ENSG00000131069

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360596 ENSG00000131069 HEK293_OSMI2_6hA HEK293_TMG_6hB ACSS2 protein_coding protein_coding 20.50613 26.61676 16.63199 1.783014 1.522488 -0.6780489 12.1117479 18.187753 9.4025565 2.1383220 0.1503140 -0.9511018 0.57959167 0.67880000 0.5727 -0.10610000 5.591599e-01 8.190113e-05 FALSE TRUE
ENST00000477932 ENSG00000131069 HEK293_OSMI2_6hA HEK293_TMG_6hB ACSS2 protein_coding nonsense_mediated_decay 20.50613 26.61676 16.63199 1.783014 1.522488 -0.6780489 1.2777627 1.520802 0.1847525 1.1265372 0.1847525 -2.9745744 0.05222083 0.05736667 0.0122 -0.04516667 7.380566e-01 8.190113e-05 FALSE TRUE
ENST00000484354 ENSG00000131069 HEK293_OSMI2_6hA HEK293_TMG_6hB ACSS2 protein_coding protein_coding 20.50613 26.61676 16.63199 1.783014 1.522488 -0.6780489 0.8710528 1.655982 0.0000000 0.6274447 0.0000000 -7.3802289 0.04050417 0.05986667 0.0000 -0.05986667 8.190113e-05 8.190113e-05 FALSE FALSE
ENST00000490464 ENSG00000131069 HEK293_OSMI2_6hA HEK293_TMG_6hB ACSS2 protein_coding retained_intron 20.50613 26.61676 16.63199 1.783014 1.522488 -0.6780489 1.7840849 1.205567 2.9077991 0.6962819 0.6580839 1.2632511 0.09720833 0.04836667 0.1709 0.12253333 5.120271e-01 8.190113e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000131069 E001 0.0000000       20 34872146 34872403 258 +      
ENSG00000131069 E002 0.0000000       20 34872882 34873001 120 +      
ENSG00000131069 E003 0.0000000       20 34874942 34874962 21 +      
ENSG00000131069 E004 0.0000000       20 34874963 34874978 16 +      
ENSG00000131069 E005 0.0000000       20 34874979 34875016 38 +      
ENSG00000131069 E006 0.0000000       20 34875017 34875127 111 +      
ENSG00000131069 E007 0.0000000       20 34875128 34875137 10 +      
ENSG00000131069 E008 0.0000000       20 34875853 34875931 79 +      
ENSG00000131069 E009 3.3980578 0.0321954635 3.732130e-01 0.6066875803 20 34876572 34876579 8 + 0.480 0.636 0.718
ENSG00000131069 E010 4.5111397 0.0179221299 2.215539e-01 0.4553368862 20 34876580 34876589 10 + 0.547 0.745 0.854
ENSG00000131069 E011 5.0996516 0.0086801955 4.107581e-01 0.6365776627 20 34876590 34876592 3 + 0.656 0.775 0.493
ENSG00000131069 E012 16.4856830 0.0138013417 1.421372e-01 0.3506170303 20 34876593 34876611 19 + 1.082 1.235 0.549
ENSG00000131069 E013 17.2533960 0.0096770790 7.706490e-02 0.2389307040 20 34876612 34876613 2 + 1.082 1.260 0.635
ENSG00000131069 E014 17.2533960 0.0096770790 7.706490e-02 0.2389307040 20 34876614 34876621 8 + 1.082 1.260 0.635
ENSG00000131069 E015 46.3933028 0.0009258014 1.311899e-05 0.0002656697 20 34876622 34876747 126 + 1.426 1.695 0.917
ENSG00000131069 E016 45.4888403 0.0008631499 2.167578e-04 0.0028601752 20 34876748 34876823 76 + 1.458 1.682 0.764
ENSG00000131069 E017 41.3361146 0.0010772424 9.080086e-02 0.2652162274 20 34882794 34882817 24 + 1.515 1.615 0.343
ENSG00000131069 E018 36.6485417 0.0016164957 6.238457e-01 0.7864958818 20 34882818 34882826 9 + 1.515 1.542 0.094
ENSG00000131069 E019 116.0477904 0.0004051361 2.583307e-01 0.4971104622 20 34882827 34882989 163 + 2.060 2.016 -0.148
ENSG00000131069 E020 0.7260870 0.1559380946 4.357529e-01   20 34882990 34882996 7 + 0.303 0.153 -1.255
ENSG00000131069 E021 0.8259751 0.1980621011 6.979654e-01   20 34893569 34893622 54 + 0.178 0.262 0.706
ENSG00000131069 E022 0.5227326 0.3728795385 8.635796e-01   20 34908716 34908903 188 + 0.179 0.152 -0.281
