ENSG00000130830

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369534 ENSG00000130830 HEK293_OSMI2_6hA HEK293_TMG_6hB MPP1 protein_coding protein_coding 30.18507 34.377 23.64015 3.8421 0.5926172 -0.5400138 25.7877821 30.68545 16.970478 4.832603 0.7083909 -0.8541477 0.83779583 0.8821333 0.7195667 -0.1625667 2.428924e-01 1.553736e-16 FALSE TRUE
ENST00000393529 ENSG00000130830 HEK293_OSMI2_6hA HEK293_TMG_6hB MPP1 protein_coding protein_coding 30.18507 34.377 23.64015 3.8421 0.5926172 -0.5400138 0.4794155 0.00000 1.995841 0.000000 0.3869799 7.6480636 0.02015833 0.0000000 0.0837000 0.0837000 1.553736e-16 1.553736e-16 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000130830 E001 1.6898272 0.0112132333 0.304808028 0.54538324 X 154778684 154778685 2 - 0.283 0.483 1.153
ENSG00000130830 E002 11.2116909 0.0710769431 0.154712811 0.36901261 X 154778686 154778722 37 - 0.890 1.129 0.881
ENSG00000130830 E003 14.7284383 0.1588535763 0.235258138 0.47119549 X 154778723 154778725 3 - 1.029 1.229 0.715
ENSG00000130830 E004 272.9246314 1.3525091317 0.449329568 0.66527603 X 154778726 154779152 427 - 2.243 2.472 0.762
ENSG00000130830 E005 220.2023137 1.2692839022 0.433663104 0.65401461 X 154779153 154779353 201 - 2.148 2.380 0.774
ENSG00000130830 E006 170.5108831 0.0055576155 0.042933649 0.16236407 X 154781239 154781313 75 - 2.131 2.239 0.362
ENSG00000130830 E007 2.6581448 0.1246531357 0.120535178 0.31667150 X 154781314 154781596 283 - 0.712 0.417 -1.366
ENSG00000130830 E008 244.1606342 0.0002845621 0.052853174 0.18636058 X 154781600 154781753 154 - 2.315 2.381 0.221
ENSG00000130830 E009 158.1866368 0.0003706630 0.258820320 0.49766753 X 154781754 154781802 49 - 2.136 2.189 0.176
ENSG00000130830 E010 39.0992783 0.1926910081 0.024060816 0.10927101 X 154781803 154782708 906 - 1.817 1.383 -1.479
ENSG00000130830 E011 19.6401331 0.3008202367 0.043532235 0.16393052 X 154782709 154783376 668 - 1.526 1.098 -1.499
ENSG00000130830 E012 2.9592311 0.0080594863 0.046985477 0.17251983 X 154783377 154783426 50 - 0.747 0.450 -1.335
ENSG00000130830 E013 174.1037772 0.0004547667 0.563105190 0.74549626 X 154783427 154783507 81 - 2.191 2.227 0.120
ENSG00000130830 E014 14.1406560 0.0388920360 0.017732402 0.08812131 X 154783653 154784027 375 - 1.325 1.041 -1.012
ENSG00000130830 E015 98.0747215 0.0017059216 0.131985316 0.33494272 X 154784028 154784030 3 - 1.997 1.954 -0.143
ENSG00000130830 E016 151.5437506 0.0004326375 0.455863544 0.67015045 X 154784031 154784108 78 - 2.159 2.154 -0.015
ENSG00000130830 E017 9.4415355 0.2666433641 0.589151774 0.76308219 X 154784701 154785050 350 - 1.031 0.971 -0.220
ENSG00000130830 E018 92.8581665 0.0004600901 0.759253914 0.87209218 X 154785051 154785056 6 - 1.924 1.955 0.102
ENSG00000130830 E019 137.0952257 0.0005064894 0.051110216 0.18233198 X 154785057 154785083 27 - 2.056 2.140 0.281
ENSG00000130830 E020 176.3486365 0.0002462148 0.090377091 0.26445842 X 154785084 154785157 74 - 2.175 2.242 0.224
ENSG00000130830 E021 111.3727615 0.0003679389 0.304750233 0.54534878 X 154786204 154786213 10 - 1.984 2.039 0.185
ENSG00000130830 E022 234.6394324 0.0002466232 0.286426427 0.52709378 X 154786214 154786340 127 - 2.348 2.341 -0.026
ENSG00000130830 E023 124.1474942 0.0003709845 0.084047852 0.25286846 X 154786341 154786365 25 - 2.095 2.055 -0.133
ENSG00000130830 E024 136.2803222 0.0018835929 0.067978759 0.22054907 X 154786366 154786400 35 - 2.140 2.092 -0.162
ENSG00000130830 E025 140.1236929 0.0056502677 0.078130814 0.24108459 X 154789954 154789988 35 - 2.161 2.100 -0.205
ENSG00000130830 E026 139.2159281 0.0003961186 0.002353898 0.01940232 X 154789989 154790022 34 - 2.168 2.090 -0.261
ENSG00000130830 E027 166.4036086 0.0003039377 0.018957383 0.09229666 X 154790983 154791068 86 - 2.228 2.178 -0.165
ENSG00000130830 E028 0.4341107 0.0222744292 0.276454114   X 154791069 154791195 127 - 0.000 0.225 11.049
ENSG00000130830 E029 2.3278080 0.0096898601 0.003271066 0.02501820 X 154791631 154791768 138 - 0.747 0.281 -2.335
ENSG00000130830 E030 157.3628406 0.0008925442 0.014011122 0.07438448 X 154791769 154791847 79 - 2.210 2.149 -0.201
ENSG00000130830 E031 126.5876344 0.0027108824 0.087459928 0.25904680 X 154792142 154792192 51 - 2.112 2.063 -0.164
ENSG00000130830 E032 146.0664111 0.0068664498 0.134687728 0.33920207 X 154792193 154792285 93 - 2.176 2.124 -0.177
ENSG00000130830 E033 0.1723744 0.0392515598 1.000000000   X 154792286 154792422 137 - 0.000 0.089 9.470
ENSG00000130830 E034 0.3503582 0.0394730371 0.588614616   X 154799745 154799893 149 - 0.164 0.089 -1.016
ENSG00000130830 E035 1.0697382 0.0197475943 0.563121171   X 154804697 154804827 131 - 0.376 0.280 -0.602
ENSG00000130830 E036 136.2605347 0.0037423673 0.167547803 0.38733952 X 154805272 154805527 256 - 2.136 2.099 -0.127
ENSG00000130830 E037 0.0000000       X 154820974 154821007 34 -