSG00000131381 E019 90.330802 0.0868666408 0.248325013 0.48610767 3 15082367 15082477 111 - 1.940 1.980 0.134
ENSG00000131381 E020 76.914984 0.0555582449 0.222112595 0.45601609 3 15082478 15082608 131 - 1.861 1.922 0.206
ENSG00000131381 E021 83.898752 0.0685831612 0.102336469 0.28596252 3 15084735 15084896 162 - 1.932 1.923 -0.031
ENSG00000131381 E022 49.813063 0.0609019721 0.034973322 0.14151238 3 15085000 15085045 46 - 1.733 1.669 -0.220
ENSG00000131381 E023 62.453691 0.0873132663 0.070398042 0.22550611 3 15085861 15085961 101 - 1.829 1.767 -0.211
ENSG00000131381 E024 2.731056 0.5674099634 0.572310294 0.75194735 3 15085962 15086112 151 - 0.582 0.545 -0.168
ENSG00000131381 E025 10.577897 0.0086538276 0.019852179 0.09536345 3 15090135 15090340 206 - 1.103 1.003 -0.364
ENSG00000131381 E026 2.577108 0.0090039307 0.057338094 0.19680910 3 15090341 15090398 58 - 0.633 0.438 -0.920
ENSG00000131381 E027 110.139065 0.0788867667 0.023338577 0.10701553 3 15090399 15090539 141 - 2.091 1.986 -0.353
ENSG00000131381 E028 11.546197 0.0853229769 0.155817161 0.37064850 3 15091339 15091493 155 - 1.116 1.073 -0.155
ENSG00000131381 E029 5.193513 0.0050306455 0.001445775 0.01323162 3 15095671 15095972 302 - 0.913 0.616 -1.199
ENSG00000131381 E030 81.297960 0.0695532190 0.023776155 0.10841304 3 15095973 15095997 25 - 1.956 1.863 -0.312
ENSG00000131381 E031 161.931599 0.0596488791 0.010722499 0.06120557 3 15095998 15096288 291 - 2.250 2.161 -0.298
ENSG00000131381 E032 34.719051 0.0893454033 0.060813675 0.20465610 3 15096535 15096551 17 - 1.580 1.517 -0.215
ENSG00000131381 E033 64.440801 0.0904098021 0.041913409 0.15971147 3 15096552 15096658 107 - 1.852 1.769 -0.279
ENSG00000131381 E034 46.770178 0.0901431338 0.057985754 0.19825877 3 15096659 15096710 52 - 1.716 1.631 -0.287
ENSG00000131381 E035 56.576173 0.0515579669 0.016126423 0.08224137 3 15098119 15098274 156 - 1.797 1.713 -0.286
ENSG00000131381 E036 1.618029 0.0132667369 0.739195625 0.85988176 3 15099022 15099034 13 - 0.397 0.438 0.217
ENSG00000131381 E037 43.047909 0.0832213405 0.093899300 0.27095022 3 15099035 15099163 129 - 1.663 1.620 -0.145