ENSG00000131069 E023 3.1454604 0.0182207220 5.961176e-01 0.7677889058 20 34908905 34908943 39 + 0.656 0.566 -0.398
ENSG00000131069 E024 0.7906259 0.1829328740 6.837569e-01   20 34913093 34913095 3 + 0.176 0.262 0.725
ENSG00000131069 E025 104.2182079 0.0004635164 1.352661e-01 0.3401519220 20 34913096 34913181 86 + 2.024 1.965 -0.200
ENSG00000131069 E026 62.7001369 0.0007713882 4.289377e-02 0.1622645867 20 34913182 34913187 6 + 1.836 1.736 -0.338
ENSG00000131069 E027 0.2027342 0.0386127823 1.000000e+00   20 34913188 34913188 1 + 0.001 0.082 6.852
ENSG00000131069 E028 81.2780653 0.0075722394 1.169604e-01 0.3107553201 20 34913393 34913440 48 + 1.941 1.848 -0.313
ENSG00000131069 E029 72.6310067 0.0032697319 6.018415e-01 0.7713874613 20 34913441 34913496 56 + 1.849 1.817 -0.108
ENSG00000131069 E030 0.6238610 0.0193874923 3.909156e-01   20 34913497 34913503 7 + 0.303 0.150 -1.287
ENSG00000131069 E031 87.9753179 0.0112094190 9.709759e-01 0.9873372056 20 34913753 34913825 73 + 1.911 1.906 -0.017
ENSG00000131069 E032 2.7945498 0.3600578323 2.208771e-01 0.4545071259 20 34913854 34913902 49 + 0.703 0.462 -1.091
ENSG00000131069 E033 5.2646620 0.2003517254 1.612865e-01 0.3786706925 20 34913903 34914095 193 + 0.935 0.650 -1.133
ENSG00000131069 E034 67.1006625 0.0030356162 7.417885e-01 0.8615233778 20 34914096 34914117 22 + 1.785 1.798 0.044
ENSG00000131069 E035 68.7750496 0.0007998567 6.814418e-01 0.8235742641 20 34914118 34914171 54 + 1.820 1.796 -0.080
ENSG00000131069 E036 93.3213742 0.0052908467 4.631067e-01 0.6752515220 20 34914323 34914437 115 + 1.965 1.920 -0.150
ENSG00000131069 E037 0.0000000       20 34915218 34915256 39 +      
ENSG00000131069 E038 129.6142348 0.0003824495 3.612309e-01 0.5967096604 20 34919435 34919572 138 + 2.100 2.065 -0.117
ENSG00000131069 E039 0.3503582 0.0330848768 5.232984e-01   20 34920532 34920538 7 + 0.177 0.082 -1.286
ENSG00000131069 E040 149.0894976 0.0022154810 8.428839e-01 0.9210841320 20 34920539 34920709 171 + 2.144 2.132 -0.041
ENSG00000131069 E041 8.0929135 0.4173545707 1.272932e-01 0.3275648031 20 34920949 34921005 57 + 1.116 0.808 -1.155
ENSG00000131069 E042 149.3210158 0.0003859900 3.105234e-01 0.5510000340 20 34921006 34921139 134 + 2.163 2.127 -0.121
ENSG00000131069 E043 140.5257456 0.0044071482 7.435739e-01 0.8626973844 20 34921330 34921462 133 + 2.124 2.101 -0.076
ENSG00000131069 E044 95.6690932 0.0004626429 1.072317e-01 0.2944022660 20 34921544 34921600 57 + 1.898 1.958 0.203
ENSG00000131069 E045 3.4148266 0.1494157056 4.654872e-01 0.6769291544 20 34921648 34921785 138 + 0.701 0.569 -0.571
ENSG00000131069 E046 107.8981886 0.0003998408 4.867209e-02 0.1765219678 20 34921786 34921866 81 + 1.945 2.015 0.236
ENSG00000131069 E047 7.8111547 0.0159512982 3.261596e-02 0.1350203533 20 34921963 34922366 404 + 1.082 0.805 -1.039
ENSG00000131069 E048 10.9547345 0.0032811068 2.976079e-05 0.0005360699 20 34922842 34923322 481 + 1.293 0.869 -1.542
ENSG00000131069 E049 122.8247603 0.0004635123 3.309004e-01 0.5698087888 20 34923323 34923431 109 + 2.027 2.056 0.099
ENSG00000131069 E050 98.1313485 0.0003942483 2.194555e-01 0.4527722341 20 34925698 34925766 69 + 1.922 1.966 0.147
ENSG00000131069 E051 148.4011210 0.0085704022 6.712837e-01 0.8171473784 20 34926105 34926281 177 + 2.152 2.122 -0.101
ENSG00000131069 E052 126.9687103 0.0225520925 6.615426e-01 0.8108167282 20 34926877 34926951 75 + 2.098 2.048 -0.166
ENSG00000131069 E053 418.6771650 0.0016226498 4.112706e-01 0.6370172357 20 34927087 34927962 876 + 2.569 2.582 0.045