ENSG00000130939

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253251 ENSG00000130939 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE4B protein_coding protein_coding 22.98575 26.41373 23.18676 4.284568 1.0625 -0.187911 12.8600030 16.155770 16.891321 2.650224 1.4783240 0.06419374 0.57527917 0.6120333 0.72730000 0.11526667 0.477018570 0.009671271 FALSE TRUE
ENST00000343090 ENSG00000130939 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE4B protein_coding protein_coding 22.98575 26.41373 23.18676 4.284568 1.0625 -0.187911 3.6517975 4.352197 2.488438 1.092429 0.2624234 -0.80402857 0.15318333 0.1588667 0.10673333 -0.05213333 0.392191755 0.009671271 FALSE TRUE
ENST00000487244 ENSG00000130939 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE4B protein_coding retained_intron 22.98575 26.41373 23.18676 4.284568 1.0625 -0.187911 4.7463506 5.187040 1.352421 0.762819 0.4760393 -1.93151733 0.19009167 0.1989333 0.05726667 -0.14166667 0.009671271 0.009671271 FALSE TRUE
MSTRG.272.1 ENSG00000130939 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE4B protein_coding   22.98575 26.41373 23.18676 4.284568 1.0625 -0.187911 0.9359097 0.000000 1.652478 0.000000 1.0082268 7.37719104 0.04594583 0.0000000 0.07443333 0.07443333 0.295970161 0.009671271 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000130939 E001 0.4702677 0.0217681645 4.502583e-01   1 10032832 10032957 126 + 0.234 0.111 -1.289
ENSG00000130939 E002 122.8280235 0.0020921157 9.460386e-02 2.722682e-01 1 10032958 10033273 316 + 2.122 2.064 -0.195
ENSG00000130939 E003 92.4806174 0.0085149291 1.704753e-01 3.910767e-01 1 10033274 10033297 24 + 2.009 1.933 -0.258
ENSG00000130939 E004 124.6824857 0.0013507356 8.923279e-05 1.358352e-03 1 10033298 10033358 61 + 2.166 2.032 -0.450
ENSG00000130939 E005 215.2594069 0.0002957925 1.347330e-04 1.917275e-03 1 10033359 10033577 219 + 2.377 2.289 -0.294
ENSG00000130939 E006 145.1553558 0.0017177946 2.717170e-03 2.166884e-02 1 10033578 10033694 117 + 2.211 2.114 -0.324
ENSG00000130939 E007 200.9002561 0.0002302217 2.977980e-06 7.389385e-05 1 10072028 10072214 187 + 2.360 2.249 -0.371
ENSG00000130939 E008 1.6482012 0.0157986280 7.664663e-01 8.764931e-01 1 10072454 10073118 665 + 0.384 0.440 0.304
ENSG00000130939 E009 217.3167118 0.0010987163 2.781775e-08 1.181024e-06 1 10095461 10095596 136 + 2.412 2.262 -0.500
ENSG00000130939 E010 0.8924920 0.0334945044 5.071144e-01   1 10100861 10101107 247 + 0.316 0.200 -0.869
ENSG00000130939 E011 164.3637968 0.0003722131 3.299437e-03 2.519199e-02 1 10101108 10101195 88 + 2.254 2.177 -0.256
ENSG00000130939 E012 167.9310319 0.0011629664 4.828096e-02 1.756545e-01 1 10102948 10103092 145 + 2.251 2.196 -0.186
ENSG00000130939 E013 0.1723744 0.0424264584 5.822063e-01   1 10103093 10103185 93 + 0.000 0.111 10.537
ENSG00000130939 E014 215.6710185 0.0038766638 2.381486e-01 4.744926e-01 1 10105516 10105744 229 + 2.355 2.313 -0.139
ENSG00000130939 E015 16.6705515 0.0024103947 9.329209e-01 9.685908e-01 1 10106197 10106583 387 + 1.249 1.247 -0.006
ENSG00000130939 E016 3.1180740 0.0074823028 4.174944e-02 1.592754e-01 1 10107222 10107374 153 + 0.751 0.440 -1.401
ENSG00000130939 E017 139.1572289 0.0063432572 4.012336e-01 6.293231e-01 1 10117459 10117600 142 + 2.161 2.128 -0.110
ENSG00000130939 E018 129.5437091 0.0014508949 7.698124e-01 8.785518e-01 1 10119513 10119613 101 + 2.111 2.107 -0.014
ENSG00000130939 E019 119.2074940 0.0004461132 1.701373e-01 3.906432e-01 1 10121962 10122041 80 + 2.096 2.056 -0.131
ENSG00000130939 E020 94.0002624 0.0005392594 2.462943e-02 1.110666e-01 1 10122042 10122076 35 + 2.012 1.935 -0.260
ENSG00000130939 E021 151.6746692 0.0021066584 5.418707e-02 1.895147e-01 1 10126794 10126877 84 + 2.210 2.148 -0.208
ENSG00000130939 E022 1.5675893 0.0216158832 7.401146e-01 8.604991e-01 1 10128339 10129391 1053 + 0.444 0.391 -0.285
ENSG00000130939 E023 132.9002193 0.0003561106 1.375955e-01 3.438481e-01 1 10129392 10129448 57 + 2.144 2.104 -0.133
ENSG00000130939 E024 157.1024808 0.0033367551 3.734092e-01 6.068409e-01 1 10130500 10130616 117 + 2.208 2.179 -0.096
ENSG00000130939 E025 125.3155014 0.0004432159 5.320772e-01 7.235082e-01 1 10130715 10130813 99 + 2.103 2.089 -0.047
ENSG00000130939 E026 116.8457622 0.0003428522 8.593935e-01 9.300243e-01 1 10132369 10132482 114 + 2.059 2.072 0.042
ENSG00000130939 E027 206.0523084 0.0052668127 3.913922e-01 6.215321e-01 1 10134988 10135186 199 + 2.331 2.299 -0.106
ENSG00000130939 E028 180.1715284 0.0002563661 9.254003e-01 9.648705e-01 1 10137067 10137205 139 + 2.252 2.256 0.014
ENSG00000130939 E029 149.8904028 0.0003076024 9.321441e-01 9.682200e-01 1 10144940 10145039 100 + 2.173 2.177 0.015
ENSG00000130939 E030 2.8616191 0.0079411064 9.845416e-01 9.941125e-01 1 10145040 10145599 560 + 0.585 0.593 0.035
ENSG00000130939 E031 147.1238002 0.0003976756 4.832789e-01 6.892863e-01 1 10146963 10147090 128 + 2.174 2.160 -0.046
ENSG00000130939 E032 126.2856834 0.0048664111 6.325487e-01 7.920233e-01 1 10149184 10149282 99 + 2.105 2.097 -0.028
ENSG00000130939 E033 264.9277743 0.0025557368 8.643011e-01 9.327686e-01 1 10151326 10151561 236 + 2.418 2.420 0.007
ENSG00000130939 E034 0.5363366 0.0241269552 1.225123e-01   1 10158354 10158355 2 + 0.000 0.274 12.402
ENSG00000130939 E035 242.0564992 0.0002141461 9.320519e-01 9.681502e-01 1 10158356 10158482 127 + 2.378 2.382 0.015
ENSG00000130939 E036 251.1404579 0.0005958343 7.426453e-02 2.332888e-01 1 10161142 10161286 145 + 2.366 2.418 0.172
ENSG00000130939 E037 0.2852693 0.3038278743 2.210185e-01   1 10166244 10166342 99 + 0.230 0.000 -11.414
ENSG00000130939 E038 222.6812208 0.0012544582 1.530356e-02 7.921692e-02 1 10168136 10168270 135 + 2.301 2.379 0.259
ENSG00000130939 E039 8.7999144 0.2623436590 9.353279e-01 9.698388e-01 1 10170956 10171137 182 + 0.988 0.993 0.018
ENSG00000130939 E040 278.5489242 0.0035872446 3.973238e-02 1.540378e-01 1 10171138 10171329 192 + 2.398 2.478 0.267
ENSG00000130939 E041 229.0416347 0.0019819267 1.230051e-02 6.763944e-02 1 10178644 10178818 175 + 2.310 2.398 0.291
ENSG00000130939 E042 1.2676005 0.1200293215 9.103265e-01   1 10179016 10179167 152 + 0.318 0.341 0.149
ENSG00000130939 E043 221.9603417 0.0032626385 8.561066e-03 5.188035e-02 1 10179416 10179562 147 + 2.286 2.391 0.349
ENSG00000130939 E044 231.2397819 0.0009531141 4.831854e-05 8.076905e-04 1 10179895 10180003 109 + 2.295 2.414 0.395
ENSG00000130939 E045 755.3929118 0.0008345695 1.922345e-15 3.097328e-13 1 10180004 10181175 1172 + 2.786 2.936 0.498
ENSG00000130939 E046 31.6767677 0.0111234993 9.417450e-05 1.422105e-03 1 10181176 10181239 64 + 1.290 1.631 1.174